Research Progress on the Mechanisms of Action of Artemisinin and Its Derivatives in Cancer Therapy
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摘要: 青蒿素及其衍生物由于其独特的过氧化桥结构，不仅对恶性疟疾显示出显著的疗效，也展现了强大的抗肿瘤能力。这些化合物通过多效机制干扰癌细胞生长，包括抑制细胞增殖、引起细胞周期阻滞、诱导多种细胞死亡模式、调节肿瘤微环境和调节肿瘤代谢等。临床试验已证实青蒿素类化合物具有显著的抗癌活性。综述近年来关于青蒿素及其衍生物作为潜在抗癌药物的作用机制的最新进展和发现，为未来青蒿素类化合物的抗癌机制研究提供参考。Abstract: Due to their unique peroxide bridge structure, artemisinin and its derivatives have demonstrated the remarkable efficacy in treating severe malaria and exhibited the potent anticancer properties. These compounds interfere with the cancer cell growth through the multiple mechanisms, including the inhibition of cell proliferation, induction of various forms of cell death, cell cycle arrest, suppression of angiogenesis and modulation of the tumor microenvironment. Clinical trials have confirmed the significant anticancer activity of artemisinin-based compounds. This paper summarizes the recent advances and findings regarding the mechanisms of action of artemisinin and its derivatives as the potential anticancer agents, providing the valuable insights for future researches on the anticancer mechanisms of these compounds.
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Key words:
- Artemisinin /
- Artemisinin derivatives /
- Anticancer /
- Mechanisms of action
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图 1 青蒿素及其衍生物的化学结构
A：青蒿素；B：双氢青蒿素；C：青蒿琥酯；D：蒿甲醚；E：蒿乙醚。
Figure 1. Chemical structures of artemisinin and its derivatives
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