Changes of Plasma NT-proBNP and Left Ventricular Remodeling in Patients with Acute myocardial infarction after PCI

［Abstract］Objective　To explore the relationship between the changes of plasma N-terminal pro-B-type natriuretic peptide（NT-proBNP）and left ventricular remodeling（LVRM）in early acute myocardial infarction（AMI）patients before and after PCI．Methods　Seventy-two patients admitted to our hospital with AMI were randomly divided into two groups，35 were in medicine treated group（M-group）and another 37 were in the medicine plus emergent PCI group（PCI-group）．The plasma NT-proBNP was measured within 24 hours after admission or before PCI and on the 10 th day after admission， and echocardiogram were performed for all of the patients at admission and on the 9th or 10th day after admission to evaluate the left ventricular remolding by measuring the left ventricular end-diastolic dimension （LVEDD）， left ventricular ejection fraction（LVEF），left ventricular shortening（FS）and left ventricular end-diastolic volume（LVEDV）to analyze the relationship between the NT-proBNP and the morphology and function of the left ventricle．Results　The levels of plasma NT-proBNP decreased，LVEF and FS increased after the treatment in both of the two groups than that before treatment significantly（P＜0.05），and no significant difference were observed for LVEDD and LVEDV（P＞0.05）．No significant difference was observed for the plasma NT-proBNP，LVEF，FS，LVEDD，LVEDV between the two groups before the treatment（P＞0.05）．The levels of plasma NT-proBNP decreased and LVEF， FS increased significantly after the different treatment in PCI-group than that of M-group（P＜0.05），but LVEDD，LVEDV decreased insignificantly（P＞0.05）．Conclusions　The increased plasma NT-proBNP in AMI patients may reflect the left ventricular remodeling．PCI may decrease significantly the plasma NT-proBNP，imorove the left ventricular function and reduce the incidence of left ventricular remodeling