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铁死亡在心肌病中的研究进展

李威 蒋立虹 马丽晶 陈锐 杨童硕

李威, 蒋立虹, 马丽晶, 陈锐, 杨童硕. 铁死亡在心肌病中的研究进展[J]. 昆明医科大学学报, 2024, 45(3): 180-185. doi: 10.12259/j.issn.2095-610X.S20240327
引用本文: 李威, 蒋立虹, 马丽晶, 陈锐, 杨童硕. 铁死亡在心肌病中的研究进展[J]. 昆明医科大学学报, 2024, 45(3): 180-185. doi: 10.12259/j.issn.2095-610X.S20240327
Wei LI, Lihong JIANG, Lijing MA, Rui CHEN, Tongshuo YANG. Research Progress of Iron Death in Cardiomyopathy[J]. Journal of Kunming Medical University, 2024, 45(3): 180-185. doi: 10.12259/j.issn.2095-610X.S20240327
Citation: Wei LI, Lihong JIANG, Lijing MA, Rui CHEN, Tongshuo YANG. Research Progress of Iron Death in Cardiomyopathy[J]. Journal of Kunming Medical University, 2024, 45(3): 180-185. doi: 10.12259/j.issn.2095-610X.S20240327

铁死亡在心肌病中的研究进展

doi: 10.12259/j.issn.2095-610X.S20240327
基金项目: 国家自然科学基金资助项目(81960068);云南省科技厅科技计划项目(202101AY070001-265)
详细信息
    作者简介:

    李威(1997~),男,安徽合肥人,在读硕士研究生,主要从事心血管疾病研究工作

    通讯作者:

    蒋立虹,E-mail:jianglihong@kmmu.edu.cn

  • 中图分类号: R542.2

Research Progress of Iron Death in Cardiomyopathy

  • 摘要: 心肌病是一组具有多种特定表型的异质性心肌疾病,严重者会引起心血管性死亡或进行性心力衰竭。由于这类疾病的严重性和复杂性,寻找新的调节机制来防治心肌病显得尤为紧迫。铁死亡是一种不同于其他形式的铁依赖性的细胞程序性死亡形式,其特征是铁依赖性脂质过氧化物的积累。研究表明,铁死亡可通过不同的信号通路参与心肌病的发生和进展。因此通过靶向调控铁死亡是防治心肌病的一种新策略。就铁死亡的发生机制及其在心肌病中的重要作用进行综述,以期寻找铁死亡与心肌病之间的潜在联系,为今后各种心肌病的治疗提供更多思路。
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  • 收稿日期:  2023-04-04
  • 网络出版日期:  2024-03-06
  • 刊出日期:  2024-03-30

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