Advances in Epigenetic Regulatory Mechanisms in HSV1 Infection

Changjing WU; Yufang ZOU; Xinwei HUANG

doi:10.12259/j.issn.2095-610X.S20240129

Volume 45 Issue 1

Jan. 2024

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Changjing WU, Yufang ZOU, Xinwei HUANG. Advances in Epigenetic Regulatory Mechanisms in HSV1 Infection[J]. Journal of Kunming Medical University, 2024, 45(1): 172-178. doi: 10.12259/j.issn.2095-610X.S20240129

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Advances in Epigenetic Regulatory Mechanisms in HSV1 Infection

doi: 10.12259/j.issn.2095-610X.S20240129

1.
Central Laboratory，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650033，China

Received Date: 2023-09-01
Available Online: 2023-12-21
Publish Date: 2024-01-25

Abstract

Abstract

Herpes simplex viruses type 1（HSV1） is among the most ubiquitous human pathogens that cause a wide variety of disease states. The latent infection of the central nervous system and sporadically reactivation is the central part of HSV1 pathogenesis, which also brings challenges to antiviral therapies. At present, the mechanism of establishing, maintaining and reactivation of HSV1 has not been fully clarified, whereas it has been generally accepted that the epigenetic regulation may play an important role. Accumulating researches have also indicated that the lytic and latent viral genomes exhibit the different chromatin structures, and the accumulation of diverse post-translational modifies the histones endow viral genes with transcriptional activation or repression features. In addition, the latency-associate transcripts of virus may also participate in the genome epigenetic modification. In this review, we summarize the research progress of epigenetic regulation of HSV1 and highlight the critical role of chromatin remodeling in HSV1 lytic proliferation and establishment of latent infection.
- Herpes simplex virus type 1,
- Latency associated transcripts,
- Epigenetic regulation,
- Post-translational modifications of histone

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References

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