The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in <styled-content style-type="number">6462</styled-content> Adult Population in Kunming Area

Wenping SHAO; Ying ZHAO; Xin LI; Ruizhu TANG

doi:10.12259/j.issn.2095-610X.S20241118

Volume 45 Issue 11

Nov. 2024

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Wenping SHAO, Ying ZHAO, Xin LI, Ruizhu TANG. The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area[J]. Journal of Kunming Medical University, 2024, 45(11): 130-136. doi: 10.12259/j.issn.2095-610X.S20241118

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Wenping SHAO, Ying ZHAO, Xin LI, Ruizhu TANG. The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area[J]. Journal of Kunming Medical University, 2024, 45(11): 130-136. doi: 10.12259/j.issn.2095-610X.S20241118

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The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area

doi: 10.12259/j.issn.2095-610X.S20241118

Dept. of Clinical Laboratory，The 1st Affiliated Hospital of Kunming Medical University/Yunnan Key Laboratory of Laboratory Medicine/ Yunnan Innovation Team of Clinical Laboratory and Diagnosis，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-08-22
Available Online: 2024-11-07
Publish Date: 2024-11-25

Abstract

Abstract

Objective To investigate the relationship between the biochemical indexes of bone metabolism and gender, age and season in adult residents. Methods The data of 6462 cases of physical examination in the physical examination center of the First Affiliated Hospital of Kunming Medical University from January 2021 to April 2024 were retrospectively analyzed. Gender, age, 25-hydroxyvitamin D（25-OH-VD）, calcitonin （CT）, n-terminal osteocalcin （N-MID）, and β-collagen degradation products （Beta-CrossLaps, β-CTX） of all subjects were collected. The data were grouped according to the reference value range, gender, age and season of biochemical indicators of bone metabolism. SPSS29.0 software was used to conduct the overall level distribution statistics of the data, compare the differences in the level of biochemical indicators of bone metabolism between groups, analyze the correlation between the level of biochemical indicators of bone metabolism, and explore the influencing factors of biochemical indicators of bone metabolism. Results The overall median levels of biochemical indices were 25-OH-VD 61.93 （49.17, 77.12） nmol/L, CT1.43 （.53, 3.01） pg/mL, N-MID16.0 （12.8, 20.2） ng/mL, β-CTX397.0 （295.0, 527.0） pg/mL. N-MID was significantly positively correlated with β-CTX （r_s = 0.748）. The effects of gender, age and season on 25-OH-VD and N-MID were statistically significant （P < 0.05）. Conclusion The overall median 25-OH-VD levels in this study population are lower than the normal reference range, and vitamin D levels are generally insufficient and more common in the younger study population, suggesting that vitamin D supplementation may be an general public health issue. The overall median CT, N-MID and β-CTX levels are in the normal reference range, indicating that the population is in good health on these indicators. Gender and age are significant factors affecting 25-OH-VD, CT and N-MID levels. Age is a significant factor affecting 25-OH-VD and N-MID levels. Season is a significant factor affecting the levels of 25-OH-VD, N-MID and β-CTX. N-MID and β-CTX may have a close biological relationship.
- Biochemical indexes of bone metabolism,
- 25-hydroxyvitamin D,
- Calcitonin,
- N-terminal osteocalcin,
- β-collagen degradation products

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References(24)

