Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases

Feifei XIE; Yinzi XIN; Min XU; Jinghan LI; Wei WANG

doi:10.12259/j.issn.2095-610X.S20241001

Volume 45 Issue 10

Oct. 2024

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Feifei XIE, Yinzi XIN, Min XU, Jinghan LI, Wei WANG. Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases[J]. Journal of Kunming Medical University, 2024, 45(10): 1-7. doi: 10.12259/j.issn.2095-610X.S20241001

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Feifei XIE, Yinzi XIN, Min XU, Jinghan LI, Wei WANG. Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases[J]. Journal of Kunming Medical University, 2024, 45(10): 1-7. doi: 10.12259/j.issn.2095-610X.S20241001

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Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases

doi: 10.12259/j.issn.2095-610X.S20241001

Feifei XIE^{1, 2},
Yinzi XIN^{1, 2},
Min XU¹,
Jinghan LI^{1, 2},
Wei WANG^{1
,
,}

1.
Dept. of Orthodontics，School / Hospital of Stomatology Kunming Medical University，Kunming Yunnan 650106
2.
Yunnan Key Laboratory of Stomatology，Kunming Yunnan 650106，China

More Information

Corresponding author: 王伟，博士，主治医师，硕士研究生导师。担任云南省口腔正畸学专业住院医师规范化培训指导教师，口腔执业医师资格实践技能考试考官；中华口腔医学会第八届、第九届口腔正畸专业委员会青年委员，云南省口腔医学会第三届口腔正畸专业委员会委员兼秘书；世界正畸医师联盟（WFO）会员，国际牙科研究学会（IADR）会员。入选云南省“兴滇英才支持计划”青年人才。获云南省科技进步三等奖1项，授权专利1项。主持包括国家自然科学基金在内的3项国家及省厅级科研项目，第一作者发表SCI论文3篇。
Received Date: 2024-05-16
Available Online: 2024-10-12
Publish Date: 2024-10-31

Abstract

Abstract

The growth and disease progression of cartilage are highly complex, influenced by various growth factors, cytokines, and both internal and external environmental factors. This process is regulated by multiple intersecting biological signaling pathways. Consequently, the study of its molecular mechanisms is crucial for the development and treatment of cartilage-related diseases. Long non-coding RNAs （lncRNAs） are a class of regulatory non-coding RNAs with transcript lengths exceeding 200 nucleotides. They play a complex and precise role in biological development, gene expression and epigenetics, and are closely associated with the onset, progression and prevention of human diseases. In recent years, numerous lncRNAs related to cartilage growth and disease have been discovered. This article systematically reviews the classification, function and mechanisms of action of lncRNAs in cartilage development and disease. It reveals that various lncRNAs are involved in the onset and progression of cartilage growth and diseases. Regulating the expression of relevant lncRNAs can alleviate cartilage inflammation and slow disease progression. This paper aims to provide a scientific basis for basic research and clinical application of lncRNAs in cartilage growth and disease.
- Osteoarthritis,
- Long non-coding RNA,
- Regulation of genes,
- Cartilage growth and development,
- Cartilage diseases

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References(45)

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