The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis

Xinyi MEN; Jing ZHAO; Yongchun SHEN; Hui JI; Xiuxia WANG

doi:10.12259/j.issn.2095-610X.S20241217

Volume 45 Issue 12

Dec. 2024

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Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG. The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis[J]. Journal of Kunming Medical University, 2024, 45(12): 122-128. doi: 10.12259/j.issn.2095-610X.S20241217

Citation:

Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG. The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis[J]. Journal of Kunming Medical University, 2024, 45(12): 122-128. doi: 10.12259/j.issn.2095-610X.S20241217

Citation:

Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG. The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis[J]. Journal of Kunming Medical University, 2024, 45(12): 122-128. doi: 10.12259/j.issn.2095-610X.S20241217

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The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis

doi: 10.12259/j.issn.2095-610X.S20241217

1.
Dept. of Pediatrics，The 2nd Hospital of Hebei Medical University，Shijiazhuang 050000
2.
Dept. of Neurology，Hebei Veterans General Hospital，Xingtai 054000
3.
Dept. of Pediatrics，The 2nd Hospital of Hebei Medical University，Shijiazhuang 050000，China

Received Date: 2024-01-30
Available Online: 2024-05-23
Publish Date: 2024-12-31

Abstract

Abstract

Objective To investigate the relationship between peripheral blood immunoglobulin, erythrocyte sedimentation rate （ESR）, homocysteine （Hcy） and the severity of central nervous system vasculitis （CNSV） in children, as well as its impact on prognosis. Methods A total of 103 children with CNSV from February 2018 to February 2023 were selected as the study group, and 103 healthy children as the control group. The peripheral blood levels of immunoglobulin A （IgA）, immunoglobulin G （IgG）, immunoglobulin M （IgM）, ESR and Hcy were compared between the 2 groups to evaluate the relationship between each index and the degree of CNSV disease [Birmingham vasculitis disease activity score （BVAS）] and its predictive value for prognosis. Results The levels of peripheral blood IgA, IgG, IgM, ESR and Hcy in the study group were higher than those in the control group of healthy children （P < 0.05）; the BVAS scores and the levels of peripheral blood IgA, IgG, IgM, ESR and Hcy in children with active disease were higher than those in children with inactive disease （P < 0.05）; the levels of peripheral blood IgA, IgG, IgM, ESR and Hcy were positively correlated with the BVAS scores in children with CNSV （P < 0.05）; two cases were lost to follow-up after 6 months. Among the children with CNSV, 76 had good prognosis and 25 poor prognosis. The levels of peripheral blood IgA, IgG, IgM, ESR and Hcy in children with poor prognosis were higher than those in children with good prognosis （P < 0.05）; before and after correcting for other factors, peripheral blood IgA, IgG, IgM, ESR and Hcy were all independent factors affecting the prognosis of children with CNSV （P < 0.05）; the area under curve （AUC） of peripheral blood IgA, IgG, IgM, ESR and Hcy for predicting the prognosis of children with CNSV was 0.747, 0.808, 0.841, 0.839, and 0.746, respectively, with optimal cutoff values of 350.58 mg/dL, 1513.06 mg/dL, 124.84 mg/dL, 51.22 mm/h, and 13.66 μmol/L, respectively; the AUC of peripheral blood IgA, IgG, IgM, ESR and Hcy for jointly predicting the prognosis of children with CNSV was 0.943 （95%CI 0.878-0.979）, with a sensitivity of 92.00% and a specificity of 93.42%, which was superior to individual prediction of each indicator. Conclusion Peripheral blood IgA, IgG, IgM, ESR and Hcy are positively correlated with the severity of CNSV. Abnormally high expression increases the risk of poor prognosis, and the combined predictive value is reliable.
- Children's central nervous system vasculitis,
- Immunoglobulin,
- Blood sedimentation rate,
- Homocysteine,
- Degree of illness,
- Prognosis,
- Predictive value

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References(24)

