Volume 45 Issue 1
Jan.  2024
Turn off MathJax
Article Contents
Songqin LYU, Shan HUANG, Litang MA, Xiu WANG, Hongtao ZHANG, Qin LI, Chunping WAN, Zhengchao LYU. The Investigation and Analysis of the Situation of COVID-19 Vaccination and Vaccination Willingness in HIV/AIDS Population in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(1): 48-54. doi: 10.12259/j.issn.2095-610X.S20240108
Citation: Songqin LYU, Shan HUANG, Litang MA, Xiu WANG, Hongtao ZHANG, Qin LI, Chunping WAN, Zhengchao LYU. The Investigation and Analysis of the Situation of COVID-19 Vaccination and Vaccination Willingness in HIV/AIDS Population in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(1): 48-54. doi: 10.12259/j.issn.2095-610X.S20240108

The Investigation and Analysis of the Situation of COVID-19 Vaccination and Vaccination Willingness in HIV/AIDS Population in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20240108
  • Received Date: 2023-10-26
    Available Online: 2024-01-05
  • Publish Date: 2024-01-25
  •   Objective  To investigate the vaccination status and vaccination willingness of novel coronavirus in HIV/AIDS population in Yunnan.   Methods   From October 2021 to June 2022, a questionnaire survey was conducted among 2180 HIV/AIDS patients in Kunming, Qujing, Yuxi, Zhaotong, Puer, Baoshan, Lincang, Honghe, Wenshan, Xishuangbanna, Dali, Dehong and Nujiang prefectures. The questionnaire included age, sex, education, nationality, education level, vaccination, adverse reactions within 7 days after the vaccination, safety of COVID-19 vaccine, awareness of effectiveness, vaccination willingness and so on.   Results   Among the subjects, 2109 completed 3 injections, accounting for 96.74%, and 71 were not vaccinated, accounting for 3.26%. Within 7 days of inoculation, local adverse reactions occurred in 116 cases, accounting for 5.50%, and systemic adverse reactions occurred in 56 cases, accounting for 2.66%. Injection site pain, fatigue and muscle pain accounted for the highest proportion of adverse symptoms in different sex, age and the Han nationality, while the proportion of minority adverse reactions was very low, and there was no difference among the different sex and age (P > 0.05). The main reasons for the reluctance of HIV/AIDS population to be vaccinated were(recommended by doctors) that HIV/AIDS patients could not be vaccinated (67.61%) and may have serious adverse reactions after the vaccination (19.72%). The factors affecting the vaccination were found by logistic regression analysis, whether they were worried about infecting novel coronavirus (OR = 0.121, 95%CI = 0.083~0.640, P < 0.001) and how much they knew about COVID-19 vaccine (OR = 28.932, 95%CI = 15.469~54.115, P < 0.001), safety of vaccination(OR = 13.953, 95%CI = 4.819~40.404, P < 0.001) and belief in the preventive effect of vaccine (OR = 14.017, 95%CI = 4.752~41.348, P < 0.001) were significant factors affecting vaccination. Among the 13 prefectures and cities, Dehong (20), Zhaotong (21) and Lincang (14) had the largest number of unvaccinated people.   Conclusion   After the mass vaccination, the rate of adverse reaction in HIV/AIDS population is low, the symptoms are mild, the correct and scientific advice and guidance from doctors and the full understanding of the harmfulness of the disease, the safety, prevention and effectiveness of the vaccine are the key to complete vaccination and put an end to vaccine hesitancy.
  • loading
  • [1]
    Ryan J, Malinga T. Interventions for vaccine hesitancy[J]. Curr Opin Immunol, 2021, 71(期号?): 89-91.

