泮托拉唑联合多潘立酮诊断性治疗咽喉反流性疾病疗效观察
Treatment Efficacy of Pantoprazole and Domperidone on Larygopharyngeal Reflux Disease
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摘要: 目的 探讨泮托拉唑联合多潘立酮诊断性治疗咽喉反流性疾病的疗效.方法 收集80例初步诊断为咽喉反流性疾病(larygopharyngeal reflux disease,LPRD)患者,按治疗方法不同分为观察组40例和对照组40例,观察组在常规予清咽利喉的基础上服用泮托拉唑肠溶片,20 mg/次,2次/d,餐前30 min服用;多潘立酮片,10 mg/次,3次/d,餐前30 min服用,疗程8周.对照组予常规清咽利喉药物治疗,记录对比2组患者临床症状及体征的改变.结果 观察组显效20例,有效11例,无效9例,总有效率77.5%;对照组显效3例,有效5例,无效32例,总有效率20%.2组总有效率差异有统计学意义(P<0.01).结论 泮托拉唑联合多潘立酮诊断性治疗咽喉反流性疾病是一种有效的方法.Abstract: Objective To explore the clinical effects of Pantoprazole and Domperidone on larygopharyngeal reflux disease. Methods Eighty patients with initial diagnosis of laryngopharyngeal reflux disease(LPRD) were divided into observation group(40 cases) and control group(40 cases) according to different treatment methods.In the observation group,patients were given pantoprazole 10 mg/times,3 times/day,at 30 minutes before meals,for 8 weeks. The patients in the control group were treated with conventional pharyngeal and pharyngeal laryngeal drugs. The clinical symptoms and signs of the two groups were recorded and compared. Results In the observation group,the significantly effective was in 20 cases,effective in 11 cases, ineffective in 9 cases, the total effective rate was 77.5%;in the control group, the significantly effective was in 3 cases,effective in 5 cases,32 cases were ineffective,the total effective rate was 20%. There was significant difference in total effective rate between the two groups(P<0.05). Conclusion Pantoprazole combined with domperidone is an effective method for the treatment of larypharyngeal reflux disease.
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Key words:
- Pantoprazole /
- Domperidone /
- Larygopharyngeal reflux disease /
- Treatment
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[1]汪安江.反流性咽喉炎的发病机制和诊治进展[J].国际内科学杂志,2008,5(4):213-217. [2]李彦,田兴德,周倩,等.胃食道反流与慢性咽喉炎相关性研究[J].长江大学学报(自然科学版),2013,14(18):169-171. [3]郑宏良,陈东辉.咽喉反流疾病的诊治亟待规范[J].中华耳鼻咽喉头颈外科杂志,2013,48(6):441-444. [4]张燕玲.胃食管反流性咽喉炎126例分析[J].江西医药,2010,45(2):144-146. [5]张萍,余杰情,桂誉琳,等.咽喉反流的研究进展[J].江西医药,2016,51(8):859-861. [6] [6]CARROLL T L,FEDORE L W,ALDAHLAW I M M.p H Impedance and high-resolution manometry in laryngopharyngeal reflux disease high-dose proton pump inhibitor failures[J].Laryngoscope,2012,122(10):2473-2481. [7]史芸,江月萍.铝碳酸镁联合质子泵抑制剂治疗胃食管反流性咳嗽的临床观察[J].中华内科杂志,2014,53(8):403-404. [8] [8]NASSERI-MOGHADDAM S,NOKHBEH-ZAEEM H,SANIEE P,et al.Oral nitrate reductase activity and erosive gastro-esophageal reflux disease:a nitrate hypothesis for GERD pathogenesis[J].Dig Dis Sci,2012,57(12):413-418. [9]秦辉.咽喉反流和嗓音疾病相关性的初步探讨[J].四川医学,2015,36(12):1621-1624. [10]邱新峰,程万民.咽喉反流性疾病的治疗策略[J].继续医学教育,2014,28(6):58-60. [11]张立红,李娜,郑宏伟,等.咽喉反流的初步诊断[J].中华耳鼻咽喉头颈外科杂志,2009,44(2):105. [12]李进让,PETER C BELAFSKY,张立红.中国喉科医师应用反流体征评分量表的信度研究[J].中国耳鼻咽喉头颈外科,2012,19(7):388-390. [][13郑杰元,张立红,李克兢,等.咽喉反流症状指数量表中文版的信度及效度[J].中华耳鼻咽喉头颈外科杂志,2012,47(11):894-898. [14]刘钧.奥美拉唑联合多潘立酮治疗咽喉反流的临床研究[J].中国当代医药,2013,20(1):81. [15]司卫锋,张珊娜.兰索拉唑治疗反流性咽喉炎的疗效观察[J].河北联合大学学报(医学版),2013,15(5):676. [16]邓智锋,许昱,周涛.质子泵抑制剂与促胃肠动力药治疗咽喉反流的Meta分析[J].听力学及言语疾病杂志,2014,22(1):39-45. -
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