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RSS2018 Vol. 39, No. 01
2018, 39(01): 1-4.
Abstract:
Oxytocin (OT) is a 9-amino-peptide hormone synthesized mainly in the Paraventricular Nucleus (PVN) and Supraoptic Nucleus (SON) of mammals’hypothalamus.Small part of OT is synthesized in peripheral organs.In addition to promoting the lactation and uterine contraction, OT has many other physiological functions, such as analgesia.It has been proved that neuropeptide can exert analgesic effect.OT is indeed a neuropeptide secreted naturally by mammals.Sdudies have shown that OT plays an important role in relieving pain and can avoid problems like addiction and other side effects.However, its underlying mechanism of analgia is still unclear.Therefore, further study of the analgesic mechanism of oxytocin has a great theoretic significance and very broad clinical prosperities.
Oxytocin (OT) is a 9-amino-peptide hormone synthesized mainly in the Paraventricular Nucleus (PVN) and Supraoptic Nucleus (SON) of mammals’hypothalamus.Small part of OT is synthesized in peripheral organs.In addition to promoting the lactation and uterine contraction, OT has many other physiological functions, such as analgesia.It has been proved that neuropeptide can exert analgesic effect.OT is indeed a neuropeptide secreted naturally by mammals.Sdudies have shown that OT plays an important role in relieving pain and can avoid problems like addiction and other side effects.However, its underlying mechanism of analgia is still unclear.Therefore, further study of the analgesic mechanism of oxytocin has a great theoretic significance and very broad clinical prosperities.
2018, 39(01): 5-9.
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Objective To detect the changes of mRNA isoforms in multiple cancer cell lines with dose of cisplatin. Methods Total RNA of the cells treated by cisplatin were abstracted 24 h after the treatment. mRNA isoforms of SRSF12 gene were detected by semiquantitative RT-PCR. The ratios of mRNA isoforms were analyzed by gel image software and statistical analysis. Results Under the cisplatin treatment, 2 mRNA isoforms of SRSF12 were detected in five cells except Caski cells, their ratios and relative mRNA levels were changed. With the increase of dose of cisplatin, the ratio of isoform-a was slightly increased; but the ratio of isoform-b was different, the changes were not obvious in the A549 and 293 FT cells, the weaker expression was expressed in the H1299 and C33 A cells, and the two isoforms were gradually weakening in the Siha cells. Conclution Under the cisplatin treatment in multiple cancer cells, the expression of SRSF12 shows tissue-specific and cell type-specific patterns.
Objective To detect the changes of mRNA isoforms in multiple cancer cell lines with dose of cisplatin. Methods Total RNA of the cells treated by cisplatin were abstracted 24 h after the treatment. mRNA isoforms of SRSF12 gene were detected by semiquantitative RT-PCR. The ratios of mRNA isoforms were analyzed by gel image software and statistical analysis. Results Under the cisplatin treatment, 2 mRNA isoforms of SRSF12 were detected in five cells except Caski cells, their ratios and relative mRNA levels were changed. With the increase of dose of cisplatin, the ratio of isoform-a was slightly increased; but the ratio of isoform-b was different, the changes were not obvious in the A549 and 293 FT cells, the weaker expression was expressed in the H1299 and C33 A cells, and the two isoforms were gradually weakening in the Siha cells. Conclution Under the cisplatin treatment in multiple cancer cells, the expression of SRSF12 shows tissue-specific and cell type-specific patterns.
2018, 39(01): 10-15.
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Objective To study the inhibitory effect of ursolic acid on the proliferation of human papillary thyroid carcinoma cell line TPC-1 in vitro. Method TPC-1 cells were treated with different concentrations of ursolic acid (control group:0μM, experimental group:3μM, 6μM, 12μM) ; MTT assay was used to observe the effect of the growth of TPC-1 cells on different concentrations of ursolic acid at the same time; Apoptosis and cell cycle distribution of TPC-1 cells were treated with ursolic acid by flow cytometry; The expression of Bcl-2, Bax and Caspase-9 mRNA in TPC-1 cells were treated with ursolic acid by QRT-PCR; The expression of Bcl-2, Bax and Caspase-9 protein in TPC-1 cells were treated with ursolic acid by Western blot. Results MTT assay showed that ursolic acid inhibited the proliferation of TPC-1 cells in a concentration and time-dependent manner, and the IC50 at 24 h, 48 h and 72 h was 14.21 μM, 10.56 μM, 10.39 μM; Flow cytometry showed that ursolic acid inhibited the apoptosis of TPC-1 cells in a concentration-dependent manner, and the growth of TPC-1 cells was arrested in S phase; QRT-PCR showed that Bcl-2, Bax and Caspase-9 mRNA were expressed in the control and experimental groups, ursolic acid inhibited the expression of Bcl-2 mRNA in a concentration-dependent manner and up-regulated the expression of Bax and Caspase-9 mRNA; Western blot results showed that Bcl-2, Bax and Caspase-9 were expressed in the control and experimental groups, ursolic acid inhibited the expression of Bcl-2 protein in a concentration-dependent manner and up-regulated the expression of Bax protein and Caspase-9 protein.Conclusion Ursolic acid can significantly inhibit the proliferation and induce apoptosis of human papillary thyroid TPC-1 cells, providing some ideas for the treatment of thyroid cancer.
