The Correlation of Iron Metabolism Indexes，Cytokines，and Liver Function in Patients with Hemophagocytic Syndrome

Fen LI; Jie ZHAO; Haixi ZHANG; Lin ZHANG; Xuezhong GU

doi:10.12259/j.issn.2095-610X.S20241115

Volume 45 Issue 11

Nov. 2024

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Fen LI, Jie ZHAO, Haixi ZHANG, Lin ZHANG, Xuezhong GU. The Correlation of Iron Metabolism Indexes，Cytokines，and Liver Function in Patients with Hemophagocytic Syndrome[J]. Journal of Kunming Medical University, 2024, 45(11): 110-116. doi: 10.12259/j.issn.2095-610X.S20241115

Citation:

Fen LI, Jie ZHAO, Haixi ZHANG, Lin ZHANG, Xuezhong GU. The Correlation of Iron Metabolism Indexes，Cytokines，and Liver Function in Patients with Hemophagocytic Syndrome[J]. Journal of Kunming Medical University, 2024, 45(11): 110-116. doi: 10.12259/j.issn.2095-610X.S20241115

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The Correlation of Iron Metabolism Indexes，Cytokines，and Liver Function in Patients with Hemophagocytic Syndrome

doi: 10.12259/j.issn.2095-610X.S20241115

Dept. of Hematology，The 1st People’s Hospital of Yunnan Province/ Affiliated Hospital of Kunming University of Science and Technology/Yunnan Provincial Clinical Medical Center for Hemotology/Yunnan Provincial Clinical Research Center for Hemotology/National Clinical Research Center for Hemotology/Yunnan Provincial Atherosclerosis Traditional Chinese and Western Medicine Collaborative Base，Kunming Yunnan 650032，China

Received Date: 2024-05-27
Available Online: 2024-11-09
Publish Date: 2024-11-25

Abstract

Abstract

Objective To investigate preliminarily the causes of elevated ferritin in patients with hemophagocytic syndrome by analyzing the iron metabolism indexes, liver function and cytokine levels. Methods 41 patients with the hemophagocytic syndrome and another 41 non-hemophagocytic syndrome patients with the elevated ferritin levels （as the control group） admitted to the First People’ s Hospital of Yunnan Province from September 2021 to May 2024 were recruited for iron metabolism, cytokine and liver function tests, and the differences between these indexes and their relationship with the ferritin were analyzed. Results Patients with the hemophagocytic syndrome had the significantly higher levels of ferritin and lower levels of soluble transferrin receptor compared to the control group. Cytokines IL-4, IL-8, IL-10, IL-1 β, IL-2, IFN - γ, TNF - α, TNF - β, IL-17A, and IL-17F were significantly higher than those in the control group, while transaminase, bilirubin, and lactate dehydrogenase were significantly higher than those in the control group. There was no significant correlation between ferritin and iron metabolism indicators, but it was negatively correlated with cytokine IL-4, positively correlated with IL-8 and IL-10, and positively correlated with LDH, ALT, and AST. Conclusion The ferritin of patients with hemophagocytic syndrome is significantly increased, but the iron metabolism process is not significantly different from that of the control group, and there are obvious inflammatory reactions and liver damage at the onset of the disease.The increase of ferritin is not correlated with iron metabolism indexes, but is related to the inflammation and liver damage.
- Hemophagocytic syndrome,
- Ferritin,
- Iron metabolism,
- Cytokines,
- Liver function

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References(22)

References

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