抗菌肽作为免疫调节剂治疗细菌感染的潜力

梁国柱; 阮诗媚; 何艳梅; 杨海龙

doi:10.12259/j.issn.2095-610X.S20231013

抗菌肽作为免疫调节剂治疗细菌感染的潜力

doi: 10.12259/j.issn.2095-610X.S20231013

昆明医科大学基础医学院，云南昆明　650500

基金项目: 国家自然科学基金资助项目（82372259）；云南省科技厅科技计划基金资助项目（202301AY070001-015）

详细信息

作者简介:
梁国柱（1995～），男，山西忻州人，医学硕士，主要从事抗菌肽的结构与功能研究工作

杨海龙，博士，教授，博士生导师，云南省中青年学术和技术带头人，主要从事免疫调节肽与抗感染研究。以第一或通讯（含共同第一或通讯）作者发表SCI收录研究论文22篇，包括eLife、 ACS infectious dieases、Molecular & Cellular Proteomics、Free RadicBiol Med、Biochemical Journal和Parasit Vectors等期刊。以第一发明人获授权的国家发明专利4项。主持国家自然科学基金4项（面上项目3项，地区基金1项），主持云南省科技厅-昆明医科大学应用基础研究联合重点项目1项。2019年获云南省自然科学一等奖（排名第4），2010年获云南省自然科学二等奖（排名第2）

通讯作者:
杨海龙，E-mail：jxauyhl@aliyun.com

中图分类号: R392.11
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出版历程
- 收稿日期: 2023-07-09
- 网络出版日期: 2023-09-07
- 刊出日期: 2023-10-25

Prospects of Antimicrobial Peptides as Immunomodulators in the Treatment of Bacterial Infections

School of Basic Medicine，Kunming Medical University， Kunming Yunnan 650500，China

摘要

摘要: 自1928年青霉素被用于治疗细菌感染性疾病以来，抗生素拯救了无数患者的生命。然而，随着细菌抗药性的增加，细菌感染性疾病的临床治疗变得愈发困难。抗菌肽因其功能广泛且毒副作用低等特点，被认为是理想的传统抗生素替代品。其中，一些具有免疫调节功能的抗菌肽能够调节机体自身的固有免疫和获得性免疫反应，直接靶向机体免疫系统而非病原微生物，从而避免对病原微生物的选择压力，不易产生耐药性，在抗感染治疗方面具有广阔的应用价值。将从抗菌肽的免疫调节活性、临床治疗中的应用潜力以及局限性等方面进行概述，为新型抗生素的开发利用提供新的视野。
- 细菌感染 /
- 抗菌肽 /
- 免疫调节
Abstract: Since penicillin was used to treat bacterial infectious diseases in 1928, antibiotics have saved countless patients’ lives. However, with the increase of bacterial drug resistance, the clinical treatment of bacterial infectious diseases has become increasingly difficult. Antimicrobial peptides is considered as an ideal substitute for traditional antibiotics because of its wide range of functions and low toxicity. Among them, some antimicrobial peptides with immune regulation function can regulate the innate immunity and acquired immune response of the body, directly target the immune system of the body rather than pathogenic microorganisms, thus avoiding the selection pressure on pathogenic microorganisms, and are not easily resistant to antibiotics. They have broad application value in infection treatment. This article reviews the immunomodulatory activity of antimicrobial peptides, its potential application in clinical treatment, and its limitations, so as to provide a new perspective for the development and utilization of new antibiotics.
- Bacterial infection /
- Antimicrobial peptides /
- Immune regulation

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图 1 抗菌肽的免疫调节活性

Figure 1. Immunomodulatory activity of AMPs

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参考文献(69)

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抗菌肽作为免疫调节剂治疗细菌感染的潜力

doi: 10.12259/j.issn.2095-610X.S20231013

通讯作者:
杨海龙，E-mail：jxauyhl@aliyun.com

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Prospects of Antimicrobial Peptides as Immunomodulators in the Treatment of Bacterial Infections

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目录

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[14]	卯建. 降钙素原、超敏C-反应蛋白和淀粉样蛋白检测在细菌性感染诊断中的应用价值, 昆明医科大学学报.
[15]	高振华. 蛇毒抗菌肽OH-CATH在血浆环境中对大肠杆菌的抗菌作用, 昆明医科大学学报.
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抗菌肽作为免疫调节剂治疗细菌感染的潜力

doi: 10.12259/j.issn.2095-610X.S20231013

通讯作者: 杨海龙，E-mail：jxauyhl@aliyun.com

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Prospects of Antimicrobial Peptides as Immunomodulators in the Treatment of Bacterial Infections

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通讯作者:
杨海龙，E-mail：jxauyhl@aliyun.com