Objective To study the inhibitory effect of ursolic acid on the proliferation of human papillary thyroid carcinoma cell line TPC-1 in vitro. Method TPC-1 cells were treated with different concentrations of ursolic acid (control group:0μM, experimental group:3μM, 6μM, 12μM) ; MTT assay was used to observe the effect of the growth of TPC-1 cells on different concentrations of ursolic acid at the same time; Apoptosis and cell cycle distribution of TPC-1 cells were treated with ursolic acid by flow cytometry; The expression of Bcl-2, Bax and Caspase-9 mRNA in TPC-1 cells were treated with ursolic acid by QRT-PCR; The expression of Bcl-2, Bax and Caspase-9 protein in TPC-1 cells were treated with ursolic acid by Western blot. Results MTT assay showed that ursolic acid inhibited the proliferation of TPC-1 cells in a concentration and time-dependent manner, and the IC50 at 24 h, 48 h and 72 h was 14.21 μM, 10.56 μM, 10.39 μM; Flow cytometry showed that ursolic acid inhibited the apoptosis of TPC-1 cells in a concentration-dependent manner, and the growth of TPC-1 cells was arrested in S phase; QRT-PCR showed that Bcl-2, Bax and Caspase-9 mRNA were expressed in the control and experimental groups, ursolic acid inhibited the expression of Bcl-2 mRNA in a concentration-dependent manner and up-regulated the expression of Bax and Caspase-9 mRNA; Western blot results showed that Bcl-2, Bax and Caspase-9 were expressed in the control and experimental groups, ursolic acid inhibited the expression of Bcl-2 protein in a concentration-dependent manner and up-regulated the expression of Bax protein and Caspase-9 protein.Conclusion Ursolic acid can significantly inhibit the proliferation and induce apoptosis of human papillary thyroid TPC-1 cells, providing some ideas for the treatment of thyroid cancer.
2018, 39(01): 16-19.
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目的 研究有氧运动对2型糖尿病 (T2DM) 大鼠AGE-RAGE轴及NF-κB通路的影响, 探讨T2DM运动康复作用.方法 8周龄雄性Wister大鼠高糖高脂饮食后, 应用链脲佐菌素诱导建立T2DM大鼠.将30只造模成功的T2DM大鼠随机分成3组 (n=10) :T2DM组、T2DM加低强度运动组 (T2DML) 和T2DM加中强度运动组 (T2DMM) .运动组实施运动方案.采用ELISA法分别测定实验大鼠血浆、骨骼肌和心肌的晚期糖基化终产物 (AGEs) 及其受体 (RAGE) 和核因子κB (NF-κB) 水平.结果 与T2DM组相比, T2DML组血、骨骼肌和心肌的NF-κB水平显著下降 (P<0.05) ;T2DMM组血、骨骼肌和心肌的AGEs、RAGE和NF-κB水平均显著下降 (P<0.05) ;与T2DML组相比, T2DMM组血、骨骼肌和心肌的NF-κB水平均显著下降 (P<0.05) .结论 中强度有氧运动能抑制AGE-RAGE轴和NF-κB通路, 降低T2DM氧化应激和炎症反应, 减轻组织损伤, 对T2DM及其并发症具有防治作用.
2018, 39(01): 20-25.
