The Role of DDX46 in the Occurrence And Development of Malignant Tumors

Yu HUO; Yunhe JU; Yutao WANG; Yalin ZENG; Junfeng LIANG

doi:10.12259/j.issn.2095-610X.S20241123

Volume 45 Issue 11

Nov. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(11): 161-165

Yu HUO, Yunhe JU, Yutao WANG, Yalin ZENG, Junfeng LIANG. The Role of DDX46 in the Occurrence And Development of Malignant Tumors[J]. Journal of Kunming Medical University, 2024, 45(11): 161-165. doi: 10.12259/j.issn.2095-610X.S20241123

Citation:

Yu HUO, Yunhe JU, Yutao WANG, Yalin ZENG, Junfeng LIANG. The Role of DDX46 in the Occurrence And Development of Malignant Tumors[J]. Journal of Kunming Medical University, 2024, 45(11): 161-165. doi: 10.12259/j.issn.2095-610X.S20241123

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The Role of DDX46 in the Occurrence And Development of Malignant Tumors

doi: 10.12259/j.issn.2095-610X.S20241123

1.
Dept. of Radiotherapy，The 3rd Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital，Kunming Yunnan 650118
2.
Dept. of Experimental Animals，Kunming Medical University， Kunming Yunnan 650500，China)

Received Date: 2024-08-25
Available Online: 2024-11-09
Publish Date: 2024-11-25

Abstract

Abstract

With the deepening development of molecular biology, people's understanding of the mechanisms of cancer occurrence is becoming increasingly profound. In recent years, DDX46 has been found to be overexpressed in various cancers such as colorectal cancer, esophageal squamous cell carcinoma, and gastric cancer. It can promote the proliferation of various malignant tumor cells, activate invasion and migration, resist cell apoptosis, and participate in the cell cycle. Therefore, it may become a potential target and biomarker for anti-tumor drugs. To provide a more intuitive understanding of the role of DDX46 in cancer, we systematically describe its functions and related mechanisms in various aspects of tumorigenesis and development. It provides a new idea for the research and development of DDX46 targeted drugs.
- Molecular biology,
- DDX46,
- Cancer,
- RNA helicase

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References(30)

