Abstract: ［Abstract］Objective To investigate the correlation between prenatal infection and premature rupture of membranes（PROM）. Methods　Eighty-three cases of PROM in People's Hospital of Chengmai County from July 2014 to July 2015 were selected as observation group， and 80 cases of normal pregnant women were randomly selected as control group．Prenatal genital tract infection， neonatal morbidity，maternal serum C reactive protein （CRP） and white blood cell count level， maternal amniotic fluid cell factor level were compared between two groups. Results　The total incidence rate in the control group was 23.75%，and the difference was statistically significant （P＜0.05）. The incidence of respiratory distress syndrome， pneumonia and high serum bilirubin in the observation group was significantly higher than those in the control group（P＜0.05）. The IL-6， IL-8 and TNF-α in the observation group were significantly higher than those in the control group （P＜0.05）. Conclusion　Prenatal reproductive tract infection and PROM are closely related．Infection is a factor causing PROM，which increases the rate of neonatal morbidity. Through prenatal test of blood CRP，amniotic fluid IL-6， IL-8，and detection of TNF - levels， the risk of PROM can be predicted in advance so that measures can be taken to avoid PROM and PROM-related maternal and fetal complications can be taken.