Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function

Xinbang WANG; An HU; Xipeng ZHAO; Yan WANG; Wei DING; Lipeng CAO; Yu GU; Ke XU; Yunfeng ZHANG

doi:10.12259/j.issn.2095-610X.S20241015

Volume 45 Issue 10

Oct. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(10): 96-104

Xinbang WANG, An HU, Xipeng ZHAO, Yan WANG, Wei DING, Lipeng CAO, Yu GU, Ke XU, Yunfeng ZHANG. Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function[J]. Journal of Kunming Medical University, 2024, 45(10): 96-104. doi: 10.12259/j.issn.2095-610X.S20241015

Citation:

Xinbang WANG, An HU, Xipeng ZHAO, Yan WANG, Wei DING, Lipeng CAO, Yu GU, Ke XU, Yunfeng ZHANG. Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function[J]. Journal of Kunming Medical University, 2024, 45(10): 96-104. doi: 10.12259/j.issn.2095-610X.S20241015

Citation:

Xinbang WANG, An HU, Xipeng ZHAO, Yan WANG, Wei DING, Lipeng CAO, Yu GU, Ke XU, Yunfeng ZHANG. Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function[J]. Journal of Kunming Medical University, 2024, 45(10): 96-104. doi: 10.12259/j.issn.2095-610X.S20241015

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Effect of Ommaya Capsule on Cerebral Hemorrhage Complicated with Acute Hydrocephalus and its Effect on Blood-brain Barrier Function

doi: 10.12259/j.issn.2095-610X.S20241015

Dept. of Neurosurgery，Anqing 116 Hospital，Anqing Anhui 246003，China

Received Date: 2024-05-16
Available Online: 2024-10-15
Publish Date: 2024-10-31

Abstract

Abstract

Objective To investigate the application of Ommaya capsule in the treatment of cerebral hemorrhage complicated with acute hydrocephalus and its effect on blood-brain barrier function and prognosis. Methods A total of 80 patients with cerebral hemorrhage complicated with acute hydrocephalus from January 2021 to January 2023 were selected and divided into 40 cases each according to random number table method. The control group was given lumbocisterna interventional therapy, and the observation group was given Ommaya capsule interventional therapy. Compare the therapeutic effect of the two groups, as well as blood-brain barrier （BBB） index, serum S100β protein （S100β）, cerebrospinal fluid cell count, glucose, myelin basic protein （MBP）, National Institutes of Health Stroke Scale （NIHSS）, specific enolase （NSE）, chloride, Chinese Stroke Clinical Neurological Deficit Scale （CSS） score and occurrence of complications before and after treatment, were followed up for 6 months, and the prognosis of the two groups was statistically compared, after 6 months of follow-up, the prognosis of the two groups was statistically compared. Results The total effective rate of observation group was 90.00% （36/40）, which is higher than that of control group （72.50% （29/40）（P < 0.05）. The levels of serum S100β, MBP, BBB index, NSE and CSF cell number in observation group were lower than those in control group 1 week and 2 weeks after treatment, and the levels of CSF glucose and chloride were higher than those in control group （P < 0.05）. The CSS and NIHSS scores of observation group were lower than those of control group 1 and 2 weeks after treatment （P < 0.05）; The complication rate of the observation group was 7.50% （3/40） lower than that of the control group （25.00% （10/40）（P < 0.05）. The prognosis of observation group was better than control group （P < 0.05） after 6 months of follow-up. Conclusion The application of Ommaya capsule therapy in patients with cerebral hemorrhage complicated with acute hydrocephalus can regulate the level of nerve injury factors, restore the blood-brain barrier, improve nerve function, and reduce the risk of complications, so as to improve the treatment effect and promote the prognosis.
- Cerebral hemorrhage,
- Cerebrospinal fluid,
- Hydrocephalus,
- Nerve function,
- Barrier function,
- Ommaya sac,
- Lumbar cisterna intervention

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