The Effect of Terlipressin and FK-409 on Protection of Liver Graft Injury after Reduced-Size Liver Transplantation in Rats

Mang Yuan 祎; Li Li; Ran Jiang Hua; Zhang Sheng Ning; Liu Jing; Liu Jian; Gao Yang; Li Lai Bang

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(04): 16-20

Mang Yuan 祎, Li Li , Ran Jiang Hua , Zhang Sheng Ning , Liu Jing , Liu Jian , Gao Yang , Li Lai Bang . The Effect of Terlipressin and FK-409 on Protection of Liver Graft Injury after Reduced-Size Liver Transplantation in Rats[J]. Journal of Kunming Medical University, 2018, 39(04): 16-20.

Citation:

Mang Yuan 祎, Li Li , Ran Jiang Hua , Zhang Sheng Ning , Liu Jing , Liu Jian , Gao Yang , Li Lai Bang . The Effect of Terlipressin and FK-409 on Protection of Liver Graft Injury after Reduced-Size Liver Transplantation in Rats[J]. Journal of Kunming Medical University, 2018, 39(04): 16-20.

Citation:

Mang Yuan 祎, Li Li , Ran Jiang Hua , Zhang Sheng Ning , Liu Jing , Liu Jian , Gao Yang , Li Lai Bang . The Effect of Terlipressin and FK-409 on Protection of Liver Graft Injury after Reduced-Size Liver Transplantation in Rats[J]. Journal of Kunming Medical University, 2018, 39(04): 16-20.

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The Effect of Terlipressin and FK-409 on Protection of Liver Graft Injury after Reduced-Size Liver Transplantation in Rats

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基金：云南省科技厅昆明医科大学应用基础研究联合专项基金资助项目 (2010CD213);

Received Date: 2017-12-19

Abstract

Abstract

Object To detect the effect of terlipressin and FK-409 on protection of liver graft injury after reduced-size liver transplantation in rats. Me thods We performed liver transplantation using 30% volume liver graft in rats. ALT, total bilirubin, portal vein pressure and survival rate were detected after operation. We divided recipient rats into four groups including terlipressin treatment group, FK-409 treatment group, terlipressin groups and FK-409 treatment group. ALT, total bilirubin, portal vein pressure and survival rate were detected in each group after operation. We compared results of four groups and found potential therapy which protected liver graft injury after reduced-size liver transplantation. Re s ults In reduced-size liver transplantation model, terlipressin and FK-409 treatment group showed lower portal vein pressure (P <0.05) , lower level of ALT and bilirubin (P<0.05) and longer survival time (P<0.05) compared with the control group. Using terlipressin and FK-409 could reduce liver graft injury after reduced-size liver transplantation. Conclus ion Using terlipressin and FK-409 could reduced liver graft injury, which might be the potential therapy for small-for-size syndrome after reduced-size liver transplantation.
- Terlipressin,
- FK-409,
- Reduced-size liver transplantation

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References(21)

References

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