Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus

Li LI; Ruixian ZHANG

doi:10.12259/j.issn.2095-610X.S20240622

Volume 45 Issue 6

Jul. 2024

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Li LI, Ruixian ZHANG. Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(6): 161-165. doi: 10.12259/j.issn.2095-610X.S20240622

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Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus

doi: 10.12259/j.issn.2095-610X.S20240622

Li LI¹,
Ruixian ZHANG^{2
,
,}

1.
School of Public Health，Dali University，Dali Yunnan 671013
2.
Dept. of Disease Control and Prevention，The 1st People’s Hospital of Yunnan Province，Kunming Yunnan 650034，China

Received Date: 2023-09-22
Available Online: 2024-05-23
Publish Date: 2024-06-25

Abstract

Abstract

Circular RNA （circRNA）, formed by reverse splicing of pre-mRNA, constitutes a closed-loop RNA structure with diversity in molecular characteristics, biological functions, and regulatory mechanisms. In recent years, there has been growing recognition of the roles of circRNA in various human diseases, serving potentially as molecular biomarkers for disease diagnosis and prognosis prediction, including the classical autoimmune disease systemic lupus erythematosus （SLE）. Currently, dysregulated expression of some circRNAs has been observed in SLE, which can promote the occurrence and development of SLE through different mechanisms such as "molecular sponge" effects, modulation of signaling pathways, inhibition of protein kinase activation, and induction of cell apoptosis. Another part may serve as potential clinical biomarkers for SLE, holding translational potential. This paper reviews the research on circRNA in SLE over the past years, aiming to provide scientific evidence and references for subsequent studies on circRNA in SLE.
- Circular RNA,
- Systemic lupus erythematosus,
- Biomarkers,
- Molecular mechanisms

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References(34)

References

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