The Effects of NLR，PLR，and FRA in Peripheral Blood on Normal Bone Mass and Bone Loss after Fractures

Jingyu YAO; Rui WEI; Lin ZHANG; Shengliu SHI; Peng BAI

doi:10.12259/j.issn.2095-610X.S20241117

Volume 45 Issue 11

Nov. 2024

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Jingyu YAO, Rui WEI, Lin ZHANG, Shengliu SHI, Peng BAI. The Effects of NLR，PLR，and FRA in Peripheral Blood on Normal Bone Mass and Bone Loss after Fractures[J]. Journal of Kunming Medical University, 2024, 45(11): 125-129. doi: 10.12259/j.issn.2095-610X.S20241117

Citation:

Jingyu YAO, Rui WEI, Lin ZHANG, Shengliu SHI, Peng BAI. The Effects of NLR，PLR，and FRA in Peripheral Blood on Normal Bone Mass and Bone Loss after Fractures[J]. Journal of Kunming Medical University, 2024, 45(11): 125-129. doi: 10.12259/j.issn.2095-610X.S20241117

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The Effects of NLR，PLR，and FRA in Peripheral Blood on Normal Bone Mass and Bone Loss after Fractures

doi: 10.12259/j.issn.2095-610X.S20241117

Jingyu YAO¹,
Rui WEI²,
Lin ZHANG^{1
,
,},
Shengliu SHI¹,
Peng BAI^{3
,
,}

1.
Dept. of Rehabilitation Medicine
2.
Dept. of Emergency Medicine
3.
Dept. of Intervention，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-08-28
Available Online: 2024-11-08
Publish Date: 2024-11-25

Abstract

Abstract

Objective To investigate the effects of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and fibrin/albumin ratio in systemic inflammatory markers on bone loss and normal bone function after fractures. Methods A retrospective study was conducted from January 2023 to September 2023 on the medical records of 2652 postoperative fracture patients publicly available in the electronic case system of the 1st Affiliated Hospital of Kunming Medical University. According to the results of bone density testing, patients were divided into two groups: 141 patients with the reduced bone mass and 79 patients with the normal bone mass. According to the collected data, the relevant information of each group, including NLR, PLR, FAR, gender, age, triglycerides, blood glucose, blood pressure, etc, was analyzed using SPSS 25.0 software. Results There was no significant statistical difference in NLR, PLR, and FAR between the two groups（P > 0.05）. There were statistical differences in BMI , age and gender（P < 0.05）. Conclusion The inflammatory response of bone loss after the fracture may be different from the inflammatory factors of female osteoporosis.
- Bone,
- Inflammatory factors,
- Peripheral blood,
- Fracture

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References(18)

References

[1]	Marsell R,Einhorn T A. The biology of fracture healing[J]. Injury,2011,42(6):551-555. doi: 10.1016/j.injury.2011.03.031
[2]	Claes L,Recknagel S,Ignatius A. Fracture healing under healthy and inflammatory conditions[J]. Nat Rev Rheumatol,2012,8(3):133-143. doi: 10.1038/nrrheum.2012.1
[3]	Fullerton J N,Gilroy D W. Resolution of inflammation: A new therapeutic frontier[J]. Nat Rev Drug Discov,2016,15(8):551-567. doi: 10.1038/nrd.2016.39
[4]	Lin T H,Tamaki Y,Pajarinen J,et al. Chronic inflammation in biomaterial-induced periprosthetic osteolysis: NF-κB as a therapeutic target[J]. Acta Biomater,2014,10(1):1-10. doi: 10.1016/j.actbio.2013.09.034
[5]	张胜利,谢玲霞,杨欣建. 创伤后骨质疏松症的研究进展[J]. 临床医学,2006,26(6):88-89.
[6]	周泽霖,尚奇,卓航,等. 男性原发骨质疏松症骨密度与新型炎症指标的相关性[J]. 中国骨质疏松杂志,2023,29(5):636-640.
[7]	Du Y N,Chen Y J,Zhang H Y,et al. Inverse association between systemic immune-inflammation index and bone mineral density in postmenopausal women[J]. Gynecol Endocrinol,2021,37(7):650-654. doi: 10.1080/09513590.2021.1885642
[8]	董晓芬,李香波,吴震宇,等. 绝经后2型糖尿病合并骨质疏松症患者外周血NLR、PLR、Cys-C水平与骨密度的相关性分析[J]. 临床和实验医学杂志,2022,21(2):174-177. doi: 10.3969/j.issn.1671-4695.2022.02.016
[9]	宋云霄,童巍,张海晨,等. 系统性炎症指标与老年骨质疏松症患者骨折发生的相关性[J]. 检验医学,2022,37(3):235-239.
[10]	Cun‐Yu Wang,Yu B. Osteoporosis and periodontal diseases - An update on their association and mechanistic links[J]. Periodontology 2000,2022,89(1):99-113.
[11]	Heuchert J ,Kozie S ,Spinek A E . Radiomorphometric indices of the mandible as indicators of decreased bone mineral density and osteoporosis - meta-analysis and systematic review[J]. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA,2024,35(3): 401-412.
[12]	Karunanithi R,Ganesan S,Panicker T M,et al. Assessment of bone mineral density by DXA and the trabecular microarchitecture of the calcaneum by texture analysis in pre- and postmenopausal women in the evaluation of osteoporosis[J]. J Med Phys,2007,32(4):161-168. doi: 10.4103/0971-6203.37481
[13]	Zupan J ,Komadina R ,Marc J . The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues[J]. Journal of Biomedical Science,2012,19(1): 1-10.
[14]	Kamel H M ,Amin E S ,El-Adawy A R . Endothelial and some cytokine inflammatory markers as risk factors of hypertension in postmenopausal women[J]. Life Science Journal,2014,11(3): 220-223.
[15]	冯红红,高飞. 新型炎症因子与原发性骨质疏松症的研究进展[J]. 中国骨质疏松杂志,2022,28(1):152-156.
[16]	Zhao L J,Jiang H,Papasian C J,et al. Correlation of obesity and osteoporosis: Effect of fat mass on the determination of osteoporosis[J]. J Bone Miner Res,2008,23(1):17-29. doi: 10.1359/jbmr.070813
[17]	Liu H W ,Lee K S. Effects of resistance training with elastic bands on bone mineral density,body composition,and osteosarcopenic obesity in elderly women: A meta-analysis[J]. Journal of Orthopaedics,2024,53(4):168-175.
[18]	Li Y. Association between obesity and bone mineral density in middle-aged adults[J]. J Orthop Surg Res,2022,17(1):268-274. doi: 10.1186/s13018-022-03161-x

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