Effect of Material Structure on Angiogenesis in Bone Regeneration
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摘要: 骨修复再生目前仍是临床治疗中常见的棘手问题，而骨组织工程近年来发展成为一种可能的骨修复再生替代方案。但骨作为高度血管化的组织，其发育、成熟、重塑和再生与修复再生过程中的血管生成息息相关。既往研究多倾向于材料结构特性对成骨的直接影响，关于材料结构所形成的物理线索对骨再生中血管生成的影响关注不足，而材料结构对于骨再生中血管生成的影响也是一个重要的环节，关系到最终的骨修复成效。阐述了材料结构对骨再生中血管生成的影响，简要介绍了骨再生中血管生成的过程及作用，着重讨论了现今骨组织工程中材料基地刚度、表面形貌、孔结构、空间结构四类主要结构因素对于骨再生中血管生成的影响作用，以期为将来骨修复材料的设计与构建提供借鉴。Abstract: Bone repair and regeneration is still a common and difficult problem in clinical treatment, and bone tissue engineering has been developed as a possible alternative to bone repair and regeneration in recent years. However, bone is a highly vascularized tissue, and its development, maturation, remodeling and regeneration are closely related to angiogenesis in the process of repair and regeneration. Previous studies tended to focus on the direct influence of material structure characteristics on osteogenesis, and insufficient attention was paid to the influence of physical cues formed by material structure on angiogenesis in bone regeneration. However, the influence of material structure on angiogenesis in bone regeneration is also an important link, which is related to the final effect of bone repair. Therefore, this paper expounds the influence of material structure on angiogenesis in bone regeneration, briefly introduces the process and role of angiogenesis in bone regeneration, and focuses on discussing the influence of the four main structural factors of material base stiffness, surface morphology, pore structure, and spatial structure in current bone tissue engineering on angiogenesis in bone regeneration. In the hope of providing reference for the design and construction of bone repair materials in the future.
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Key words:
- Material /
- Structure /
- Morphology /
- Bone regeneration /
- Angiogenesis /
- Tissue engineering
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图 1 骨修复材料四种不同结构示意图
Figure 1. Diagram of four different structures of bone repair materials
图 2 材料影响血管生长的结构特性
Figure 2. Structural properties of materials affecting blood vessel growth
表 1 材料结构对血管生成的影响
Table 1. Effect of material structure on angiogenesis
材料结构 对血管生成的影响 孔隙率 较高的孔隙率有利于血管细胞的长入 亲水性 材料的亲水性越强越有利于血管生长 表面能 材料的表面能越高越有利于血管生长 粗造度 较粗糙表面比较光滑表面有利于血管生长 孔径大小 一定范围内，增加孔径有利于血管生长 基地刚度 相较于较高基地刚度，较低基地刚度有利于血管生长 微观粒径 亚微米级较微米级有利于血管生长 排列方式 有序结构较无序结构有利于血管生长 空间结构 对天然组织的仿生程度越高越有利于血管生长 孔的互连性 孔的互连性越高越有利于血管生长 
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