Early Predictive Value of Lymphocyte Subsets for Cognitive Dysfunction in Cerebral Ischemia-reperfusion Injury

Jibo QU; Ling ZHU; Binghui HOU; Song BAI; Anmu XIE

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Jibo QU, Ling ZHU, Binghui HOU, Song BAI, Anmu XIE. Early Predictive Value of Lymphocyte Subsets for Cognitive Dysfunction in Cerebral Ischemia-reperfusion Injury[J]. Journal of Kunming Medical University.

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Jibo QU, Ling ZHU, Binghui HOU, Song BAI, Anmu XIE. Early Predictive Value of Lymphocyte Subsets for Cognitive Dysfunction in Cerebral Ischemia-reperfusion Injury[J]. Journal of Kunming Medical University.

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Early Predictive Value of Lymphocyte Subsets for Cognitive Dysfunction in Cerebral Ischemia-reperfusion Injury

Jibo QU¹,
Ling ZHU²,
Binghui HOU³,
Song BAI¹,
Anmu XIE^{3
,
,}

1.
Dept. of neurology, Affiliated Honghe Hospital of Kunming Medical University/ Diannan Central Hospital, Mengzi Yunnan 661100
2.
Dept. of neurology, 5th Affiliated Hospital of Kunming Medical University/Diannan Central Hospital of Honghe Region，Gejiu Yunnan 661000
3.
Dept. of neurology, Affiliated Hospital of Qingdao University，Qingdao Shandong 266003，China

Received Date: 2024-10-28
Available Online: 2024-11-23

Abstract

Abstract

Objective To explore the early predictive value of lymphocyte subsets for cognitive impairment in cerebral ischemia-reperfusion injury. Methods A study was conducted on 68 patients with cerebral ischemia admitted to Honghe Hospital affiliated to Kunming Medical University from January 2023 to December 2023, divided into observation group (n = 30) and control group (n = 38).The general situation, lymphocyte subsets detection results and Montreal Cognitive Assessment Scale （MoCA） score were compared. Their correlation, sensitivity, specificity were analyzed. Results The proportion of patients with diabetes and levels of CD3⁺, CD8⁺ and MoCA score in the observation group were lower than those in the control group （P < 0.05）, the levels of CD4⁺, CD4⁺/CD8⁺, NK and CD19⁺ in the observation group were higher than those in the control group （P < 0.05）; CD3⁺ and CD8⁺ were positively correlated with MoCA score （P < 0.05）; CD4⁺, CD4⁺/CD8⁺, NK and CD19⁺ were negatively correlated with MoCA score （P < 0.05）. The sensitivity and specificity of lymphocyte subsets combined detection for the diagnosis of cognitive dysfunction in cerebral ischemia-reperfusion injury were 93.45% and 100.00%, respectively. Conclusion The lymphocyte subsets have good predictive value for the occurrence of cognitive dysfunction in cerebral ischemia-reperfusion injury. It can be used as a specific marker.
- Cerebral ischemia,
- Reperfusion injury,
- Cognitive dysfunction,
- Lymphocyte subsets

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References(19)

References

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