References

[1]	张萌萌,马倩倩,毛未贤. 骨代谢生化指标临床应用专家共识(2023修订版)[J]. 中国骨质疏松杂志,2023,29(4):469-476.
[2]	中华医学会骨质疏松和骨矿盐疾病分会. 中国骨质疏松症流行病学调查及"健康骨骼" 专项行动结果发布[J]. 中华骨质疏松和骨矿盐疾病杂志,2019,12(4):317-318.
[3]	廖祥鹏,张增利,张红红,等. 维生素D与成年人骨骼健康应用指南(2014年标准版)[J]. 中国骨质疏松杂志,2014,20(9):1011-1030. doi: 10.3969/j.issn.1006-7108.2014.09.002
[4]	中华人民共和国卫生部. 骨代谢标志物临床应用指南: WS/T 357-2011[S]. 2011.
[5]	张萌萌,张岩,吴涤,等. 骨代谢生化指标实验推荐方案[J]. 中国骨质疏松杂志,2021,27(10):1405-1412,1549. doi: 10.3969/j.issn.1006-7108.2021.10.001
[6]	Jorde R,Grimnes G. Vitamin D and health: The need for more randomized controlled trials[J]. The Journal of Steroid Biochemistry and Molecular Biology,2015,148(4):269-274. doi: 10.1016/j.jsbmb.2015.01.021
[7]	Van Driel M,Van Leeuwen JPTM. Vitamin D and bone: A story of endocrine and auto/paracrine action in osteoblasts[J]. Nutrients,2023,15(3):480. doi: 10.3390/nu15030480
[8]	Bouillon,R. ,Manousaki,D. ,Rosen,C,et al. The health effects of vitamin D supplementation: Evidence from human studies[J]. Nat Rev Endocrinol,2022,18(2):96-110.
[9]	Raymond-Lezman J R,Riskin S I. Benefits and risks of sun exposure to maintain adequate vitamin D levels[J]. Cureus,2023,15(5):e38578.
[10]	周望展,何卫,赵峰. 6项骨代谢标志物与老年骨质疏松性骨折的相关性研究[J]. 中国卫生检验杂志,2023,33(16):2012-2014,2030.
[11]	许海琦,杨历新,李金娟,等. 青海高原成年居民血清25(OH)D水平及相关骨代谢指标的测定和影响因素[J]. 中国骨质疏松杂志,2023,29(3):385-389,402.
[12]	唐毅,杨靖,曹洪义,等. 成都地区不同年龄城乡妇女维生素D和骨代谢指标及骨密度的状况分析[J]. 中国骨质疏松杂志,2016,22(6):756-760. doi: 10.3969/j.issn.1006-7108.2016.06.021
[13]	Holick M F. Vitamin D: Evolutionary,physiological and health perspectives[J]. Curr Drug Targets,2011,12(1):4-18. doi: 10.2174/138945011793591635
[14]	Mithal A,Wahl D A,Bonjour J P,et al. Global vitamin D status and determinants of hypovitaminosis D[J]. Osteoporosis International,2009,20(11):1807-1820 doi: 10.1007/s00198-009-0954-6
[15]	Wechsung K,Schnabel D,Wiegand S. Longitudinal analysis of vitamin D levels considering sunshine duration and suggestion for a standardised approach for vitamin D supplementation in children and adolescents with obesity[J]. BMC Pediatr,2024,24(1):337.
[16]	张萌萌,张艳会,毛未贤,等. 1084例女性TRACP、CTX-1、BALP、BGP、钙磷代谢指标与BMD相关性[J]. 中国骨质疏松杂志,2013,19(9):902-906. doi: 10.3969/j.issn.1006-7108.2013.09.002
[17]	文碧. 中青年Graves病患者骨代谢生化指标状况调查[D]. 昆明: 昆明医科大学,2022.
[18]	叶竹,张金赫,张亚松,等. 围绝经期女性骨生化指标与骨密度的相关性分析[J]. 华南国防医学杂,2011,25(6):473-476,486.
[19]	史豳豳,陶初华,俞钰贤,等. 骨代谢4项与骨质疏松症的相关性研究[J]. 中国骨与关节损伤杂志,2019,34(2):212-213. doi: 10.7531/j.issn.1672-9935.2019.02.039
[20]	张萌萌. 骨代谢生化指标实验规范(2024)[J/OL]. 中国骨质疏松杂志,(2024-06-18)[2024-08-10]. https://link.cnki.net/urlid/11.3701.r.20240617.0909.002.
[21]	严海燕,曾华,罗玲,等. 三种骨代谢标志物在诊断及鉴别骨疾病中的应用[J]. 中国骨与关节损伤杂志,2012,27(9):859-860.
[22]	柳扬,刘光耀,李忠军. β-胶原降解产物,N-端骨钙素,总Ⅰ型胶原氨基端延长肽在肿瘤骨转移诊断中的应用[J]. 中国实验诊断学,2012,16(4):644-647. doi: 10.3969/j.issn.1007-4287.2012.04.025
[23]	安娜,纪丽慧,孟海燕,等. 2型糖尿病患者N-MID和β-CTX与骨密度的相关性研究[J]. 中国骨质疏松杂志,2018,24(12):1591-1595,1605. doi: 10.3969/j.issn.1006-7108.2018.12.007
[24]	赵滢,苏艳丹,唐睿珠,等. 昆明地区2563例人群维生素D营养的状况[J]. 昆明医科大学学报,2022,43(4):19-25. doi: 10.12259/j.issn.2095-610X.S20220405

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