A Survey on the Prevalence of Hyperuricemia among Ethnic Minorities in Gongshan County，Yunnan Province
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摘要:
目的 通过横断面调查研究云南省贡山县少数民族群体高尿酸血症患病率情况。 方法 在云南省贡山县随机选取独龙族、怒族、藏族、白族、傈僳族等≥18 岁居民共229人进行问卷调查、体格检查和实验室检测。采用 SPSS 22.0 进行t检验、卡方检验、相关性分析和多因素Logistic 回归分析。 结果 共检出高尿酸血症患者107例，检出率为 46.7% ， 其中男性为43.9% 、女性为52.63%；独龙族48%，傈僳族51%，怒族47%，白族37.5%，藏族52%，汉族50%，各民族间患病率差异无统计学意义（P > 0.05）。高尿酸血症组人群组糖尿病史占比和尿素氮、血肌酐水平明显高于非高尿酸血症组（P < 0.05），相关性分析显示高尿酸血症与糖尿病、尿素氮、血肌酐呈正相关（P < 0.05），多因素回归分析显示，糖尿病、血肌酐升高，是高尿酸血症发病的独立高危因素（P < 0.05）。 结论 云南省贡山县高尿酸血症检出率较高，各少数民族之间高尿酸血症患病率无明显差异，糖尿病、血肌酐升高与高尿酸血症存在关联性，同时也会增加高尿酸血症发生的风险。 Abstract:Objective To investigate the prevalence of hyperuricemia among ethnic groups in Gongshan county, Yunnan province through a cross-sectional study. Methods A total of 229 residents aged ≥18 years from Dulong, Nu, Tibetan, Bai and Lisu ethnic groups were randomly selected in Gongshan County of Yunnan Province for questionnaire survey, physical examinations and laboratory tests. SPSS 22.0 was used for t test, Chi-square test, correlation analysis, and multivariate logistic regression analysis. Results A total of 107 cases of hyperuricemia were identified, with a detection rate of 46.7%, among which the prevalence was 43.9% in males, 52.63% in female, 48% in the Tulong, 51% in the Lisu, 47% in the Nu, 37.5% in the Bai, 52% in the Tibetan and 50% in the Han. There were no statistically significant differences in prevalence among all nationalities （P > 0.05）. The proportion of individuals with a history of diabetes, as well as levels of urea nitrogen and serum creatinine, were significantly higher in the hyperuricemia group compared to the non-hyperuricemia group （P < 0.05）. Correlation analysis showed a positive correlation between hyperuricemia and diabetes, urea nitrogen and serum creatinine. （P < 0.05）. Multivariate regression analysis showed that diabetes and elevated serum creatinine were independent risk factors for the onset of hyperuricemia（P < 0.05）. Conclusion The detection rate of hyperuricemia is relatively high in Gongshan County, Yunnan Province, and there is no significant differences in prevalence among ethnic groups. Diabetes and elevated serum creatinine are associated with hyperuricemia, which increase the risk of developing hyperuricemia. -
Key words:
- hyperuricemia /
- Gongshan County /
- The Dulong nationality /
- The Nu nationality
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表 1 研究观察人群临床资料及实验室结果基本信息[n（%）/$\bar x \pm s $]
Table 1. Basic information of clinical data and laboratory results of the study population[n（%）/$\bar x \pm s $]
项目 Total总数（n = 229） 项目 Total总数（n = 229） 年龄（岁） 56 ± 15 男性（n） 105（45.9） 白族（n） 8（3.5） 女性（n） 124（54.1） 藏族（n） 25（10.9） 糖尿病（n） 34（14.8） 独龙族（n） 25（10.9） 高血压（n） 82（35.8） 汉族（n） 15（6.6） 吸烟史（n） 64（27.9） 傈僳族（n） 116（50.7） 饮酒史（n） 104（45.4） 怒族（n） 39（17） 高尿酸血症（n） 107（46.7） 彝族（n） 1（0.4） BMI（kg/m2） 23.75 ± 4.17 TG（mmol/L） 1.88 ± 0.22 BUN（mmol/L） 6.41 ± 1.87 TC（mmol/L） 4.94 ± 1.28 Scr（μmol/L） 98.9 ± 49.7 LDL（mmol/L） 3.17 ± 0.95 SUA（μmol/L） 371.3 ± 24.2 HDL（mmol/L） 1.33 ± 0.49 
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表 2 高尿酸血症与各观察指标相关性分析结果
Table 2. Correlation analysis results of hyperuricemia and various observation index
项目 R P 项目 R P 糖尿病 0.13 0.04* 民族 0.08 0.91 高血压 −0.01 0.91 年龄 0.04 0.48 吸烟史 0.15 0.82 性别 0.04 0.50 饮酒史 0.02 0.77 BMI 0.06 0.32 TG 0.07 0.29 TC 0.01 0.87 LDL 0.01 1.00 HDL −0.04 0.49 BUN 0.26 0.01* Scr 0.21 0.01*
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表 3 高尿酸血症（HUA）与非高尿酸血症人群临床资料及实验室结果基本信息[n（%）/$\bar x \pm s $]
Table 3. Tab. 3Basic information of clinical data and laboratory results of hyperuricemia （HUA） and non-hyperuricemia populations [n（%）/$\bar x \pm s $]
项目 HUA组（n = 117） 非HUA组（n = 112） t/F/χ2 P 年龄（岁） 56.87 ± 15.64 55.32 ± 16.37 0.703 0.313 BMI（kg/m2） 24.10 ± 4.44 23.53 ± 3.95 0.986 0.331 藏族（n） 13（54.1） 11（45.9） 独龙族（n） 12（48.0） 13（52.0） 傈僳族（n） 54（51.9） 50（48.1） 怒族（n） 17（47.2） 19（52.8） 其他民族# 11（47.8） 12（52.2） 1.953 0.924 男性（n） 47 51 0.460 0.498 吸烟史（n） 31 29 0.048 0.827 饮酒史（n） 49 46 0.084 0.771 糖尿病（n） 22 12 3.854 0.049* 高血压（n） 38 38 0.011 0.918 TG（mmol/L） 1.95 ± 0.37 1.67 ± 0.18 1.042 0.092 TC（mmol/L） 4.94 ± 1.24 4.91 ± 1.25 0.163 0.543 LDL（mmol/L） 3.18 ± 0.96 3.18 ± 0.96 0.001 0.973 HDL（mmol/L） 1.31 ± 0.52 1.35 ± 0.47 0.682 0.547 BUN（mmol/L） 7.67 ± 0.62 5.14 ± 0.25 3.858 0.001* Scr（μmol/L） 124.43 ± 16.07 73.62 ± 13.75 3.123 0.001* *P < 0.05；#其他民族：汉族、白族、彝族。
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表 4 高尿酸血症单因素及多因素logistics回归分析结果
Table 4. Tab. 4Univariate and multifactorial logistic regression analysis of hyperuricemia
项目 单因素 Model 1* OR（95% Cl） P OR（95% Cl） P 糖尿病 0.41（0.17−0.96） 0.041* 2.33（0.72−7.51） 0.154 BUN 1.10（0.95−1.27） 0.190 0.90（0.75−1.01） 0.031 Scr 1.01（0.95−1.27） 0.049* 0.98（0.96−1.00） 0.047* *Model 1=校对年龄、性别、民族。
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