肠道菌群及其代谢产物在动脉粥样硬化发生发展中的作用

王艾云; 王雨婷; 蔡静; 倪若妍; 罗彩莹; 喻卓; 陈鹏

肠道菌群及其代谢产物在动脉粥样硬化发生发展中的作用

王艾云^{1, 2},
王雨婷^{1, 2},
蔡静^{1, 2},
倪若妍^{1, 2},
罗彩莹^{1, 2},
喻卓^3, ,,
陈鹏^{1, 2, ,}

1.
昆明医科大学药学院暨云南省天然药物药理重点实验室
2.
昆明医科大学现代生物医药产业学院，云南昆明　650500
3.
昆明医科大学第一附属医院心内科，云南昆明　650032

基金项目: 国家自然科学基金（82360088）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（2201AY070001-001）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202101AY070001-020）；云南省老年疾病临床医学研究中心专项资金（202102AA310069）。

详细信息

作者简介:
王艾云（1999～），女，云南楚雄人，在读硕士研究生，主要从事老年病药理学的研究工作

王雨婷对本文有同等的贡献

通讯作者:
喻卓，E-mail：dr-yuzhuo@163.com

陈鹏，E-mail：chenpeng@kmmu.edu.cn

中图分类号: R543
计量
- 文章访问数: 33
- HTML全文浏览量: 25
- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2024-09-23
- 网络出版日期: 2024-12-10

The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis

Aiyun WANG^{1, 2},
Yuting WANG^{1, 2},
Jing CAI^{1, 2},
Ruoyan NI^{1, 2},
Caiying LUO^{1, 2},
Zhuo YU^{3
, ,},
Peng CHEN^{1, 2
, ,}

1.
School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University
2.
College of Modern Biomedical Industry，Kunming Medical University，Kunming Yunnan 650500
3.
Dept. of Cardiology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

摘要

摘要: 肠道菌群及其代谢产物对动脉粥样硬化（Atherosclerosis，AS）等心血管疾病的发生和发展起到重要作用，已经成为预防和治疗AS的重要影响因素。本文聚焦肠道微生态环境，主要阐述氧化三甲胺（Trimethylamine Oxide，TMAO）、短链脂肪酸（Short-chain Fatty Acids，SCFA）、苯乙酰谷氨酰胺（Phenylacetylglutamine，PAG）、脂多糖（Lipopolysaccharides，LPS）和胆汁酸（Bile Acids，BA）等肠道菌群代谢产物与AS的关系，同时探讨以调整肠道菌群及其代谢产物为出发点的AS治疗策略，期望为AS的预防和治疗开辟新途径。
- 肠道菌群 /
- 代谢产物 /
- 动脉粥样硬化 /
- 治疗
Abstract: Intestinal flora and their metabolites play an important role in the occurrence and development of cardiovascular diseases such as atherosclerosis （AS）, and have become an important target for the prevention and treatment of AS. In this paper, we focus on the intestinal microecological environment and focus on the relationship between intestinal flora metabolites such as trimethylamine oxide （TMAO）, short-chain fatty acids （SCFA）, phenylacetylglutamine （PAG）, lipopolysaccharides （LPS）, and bile acids （BA）, and AS. At the same time, we also discuss the therapeutic strategies of AS that start from adjusting the intestinal flora and its metabolites, with the hope of opening up a new avenue of AS prevention and treatment. We hope to open up new avenues for the prevention and treatment of AS.
- Intestinal flora /
- Metabolites /
- Atherosclerosis /
- Treatment

HTML全文

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