    Kelso J M. The adverse reactions to vaccines practice parameter 10 years on-what have we learned?[J]. Ann Allergy Asthma Immunol,2022,129(1):35-39.
    [2]
    Wibawa T. COVID-19 vaccine research and development: Ethical issues[J]. Trop Med Int Health,2021,26(1):14-19. doi: 10.1111/tmi.13503
    [3]
    王珞,范俊平,徐燕,等. 新型冠状病毒疫苗的研发现状与挑战[J]. 中华结核和呼吸杂志,2021,44(5):492-496.
    [4]
    廖聪慧,王子晨,邓强,等. COVID-19疫苗上市后安全性及有效性的研究进展[J]. 暨南大学学报(自然科学与医学版),2021,42(5):547-556. doi: 10.11778/j.jdxb.2021.05.011
    [5]
    Polack F P,Thomas S J,Kitchin N,et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine[J]. N Engl J Med,2020,383(27):2603-2615. doi: 10.1056/NEJMoa2034577
    [6]
    Fiolet T,Kherabi Y,MacDonald CJ,et al. Comparing COVID-19 vaccines for their characteristics,efficacy and effectiveness against SARS-CoV-2 and variants of concern: A narrative review[J]. Clin Microbiol Infect,2022,28(2):202-221. doi: 10.1016/j.cmi.2021.10.005
    [7]
    World Health Organization. Coronavirus (COVID-19) dashboard[EB/OL]. (2022-11-28)[2022 -11-28]. https://covid19.who.int/.
    [8]
    Xia S,Duan K,Zhang Y,et al. Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: Interim analysis of 2 randomized clinical trials[J]. JAMA,2020,324(10):951-960. doi: 10.1001/jama.2020.15543
    [9]
    Hippisley-Cox J,Coupland CA,Mehta N,et al. Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study[J]. BMJ,2021,374(5):n2244.
    [10]
    麦迪娜·金格斯,郑碧芸,尹平. 新型冠状病毒疫苗Ⅲ期临床试验及真实世界研究[J]. 医药导报,2021,40(9):1159-1168.
    [11]
    Li M,Wang H,Tian L,et al. COVID-19 vaccine development: Milestones,lessons and prospects[J]. Signal Transduct Target Ther,2022,7(1):146. doi: 10.1038/s41392-022-00996-y
    [12]
    Meo SA,Bukhari IA,Akram J,et al. COVID-19 vaccines: Comparison of biological,pharmacological characteristics and adverse effects of Pfizer/BioNTech and moderna vaccines[J]. Eur Rev Med Pharmacol Sci,2021,25(3):1663-1669.
    [13]
    Yamamoto K. Adverse effects of COVID-19 vaccines and measures to prevent them[J]. Virol J,2022,19(1):100. doi: 10.1186/s12985-022-01831-0
    [14]
    杨惠洁,孙誉芳,王军志,等. 新型冠状病毒肺炎疫苗有效性和安全性概述[J]. 中国新药杂志,2022,31(21):2082-2089.
    [15]
    Chen Y,Xu Z,Wang P,et al. New-onset autoimmune phenomena post-COVID-19 vaccination[J]. Immunology,2022,165(4):386-401. doi: 10.1111/imm.13443
    [16]
    Guo M,Liu X,Chen X,et al. Insights into new-onset autoimmune diseases after COVID-19 vaccination[J]. Autoimmun Rev,2023,22(7):103340. doi: 10.1016/j.autrev.2023.103340
    [17]
    Gao Y,Yang X,Chen H,et al. A pangenome reference of 36 Chinese populations[J]. Nature,2023,619(7968):112-121. doi: 10.1038/s41586-023-06173-7
    [18]
    苏品璨, 何知航, 纪欣, 等. 云南九个少数民族HLA/KIR配受体对研究[C]//云南省环境科学学会, 云南省林学会, 生物多样性研究. 云南出版集团, 2021: 9.
    [19]
    张志丹. 云南四种少数民族G6PD基因罕见突变致病性研究[D]. 北京: 北京协和医学院硕士学位论文, 2022.
    [20]
    张信辉,孙永根,李小英,等. PIMA T淋巴细胞分析仪在少数民族地区健康人外周血CD4+T淋巴细胞正常参考值的建立[J]. 中国艾滋病性病,2018,24(11):1085-1087,1096.
    [21]
    Kricorian K,Civen R,Equils O. COVID-19 vaccine hesitancy: Misinformation and perceptions of vaccine safety[J]. Hum Vaccin Immunother,2022,18(1):1950504. doi: 10.1080/21645515.2021.1950504
    [22]
    Wiysonge CS,Ndwandwe D,Ryan J,et al. Vaccine hesitancy in the era of COVID-19: Could lessons from the past help in divining the future?[J]. Hum Vaccin Immunother,2022,18(1):1-3.
    [23]
    Lee W S,Wheatley A K,Kent S J,et al. Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies[J]. Nat Microbiol,2020,5(10):1185-1191. doi: 10.1038/s41564-020-00789-5
    [24]
    Vinhaes CL,Araujo-Pereira M,Tibúrcio R,et al. Systemic inflammation associated with immune reconstitution inflammatory syndrome in persons living with HIV[J]. Life (Basel),2021,11(1):65. doi: 10.3390/life11010065
    [25]
    Giacomelli A,Pezzati L,Rusconi S. The crosstalk between antiretrovirals pharmacology and HIV drug resistance[J]. Expert Rev Clin Pharmacol,2020,13(7):739-760. doi: 10.1080/17512433.2020.1782737
  • Relative Articles

