A Two-sample Mendelian Randomization Study of Oily Nut Intake and Primary Lung Cancer

Xueyun GUO; Na LI; Guozhong TAO; Zheng HUANG

doi:10.12259/j.issn.2095-610X.S20240606

Volume 45 Issue 6

Jul. 2024

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Xueyun GUO, Na LI, Guozhong TAO, Zheng HUANG. A Two-sample Mendelian Randomization Study of Oily Nut Intake and Primary Lung Cancer[J]. Journal of Kunming Medical University, 2024, 45(6): 44-50. doi: 10.12259/j.issn.2095-610X.S20240606

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Xueyun GUO, Na LI, Guozhong TAO, Zheng HUANG. A Two-sample Mendelian Randomization Study of Oily Nut Intake and Primary Lung Cancer[J]. Journal of Kunming Medical University, 2024, 45(6): 44-50. doi: 10.12259/j.issn.2095-610X.S20240606

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A Two-sample Mendelian Randomization Study of Oily Nut Intake and Primary Lung Cancer

doi: 10.12259/j.issn.2095-610X.S20240606

1.
Dept. of Oncology
2.
Dept. of Infectious Diseases , Tianchang People’s Hospital，Tianchang Anhui 239321，China

Received Date: 2024-03-10
Available Online: 2024-05-11
Publish Date: 2024-06-25

Abstract

Abstract

Objective To investigate the potential causal relationship between oily nut consumption and primary lung cancer by two-sample Mendelian randomization method. Methods Single nucleotide polymorp hisms （P < 5×10^-7） associated with oily nut intake were screened from the openGWAS public database of genome - wide association study as instrumental variables. The inverse variance weighting method was the main analysis method to evaluate the causal effect of this study, and MR-Egger regression and weighted median method were used to supplement the explanation. OR value and 95%CI were used to evaluate whether there was a causal relationship between oily nut intake and primary lung cancer. The mr_pleiotropy_test and MR-PRESSO were used to test the level pleiotropy, and the leave-one-out method was used to test the sensitivity. Results A total of 100 SNPs were extracted from the ukb-b-16576 dataset as instrumental variables. The MR-Egger regression, weighted median, and inverse variance weighting methods yielded OR values and 95% confidence intervals [0.63, 95%CI （0.11-3.65）, P = 0.611], [0.34, 95%CI （0.19-0.61）, P = 0.001], [0.32, 95%CI （0.21-0.48）, P = 0.001], rerespectively. The mr_pleiotropy_test showed that the MR-Egger intercept was close to 0 （-7.66E-03） with a p-value of 0.441, indicating no significant horizontal pleiotropy. Similarly, the MR-PRESSO package GlobalTest yielded a p-value of 0.162, further confirming the absence of horizontal pleiotropy among the selected instrumental variables.After conducting the leave-one-out sensitivity analysis, no significant influence on the results was observed from any specific SNP locus, indicating that the results are highly stable and reliable. Conclusions The two-sample Mendelian randomization analysis revealed a negative causal relationship between oily nut intake and the risk of primary lung cancer. However, further verification is needed with larger sample sizes and data from individuals of different ethnic backgrounds to strengthen the findings.
- Oily nuts,
- Primary lung cancer,
- Mendel randomization,
- Causal inference

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References(21)

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