The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer

Hong Chao

Article Contents

Article Navigation > Journal of Kunming Medical University > 2016 > 37(06):

Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

Citation:

Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

Citation:

Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

PDF( 100 KB)

The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer

Hong Chao

(1)Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118;2)Dept. of Geriatrics,The No.1 Affiliated Hospital of Kunming Medical University, Kunming 650032;3)Dept. of Thoracic Surgery,The No.3 Affiliated Hospital of Kunming Medical University,Kunming 650118,China)

Abstract

Abstract

［Abstract］Objective To evaluate the correlation of the single nucleotide polymorphisms （SNPs） in CDH13 with non-small cell lung cancer （NSCLC）. Methods 115 patients with NSCLC and 110 healthy controls were included in present study. Two SNPs （rs11646213 and rs7195409） in CDH13 were genotyped using TaqMan method. The association of these two SNPs with NSCLC was calculated and assessed. Results The genotypic and allelic frequencies of rs11646213 showed significant difference between NSCLC patients and the control group （P＜0.05），（OR＝0.464，95% CI：0.273～0.789）. The genotypic and allelic frequencies of rs7195409 showed significant difference between the stage I+II and stage III+IV groups （P＜0.05），（OR＝0.491，95% CI：0.243～0.991）. Conclusions　The rs16146213 has a strong association with NSCLC and G allelic showed a protective effect. The rs7195409 has a strong association between stage I+II and III + IV in NSCLC， and G allele may play a protective role in the development of NSCLC.
- ［Key words］Non-small cell lung cancer ；CDH13；Single-nucleotide polymorphisms,

FullText(HTML)

References(0)

References

Relative Articles(20)

Relative Articles

[1]	Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia. Journal of Kunming Medical University, 2024, 45(11): 16-21. doi: 10.12259/j.issn.2095-610X.S20241103
[2]	Chao HONG, Xudong XIANG, Yingfu LI, Yang CAO, Xueya CHEN, Shuai LI, Anhao XING, Mu LIN, Qianli MA. Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer. Journal of Kunming Medical University, 2024, 45(3): 7-17. doi: 10.12259/j.issn.2095-610X.S20240302
[3]	Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population. Journal of Kunming Medical University, 2024, 45(5): 8-15. doi: 10.12259/j.issn.2095-610X.S20240502
[4]	Ni GUO, Cheng ZHANG, Chao HONG, Weipeng LIU, Yufeng YAO, Zhiling YAN. Correlation of KRAS Gene 3′ UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province. Journal of Kunming Medical University, 2024, 45(2): 14-22. doi: 10.12259/j.issn.2095-610X.S20240203
[5]	Yuhan SHI, Jianghong CHAI, Jinmei XU, Mu LIN, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association between miR-146a Gene Polymorphism and Cervical Intraepithelial Neoplasia. Journal of Kunming Medical University, 2024, 46(): 1-7.
[6]	Yunfang ZHANG, Shanshan ZHUANG, Yan YU, Zheng LI, Xiaoming WU, Xiaogai NIE. Correlation between PEAR1 Gene Polymorphisms and Ischemic Stroke. Journal of Kunming Medical University, 2023, 44(11): 135-139. doi: 10.12259/j.issn.2095-610X.S20231120
[7]	Yuhan SHI, Jing LI, Shuyuan LIU, Ting ZHAO, Jingsi YANG, Li SHI, Jiangli LIANG. Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine. Journal of Kunming Medical University, 2023, 44(7): 22-28. doi: 10.12259/j.issn.2095-610X.S20230711
[8]	Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014
[9]	Rongshuang WU, Jiangli PENG, Yonggang CHEN, Jie CHEN, Guowei MA, Xianrui LI, Xie LI, Chunhong YU. Associations between SLC2A9 Single Nucleotide Polymorphisms and Susceptibility to Pyrazinamide Induced Hyperuricemia. Journal of Kunming Medical University, 2023, 44(4): 40-47. doi: 10.12259/j.issn.2095-610X.S20230409
[10]	Shujin LI, Yanfei YANG, Min SU, Yu LING, Yanqiong RAO, Jihua CUI. Single Nucleotide Polymorphisms in Children with Attention Deficit Hyperactivity Disorder Comorbid Emotion Problems. Journal of Kunming Medical University, 2023, 44(4): 139-147. doi: 10.12259/j.issn.2095-610X.S20230420
[11]	Xiao-hui RUAN, Qian XIANG, Yu-ming WANG, Zhi-han ZHOU, Xian ZHANG, Yan GUO, Xiao-rui YANG. The Correlation between Vitamin D Receptor Gene Bg1I and Cdx-2 Polymorphism and Hashimoto’ s Thyroiditis. Journal of Kunming Medical University, 2021, 42(8): 132-139. doi: 10.12259/j.issn.2095-610X.S20210824
[12]	Cong MEI, Xiao-chun WENG, Bao-kun PENG, Sui-jun YAN, Chun LI, Qiong ZHOU, Zhe TANG. Correlation between rs4580704 Polymorphism of CLOCL Gene and Type 2 Diabetes and Sleep Quality. Journal of Kunming Medical University, 2021, 42(3): 135-139. doi: 10.12259/j.issn.2095-610X.S20210332
[13]	Dong-yun LI, Shun-kui GANG, Jie LI, Ming-xing ZHANG, Lei LI. Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China. Journal of Kunming Medical University, 2021, 42(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20210320
[14]	Xiang Xi , Li Wan Bi , Zhang Xian , Liu Hua , Wang Yu Ming , Yang Cai , Bai Yun Xia . Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients. Journal of Kunming Medical University, 2017, 38(08): 79-85.
[15]	Liu Cheng Xiu . Association Study of TNF-α and ALCAM Polymorphisms with Chronic HCV Infection in Yunnan Han Population. Journal of Kunming Medical University,
[16]	Xiang Xi . The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease. Journal of Kunming Medical University,
[17]	Dai Shu Ying . . Journal of Kunming Medical University,
[18]	Li Ying . . Journal of Kunming Medical University,
[19]	Liu Li Li . . Journal of Kunming Medical University,
[20]	Yang Xiao Lei . . Journal of Kunming Medical University,