    [1] Haiping HE. Analysis of Coagulation Function Indexes in Elderly Patients with Novel Coronavirus Pneumonia. Journal of Kunming Medical University, 2024, 45(4): 99-104.  doi: 10.12259/j.issn.2095-610X.S20240414
    [2] Zhen XU, Yu LING, Sixiang LIU, Yu SONG, Yang PENG, Jingjing SUN. Adverse Reactions of Vaccine Vaccination in Children with Special Health Conditions in Kunming and Countermeasures. Journal of Kunming Medical University, 2024, 45(3): 141-145.  doi: 10.12259/j.issn.2095-610X.S20240321
    [3] Xiaomei JIN, Jieyan HE, Jichang SHI, Hui XING, Hong WANG, Ju ZHANG, Lijuan DONG, Lihua HUANG, Min CHEN, Zhijuan CHEN, Huichao CHEN. Virus Genotypes and Drug Resistance among HIV/AIDS Patients before Antiretroviral Therapy in Dali Bai Autonomous Prefecture in 2018. Journal of Kunming Medical University, 2023, 44(11): 152-157.  doi: 10.12259/j.issn.2095-610X.S20231123
    [4] Yuhan SHI, Jing LI, Shuyuan LIU, Ting ZHAO, Jingsi YANG, Li SHI, Jiangli LIANG. Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine. Journal of Kunming Medical University, 2023, 44(7): 22-28.  doi: 10.12259/j.issn.2095-610X.S20230711
    [5] Shunqi SONG, Hongchao JIANG, Yunchao MA, Xingxing FENG, Tingyi DU, Hongfang ZHANG. Clinical Characteristics of 131 Children with Hand,Foot,and Mouth Disease Infected with EV71 and Preventive Effect of EV71 Vaccination. Journal of Kunming Medical University, 2023, 44(12): 139-143.  doi: 10.12259/j.issn.2095-610X.S20231222
    [6] Jiawei DING, Jia WANG, Shu YANG, Sulian CHEN, Jing LI. Analysis of HPV Detection in 18 449 Hospital Patients in Kunming and HPV Vaccination Recommendations. Journal of Kunming Medical University, 2023, 44(3): 81-86.  doi: 10.12259/j.issn.2095-610X.S20230302
    [7] Ying HUANG, Yun LUO, Yan WU, Bing LIU, Shan JIANG, Hua HE. The Regularity and Clinical Manifestations of Throat Swab and Fecal Detoxification in New Coronavirus Infected Patients. Journal of Kunming Medical University, 2022, 43(1): 96-101.  doi: 10.12259/j.issn.2095-610X.S20220112
    [8] Hanqing ZHAO, Shibing QIAN, Mengqi WANG, Rongyu YANG, Kaiwen DUAN. Oral Lesions Associated with 2019-nCoV. Journal of Kunming Medical University, 2022, 43(8): 156-160.  doi: 10.12259/j.issn.2095-610X.S20220831
    [9] Li WU, Yun-hui YANG, Jing ZHANG, Zhang-cong YANG, Yu SU, Yong-jian WEN, Yu-chun WU, Peng WANG, Zhi-peng LI, Wei ZHAO, Dan HAN, Rui-dong WANG, Bo HE. The Correlation between the Imaging Characteristics of Imported COVID-19 at First Diagnosis and Clinical Severity Grading. Journal of Kunming Medical University, 2021, 42(7): 49-56.  doi: 10.12259/j.issn.2095-610X.S20210708
    [10] Huan LI, Qiu-yue XU, Yun-juan WANG, Yang SU, Rui-zhu TANG. The Rapid Detection of Nucleic Acid in SARS-CoV-2 by Reverse Transcription Loop Mediated Isothermal Amplification. Journal of Kunming Medical University, 2021, 42(9): 25-31.  doi: 10.12259/j.issn.2095-610X.S20210904
    [11] Yun-hui YANG, Bo HE, Ding-yun YOU, Jun-tao YANG, Qian GAO. Applications of CT in the Early Prediction of Different Clinical Types of COVID -19 Pneumonia. Journal of Kunming Medical University, 2021, 42(5): 131-137.  doi: 10.12259/j.issn.2095-610X.S20210524
    [12] Yuan Yu , Li Xiang . . Journal of Kunming Medical University, 2020, 41(04): 1-5.
    [13] Gu Li Ming , Zeng Yong , Chen Jun Hui , Wang Fu Ping , Hao Ying Lu , Wu Hai Ying , Ruan Ji Yin , Li Yan Jiao , Chen Yun , Xia Jing , Sun Jia , Hu Juan Yuan , Li Wei , Yu Cong Tao , Ma Chao Xia , Qian Chuan Yun , Hu Min . . Journal of Kunming Medical University, 2020, 41(03): 96-100.
    [14] Ye Wen Jun , Wang Rui Hang , Zeng Xiao Ju , Liu Wei Qing , Liu Fang . . Journal of Kunming Medical University, 2020, 41(02): 137-140.
    [15] Ma Xue Ting , Li Ya . The Analysis of T Lymphocyte Subset Among Newly-discovered HIV Infectors and Patients. Journal of Kunming Medical University, 2017, 38(11): 112-117.
    [16] Sun Li Li . Research Progress of Rotavirus and Rotavirus Vaccine. Journal of Kunming Medical University,
    [17] Qiao Jian Bin . . Journal of Kunming Medical University,
    [18] Zhou Gui . . Journal of Kunming Medical University,
    [19] . Clinical Results of 232 Treatment-naive HIV/AIDS Patients after HAART. Journal of Kunming Medical University,
    [20] Zhu Xing Bao . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(5)

    Article Metrics

    Article views (1322) PDF downloads(9) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return