Comparative Study of the Effects of Etomidate and Propofol Anesthesia Induction on Cardiovascular Stability in Elderly Patients

［Abstract］Objective　To compare the effects of etomidate and propofol anesthesia induction on cardiovascular stability in elderly patients，and to guide drugs use in the anesthesia induction in elderly patients. Methods　60 elderly patients were randomly divided into two groups：acupuncture group etomidate（A），propofol needle group（B），induced by 0.2 mg/kg of midazolam maleate tallet．Patients in A group were given 0.3 mg/kg of etomidate，and patients in B group were given 1.5 mg/kg of propofol-pin. All patients were also intravenously injected 3 μg/kg of Norcuron and 0.1 mg/kg of Fentanyl．HR，SBP，DBP and MAP of patients were recorded before induction，1 min，2 min and 5 min after induction．The adverse reactions including nausea，vomiting， intravenous pain，involuntary muscle activity and allergic reactions were also observed．Results　Compared with baseline values before induction of anesthesia，HR，SBP，DBP and MAP of patients in both groups were decreased in different degrees after induction of anesthesia．The decrease was statistically significant at 1 min and 5 min after induction of anesthesia（P＜0.5）．Compared with B group，The decrease of SBP and MAP was more obvious in A group at 2 mins and 5 mins after induction of anesthesia（P＜0.5）. There were no nausea， vomiting and allergic reactions in two groups．There was intravenous injection pain in B group and involuntary muscle activity in A group，there was a significant difference（P ＜0.05）．Conclusion　Both etomidate and propofol inhibit the cardiovascular stability in elderly patients in different degrees，but etomidate has less effect on the circulation of patients and vascular stability，so etomidate is more suitable as the preferred intravenous anesthetic induction drug for elderly patients