水仙环素的抗肿瘤活性及机制研究进展

杨敏; 林琪琪; 刘丹丹; 周宏宇

doi:10.12259/j.issn.2095-610X.S20240222

水仙环素的抗肿瘤活性及机制研究进展

doi: 10.12259/j.issn.2095-610X.S20240222

杨敏¹,
林琪琪¹,
刘丹丹^{1, 2, ,},
周宏宇^{1, 2, ,}

1.
昆明医科大学药学院暨云南省天然药物药理重点实验室，云南昆明　650500
2.
昆明医科大学现代生物医药产业学院，云南昆明　650500

基金项目: 国家自然科学基金资助项目（21907044，82160697）；云南省基础研究计划面上项目（202101AT070155）；云南省科技厅-昆明医科大学联合专项基金资助项目（ 202101AY070001-011）; 云南省“兴滇英才支持计划”青年人才项目（YNWR-QNBJ-2018-380，YNWR-QNBJ-2020-276）

详细信息

作者简介:
杨敏（2001～），女，重庆大足人，在读2020级药学专业本科生

通讯作者:
刘丹丹，E-mail：liudandan@kmmu.edu.cn

周宏宇，E-mail：zhouhongyu@kmmu.edu.cn

中图分类号: R966
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出版历程
- 收稿日期: 2023-05-05
- 网络出版日期: 2024-02-27
- 刊出日期: 2024-02-25

Research Progress on the Anti-tumor Activity and Mechanism of Narciclasine

Min YANG¹,
Qiqi LIN¹,
Dandan LIU^{1, 2
, ,},
Hongyu ZHOU^{1, 2
, ,}

1.
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500
2.
College of Modern Biomedical Industry，Kunming Medical University，Kunming Yunnan 650500，China

摘要

摘要: 水仙环素（narciclasine，NCS）是从石蒜科水仙属植物水仙的鳞茎中提取出的水鬼蕉碱型生物碱，被证实对多种肿瘤细胞具有显著的抑制活性。NCS的抗肿瘤作用机制多样，通过不同途径产生抗肿瘤作用，适应了当前研发多靶点抗肿瘤药物的趋向。本文结合NCS抑制乳腺癌细胞、结肠癌细胞、胃癌细胞、黑色素瘤细胞、多形性胶质母细胞瘤细胞、口腔癌细胞和原发性渗出性淋巴瘤细胞的作用及分子机制，对NCS近年来的抗肿瘤活性及作用机制研究进行综述，旨在为将来NCS类抗肿瘤药物的研发与设计提供思路和借鉴。
- 水仙环素 /
- 水鬼蕉碱型生物碱 /
- 抗肿瘤活性 /
- 分子机制
Abstract: Narciclasine（NCS）, a hymenocallis littoralis alkaloid extracted from the bulbs of the genus Narcissus in the Lycoriaceae family, has been proven to have significant anti-tumor activity against a variety of tumor cells. The antitumor mechanisms of NCS are diverse and NCS exhibits antitumor effects through different pathways, which adapts to the current trend of developing multi-target anti-tumor drugs. This review introduces the research progress of the anti-tumor activity and mechanism of NCS in recent years based on the inhibitory effect of NCS on gastric cancer cells, oral cancer cells, polymorphous glioblastoma cells, colon cancer cells, breast cancer cells, melanoma cells and primary exudative lymphoma cells, aiming to provide ideas and references for the research and development, and design of NCS type anti-tumor drugs in the future.
- Narciclasine /
- Hymenocallis Littoralis Alkaloids /
- Antitumor Activity /
- Molecular Mechanism

HTML全文

图 1 水仙环素的化学结构^[4]

Figure 1. Chemical structure of NCS

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水仙环素的抗肿瘤活性及机制研究进展

doi: 10.12259/j.issn.2095-610X.S20240222

作者简介:
杨敏（2001～），女，重庆大足人，在读2020级药学专业本科生

通讯作者:
刘丹丹，E-mail：liudandan@kmmu.edu.cn

周宏宇，E-mail：zhouhongyu@kmmu.edu.cn

计量

Research Progress on the Anti-tumor Activity and Mechanism of Narciclasine

计量

目录

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水仙环素的抗肿瘤活性及机制研究进展

doi: 10.12259/j.issn.2095-610X.S20240222

作者简介: 杨敏（2001～），女，重庆大足人，在读2020级药学专业本科生

通讯作者: 刘丹丹，E-mail：liudandan@kmmu.edu.cn 周宏宇，E-mail：zhouhongyu@kmmu.edu.cn

计量

出版历程

Research Progress on the Anti-tumor Activity and Mechanism of Narciclasine

计量

出版历程

目录

作者简介:
杨敏（2001～），女，重庆大足人，在读2020级药学专业本科生

通讯作者:
刘丹丹，E-mail：liudandan@kmmu.edu.cn

周宏宇，E-mail：zhouhongyu@kmmu.edu.cn