Abstract: ［Abstract］Objective To investigate the changes of serum C reactive protein （CRP）， Interleukin-2 （IL-2）， Monocyte chemoattractant protein-1（MCP-1）and hemorheology in patients with pelvic inflammatory disease. Methods　Eighty patients with pelvic inflammatory disease were enrolled as observation group from May 2013 to May 2015， 60 healthy women in the same age were selected as control group at the same period. The serum CRP， IL-2， MCP-1 and hemorheology were compared between observation group and control group; the detection indexes were compared in patients with mild， moderate and severe pelvic inflammatory disease in observation group. Results The serum levels of CRP and MCP-1 and hemorheology of observation group were higher than those of control group， the differences were statistically significant（P＜0.05）. The detection indexes of patients with severe pelvic inflammatory disease were higher than those of mild and moderate pelvic inflammatory disease， the detection indexes of patients with moderate pelvic inflammatory disease were higher than those of mild pelvic inflammatory disease， the differences were all statistically significant （P＜0.05）. The level of IL-2 of was significantly lower than that of control group， the level of IL-2 of patients with severe pelvic inflammatory disease was lower than that of mild and moderate pelvic inflammatory disease， the level of IL-2 of patients with moderate pelvic inflammatory disease was significantly lower than that of mild pelvic inflammatory disease， the differences were all statistically significant（P＜0.05）. Conclusion The serum levels of CRP，IL-2，MCP-1 and hemorheology of patients with pelvic inflammatory disease have significant changes， and the detection indexes of patients with mild， moderate and severe pelvic inflammatory disease have significant differences.