Abstract: ［Abstract］Objective　To observe the clinical effects and complications of coronary intervention through radial artery and femoral artery．Methods　A hundred and sixty patients received coronary intervention treatment or coronary angiogram in the Second Affiliated Hospital of Bengbu Medical College from March 2010 to March 2015 were enrolled in this study. The patients were divided into radial artery puncture group （n＝80），who received radial artery puncture and femoral artery puncture group （n＝80）who received femoral artery puncture. The general date such as puncture time， intervention success rate， time in bed， postpuncture compression time and complications such as postoperative bleeding， arterial occlusion and postoperative untoward reactions were recorded and compared. Results　The intervention success rate of radial artery puncture group was 90.0% lower than that of femoral artery puncture group （97.5%），with statistically significant differences（P＜0.05）. The puncture time， postpuncture compression time，time in bed and hospital stays of radial artery puncture group were significantly shorter than those of femoral artery puncture group （P＜0.01）. As for complications， the incidences of postpuncture bleeding and vagus nerve reflex in radial artery puncture group were significantly lower than that in femoral artery puncture group（P＜0.05）. As for postoperative untoward reactions， the incidences of irritable and insomnia， uroschesis，pain caused by puncture，local skin injure， back pain in radial artery puncture group were significantly lower than those in femoral artery puncture group（P＜0.01）. Conclusion　With the advantages of mini-invasion，such as shorter time in bed and hospital stays，lower complications and untoward reactions rates， coronary intervention through radial artery is worth of clinical application.