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自噬在膀胱癌发展和治疗中的研究进展

陈诗 付什 谭智勇 王剑松 王海峰

陈诗, 付什, 谭智勇, 王剑松, 王海峰. 自噬在膀胱癌发展和治疗中的研究进展[J]. 昆明医科大学学报, 2023, 44(5): 168-174. doi: 10.12259/j.issn.2095-610X.S20230503
引用本文: 陈诗, 付什, 谭智勇, 王剑松, 王海峰. 自噬在膀胱癌发展和治疗中的研究进展[J]. 昆明医科大学学报, 2023, 44(5): 168-174. doi: 10.12259/j.issn.2095-610X.S20230503
Shi CHEN, Shi FU, Zhiyong TAN, Jiansong WANG, Haifeng WANG. Research Progress of Autophagy in the Development and Treatment of Bladder Cancer[J]. Journal of Kunming Medical University, 2023, 44(5): 168-174. doi: 10.12259/j.issn.2095-610X.S20230503
Citation: Shi CHEN, Shi FU, Zhiyong TAN, Jiansong WANG, Haifeng WANG. Research Progress of Autophagy in the Development and Treatment of Bladder Cancer[J]. Journal of Kunming Medical University, 2023, 44(5): 168-174. doi: 10.12259/j.issn.2095-610X.S20230503

自噬在膀胱癌发展和治疗中的研究进展

doi: 10.12259/j.issn.2095-610X.S20230503
基金项目: 国家自然科学基金资助项目(81660422,81860452)
详细信息
    作者简介:

    陈诗(1992~),男,湖北宜昌人,在读硕士研究生,住院医师,主要从事膀胱癌基础研究工作

    通讯作者:

    王海峰,E-mail:wanghaifeng@kmmu.edu.cn

  • 中图分类号: R737.14

Research Progress of Autophagy in the Development and Treatment of Bladder Cancer

  • 摘要: 自噬是细胞通过溶酶体降解细胞内物质的一种自我消化过程,被认为是肿瘤在应激条件下维持生存的重要保护机制。大量证据表明,自噬是一把双刃剑,通过不同的信号通路,既可抑制肿瘤的发生,又可促进肿瘤的存活与生长。因此,越来越多的学者认为自噬有望成为肿瘤治疗的新策略。通过总结自噬调控膀胱癌侵袭、转移等生物学行为,以及在膀胱癌治疗的最新进展,以期为靶向自噬抗肿瘤药物的研发和治疗提供新的思路。
  • 表  1  自噬与膀胱癌发展

    Table  1.   Autophagy and the development of bladder cancer

    靶标信号通路自噬状态肿瘤调控
    不确定 自噬缺陷 肿瘤发生
    Rab14 MAPK/ERK 抑制 肿瘤发生
    MIR-516A PHLPP2/BECN1 抑制 肿瘤发生
    低营养 TGF-β1/Smad3 激活 上皮间质转化
    MIR-21 不确定 抑制 上皮间质转化
    缺氧 不确定 激活 血管生成
    肿瘤微环境 PI3K/AKT 激活 血管生成
    顺铂 BECN1 激活 化疗耐药
    吡柔比星 p70S6K/4E-BP1 激活 化疗耐药
    IFN-γ JAK2/STAT3 激活 干性维持
    ATG7 USP28/CD44 激活 干性维持
    NBR1 Not determined 激活 免疫逃逸
    ATG7 FOXO3a/miR-145/PD-L1 激活 免疫逃逸
    下载: 导出CSV

    表  2  膀胱癌中的靶向自噬治疗

    Table  2.   Targeted autophagy therapy in bladder cancer

    类型治疗物质自噬状态调控作用测试细胞系
    天然活性物质 没食子酸酯 激活 凋亡 T24.5637
    桦木酸 激活 凋亡 T24.EJ
    灵菌红素 抑制 化疗敏感 RT-112
    小分子化合药 罗帕洛酸 激活 凋亡 T24.J82
    甲磺酸 抑制 化疗敏感 5637.HT1197
    厄达替尼 激活 凋亡 T24.UMUC-3
    非编码RNA MIR-24-3p 激活 肿瘤发展 T24.BIU-87
    MIR-222 抑制 化疗敏感 T24.5637
    ADAMTS9-AS2 激活 凋亡 5637.UM-UC-3
    其他 重组腺病毒 激活 凋亡 T24.5637.EJ
    重组精氨酸酶 激活 凋亡 T24.5637.J82
    下载: 导出CSV
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  • 收稿日期:  2023-01-01
  • 网络出版日期:  2023-05-12
  • 刊出日期:  2023-05-25

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