The Prognostic Value of Preoperative Peripheral Blood Inflammatory Markers Combined with Tumor Markers in Resectable Colon Cancer Patients

Bowen TAN; Yun LIANG; Huan CHEN; Yi LEI; Yuhan WANG; Yan TIAN

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Bowen TAN, Yun LIANG, Huan CHEN, Yi LEI, Yuhan WANG, Yan TIAN. The Prognostic Value of Preoperative Peripheral Blood Inflammatory Markers Combined with Tumor Markers in Resectable Colon Cancer Patients[J]. Journal of Kunming Medical University.

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The Prognostic Value of Preoperative Peripheral Blood Inflammatory Markers Combined with Tumor Markers in Resectable Colon Cancer Patients

1.
Gastroenterology Department
2.
Hepatobiliary Dept. of The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-01-26
Available Online: 2024-05-23

Abstract

Abstract

Objective To analyze the prognostic value of preoperative peripheral blood inflammatory markers neutrophil to lymphocyte ratio （NLR） combined with tumor markers carcinoembryonic antigen （CEA） and glycoprotein antigen CA19-9 in patients with colon cancer. Methods A retrospective study was conducted on 158 cases of colon cancer patients who visited the 1st Affiliated Hospital of Kunming Medical University from May 2018 to October 2020. The receiver operating characteristic curve （ROC） was used to determine the critical values of various indicators and group them. The Kaplan Meier method was used to analyze the relationship between NLR, CEA, CA19-9, and combined detection of different groups and patient survival prognosis. Multivariate Cox regression analysis was used to analyze the factors affecting patient prognosis. Results The preoperative NLR level （P = 0.035）, combined testing group （P = 0.008）, and postoperative pathological N stage （P < 0.001） were independent risk factors for OS, and the joint testing group has the highest risk ratio among preoperative indicators （P = 0.008, HR = 2.664, 95%CI 1.503～4.315）. Conclusion The combined detection of NLR, CEA, and CA19-9 in peripheral blood before surgery has independent prognostic value for patients with colon cancer.
- Neutrophil to lymphocyte ratio,
- Carcinoembryonic antigen （CEA）,
- Glycoprotein antigen （CA19-9）,
- Prognosis,
- Colon cancer

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References(19)

References

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