The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis

Xiaoling YANG; Zhen LIU; Yu WANG; Jing WANG

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Xiaoling YANG, Zhen LIU, Yu WANG, Jing WANG. The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis[J]. Journal of Kunming Medical University.

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Xiaoling YANG, Zhen LIU, Yu WANG, Jing WANG. The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis[J]. Journal of Kunming Medical University.

Xiaoling YANG, Zhen LIU, Yu WANG, Jing WANG. The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis[J]. Journal of Kunming Medical University.

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The Predictive Value of sFlt-1，SDC4，and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis

Dept. of Pediatrics，Xinyang 154th Hospital，Xinyang Henan 464000，China

Received Date: 2023-09-18
Available Online: 2024-05-20

Abstract

Abstract

Objective To investigate the correlation between the levels of soluble vascular endothelial growth factor receptor-1 （sFlt-1）, polyligand proteoglycan-4 （SDC4）, soluble human stromal lysin 2 （sST2） in serum and renal histopathological grading in children with Henoch-Schnlein purpura nephritis （HSPN）, and analyze their predictive value for therapeutic efficacy. Methods A retrospective study was conducted, in which 98 children with HSPN admitted to Xinyang 154th Hospital from April 2021 to April 2023 were selected as the research subjects. According to the clinical efficacy after 2 months of treatment, they were divided into an effective group of 78 cases and an ineffective group of 20 cases. Their clinical data and the levels of serum sFlt-1, SDC4, and sST2 before and after treatment were compared. Multivariate logistic regression analysis was used to analyze the factors affecting the efficacy. The predictive value of serum sFlt-1, SDC4, and sST2 levels after 1 month of treatment on the efficacy after 2 months of treatment was analyzed. Results As the pathological grade increased, the levels of serum sFlt-1, SDC4, and sST2 showed an upward trend （P < 0.05）; the levels of serum sFlt-1, SDC4, and sST2 in the ineffective group after 1 month of treatment were higher than those in the effective group （P < 0.05）; the symptom score of purpura, immunoglobulin A （IgA） level, and the levels of serum sFlt-1, SDC4, and sST2 after 1 month of treatment were independent risk factors for efficacy （P < 0.05）; the AUC of serum sFlt-1, SDC4, and sST2 levels combined to predict efficacy after 1 month of treatment was greater than that of any two combined predictions or single indicator predictions （P < 0.05）. Conclusion The levels of serum sFlt-1, SDC4, and sST2 in children with HSPN are closely related to the pathological grading of the kidney tissue. The combined detection of their levels has certain predictive value for the therapeutic effect.
- Purpuric nephritis,
- Soluble vascular endothelial growth factor receptor-1,
- Multiligand proteoglycan-4,
- Soluble human matrix metalloproteinase-2,
- Prediction

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References(17)

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