The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis

Xiaoling YANG; Zhen LIU; Yu WANG; Jing WANG

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 >

Xiaoling YANG, Zhen LIU, Yu WANG, Jing WANG. The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis[J]. Journal of Kunming Medical University.

Citation:

Xiaoling YANG, Zhen LIU, Yu WANG, Jing WANG. The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis[J]. Journal of Kunming Medical University.

Xiaoling YANG, Zhen LIU, Yu WANG, Jing WANG. The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis[J]. Journal of Kunming Medical University.

Citation:

PDF( 698 KB)

The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis

Dept. of Pediatrics，Xinyang 154th Hospital，Xinyang Henan 464000，China

Received Date: 2023-09-18
Available Online: 2024-05-20

Abstract

Abstract

Objective To investigate the correlation between the levels of soluble vascular endothelial growth factor receptor-1 （sFlt-1）, polyligand proteoglycan-4 （SDC4）, soluble human stromal lysin 2 （sST2） in serum and renal histopathological grading in children with Henoch-Schnlein purpura nephritis （HSPN）, and analyze their predictive value for therapeutic efficacy. Methods A retrospective study was conducted, in which 98 children with HSPN admitted to Xinyang 154th Hospital from April 2021 to April 2023 were selected as the research subjects. According to the clinical efficacy after 2 months of treatment, they were divided into an effective group of 78 cases and an ineffective group of 20 cases. Their clinical data and the levels of serum sFlt-1, SDC4, and sST2 before and after treatment were compared. Multivariate logistic regression analysis was used to analyze the factors affecting the efficacy. The predictive value of serum sFlt-1, SDC4, and sST2 levels after 1 month of treatment on the efficacy after 2 months of treatment was analyzed. Results As the pathological grade increased, the levels of serum sFlt-1, SDC4, and sST2 showed an upward trend （P < 0.05）; the levels of serum sFlt-1, SDC4, and sST2 in the ineffective group after 1 month of treatment were higher than those in the effective group （P < 0.05）; the symptom score of purpura, immunoglobulin A （IgA） level, and the levels of serum sFlt-1, SDC4, and sST2 after 1 month of treatment were independent risk factors for efficacy （P < 0.05）; the AUC of serum sFlt-1, SDC4, and sST2 levels combined to predict efficacy after 1 month of treatment was greater than that of any two combined predictions or single indicator predictions （P < 0.05）. Conclusion The levels of serum sFlt-1, SDC4, and sST2 in children with HSPN are closely related to the pathological grading of the kidney tissue. The combined detection of their levels has certain predictive value for the therapeutic effect.
- Purpuric nephritis,
- Soluble vascular endothelial growth factor receptor-1,
- Multiligand proteoglycan-4,
- Soluble human matrix metalloproteinase-2,
- Prediction

FullText(HTML)

References(20)

References

[1]	秦艳妮,党清华,景芳丽,等. 过敏性紫癜肾炎患儿血清IL-16、IL-18、IGF-1及IGFBP-3水平变化及临床意义[J]. 海南医学,2020,31(1):31-34. doi: 10.3969/j.issn.1003-6350.2020.01.009
[2]	代彦林,韩姗姗,丁樱,等. 清热止血方联合雷公藤多苷治疗儿童紫癜性肾炎疗效及其对血清sFlt-1、vWF的影响[J]. 中国中医基础医学杂志,2022,28(8):1296-1299. doi: 10.3969/j.issn.1006-3250.2022.8.zgzyjcyx202208025
[3]	Tang R, Lin W, Shen C J, et al. Single-cell transcriptomics uncover hub genes and cell-cell crosstalk in patients with hypertensive nephropathy[J]. Int Immunopharmacol,2023,125(1):111104-111114.
[4]	Moreau A,Nicaise C,Awada A,et al. Soluble ST2 is increased in systemic lupus erythematous and is a potential marker of lupus nephritis[J]. Clin Exp Rheumatol,2022,40(5):897-903.
[5]	何传梅, 刘锦秀, 韩红, 等. 雷公藤多苷治疗紫癜性肾炎患儿的疗效和安全性分析[J]. 世界中医药,2020,15(20):3094-3096.
[6]	中华医学会儿科学分会肾脏学组. 紫癜性肾炎诊治循证指南(2016)[J]. 中华儿科杂志,2017,55(9):647-651. doi: 10.3760/cma.j.issn.0578-1310.2017.09.003
[7]	陈宾, 邢舒旺, 陈东旭, 等. 肾炎康复片对紫癜性肾炎患儿的临床疗效分析以及对IL-17和IL-10因子的影响[J]. 中国中西医结合肾病杂志,2020,21(7):603-604.
[8]	张致远,高振中. 肾炎康复片对过敏性紫癜肾炎患儿血清及尿MCP-1、TGF-β1水平的影响[J]. 国际医药卫生导报,2019,25(4):606-610. doi: 10.3760/cma.j.issn.1007-1245.2019.04.033
[9]	Fessatou S,Nicolaidou P,Gourgiotis D,et al. Endothelin 1 levels in relation to clinical presentation and outcome of Henoch Schonlein purpura[J]. BMC Pediatr,2008,8(1):33-43. doi: 10.1186/1471-2431-8-33
[10]	Kurokawa M,Maehara K,Kaku Y,et al. Necessity and choice of therapy for Henoch-Schönlein purpura nephritis[J]. Pediatr Int,2022,64(1):e15282-e15292. doi: 10.1111/ped.15282
[11]	代彦林,张霞,高敏,等. 紫癜性肾炎患儿血清sFlt-1、vWF水平变化及其意义[J]. 山东医药,2021,61(12):51-53. doi: 10.3969/j.issn.1002-266X.2021.12.012
[12]	张迎旭,樊淑娟. 紫瘢性肾炎患儿血清FiB、D-D、sFlt-1、vWF水平变化及其临床意义[J]. 医学临床研究,2022,39(7):1033-1036. doi: 10.3969/j.issn.1671-7171.2022.07.020
[13]	张丽丽,林慧晶,蒋丽军,等. 血清骨膜蛋白、多配体蛋白聚糖4与紫癜性肾炎患儿肾脏病理分级的关系[J]. 实用临床医药杂志,2023,27(6):112-116. doi: 10.7619/jcmp.20222389
[14]	刘剑锋,霍佳雯,朱栋梁,等. 血清POSTN、SDC4水平和24 h尿蛋白定量与紫癜性肾炎患儿肾脏病理分级的相关性[J]. 天津医药,2020,48(2):128-131. doi: 10.11958/20191936
[15]	张雨,高爽,张媛. 血清sPLA2-IB、GDF-15、sST2在特发性膜性肾病患者中表达及临床意义[J]. 标记免疫分析与临床,2022,29(1):96-100.
[16]	杨晶,邱晓楠,柳彩侠. 血清抗PLA2R抗体和sST2在特发性膜性肾病中的水平及临床意义[J]. 检验医学与临床,2022,19(6):758-761.
[17]	任宏伟,行敏. 过敏性紫癜患儿血清IL-21、TGF-β、SST2、IgA1水平变化的临床意义[J]. 中国中西医结合皮肤性病学杂志,2022,21(5):408-411.
[18]	吕霞,周小燕,焦黛妍. 血清sCAM-1、IGF-1和sFlt-1对自发性蛛网膜下腔出血后脑血管痉挛的病情与预后评估的价值[J]. 河北医药,2022,44(8):1194-1197. doi: 10.3969/j.issn.1002-7386.2022.08.017
[19]	冯凯,范贤明,欧阳晓莉,等. 不同病情老年社区获得性肺炎患者血清ALB、NT-proBNP、PTX3、SDC4的变化及对预后的影响分析[J]. 现代生物医学进展,2023,23(1):152-157.
[20]	何新平,金岚,杨非柯,等. 老年慢性心力衰竭患者血清sST2、CTGF、suPAR与心功能的关系及其联合检测对心血管事件的预测价值[J]. 现代生物医学进展,2023,23(12):2347-2352.

