Research Progress and Application Prospects of Neuroglia-associated Exosomes in Schizophrenia
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摘要: 精神分裂症是一种病因复杂的重型精神障碍，其发病机制涉及遗传、环境及神经生物学等多因素的交互作用。近年来，外泌体是细胞间信息传递的主要媒介，为精神分裂症的病因研究、诊断方法及治疗手段提供了新的可能性。对神经胶质细胞作为外泌体来源细胞和靶点，参与精神分裂症发生发展以及作为诊断标志物和药物载体的潜力进行综述，为外泌体在精神分裂症诊疗中的应用提供了新的思路和理论依据。Abstract: Schizophrenia is a severe mental disorder with complex etiology, and its pathogenesis involves the interaction of multiple factors including genetics, environment, and neurobiology. In recent years, exosomes, as the primary mediators of intercellular communication, have provided new possibilities for studying the etiology of schizophrenia, developing diagnostic methods, and identifying therapeutic approaches. This review summarizes the role of glial cells as both source cells and targets of exosomes, their involvement in the pathogenesis and development of schizophrenia, and their potential as diagnostic biomarkers and drug delivery vehicles.The review provides new perspectives and theoretical evidence for the application of exosomes in the diagnosis and treatment of schizophrenia.
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Key words:
- Schizophrenia /
- Exosomes /
- Neuroglia /
- Neuroinflammation /
- Biomarkers /
- Drug delivery
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图 1 外周与中枢神经系统的外泌体通信
Figure 1. Exosomal communication between the peripheral and central nervous systems
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