An Analysis of Biochemical Characteristics of Liver Injury In Duced by Statins

Yu Ming Li; Chen Jie; Chen Yong Gang; Luo Ji; Peng Jiang Li

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(08): 13-17

Yu Ming Li , Chen Jie , Chen Yong Gang , Luo Ji , Peng Jiang Li . An Analysis of Biochemical Characteristics of Liver Injury In Duced by Statins[J]. Journal of Kunming Medical University, 2018, 39(08): 13-17.

Citation:

Yu Ming Li , Chen Jie , Chen Yong Gang , Luo Ji , Peng Jiang Li . An Analysis of Biochemical Characteristics of Liver Injury In Duced by Statins[J]. Journal of Kunming Medical University, 2018, 39(08): 13-17.

Citation:

PDF( 220 KB)

An Analysis of Biochemical Characteristics of Liver Injury In Duced by Statins

Funds:

基金：昆明市卫计委基础研究基金资助项目 (2012-01-03);

Received Date: 2018-04-19

Abstract

Abstract

Objectives To provide theoretical basis for the clinical rational using of drugs, biochemical characteristics of the liver injuries induced by the atorvastatin, simvastatin and lovastatin were analyzed and compared by replicating the rats model of liver injuries induced by statins, Methods 80 SPF SD rats (8 weeks of age) , half male and half female, were divided into four groups randomly: control group, simvastatin group, lovastatin group, atorvastatin group. Human equivalent doses were administered to the latter three groups of rats which were sacrificed to draw blood on the 10 th, 35 th and 55 th day respectively (via the femoral artery) for testing liver function index, including total bilirubin (TBIL) , direct bilirubin (DBIL) , indirect bilirubin (IBIL) , aspartateaminotransferase (AST) , alanineaminotransferase (ALT) , alkalinephosphatase (ALP) . Results (1) The increases in TBIL, DBIL, IBIL for treatment group in comparison with control group had statistical significance (P<0.01) .2) At the 55 th day of administration, there was a significant statistical difference between the simvastatin group and the lovastatin group in AST (P<0.05) ;3) Meanwhile, there was great statistical difference between the atorvastatin group and lovastatin group in ALP (P<0.01) . Conclusion The rats in the three experimental groups suffered from minor to moderate liver injuries, most of which being cholestasis type. It is speculated that this kind of liver injuries are closely related to the obstacle of transfering bile.
- Statins,
- Drug inducedliver injury,
- Biochemical characteristics,
- The mechanism of the liver injury

FullText(HTML)

References(15)

References

[1]于乐成, 茅益民, 陈成伟, 等.药物性肝损伤诊治指南[J].临床肝胆病杂志, 2015, 31 (11) :1752-1769.
[2]	[2]CHALASANI N P, HAYASHI PH, BONKOVSKY H L, et al.ACG Clinical Guideline:the diagnosis and management of idiosyncratic drug-induced liver injury[J].Am J Gastroenterol, 2014, 109 (7) :950-966.
[3]	[3]HAYASHI P H, FONTANA R J.Clinical features, diagnosis, and natural history of drug-induced liver injury[J].Semin Liver Dis, 2014, 34 (2) :134-144.
[4]	[4]ROBLES-DIAZ M, LUCENA MI, KAPLOWITZ N, et al.Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury[J].Gastroenterology, 2014, 147 (1) :109-118.
[5]马葵芬, 谢先吉, 刘莹, 等.细胞色素P450酶基因多态性及其介导的药物性肝损伤研究进展[J].中国药理学与毒理学杂志, 2013, 27 (5) :889-892.
[6]曾含清, 张琼, 彭文兴, 等.阿托伐他汀致肝损伤的机制[J].药物不良反应志, 2012, 14 (4) :232-235.
[7]刘敏惠, 陈崇泽.阿托伐他汀致11例患者肝损伤及费用分析[J].海峡药学, 2018, 30 (02) :265-268.
[8]彭江丽, 马国伟, 喻明丽, 等.洛伐他汀联合异烟肼、利福平、吡嗪酰胺致大鼠肝损伤的实验研究[J].安徽医药, 2017, 21 (12) :2157-2163.
[9]陈洁, 王俊龙, 马国伟, 等.抗结核药与辛伐他汀联用致肝损伤的特征及其机制研究[J].抗感染药学, 2016, 13 (04) :729-735.
[10]罗季, 陈永刚, 喻明丽, 等.抗结核药与阿托伐他汀联用致肝损伤的特征及其机制研究[J].抗感染药学, 2016, 13 (05) :978-985.
[11] 丁德云, 张淑芳, 马力, 等.阿托伐他汀的药物专论[M].重庆:重庆出版社, 2014:644-649.
[12]刘志军, 熊玉卿.药代动力学/药效学模型研究进展及其在他汀类药物临床治疗的应用[J].中国临床药理学杂志, 2015, 31 (15) :1552-1554.
[13]	[13]BOELSTERLI U A, LIM P L.Mitochondrial abnormalitiesa link to idiosyncratic hepatotoxicity drug[J].Toxicol Appl Pharmacol, 2007, 220 (1) :92-107.
[14]	[14]AU J S, NAVARRO V J, ROSSI S.et al.Review article:drug-induced liver injure-its pathophysiology and evolving diagnostic tools[J].Aliment Pharmacol Ther, 2011, 34 (1) :11-20.
[15] 范颖, 赵红, 药物性肝损伤防治指南[J], 中华全科医师杂志, 2016, 15 (6) :416-420.

