The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol

Nian Xin

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Nian Xin . The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol[J]. Journal of Kunming Medical University, 2012, 33(02): 1-1.

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Nian Xin . The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol[J]. Journal of Kunming Medical University, 2012, 33(02): 1-1.

Nian Xin . The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol[J]. Journal of Kunming Medical University, 2012, 33(02): 1-1.

Citation:

Nian Xin . The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol[J]. Journal of Kunming Medical University, 2012, 33(02): 1-1.

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The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol

Nian Xin

Abstract

Abstract

［Abstract］Objective　To investigate the association between the forkhead transcription factor C2（FOXC2）C-1702T transition in the putative promoter region and type 2 diabetes．Methods　280 han people in Yunnan province were selected as subjects. A case-control study was performed in 159 type 2 diabetic patients and 121 control subjects．The FOXC2 gene C-1702T polymorphism was detected by heminested PCR．Results　FOXC2 C-1702T allele and genotype distribution did not differ between patients with type 2 diabetes and control subjects（P＞0.05）， and had no association with gender. The C/C genotype was associated with higher level of cholesterol（P＜0.05）among type 2 diabetic patients．Conclusions　FOXC2 C-1702T is not associated with gender and type 2 diabetes. FOXC2 C-1702T is associated with serum cholesterol.
- ［Key words］Forkhead transcription factor；Type 2 diabetes；Polymorphism,

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