Abstract: ［Abstract］Objective　To observe the effect of high quality nursing care on the negative emotion and treatment compliance of patients with leukemia. Methods　116 patients with leukemia in our hospital from January 2010 to April 2014 were randomly divided into study group and control group，58 cases in each group. The control group was given routine nursing measures， and the research group was given high quality care measures based on the control group. Self rating Depression Scale（SDS）and self rating Anxiety Scale（SAS）was used to evaluate the adverse mood changes between the two groups before and after the intervention，and the treatment compliance， nursing satisfaction and the incidence of complications of the two groups were compared. Results After the intervention， SDS and SAS scores of the study group were significantly lower than those of the control group after the intervention， the difference was statistically significant（P＜0.05）.The treatment compliance and satisfaction with nursing care of the study group were improved significantly than those of the control group（87.93% vs 68.97%，96.55% vs 81.03%），the difference was statistically significant（P＜0.05）.The complication rate of the study group decreased significantly than that of the control group（15.52% vs 31.03%），the difference was statistically significant（P＜0.05）. Conclusion　High quality nursing for patients with leukemia can significantly improve the psychological status of patients， improve the treatment compliance and nursing satisfaction，the incidence of complications decreased significantly.