Relative Articles(20)

Relative Articles

[1]	Yihan YANG, Huamei CHEN, Yu FANG, Yuxin WANG, Xi ZHAN. Mechanism of Rosiglitazone in Reducing Liver Ischemia Reperfusion Injury in Rats by Inducing HO-1. Journal of Kunming Medical University, 2024, 45(7): 14-22. doi: 10.12259/j.issn.2095-610X.S20240703
[2]	Nihong LU, Honglu LIU, Yangjun CHEN, Yaping SUN, Yan YANG, Yongrui YANG, Jie LI. The Association between ESAT-6 Combined Multiple Detection Indicators and the Severity of Anti-tuberculosis Drug-induced Liver Injury. Journal of Kunming Medical University, 2024, 45(8): 52-57. doi: 10.12259/j.issn.2095-610X.S20240808
[3]	Xuejiao WU, Jiangli PENG, Hao FAN, Lu WANG, Jie CHEN, Hui LIU. Clinical Features and Prognostic Factors of 310 Patients with Antituberculosis Drug-induced Liver Injury. Journal of Kunming Medical University, 2024, 45(3): 157-165. doi: 10.12259/j.issn.2095-610X.S20240324
[4]	Nihong LU, Honglu LIU, Yangjun CHEN, Meiyan LIU, Yongrui YANG, Yingrong DU. Analysis of Characteristic Indexes of Liver Injury Model Induced by Different Antituberculosis Drugs in Mice. Journal of Kunming Medical University, 2023, 44(6): 6-13. doi: 10.12259/j.issn.2095-610X.S20230615
[5]	Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs. Journal of Kunming Medical University, 2022, 43(4): 50-54. doi: 10.12259/j.issn.2095-610X.S20220410
[6]	Jing TANG, Jun-chao HUANG, Ya-fei HUANG, Ming-zhu GENG, Xiao-qin MAO, Jian-ping PU. Application of Lipoprotein-associated Phospholipase A2 in Coronary Heart Disease Patients Taking Statins. Journal of Kunming Medical University, 2021, 42(12): 6-10. doi: 10.12259/j.issn.2095-610X.S20211205
[7]	Yan LIANG, Jian-bo GAO, Jun-yan MA, Hao YANG. Diagnostic Effect and Imaging Characteristics of High Frequency Ultrasound in Limb Skeletal Muscle Injury. Journal of Kunming Medical University, 2021, 42(10): 157-161. doi: 10.12259/j.issn.2095-610X.S20211015
[8]	Ni-hong LU, Hong-lu LIU, Yang-jun CHEN, Yan YANG, Yong-rui YANG, Ying-rong DU. Characteristics of Infection Indexes in Patients with Antituberculous Drug-induced Liver Injury. Journal of Kunming Medical University, 2021, 42(11): 57-61. doi: 10.12259/j.issn.2095-610X.S20211111
[9]	Jing LUO, Xian-ling GAO, Jian-lin SHAO, Chao ZHANG, Qi ZHANG. Mechanism of Biliverdin in Improving Cerebral Ischemia-reperfusion Injury in Rats. Journal of Kunming Medical University, 2020, 41(11): 1-6. doi: 10.12259/j.issn.2095-610X.S20201107
[10]	Liu Chun Ming , Liu Yun , He Li Ping , Zhang Yang Ping , Zhao Yi Bin , Zhou Yi Qing , Cao Xuan Lan , Deng Xiao Li . Clinical Characteristics of Brainstem Auditory Evoked Potential in Children with Brain Injury Syndrome. Journal of Kunming Medical University, 2019, 40(03): 78-82.
[11]	Li Hong Yang , Su Tian Yi , Gong Jian Ping , Gan Ping , Yang Bu Rong , Cun Ying Li , Cha Yong , Zhao Gong Fang . . Journal of Kunming Medical University, 2018, 39(09): 11-14.
[12]	Meng Hong Qiong , Su Hui Peng , Long Qiong Hua , Wang Ting Ting , Hu Yang . Effect of Statins on Lower Airway Bacterial Colonization in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease of Different Severity. Journal of Kunming Medical University, 2018, 39(07): 61-66.
[13]	Zhao Yi, Yan Zi Jun . A Study on the Influence of Atorvastatin for the CXCL Chemokines and Vascular Endothelial Damage Indexes of Patients with Angina Pectoris of Coronary Heart Disease. Journal of Kunming Medical University, 2018, 39(08): 59-63.
[14]	Wang Lu , Chen Jie , Kong Wei Long , Yu Ming Li . Biochemical Characteristics of Liver Injury Induced by Atorvastatin Combined HRZ. Journal of Kunming Medical University, 2018, 39(03): 42-48.
[15]	Liu Hu Jun , Gao Li Ping . . Journal of Kunming Medical University, 2017, 38(03): 94-97.
[16]	Zhang Wei . Effect of SGK1 on the Protection of Ischemia Reperfusion Model Rats. Journal of Kunming Medical University,
[17]	Li Sheng Hao . Characteristic of Liver Injury Induced by Simvastatin Combined with HRZ in SD Rats. Journal of Kunming Medical University,
[18]	Wang Wei Li . . Journal of Kunming Medical University,
[19]	Ma Jia . . Journal of Kunming Medical University,
[20]	. Protecton Mechanism of Shuanghuanglian against Liver Ischemia/Reperfusion injury in Rats. Journal of Kunming Medical University,