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Objective To study the effect of Carthamin Yellow (CY) on cell proliferation, apoptosis, migration and invasion ability of breast cancer and its related molecular mechanisms. Methods CCK-8 assay was used to detect cell viability of MDA-MB-231 human breast cancer cells by different concentrations of CY at different time;flow cytometry was used to test the apoptosis rate of MDA-MB-231 cells treated by different concentrations of CY and transwell assay was used to investigate the effect of various concentrations of CY on MDA-MB-231 cell migration and invasion.After the intervention of different concentrations of CY on MDA-MB-231 cells, apoptosis-related protein Cleaved-Caspase-3, survival protein p-Akt and metastasis-related protein MMP2 were detected by western blot. Results (1) CY could inhibit the proliferation of MDA-MB-231 cells in a dose-andtime-dependent manner. (2) CY significantly promoted the apoptosis of breast cancer cells (P<0.01) . (3) CY could decrease the expression of p-Akt and increase the expression of Cleaved-Caspase-3. (4) CY impaired migration and invasion of MDA-MB-231 cells (P<0.01) , and can inhibit the expression of MMP2. Conclusion CY could promote the apoptosis of breast cancer cells through activation of apoptosis signaling, and can inhibit breast cancer cell metastasis by suppressing MMP2. And CY may be a potential therapeutic drug for human breast cancer.
Objective To study the effect of Carthamin Yellow (CY) on cell proliferation, apoptosis, migration and invasion ability of breast cancer and its related molecular mechanisms. Methods CCK-8 assay was used to detect cell viability of MDA-MB-231 human breast cancer cells by different concentrations of CY at different time;flow cytometry was used to test the apoptosis rate of MDA-MB-231 cells treated by different concentrations of CY and transwell assay was used to investigate the effect of various concentrations of CY on MDA-MB-231 cell migration and invasion.After the intervention of different concentrations of CY on MDA-MB-231 cells, apoptosis-related protein Cleaved-Caspase-3, survival protein p-Akt and metastasis-related protein MMP2 were detected by western blot. Results (1) CY could inhibit the proliferation of MDA-MB-231 cells in a dose-andtime-dependent manner. (2) CY significantly promoted the apoptosis of breast cancer cells (P<0.01) . (3) CY could decrease the expression of p-Akt and increase the expression of Cleaved-Caspase-3. (4) CY impaired migration and invasion of MDA-MB-231 cells (P<0.01) , and can inhibit the expression of MMP2. Conclusion CY could promote the apoptosis of breast cancer cells through activation of apoptosis signaling, and can inhibit breast cancer cell metastasis by suppressing MMP2. And CY may be a potential therapeutic drug for human breast cancer.
2018, 39(01): 26-29.
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Objective To explore the feasibility of the adjustable brace asymmetric tethering in concave side for establishing a porcine scoliosis model.Methods Six minority piglets (aged 8-10-week-old, weight 8-10 kg) were selected and the adjustable brace asymmetric tethering in concave side were applied during the procedure.Roentgenography was performed before and immediately after the operation, and 1, 2 and 3 months after the procedure.Cobb angles were measured based in the plain radiograph.Results A piglet died for narcotic drug overdose and the other 5 pigs succeeded in modeling.The cobb angles were (9.0±1.6) °in one month, (11.8 ±1.3) ° in two months and (21.6 ±2.4) ° in three months after the operation. Conclusion It's is an effective way to establish the porcine model of rapidly progressive structural scoliosis by the adjustable brace asymmetric tethering in concave side.It avoids the damage to the spinal elements and could be an ideal model for further study on corrective techniques.
Objective To explore the feasibility of the adjustable brace asymmetric tethering in concave side for establishing a porcine scoliosis model.Methods Six minority piglets (aged 8-10-week-old, weight 8-10 kg) were selected and the adjustable brace asymmetric tethering in concave side were applied during the procedure.Roentgenography was performed before and immediately after the operation, and 1, 2 and 3 months after the procedure.Cobb angles were measured based in the plain radiograph.Results A piglet died for narcotic drug overdose and the other 5 pigs succeeded in modeling.The cobb angles were (9.0±1.6) °in one month, (11.8 ±1.3) ° in two months and (21.6 ±2.4) ° in three months after the operation. Conclusion It's is an effective way to establish the porcine model of rapidly progressive structural scoliosis by the adjustable brace asymmetric tethering in concave side.It avoids the damage to the spinal elements and could be an ideal model for further study on corrective techniques.
2018, 39(01): 30-34.
