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IL1RN基因多态性与脑胶质瘤患病风险的相关性

李国林 李超 李峰

李国林, 李超, 李峰. IL1RN基因多态性与脑胶质瘤患病风险的相关性[J]. 昆明医科大学学报, 2018, 39(04): 47-51.
引用本文: 李国林, 李超, 李峰. IL1RN基因多态性与脑胶质瘤患病风险的相关性[J]. 昆明医科大学学报, 2018, 39(04): 47-51.
Li Guo Lin , Li Chao , Li Feng . The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma[J]. Journal of Kunming Medical University, 2018, 39(04): 47-51.
Citation: Li Guo Lin , Li Chao , Li Feng . The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma[J]. Journal of Kunming Medical University, 2018, 39(04): 47-51.

IL1RN基因多态性与脑胶质瘤患病风险的相关性

基金项目: 

基金: 陕西省科技攻关基金资助项目 (2016SF-110);

The Research of Correlation of Genetic Polymorphisms in IL1RN with Risk of Glioma

Funds: 

基金: 陕西省科技攻关基金资助项目 (2016SF-110);

  • 摘要: 目的 研究IL1RN基因多态性与脑胶质瘤患病风险的相关性.方法 选择2012年1月至2016年12月于铜川矿务局中心医院就诊的符合入选条件的脑胶质瘤患者共200例, 以及健康对照人群200例, 分别采集血样.采用Mass ARRAY方法对rs17042888、rs315919、rs928940、rs3181052、rs452204和rs4252019六个位点的基因型进行测定, 用SPSS软件统计基因多态性与脑胶质瘤患病风险的相关性.结果 比较各位点的等位基因频率, 发现IL1RN基因上的rs315919位点的等位基因“G”和rs4252019位点的等位基因“C”会显著降低脑胶质瘤的患病风险 (rs315919:OR=0.841, 95%CI为0.7120.993, P=0.041;rs4252019:OR=0.835, 95%CI为0.7070.987, P=0.034) .引入遗传模型后, rs315919位点在隐性模型下, 携带G/G基因型的个体脑胶质瘤患病风险显著降低, 是携带T/T和G/T基因型的0.75倍 (OR=0.75, 95%CI为0.520.96, P=0.026) ;rs4252019位点在显性模型下, 携带C/T和C/C基因型的个体脑胶质瘤患病风险显著降低, 是携带T/T基因型的0.76倍 (OR=0.76, 95%CI为0.590.97, P=0.025) .结论 IL1RN基因上rs315919和rs4252019两个位点与降低脑胶质瘤的患病风险具有相关性.
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  • 收稿日期:  2017-11-21

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