人类胎盘的葡萄糖转运机制及GDM对胎盘葡萄糖转运的影响

何银东; 张峻; 黄桦; 柳汝明; 王茜

doi:10.12259/j.issn.2095-610X.S20220903

人类胎盘的葡萄糖转运机制及GDM对胎盘葡萄糖转运的影响

doi: 10.12259/j.issn.2095-610X.S20220903

昆明医科大学第一附属医院临床药学科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（82160297，H0416）；云南省高层次卫生计生技术人才培养专项基金资助项目（L-201614，H-2018077，H-201705，H-2018081）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001（-200），2018FE001（-167），202001AY070001-045，2018FE001（-310）]

详细信息

作者简介:
何银东（1997～），女，云南保山人，在读硕士研究生，主要从事妊娠期糖尿病患者治疗药物安全性相关的研究工作

通讯作者:
王茜，E-mail：crynner@126.com

中图分类号: R713.1
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出版历程
- 收稿日期: 2022-06-09
- 网络出版日期: 2022-09-07
- 刊出日期: 2022-09-29

Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport

Dept. of Clinical Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

摘要

摘要: 胎盘是将母体葡萄糖转运至子体的重要器官，正常的胎盘结构和功能为胎儿从母体有效摄取葡萄糖提供保障。胎盘上葡萄糖转运主要依赖于胎盘上的葡萄糖转运体（glucose transporters，GLUTs）。此外，胎盘自身对葡萄糖代谢也会影响经胎盘的葡萄糖转运。妊娠期糖尿病（gestational diabetes mellitus，GDM）是一种常见的妊娠期并发症。GDM患者胎盘上葡萄糖转体运功能的异常，可能是造成其子代产生不良结局的原因之一。就正常胎盘上的葡萄糖转运进行论述，并且探讨GDM患者胎盘上葡萄糖转运的改变及可能的分子机制。
- 胎盘 /
- 葡萄糖转运 /
- 葡萄糖转运体 /
- 妊娠期糖尿病
Abstract: Placenta plays an important role in the process of glucose transfer from maternal to fetus. The normal structure and function of the placenta guarantee the fetus to take up glucose effectively from maternal side over the gestation. Glucose transplacental transfer mainly depends on the glucose transporters （GLUTs）. And the placenta and other factors such as placental glucose metabolic activity could also affect the glucose transplacental transfer. Gestational diabetes mellitus （GDM） is a main complication of pregnancy. Fetal adverse outcomes from GDM patients may be caused by the abnormality of glucose transport in the placenta. This review aims to discuss the glucose transplacental transfer on the normal placenta and summarize some changes and molecular mechanism that have been reported about glucose transplacental transfer in the GDM.
- Placenta /
- Glucose transport /
- Glucose transporters /
- GDM

HTML全文

图 1 胎盘上的葡萄糖转运简图^[1]

注：K_mi ：葡萄糖的胞间转运米氏常数；K_mo ：葡萄糖的胞外转运米氏常数; [glucose] ：葡萄糖浓度。葡萄糖通过GLUTs从血糖浓度较高的母体侧扩散到血糖浓度较低的胎儿侧。母体侧血糖浓度从动脉到静脉依次是[glucose] _A > [glucose ]_B > [glucose] _C > > [glucose] _H，胎盘各个区域的葡萄糖浓度由母体侧转运进来的血糖和各个区域向胎儿侧扩散的葡萄糖共同决定。

Figure 1. Transplacental glucose transport

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