Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients

Yuanjia TAO; Yuqi CHENG; Hezhi YAN; Xiangyu SU; Xianyu CHEN; Hongyan JIANG

doi:10.12259/j.issn.2095-610X.S20240612

Volume 45 Issue 6

Jul. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(6): 94-99

Yuanjia TAO, Yuqi CHENG, Hezhi YAN, Xiangyu SU, Xianyu CHEN, Hongyan JIANG. Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients[J]. Journal of Kunming Medical University, 2024, 45(6): 94-99. doi: 10.12259/j.issn.2095-610X.S20240612

Citation:

Yuanjia TAO, Yuqi CHENG, Hezhi YAN, Xiangyu SU, Xianyu CHEN, Hongyan JIANG. Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients[J]. Journal of Kunming Medical University, 2024, 45(6): 94-99. doi: 10.12259/j.issn.2095-610X.S20240612

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Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients

doi: 10.12259/j.issn.2095-610X.S20240612

Dept.of Psychiatry，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650031，China

Received Date: 2024-02-27
Available Online: 2024-05-23
Publish Date: 2024-06-25

Abstract

Abstract

Objective To explore the influencing factors of cognitive impairment in elderly patients with depressive disorder. Methods 119 elderly patients with depression were recruited in the 1st Affiliated Hospital of Kunming Medical University. MoCA was used to evaluate the cognitive function of the patients, and a regression model was established to analyze the influencing factors of cognitive impairment in elderly patients with depression. Results Age had a significant effect on the total score of cognition, visuospatial ability, executive function and language function （P < 0.05）. The degree of anxiety had a significant effect on the total score of cognition, visuospatial ability, executive function, attention and working memory （P < 0.05）. Dyslipidemia had a statistically significant effect on the total score of cognition, visuospatial ability and executive function （P < 0.05）. The past medical history had a significant effect on the total score of cognition and language function （P < 0.05）. The sex, onset time, degree of depression, ApoE gene, occupation status and psychotic symptoms had statistically significant effects on individual cognitive function （P < 0.05）. Conclusion Patients with late-life depressive disorder have obvious cognitive impairment. Age, anxiety, dyslipidemia, and past medical history may be the risk factors for cognitive impairment in elderly patients with depressive disorder.
- Late-life depression,
- Cognitive impairment,
- ApoE gene

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References(20)

References

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