Analysis on the Expression of Basement Membrane Protein in Endometrial Carcinoma and Its Relationship with Immune Invasion

Ying ZHANG; Xiangru LUO; Xing WANG; Pan ZHAO; Kun LIAN; Yuanqin LI; Mingkun SHAO

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Ying ZHANG, Xiangru LUO, Xing WANG, Pan ZHAO, Kun LIAN, Yuanqin LI, Mingkun SHAO. Analysis on the Expression of Basement Membrane Protein in Endometrial Carcinoma and Its Relationship with Immune Invasion[J]. Journal of Kunming Medical University.

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Analysis on the Expression of Basement Membrane Protein in Endometrial Carcinoma and Its Relationship with Immune Invasion

1.
Dept. of Obstetrics，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
2.
Dept. of Obstetrics and Gynecology，Yiliang County People's Hospital，Zhaotong Yunnan 657600
3.
Dept. of Neurosurgery，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2024-04-05
Available Online: 2024-11-22

Abstract

Abstract

Objective Immune infiltration, as well as their implications across various cancers, and to establish a clinical prognostic model based on the findings. Methods The expression profile and clinical information of endometrial cancer tissue and adjacent tissues in TCGA endometrial cancer database were used, the differential expression genes were screened out for analysis, and the mRNA co-expressed by LncRNA was analyzed by GO enrichment and KEGG signaling pathway.The differential genes between endometrial cancer and adjacent tissues were intersected with the basement membrane protein genes. The selected differentially expressed genes were combined with survival status and survival time to screen out Hub genes by Lasso-cox regression analysis. Multivariate Cox regression analysis was used to establish a prognostic model, and pan-cancer analysis and immunoinfiltration correlation analysis were further performed. Results Six basal membrane protein Hub genes, ADAMTS5, EVA1C, THBS4, CTSD, ITGAV and LAMA1, were identified as associated with the prognosis of patients with endometrial cancer, and found that the survival rate of patients decreased significantly with the increase of risk score. Pan-cancer analysis found that these 6 genes were significantly different in most cancer types, and high expression in GBMLGG （glioma）, LGG （low-grade glioma of the brain）, LAML （acute myeloid leukemia）, UVM （Uveal melanoma）, ACC （adrenal cortical cancer） and other cancers had poor prognosis. The potential role of these genes in tumor immunotherapy was also explored, and significant negative correlation was found with Th17 cells, Th2 cells, NK CD56 bright cells and other immune cells （P < 0.01）, and significant positive correlation was found with Tcm, iDC, Eosinophils, aDC and other immune cells （P < 0.01）. Conclusion Basal membrane protein gene has high clinical value in the diagnosis and prognosis of endometrial cancer, and can be used as a prognostic marker and potential therapeutic target for patients with endometrial cancer.
- Basement membrane protein gene,
- Endometrial carcinoma,
- Prognosis,
- Immune infiltration

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References(25)

