The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in <styled-content style-type="number">6462</styled-content> Adult Population in Kunming Area

Wenping SHAO; Ying ZHAO; Xin LI; Ruizhu TANG

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Wenping SHAO, Ying ZHAO, Xin LI, Ruizhu TANG. The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area[J]. Journal of Kunming Medical University.

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Wenping SHAO, Ying ZHAO, Xin LI, Ruizhu TANG. The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area[J]. Journal of Kunming Medical University.

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The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area

Dept. of Clinical Laboratory，The 1st Affiliated Hospital of Kunming Medical University/Yunnan Key Laboratory of Laboratory Medicine/ Yunnan Innovation Team of Clinical Laboratory and Diagnosis，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-08-22
Available Online: 2024-11-07

Abstract

Abstract

Objective To investigate the relationship between the biochemical indexes of bone metabolism and gender, age and season in adult residents. Methods The data of 6462 cases of physical examination in the physical examination center of the First Affiliated Hospital of Kunming Medical University from January 2021 to April 2024 were retrospectively analyzed. Gender, age, 25-hydroxyvitamin D（25-OH-VD）, calcitonin （CT）, n-terminal osteocalcin （N-MID）, and β-collagen degradation products （Beta-CrossLaps, β-CTX） of all subjects were collected. The data were grouped according to the reference value range, gender, age and season of biochemical indicators of bone metabolism. SPSS29.0 software was used to conduct the overall level distribution statistics of the data, compare the differences in the level of biochemical indicators of bone metabolism between groups, analyze the correlation between the level of biochemical indicators of bone metabolism, and explore the influencing factors of biochemical indicators of bone metabolism. Results The overall median levels of biochemical indices were 25-OH-VD 61.93 （49.17, 77.12） nmol/L, CT1.43 （.53, 3.01） pg/mL, N-MID16.0 （12.8, 20.2） ng/mL, β-CTX397.0 （295.0, 527.0） pg/mL. N-MID was significantly positively correlated with β-CTX （r_s = 0.748）. The effects of gender, age and season on 25-OH-VD and N-MID were statistically significant （P < 0.05）. Conclusion The overall median 25-OH-VD levels in this study population are lower than the normal reference range, and vitamin D levels are generally insufficient and more common in the younger study population, suggesting that vitamin D supplementation may be an general public health issue. The overall median CT, N-MID and β-CTX levels are in the normal reference range, indicating that the population is in good health on these indicators. Gender and age are significant factors affecting 25-OH-VD, CT and N-MID levels. Age is a significant factor affecting 25-OH-VD and N-MID levels. Season is a significant factor affecting the levels of 25-OH-VD, N-MID and β-CTX. N-MID and β-CTX may have a close biological relationship.
- Biochemical indexes of bone metabolism,
- 25-hydroxyvitamin D,
- Calcitonin,
- N-terminal osteocalcin,
- β-collagen degradation products

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References(24)

References

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