The Relationship between the Inflammation of Mucosa and the Curative Effect of Eosinophilic Chronic Sinusitis

Wang Cheng Gang; Wu Hai Ying

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Wang Cheng Gang , Wu Hai Ying . The Relationship between the Inflammation of Mucosa and the Curative Effect of Eosinophilic Chronic Sinusitis[J]. Journal of Kunming Medical University, 2018, 39(04): 66-69.

Citation:

Wang Cheng Gang , Wu Hai Ying . The Relationship between the Inflammation of Mucosa and the Curative Effect of Eosinophilic Chronic Sinusitis[J]. Journal of Kunming Medical University, 2018, 39(04): 66-69.

Citation:

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The Relationship between the Inflammation of Mucosa and the Curative Effect of Eosinophilic Chronic Sinusitis

Wang Cheng Gang ¹,
Wu Hai Ying ²

Funds:

基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2017FE467);

Received Date: 2017-10-24

Abstract

Abstract

Objective To explore the relationship between the mucosal inflammation and the surgical efficacy of patients with eosinophilic chronic sinusitis. Me thods From September 2014 to September 2017, 30 patients with chronic eosinophils sinusitis were selected in our hospital. We colored the sinus tissue paraffin specimens by HE staining, calculated the number of inflammatory cells by microscope observation and the number of eosinophils contained, determined the eosinophil infiltration degree, evaluated the effect of surgical treatment, and analyzed the eosinophil infiltration degree and the relationship between the clinical classification.Re s ults The infiltration degree of the mucosa related eosinophilic granulocytes was significantly lower (χ2=7.6876, P =0.0055) after1-2 weeks after surgery for patients with chronic sinusitis. The degree of infiltration of the mucosa related eosinophilic granulocytes at 4 weeks and 6 weeks after surgery was 3 and 4. There was no significant difference before surgery (χ2=0.3267, P=0.5676) . The degree of infiltration of the mucosa related eosinophils in the 10-12 weeks after surgery was significantly lower than that in grade 3 and 4 (χ2=13.4842, P=0.0002) . In 30 patients with chronic sinusitis, the treatment efficiency of the mucosa associated eosinophilic granulocytic infiltration level was level 3 and level 4 (χ2= 23.0990, 23.0990, P= 0.0000, 0.0000) . The treatment efficiency of the lesion of the mucosa of patients with chronic sinusitis was level 2 and the level of infiltration was 3 and 4 (χ2=12.2817, 12.2817, P =0.0004, 0.0004) . In the clinical fractal type 1, the degree of infiltration level 1 and 2 was distributed, and the degree of infiltration level 3 and 4 was absent; In the clinical fractal type 2, the degree of infiltration level 1 was mostly observed and the degree of infiltration level 2, 3 and 4 was distributed; In the clinical fractal type 3, the degree of infiltration level 1 was mostly observed and the degree of infiltration level 2, 3 and 4 was distributed. The comparison between infiltration degree level 1 and level 2 of the total clinical classification and the type 2 percentage infiltration degree level 3 and level 4 was not significant (χ2=0.3801, 0.3801 and 0.3801, 0.3801, P=0.5375, 0.5375, 0.5375, 0.5375) . Conclusion There is a certain relationship between the mucosal inflammation and the curative effect of eosinophilic chronic sinusitis.
- Eosinophil,
- Chronic sinusitis,
- Mucosal inflammation,
- Curative effect,
- Relationship

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References(17)

References

[1]朱洪海, 朱晓远, 程根阳.鼻渊通窍颗粒对儿童慢性鼻窦炎鼻黏膜纤毛传输功能及炎性因子的影响[J].中国实验方剂学杂志, 2014, 20 (10) :188-191.
[2]	[2]OKANO M, KARIYA S, OHTA N, et al.Association and management of eosinophilic inflammation in upper and lower airways[J].Allergology International, 2015, 64 (2) :131-138.
[3]李华斌, 冯韶燕, 程岚.嗜酸粒细胞性慢性鼻窦炎的临床特点和治疗策略[J].临床耳鼻咽喉头颈外科杂志, 2016, 30 (3) :177-179.
[4]	[4]ENDO Y, HIRAHARA K, SHINODA K, et al.Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation[M].Tokyo:Springer Japan, 2016:401-415.
[5]李莉.慢性鼻-鼻窦炎鼻内镜鼻窦手术前后黏膜形态变化及相关性分析[J].蚌埠医学院学报, 2015, 40 (1) :80-82.
[6]刘业军, 张承宏, 刘建设, 等.吡酮莫特治疗对慢性鼻窦炎患者外周T淋巴细胞亚群, NK细胞活性以及炎症因子的影响[J].海南医学院学报, 2016, 22 (3) :306-309.
[7]	[7]AKDIS M, AKDIS C A.Mechanisms of allergen-specific immunotherapy:multiple suppressor factors at work in immune tolerance to allergens[J].Journal of Allergy and Clinical Immunology, 2014, 133 (3) :621-631.
[8]巴罗, 杜进涛, 蔡舜玉, 等.不同免疫表型鼻息肉中黏膜炎症模式与组织重塑特征[J].临床耳鼻咽喉头颈外科杂志, 2016, 30 (16) :1302-1307.
[9]	[9]VAN D E VEEN W, WIRZ O F, GLOBINSKA A, et al.Novel mechanisms in immune tolerance to allergens during natural allergen exposure and allergen-specific immunotherapy[J].Current Opinion in Immunology, 2017, 48 (10) :74-81.
[10]朱顺芳.影响慢性鼻-鼻窦炎鼻内镜手术预后因素Logistic回归分析[J].现代仪器与医疗, 2016, 22 (2) :034.
[11]	[11]AKDIS C A, AKDIS M.Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens[J].World Allergy Organization Journal, 2015, 8 (1) :17.
[12]陈新野, 张春林, 洪海裕, 等.败丹黄灌洗液鼻腔灌洗对慢性鼻窦炎伴鼻息肉患者术后的临床疗效影响[J].中国中西医结合杂志, 2013, 33 (2) :180-185.
[13]	[13]KOTLYAR D S, SHUM M, HSIEH J, et al.Nonpulmonary allergic diseases and inflammatory bowel disease:a qualitative review[J].World Journal of Gastroenterology, 2014, 20 (32) :11023.
[14]	[14]FUJIEDA S, IZUHARA K.Regulation of upper airway inflammation facilitates comfortable breathing[J].Allergology International, 2015, 64 (2) :119-120.
[15]訾晓雪, 赵莉, 金鹏, 等.伴有嗅觉障碍的慢性鼻-鼻窦炎患者鼻内镜术后嗅觉及生活质量转归的研究[J].山东大学耳鼻喉眼学报, 2016, 30 (1) :21-25.
[16]	[16]PARAMASIVAN S, DRILLING A J, JARDELEZA C, et al.Methylglyoxal augmented manuka honey as a topical anti Staphylococcus aureus biofilm agent:safety and efficacy in an in vivo model[C]//International forum of allergy&rhinology, 2014, 4 (3) :187-195.
[17]程琳, 何志龙.鼻内镜下鼻窦手术同期行鼻中隔矫正术92例疗效分析[J].现代医药卫生, 2013, 29 (3) :415-417.

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