References

[1]	Zhang Z M,Yang F,Zhang J. Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly[J]. Cell Rep,2013,5(5):1269-1278. doi: 10.1016/j.celrep.2013.10.047
[2]	Will C L,Urlaub H,Achsel T. Characterization of novel SF3b and 17S U2 snRNP proteins,including a human Prp5p homologue and an SF3b DEAD-box protein[J]. EMBO,2002,21(18):4978-4988. doi: 10.1093/emboj/cdf480
[3]	Zheng Q,Hou J,Zhou Y. The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus[J]. Nat Immunol,2017,18(10):1094-1103.
[4]	Yang F,Bian T,Zhan X. Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly[J]. Nat Commun,2023,14(1):897. doi: 10.1038/s41467-023-36489-x
[5]	Chen L,Xu M,Zhong W. Knockdown of DDX46 suppresses the proliferation and invasion of gastric cancer through inactivating Akt/GSK-3β/β-catenin pathway[J]. Exp Cell Res,2020,399(1):112448.
[6]	Li M,Ma Y,Huang P. Lentiviral DDX46 knockdown inhibits growth and induces apoptosis in human colorectal cancer cells[J]. Gene,2015,560(2):237-244. doi: 10.1016/j.gene.2015.02.020
[7]	Li B,Li Y M,He W T. Knockdown of DDX46 inhibits proliferation and induces apoptosis in esophageal squamous cell carcinoma cells[J]. Oncol Rep,2016,36(1):223-230. doi: 10.3892/or.2016.4803
[8]	Bleichert F,Baserga S J. The long unwinding road of RNA helicases[J]. Mol Cell,2007,27(3):339-352. doi: 10.1016/j.molcel.2007.07.014
[9]	Tanner N K, Linder P. DExD/H box RNA helicases: From generic motors to specific dissociation functions[J]. Mol Cell,2001,8(2):251-262.
[10]	Xu Y Z,Newnham C M,Kameoka S. Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA[J]. Embo J,2004,23(2):376-385. doi: 10.1038/sj.emboj.7600050
[11]	Shao W. A U1-U2 snRNP interaction network during intron definition[J]. Mol Cell Biol,2012,32(2):470-478. doi: 10.1128/MCB.06234-11
[12]	Will C L,Lührmann R. Spliceosome structure and function[J]. Cold Spring Harbor Perspect Biol,2011,3(7):a003707.
[13]	Liang W W,Cheng S C. A novel mechanism for Prp5 function in prespliceosome formation and proofreading the branch site sequence[J]. Genes Dev,2015,29(1):81-93. doi: 10.1101/gad.253708.114
[14]	Gama-Brambila R A,Chen J,Zhou J. A PROTAC targets splicing factor 3B1[J]. Cell Chem Biol,2021,28(11):1616-1627. doi: 10.1016/j.chembiol.2021.04.018
[15]	Yoshida K,Ogawa S. Splicing factor mutations and cancer[J]. Wires Rna,2014,5(4):445-459. doi: 10.1002/wrna.1222
[16]	Xu Y Z,Query C C. Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly[J]. Mol Cell,2007,28(5):838-849. doi: 10.1016/j.molcel.2007.09.022
[17]	Abu Dayyeh B K,Quan T K,Castro M. Probing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein,Prp5[J]. J Biol Chem,2002,277(23):20221-20233. doi: 10.1074/jbc.M109553200
[18]	Ma J,Gao Z,Liu X. DDX46 accelerates the proliferation of glioblastoma by activating the MAPK-p38 signaling[J]. J Buon,2021,26(5):2084-2089.
[19]	Lin Q,Jin H J. DDX46 silencing inhibits cell proliferation by activating apoptosis and autophagy in cutaneous squamous cell carcinoma[J]. Mol Med Rep,2020,22(5):4236-4242.
[20]	Ma Z,Song J. The role of DDX46 in breast cancer proliferation and invasiveness: A potential therapeutic target[J]. Cell Biol Int,2022,47(1):283-291.
[21]	Jiang,F,Zhang. Knockdown of DDX46 Inhibits the invasion and tumorigenesis in osteosarcoma cells[J]. Oncol Res,2016,25(3):417-425.
[22]	Asher V , Warren A , Shaw R. The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line[J]. Cancer Cell International,2011,11(1):1-7.
[23]	Admoni-Elisha L,Nakdimon I,Shteinfer A. Novel biomarker proteins in chronic lymphocytic leukemia: Impact on diagnosis,prognosis and treatment[J]. PLos One,2016,11(4):e0148500. doi: 10.1371/journal.pone.0148500
[24]	Yang J, Nie J, Ma X. Targeting PI3K in cancer: Mechanisms and advances in clinical trials[J]. Mol Cancer, 18(1): 26.
[25]	Faes S,Dormond O. PI3K and AKT: Unfaithful partners in cancer[J]. Int J Mol Sci,2015,16(9):21138-21152. doi: 10.3390/ijms160921138
[26]	Peter M E. Programmed cell death: Apoptosis meets necrosis[J]. Nature,2011,471(7338):310-312. doi: 10.1038/471310a
[27]	Tanaka K, Kumano K, Ueno H. Intracellular signals of lung cancer cells as possible therapeutic targets[J]. Cancer Sci,2015,106(5):489-496.
[28]	You X,Cui H,Yu N. Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia[J]. Open Life Sci,2020,15(1):400-408. doi: 10.1515/biol-2020-0043
[29]	Li A,He J,Zhang Z. Integrated bioinformatics analysis reveals marker genes and potential therapeutic targets for pulmonary arterial hypertension[J]. Genes (Basel),2021,12(9):1339. doi: 10.3390/genes12091339
[30]	Hirabayashi,R,Hozumi. Ddx46 is required for multi-lineage differentiation of hematopoietic stem cells in zebrafish[J]. Stem Cells Dev,2013,22(18):2532-2542.

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