References

[1]	Rice C M,Scolding N J. The diagnosis of primary central nervous system vasculitis[J]. Pract Neurol,2020,20(2):109-114. doi: 10.1136/practneurol-2018-002002
[2]	Ota Y,Srinivasan A,Capizzano A A,et al. Central nervous system systemic lupus erythematosus: Pathophysiologic,clinical,and imaging features[J]. Radiographics,2022,42(1):212-232. doi: 10.1148/rg.210045
[3]	Malani Shukla N,Lotze T E,Muscal E. Inflammatory diseases of the central nervous system[J]. Neurol Clin,2021,39(3):811-828. doi: 10.1016/j.ncl.2021.04.004
[4]	Neumann T. Update on immunoglobulin a vasculitis[J]. Z Rheumatol,2022,81(4): 305-312.
[5]	Lapić I,Padoan A,Bozzato D,et al. Erythrocyte sedimentation rate and C-Reactive protein in acute inflammation[J]. Am J Clin Pathol,2020,153(1):14-29. doi: 10.1093/ajcp/aqz142
[6]	Tawfik A,Elsherbiny N M,Zaidi Y,et al. Homocysteine and age-Related central nervous system diseases: Role of inflammation[J]. Int J Mol Sci,2021,22(12):6259. doi: 10.3390/ijms22126259
[7]	中国医师协会儿科医师分会风湿免疫学组. 中国儿童血管炎诊断与治疗系列专家共识之一——总论[J]. 中国实用儿科杂志,2023,38(4):241-247.
[8]	Mukhtyar C,Lee R,Brown D,et al. Modification and validation of the Birmingham vasculitis activity score (version 3)[J]. Ann Rheum Dis,2009,68(12):1827-1832. doi: 10.1136/ard.2008.101279
[9]	Nehme A,Boulanger M,Aouba A,et al. Diagnostic and therapeutic approach to adult central nervous system vasculitis[J]. Rev Neurol (Paris),2022,178(10):1041-1054. doi: 10.1016/j.neurol.2022.05.003
[10]	Hajj-Ali R A,Calabrese L H. Central nervous system vasculitis: Advances in diagnosis[J]. Curr Opin Rheumatol,2020,32(1):41-46. doi: 10.1097/BOR.0000000000000676
[11]	Amin M,Uchino K,Hajj-Ali R A. Central nervous system vasculitis: Primary angiitis of the central nervous system and central nervous system manifestations of systemic vasculitis[J]. Rheum Dis Clin North Am,2023,49(3):603-616. doi: 10.1016/j.rdc.2023.03.011
[12]	Marriaga-N ú ñez B,Arellano-Valdez A,Paz J P A,et al. Immunoglobulin-resistant Kawasaki disease[J]. Bol Med Hosp Infant Mex,2023,80(4): 260-264.
[13]	丁小娟,倪瑞钟,王玎,等. 抗中性粒细胞细胞质抗体相关性血管炎患者血清IgG4表达水平及临床意义[J]. 现代医药卫生,2021,37(6):906-909.
[14]	Ito T,Fukui S,Kanie T,et al. Immunoglobulin G4-related coronary periarteritis: A systematic literature review with a case series[J]. Clin Rheumatol,2022,41(8):2281-2295. doi: 10.1007/s10067-022-06179-y
[15]	Fatima R,Acharya A,Bozorgnia F,et al. Sertraline-associated immunoglobulin a vasculitis[J]. Am J Ther,2022,29(4):484-486. doi: 10.1097/MJT.0000000000001516
[16]	Shaikh K J,Osio V A,Leeflang M M,et al. Procalcitonin,C-reactive protein,and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children[J]. Cochrane Database Syst Rev,2020,9(9):CD009185.
[17]	何冬,喻杉,陈露. 急性骨髓炎患者血清红细胞沉降率、白细胞、降钙素原和白细胞介素-6水平变化及意义研究[J]. 陕西医学杂志,2023,52(6):709-713.
[18]	Ying P,Lu T,Xu Y,et al. Preoperative erythrocyte sedimentation rate in patients with rheumatoid arthritis predicts deep vein thrombosis following total knee arthroplasty[J]. Clin Hemorheol Microcirc,2022,81(1):23-31. doi: 10.3233/CH-211286
[19]	杨清,马玉华,何春容,等. 血液常规分析衍生炎性参数指标在抗中性粒细胞胞浆抗体相关性血管炎中的临床意义分析[J]. 标记免疫分析与临床,2022,29(8):1330-1335.
[20]	杜莹珏,赖蓓,石婧,等. 系统性血管炎常用指标对疾病活动评估的意义[J]. 中国临床保健杂志,2014,17(2):113-115.
[21]	Smith A D,Refsum H. Homocysteine - from disease biomarker to disease prevention[J]. J Intern Med,2021,290(4):826-854. doi: 10.1111/joim.13279
[22]	Silberstein R B,Pipingas A,Scholey A B. Homocysteine modulates brain functional connectivity in a memory retrieval task[J]. J Alzheimers Dis,2022,90(1):199-209. doi: 10.3233/JAD-220612
[23]	王玉明. 中枢神经系统特发性炎性脱髓鞘疾病患者血清尿酸、同型半胱氨酸水平及其临床意义[J]. 广西医学,2020,42(3):302-304,370.
[24]	Akahoshi N,Kamichatani W,Ishii I. Homocysteine hypothesis on the impaired peripheral but not central nervous system oxytocin responses in cystathionine γ-lyase-deficient dam mice[J]. Biol Pharm Bull,2020,43(11):1810-1813. doi: 10.1248/bpb.b20-00676

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