Effect of Dapagliflozin on Cardiac Structure and Function in Patients with Heart Failure Due to Mildly Reduced Ejection Fraction

Mengdan XU; Hong XIANG; Xiaolong GAO; Jin ZHANG; Haiyan WU; Lilin WANG

doi:10.12259/j.issn.2095-610X.S20241114

Volume 45 Issue 11

Nov. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(11): 95-102

Mengdan XU, Hong XIANG, Xiaolong GAO, Jin ZHANG, Haiyan WU, Lilin WANG. Effect of Dapagliflozin on Cardiac Structure and Function in Patients with Heart Failure Due to Mildly Reduced Ejection Fraction[J]. Journal of Kunming Medical University, 2024, 45(11): 95-102. doi: 10.12259/j.issn.2095-610X.S20241114

Citation:

Mengdan XU, Hong XIANG, Xiaolong GAO, Jin ZHANG, Haiyan WU, Lilin WANG. Effect of Dapagliflozin on Cardiac Structure and Function in Patients with Heart Failure Due to Mildly Reduced Ejection Fraction[J]. Journal of Kunming Medical University, 2024, 45(11): 95-102. doi: 10.12259/j.issn.2095-610X.S20241114

Citation:

Mengdan XU, Hong XIANG, Xiaolong GAO, Jin ZHANG, Haiyan WU, Lilin WANG. Effect of Dapagliflozin on Cardiac Structure and Function in Patients with Heart Failure Due to Mildly Reduced Ejection Fraction[J]. Journal of Kunming Medical University, 2024, 45(11): 95-102. doi: 10.12259/j.issn.2095-610X.S20241114

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Effect of Dapagliflozin on Cardiac Structure and Function in Patients with Heart Failure Due to Mildly Reduced Ejection Fraction

doi: 10.12259/j.issn.2095-610X.S20241114

Dept. of Cardiology，The Affiliated Hospital of Kunming University of Science and Technology/The 1st People’s Hospital of Yunnan Province，Kunming Yunnan 650032，China

Received Date: 2024-05-12
Available Online: 2024-11-09
Publish Date: 2024-11-25

Abstract

Abstract

Objective To investigate the effects of dapagliflozin on cardiac structure and function in patients with heart failure due to mildly reduced ejection fraction. Methods Patients diagnosed with heart failure due to mildly reduced ejection fraction in the outpatient department and inpatient department of the First People's Hospital of Yunnan Province from November 1, 2021 to December 31, 2022 were selected and divided into the conventional anti-heart failure group and dapagliflozin group according to whether they were taking dapagliflozin or not. The conventional anti-heart failure group received the conventional anti-heart failure treatment （loop diuretics, ACEI/ARB/ARNI, spironolactone, β-blocker）, and the dapagliflozin group was given oral dapagliflozin on the basis of conventional anti-heart failure treatment. The improvement of cardiac function, LVEDD （left ventricular end-diastolic diameter）, LVESD （left ventricular end-systolic diameter）, LVEF （left ventricular ejection fraction）, IVST （ventricular septum thickness）, LVPWT （left ventricular posterior wall thickness）, LAD （left atrial diameter） and the incidence of adverse events after the treatment within 3 months, 6 months and 1 year were observed in both groups. Results 33 patients in the dapagliflozin group and 37 patients in the conventional anti-heart failure group completed the follow-up. （1）After 3 months, 6 months and 1 year of thefollow-up, the NYNH cardiac function grade of the two groups was improved compared with that before the treatment and the total effective rate of the dapagliflozin group was significantly higher than that of the conventional anti-heart failure group（P < 0.05）.（2）LVEF increased compared with the baseline in both groups, while LVEDD, LVESD, LAD, IVST and LVPWT decreased compared with the baseline（P < 0.05）.（3）After 3 months of treatment , there was no significant difference between LVEF, LVEDD, LVESD, LAD and IVST at 3 months（P > 0.05）and the decrease of LVPWT in dapagliflozin group was significantly higher than that in conventional anti-heart failure group. （4）After 6 months and 1 year of the treatment, the increase of LVEF and the decrease of LAD, IVST and LVPWT in dapagliflozin group were significantly higher than those in conventional anti-heart failure group （P < 0.05）.There was no significant difference in the decrease degree of LVEDD and LVESD between the two groups at 6 months after the treatment（P > 0.05） and the difference was significant at 1 year after the treatment（P < 0.05）. Conclusion On the basis of standardized anti-heart failure drug therapy, the combination of dapagliflozin can further improve the cardiac remodeling and function of patients with heart failure due to mildly reduced ejection fraction.
- Dapagliflozin,
- Heart failure with mildly reduced ejection fraction,
- Cardiac remodeling,
- Cardiac function

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References(25)

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