A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease

Su ZHANG; Zheng HUANG; Na LI; Jing XU; Yiting TAO

doi:10.12259/j.issn.2095-610X.S20241112

Volume 45 Issue 11

Nov. 2024

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Su ZHANG, Zheng HUANG, Na LI, Jing XU, Yiting TAO. A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2024, 45(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20241112

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Su ZHANG, Zheng HUANG, Na LI, Jing XU, Yiting TAO. A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2024, 45(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20241112

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A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease

doi: 10.12259/j.issn.2095-610X.S20241112

Su ZHANG¹,
Zheng HUANG¹,
Na LI¹,
Jing XU¹,
Yiting TAO^{2
,
,}

1.
Dep. of Respiratory ，Tianchang People's Hospital，Tianchang Anhui 230021
2.
Dept. of Nephrology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-05-28
Available Online: 2024-10-26
Publish Date: 2024-11-25

Abstract

Abstract

Objective To explore the causal relationship between nut intake and chronic obstructive pulmonary disease by two-sample Mendelian randomization method. Methods SNP loci closely related to nut intake was extracted from the summarized large sample open GWAS database as instrumental variables, and Mendelian randomization analysis was performed using MR-Egger regression, weighted median, inverse variance weighting, Simple mode and Weighted mode respectively. OR value and 95%CI were used to evaluate whether there was a causal relationship between nut intake and chronic obstructive pulmonary disease. The mr_pleiotropy_test method was used to test the level of pleiotropy, and the leave-one-out method was used for sensitivity analysis. Results A total of 49 SNPS were extracted from the ukb-b-16576 data set as instrumental variables. The OR values and 95% confidence intervals were calculated by MR-Egger regression, weighted median, inverse variance weighting method, Simple mode, and Weighted mode, respectively [0.91, 95%CI （0.82～1.01）, P = 0.084], [0.92, 95%CI （0.89～0.95）, P = 0.001], [0.94, 95%CI （0.92～0.96）, P = 0.001], [0.91, 95%CI （0.85～0.95）, P = 0.001], [0.91, 95%CI （0.86～0.96）, P = 0.001]. All b values were less than 0. Due to the heterogeneity （Q = 67.36, P = 0.012 ）, the random effect IVW model was concerned. The mr_pleiotropy_test showed that the MR-Egger intercept was 3.50E-04, the intercept was close to 0, P = 0.591, and the selected instrumental variables did not have horizontal pleiotropy. Leave-one-out sensitivity analysis did not find SNP loci that had a significant effect on the results, suggesting that the results were stable and reliable. Conclusion The two-sample Mendelian randomization analysis shows a negative causal relationship between nut intake and the risk of chronic obstructive pulmonary disease, but larger sample size and data of people with different ethnic backgrounds are needed for further verification.
- Nuts,
- Chronic obstructive pulmonary disease,
- Mendel randomization,
- Causal inference

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