References

[1]	Wang N,Zhang J,Fan X,et al. Identification of risk factors for the prognosis of Chinese patients with endometrial carcinoma[J]. Medicine (Baltimore),2021,100(38):e27305.
[2]	Li Y T,Yang S T,Wang P H. Molecular pathology and prognosis of endometrial cancer[J]. Taiwan J Obstet Gynecol,2022,61(6):921-922. doi: 10.1016/j.tjog.2022.06.011
[3]	Maheshwari E,Nougaret S,Stein E B,et al. Update on MRI in evaluation and treatment of endometrial cancer[J]. Radiographics,2022,42(7):2112-2130.
[4]	Liu Y,Li H,Zhao C,et al. MicroRNA-101 inhibits angiogenesis via COX-2 in endometrial carcinoma[J]. Mol Cell Biochem,2018,448(2):61-69. doi: 10.1007/s11010-018-3313-0
[5]	Nees L K,Heublein S,Steinmacher S,et al. Endometrial hyperplasia as a risk factor of endometrial cancer[J]. Arch Gynecol Obstet,2022,306(2):407-421.
[6]	Crosbie E J,Kitson S J,Mcalpine J N,et al. Endometrial cancer[J]. Lancet,2022,399(10333):1412-1428. doi: 10.1016/S0140-6736(22)00323-3
[7]	Raglan O,Kalliala I,Markozannes G,et al. Risk factors for endometrial cancer: An umbrella review of the literature[J]. Int J Cancer,2019,145(7):1719-1730. doi: 10.1002/ijc.31961
[8]	Marin-jimenez J A,Garcia-mulero S,Matias-guiu X,et al. Facts and hopes in immunotherapy of endometrial cancer[J]. Clin Cancer Res,2022,28(22):4849-4860. doi: 10.1158/1078-0432.CCR-21-1564
[9]	Karpel H,Slomovitz B,Coleman R L,et al. Biomarker-driven therapy in endometrial cancer[J]. Int J Gynecol Cancer,2023,33(3):343-350. doi: 10.1136/ijgc-2022-003676
[10]	Wilson S E. Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis[J]. Cell Mol Life Sci,2022,79(3):144-159.
[11]	Wilson S E. Fibrosis Is a Basement membrane-related disease in the cornea: Injury and defective regeneration of basement membranes may underlie fibrosis in other organs[J]. Cells,2022,11(2):309-330. doi: 10.3390/cells11020309
[12]	Kuang H,Liu J,Jia X Y,et al. Autoimmunity in anti-glomerular basement Membrane Disease: A Review of Mechanisms and Prospects for Immunotherapy[J]. Am J Kidney Dis,2023,81(1):90-99. doi: 10.1053/j.ajkd.2022.07.006
[13]	Mukwaya A,Jensen L,Lagali N. Relapse of pathological angiogenesis: Functional role of the basement membrane and potential treatment strategies[J]. Exp Mol Med,2021,53(2):189-201.
[14]	Kanazawa Y,Nagano M,Koinuma S,et al. Effects of aging on basement membrane of tibialis anterior muscle during recovery following muscle injury in rats[J]. Microscopy (Oxf),2022,71(4):245-248. doi: 10.1093/jmicro/dfac016
[15]	Fitzgerald J. WARP: A unique extracellular matrix component of cartilage,muscle,and endothelial cell basement membranes[J]. Anat Rec (Hoboken),2020,303(6):1619-1623.
[16]	Nissen N I,Karsdal M,Willumsen N. Collagens and cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology[J]. J Exp Clin Cancer Res,2019,38(1):115-127. doi: 10.1186/s13046-019-1110-6
[17]	Banerjee S,Lo W C,Majumder P,et al. Multiple roles for basement membrane proteins in cancer progression and EMT[J]. Eur J Cell Biol,2022,101(2):151220. doi: 10.1016/j.ejcb.2022.151220
[18]	Siegel R L,Miller K D,Fuchs H E,et al. Cancer statistics,2022[J]. CA Cancer J Clin,2022,72(1):7-33. doi: 10.3322/caac.21708
[19]	Liu S J,Dang H X,Lim D A,et al. Long noncoding RNAs in cancer metastasis[J]. Nat Rev Cancer,2021,21(7):446-460.
[20]	Li X,Kuang Q,Peng M,et al. Basement membrane-associated lncRNA risk model predicts Prognosis and Guides Clinical Treatment in Clear Cell Renal Cell Carcinoma[J]. Biomedicines,2023,11(10):2635-2655. doi: 10.3390/biomedicines11102635
[21]	安梦霞,王萍玉. 基于铜死亡相关LncRNAs构建肺鳞癌预后预测模型[J]. 肿瘤防治研究,2023,50(11):1084-1090.
[22]	Jayadev R,Morais M,Ellingford J M,et al. A basement membrane discovery pipeline uncovers network complexity,regulators,and human disease associations[J]. Sci Adv,2022,8(20):eabn2265. doi: 10.1126/sciadv.abn2265
[23]	Siegel L,Miller K D,Wagle N S,et al. Cancer statistics,2023[J]. CA Cancer J Clin,2023,73(1):17-48. doi: 10.3322/caac.21763
[24]	Li X,Fliegel L. Permissive role of Na(+)/H(+) exchanger isoform 1 in migration and invasion of triple-negative basal-like breast cancer cells[J]. Mol Cell Biochem,2022,477(4):1207-1216.
[25]	Deutsch J S,Lai J,Schenk K M,et al. Immune microenvironment of basal cell carcinoma and tumor regression following combined PD-1/LAG-3 blockade[J]. J Immunother Cancer,2023,11(12):e007463. doi: 10.1136/jitc-2023-007463

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