Analysis of Risk Factors for Co-Infection of Ulcerative Colitis with Epstein-barr Virus and Cytomegalovirus

Meizi RAO; Xinyi JIANG; Jiarong MIAO

doi:10.12259/j.issn.2095-610X.S20241113

Volume 45 Issue 11

Nov. 2024

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Meizi RAO, Xinyi JIANG, Jiarong MIAO. Analysis of Risk Factors for Co-Infection of Ulcerative Colitis with Epstein-barr Virus and Cytomegalovirus[J]. Journal of Kunming Medical University, 2024, 45(11): 87-94. doi: 10.12259/j.issn.2095-610X.S20241113

Citation:

Meizi RAO, Xinyi JIANG, Jiarong MIAO. Analysis of Risk Factors for Co-Infection of Ulcerative Colitis with Epstein-barr Virus and Cytomegalovirus[J]. Journal of Kunming Medical University, 2024, 45(11): 87-94. doi: 10.12259/j.issn.2095-610X.S20241113

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Analysis of Risk Factors for Co-Infection of Ulcerative Colitis with Epstein-barr Virus and Cytomegalovirus

doi: 10.12259/j.issn.2095-610X.S20241113

Dept. of Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-08-12
Available Online: 2024-11-07
Publish Date: 2024-11-25

Abstract

Abstract

Objective To analyze the risk factors of EB virus （EBV） and cytomegalovirus （CMV） infections in patients with ulcerative colitis （UC） and their relationship with drug efficacy. Methods A retrospective analysis was conducted on clinical data from 280 patients diagnosed with UC at the First Affiliated Hospital of Kunming Medical University between January 1, 2018, and December 31, 2022. Univariate and multivariate analyses were performed to identify the factors associated with EBV infections and univariate analyses was performed to identify the factors associated with CMV infections. Results Univariate analysis indicated that older age, severe disease activity, elevated C-reactive protein（CRP）, increased platelet count（PLT）, erythrocyte sedimentation rate（ESR）, fibrin degradation products（FDP）, D-dimer（D-D）, fibrinogen（FIB）, calprotectin（CAL）, higher Mayo endoscopic scores （MES）index, decreased albumin（ALB）, and corticosteroid use were linked to EBV infection （The average p value was < 0.05）. For CMV infection, significant factors included older age, severe disease activity, decreased hemoglobin （HB）, ALB, elevated CRP （The average p value was < 0.05）. Multivariate analysis confirmed that older age and severe disease activity were risk factors for EBV infection （The average p value was < 0.05）. EBV-infected patients showed a higher likelihood of steroid resistance, ineffective immunosuppressants, and loss of response to biological therapies, while CMV-infected patients also faced challenges with the treatment response. Conclusion Older age and severe disease activity are the significant risk factors for EBV infection in UC patients. UC patients infected with EBV and CMV are more prone to immune suppressant ineffectiveness and biological agent failure to respond. People infected with EBV are also prone to hormone resistance.
- Ulcerative colitis,
- Epstein-barr virus,
- Cytomegalovirus,
- Risk factors

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References(21)

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