Relative Articles(20)

Relative Articles

[1]	Chunyan LIU, Bingqing CHANG, Chao LI, Xin REN, Xiaoqin LIU. The Relationship between T Lymphocyte Subsets and Pathological Characteristics of Acute Myeloid Leukemia and the Value of Predicting Chemotherapy Prognosis. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240518
[2]	Shan ZHAO, Sai GAO, Tangchun LI, Zhongming ZHAO, Yating Wu, Min ZHENG. Construction and Evaluation of Maternal Mortality Prediction Model in Yunnan Province. Journal of Kunming Medical University,
[3]	Xiaowei YANG, Yan WANG, Liqiong ZENG, Xuelian JIANG. Efficacy Analysis Combined Prediction of Postpartum Hypertension by 24-hour Urinary Protein，Hematocrit-albumin，and BNP in Patients with Severe Preeclampsia at the End of Pregnancy. Journal of Kunming Medical University,
[4]	Lanzhu YAN, Shunyi QIAO, Yanli ZHANG, Erqiang ZHAO, Hu YANG, Jing LIN, Haiyan FU. Changes of Immunoglobulin in TACE Treatment of Hepatocellular Carcinoma and Its Value in Predicting Curative Effect. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240418
[5]	Qianwen ZHENG, Xiaoyan MA, Jihong LIU, Shanshan GUO, zhuoma ZHISHI. The Analysis between Uterocervical Angles and Cervical Length in Predicting Preterm Labor. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230515
[6]	Li CAI, Huaying YANG, Jianhong CHENG, Jia CAO, Na WEI. Changes of Serum Levels of 6-Keto-PGF1α，TGF-α and TXB2 during the Treatment of Peptic Ulcer in Children and Their Influence on Prognosis. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230928
[7]	Xifang WU, Yong WANG, Lisha PENG, Jie LUO, Feng WANG. Effect of VEGF-C on Radiation Sensitivity of Nasopharyngeal Carcinoma CNE-2 Cell Transplanted Mice. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20221205
[8]	Wei-wen WANG, De-xia LI, Jie ZHANG, Lin LI. Correlation Between Serum Soluble ST2 and Cardiac Remodeling in Patients with Heart Failure with Reduced Ejection Fraction. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210813
[9]	Zhao Heng , Xu Bin , Zhao Guang Zhou , Li Rong Jie , Zhou Bai Ling , Liu Ye , Shi Shu Lan . . Journal of Kunming Medical University,
[10]	Fu Tian , Wang Cai Feng , Zhang XuFeng , Dang Shao Nong . . Journal of Kunming Medical University,
[11]	Yang Ke , Dan Zu Jian , Zhou Qiong Hua , Wang Jun Feng . Relationship between Soluble Cytokine Receptors, Matrix Metalloproteinases and Pancreatic Cancer. Journal of Kunming Medical University,
[12]	Zhao Yu . . Journal of Kunming Medical University,
[13]	Xu Jing . . Journal of Kunming Medical University,
[14]	Ai Yi Qin . . Journal of Kunming Medical University,
[15]	Li Fan. . Journal of Kunming Medical University,
[16]	Ai Yi Qin . . Journal of Kunming Medical University,
[17]	Lin Yan . . Journal of Kunming Medical University,
[18]	Liu Jian Jun . . Journal of Kunming Medical University,
[19]	Wan Rong . . Journal of Kunming Medical University,
[20]	Hu Wan Qin . . Journal of Kunming Medical University,