维生素D受体基因FokI位点单核苷酸多态性与糖尿病肾病的相关性
The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease
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摘要: [摘要]目的 探讨VDR基因FokI位点单核苷酸多态性与2型糖尿病肾病的相关性.方法 应用TaqMan 荧光探针技术,对235例2型糖尿病患者其中正常白蛋白尿(DKD0)组82例,微量白蛋白组(DKD1)组66例,大量白蛋白尿组(DKD2)组 87例和86例健康对照者(NGT)组的VDR基因FokI位点SNP进行检测,比较和分析各组间基因型频率和等位基因频率以及相关临床资料.结果 (1)总体人群FokI位点CC、TC、TT基因型频率分别为25.23%、53.27%、21.50%,等位基因C和T频率分别为51.87%及48.13%;(2)NGT组、DM组及DKD各组间基因型频率及等位基因频率未显示统计学差异(P>0.05);(3)Logistic回归分析提示FokI位点C等位基因可能与T2DKD 发生无关(OR=2.040,P=0.05),但与T2DKD进展有关(OR=4.741,P=0.004).结论 VDR基因 FokI位点C等位基因可能是T2DKD 进展的危险因素.Abstract: [Abstract]Objetive To investgate the correlation of Vitamin D receptor gene FokI single nucleotide polymorphism with diabetic kidney disease in type 2 diabetic patients.Methods The single nucleotide polymorphism of VDR gene in 235 type 2 diabetes, [including 82 normal albuminuria(DKD0 group),66 microalbuminuria(DKDl group )and 87 macroalbuminuria(DKD2 group)]and 86 normal controls were detected by TaqMan real-time polymerase chain reaction. The genotype frequency and allele frequency and relative clinical data were compared among groups. Results(1)FokI CC,TC,TT genotype frequencies were 25.23%, 53.27%,21.50%,allele C and allele T frequencies were 51.87% and 48.13% in overall populations. (2)The genotype frequency and allele frequency among groups had no statistically significant difference(P<0.05). (3) Logistic multiple regression analysis showed that FokI C allele was not related to T2DKD occurrence(OR=2.040,P=0.05),but was related to T2DKD development(OR=4.741,P=0.004). Conclusion VDR gene FokI C allele is associated with the risk of T2DKD development.
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