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Objective To set up a favorable animal model for the drug treatment research of endometriosis by establishing the animal model of endometriosis in SCID and nude mice so as to compare the influences on implantation of human endometrial tissue derived from the eutopic and ectopic sources. Methods Eutopic and ectopic endometrium were transplanted to the lower abdominal parts subcutaneously of 30 sexually matured BALB/c-nu/nu nude mice and SCID mice respectively. The ectopic lesion sizes were under the regular observation before they were removed 6 weeks after the operation for pathological examinations. Results Nude mice and SCID mice were able to be used to establish a successful animal models of endometriosis. The success rate of SCID mice was higher than that of nude mice. The success rate of the eutopic endometrium group was significantly higher than that of the ectopic endometrium group. Nude and SCID mice endometriosis implantation models were successfully established. The modeling success rate of SCID mice is higher than that of the nude mice.The success rate of transplantation was higher in the ectopic endometrium than in the eutopic endometrium.Conclusion The SCID mice endometriosis endometriosis model provides a favorable animal model of endometriosis.
Objective To set up a favorable animal model for the drug treatment research of endometriosis by establishing the animal model of endometriosis in SCID and nude mice so as to compare the influences on implantation of human endometrial tissue derived from the eutopic and ectopic sources. Methods Eutopic and ectopic endometrium were transplanted to the lower abdominal parts subcutaneously of 30 sexually matured BALB/c-nu/nu nude mice and SCID mice respectively. The ectopic lesion sizes were under the regular observation before they were removed 6 weeks after the operation for pathological examinations. Results Nude mice and SCID mice were able to be used to establish a successful animal models of endometriosis. The success rate of SCID mice was higher than that of nude mice. The success rate of the eutopic endometrium group was significantly higher than that of the ectopic endometrium group. Nude and SCID mice endometriosis implantation models were successfully established. The modeling success rate of SCID mice is higher than that of the nude mice.The success rate of transplantation was higher in the ectopic endometrium than in the eutopic endometrium.Conclusion The SCID mice endometriosis endometriosis model provides a favorable animal model of endometriosis.
2018, 39(01): 35-38.
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Objective The aim of this study was to analyze the status and influencing factors of public health service utilization in rural patients with severe mental illness in Yunnan province. Methods The main caregivers of patients with severe mental illness in Yunnan province were selected by stratified cluster sampling method. Multivariate logistic regression was used to analyze the influencing factors of public health service utilization. Results A total of 284 cases of rural patients with severe mental illness were investigated, including144 males ( 50.7%) and 140 females ( 49.3%) . The rate of medical file filing, follow-up rate of village doctor, participation rate of free physical examination and health education acceptance rate among patients with severe mental illness were 89.8%, 84.9%, 73.2% and 56.7% respectively ( P <0.05) . Female patients had higher participation rate of free physical examination than male patients, and patients having work and patients with controlled disease condition and their caregivers had higher rates of health education acceptance rate than their counterparts ( P <0.05) . Conclusion Measures should be taken to strengthen the work of medical examination for male patients, and to expand health education activities for patients having no work and patients with uncontrolled disease condition, so as to improve the public health service utilization in rural areas of Yunnan province.
Objective The aim of this study was to analyze the status and influencing factors of public health service utilization in rural patients with severe mental illness in Yunnan province. Methods The main caregivers of patients with severe mental illness in Yunnan province were selected by stratified cluster sampling method. Multivariate logistic regression was used to analyze the influencing factors of public health service utilization. Results A total of 284 cases of rural patients with severe mental illness were investigated, including144 males ( 50.7%) and 140 females ( 49.3%) . The rate of medical file filing, follow-up rate of village doctor, participation rate of free physical examination and health education acceptance rate among patients with severe mental illness were 89.8%, 84.9%, 73.2% and 56.7% respectively ( P <0.05) . Female patients had higher participation rate of free physical examination than male patients, and patients having work and patients with controlled disease condition and their caregivers had higher rates of health education acceptance rate than their counterparts ( P <0.05) . Conclusion Measures should be taken to strengthen the work of medical examination for male patients, and to expand health education activities for patients having no work and patients with uncontrolled disease condition, so as to improve the public health service utilization in rural areas of Yunnan province.
2018, 39(01): 39-44.
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Objective To determine the awareness, treatment and control of hypertension and its determinants in the elderly hypertensive patients of Dean nationality so as to explore the associated determinants.Methods This was a cross-sectional, population-based survey. A total of 939 persons aged 60 years and older sampled by stratified sampling method from the elderly population of Dean nationality were examined from July to September 2016. Meanwhile, the data of medical history and examination were collected. Results There were 353 elderly patients with hypertension in the 939 subjects. The awareness, treatment and control of hypertension in the elderly hypertensive patients (EHP) , which was 47.3%, 36.5% and 22.1% respectively, were higher than the results of previous national study and had the upward trends with the increasing age (P<0.05) . In comparison with the reference group, EHP living in middle economic level area had the higher awareness, treatment and control of hypertension (P<0.05) . The results of covariate-adjusted multilevel logistic regression model indicated that there was a cross-level interaction effect between middle economic level area and dyslipidemia on the awareness and treatment of hypertension respectively, and a cross-level interaction effect between middle economic level area and low fat diet on the control of hypertension (P<0.05) . The individual level covariates, age (OR=1.3412, 1.3144, 95% CI 1.0217-1.7609, 1.0030-1.7225) and diabetes ( OR=2.6735, 2.3078, 95% CI1.0721-6.6672, 1.0240-5.2007) , had the positive association with the awareness and treatment of hypertension;age (OR=1.4740, 95%CI 1.0034-2.1654) , non-drinking (OR=3.2056, 95%CI 1.5554-6.6066) and low salt diet (OR=3.6969, 95%CI 1.7996-7.5946) had the positive association with the control of hypertension.Conclusion The awareness, treatment and control of hypertension in the EHP of Dean nationality were higher than those of the national level, and the dominant factors were economic level, age, dyslipidemia, diabetes, non-drinking, low fat diet and low salt diet, etc.
Objective To determine the awareness, treatment and control of hypertension and its determinants in the elderly hypertensive patients of Dean nationality so as to explore the associated determinants.Methods This was a cross-sectional, population-based survey. A total of 939 persons aged 60 years and older sampled by stratified sampling method from the elderly population of Dean nationality were examined from July to September 2016. Meanwhile, the data of medical history and examination were collected. Results There were 353 elderly patients with hypertension in the 939 subjects. The awareness, treatment and control of hypertension in the elderly hypertensive patients (EHP) , which was 47.3%, 36.5% and 22.1% respectively, were higher than the results of previous national study and had the upward trends with the increasing age (P<0.05) . In comparison with the reference group, EHP living in middle economic level area had the higher awareness, treatment and control of hypertension (P<0.05) . The results of covariate-adjusted multilevel logistic regression model indicated that there was a cross-level interaction effect between middle economic level area and dyslipidemia on the awareness and treatment of hypertension respectively, and a cross-level interaction effect between middle economic level area and low fat diet on the control of hypertension (P<0.05) . The individual level covariates, age (OR=1.3412, 1.3144, 95% CI 1.0217-1.7609, 1.0030-1.7225) and diabetes ( OR=2.6735, 2.3078, 95% CI1.0721-6.6672, 1.0240-5.2007) , had the positive association with the awareness and treatment of hypertension;age (OR=1.4740, 95%CI 1.0034-2.1654) , non-drinking (OR=3.2056, 95%CI 1.5554-6.6066) and low salt diet (OR=3.6969, 95%CI 1.7996-7.5946) had the positive association with the control of hypertension.Conclusion The awareness, treatment and control of hypertension in the EHP of Dean nationality were higher than those of the national level, and the dominant factors were economic level, age, dyslipidemia, diabetes, non-drinking, low fat diet and low salt diet, etc.
2018, 39(01): 45-49.
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Objective To analyze the prevalence, awareness, treatment, control and self-management of diabetes among the elderly in Midu County of Yunnan province. Methods A stratified random sampling method was used to carry out on-site questionnaire survey and blood glucose measurement among 1, 603 older people aged ≥60 in Midu County of Yunnan province. Results The overall prevalence, awareness, treatment and control rate of diabetes among the elderly were 10.11%, 56.17%, 75.82% and 37.36%respectively. The rates of self-monitoring of blood glucose, taking medicine prescribed by doctors and hypoglycemic measures in the last two weeks were 43.96%, 80.22% and 98.90% respectively. People with higher average annual income had higher prevalence of diabetes (P<0.05) . The awareness rate of diabetes in women (67.42%) was significantly higher than that in males (42.47%, P<0.01) . Self monitoring of blood glucose in patients with house toilet (46.99%) in house was higher than those without toilet (12.50%, P<0.05) . The higher the level of education, the higher the rate of taking medicine prescribed by doctors ( P <0.05) . Patients who do not live alone and have toilet in house have a higher rate of weight control (67.07% and66.27%) than those living alone and without toilet (22.22% and 25%, P<0.05) .Conclusions The findings indicate a relatively high prevalence of diabetes and low level of self-management of diabetes among older people in Midu County. It should adopt targeted diabetes health education and intervention according to different characteristics of the population so as to improve their level of diabetes self-management.
Objective To analyze the prevalence, awareness, treatment, control and self-management of diabetes among the elderly in Midu County of Yunnan province. Methods A stratified random sampling method was used to carry out on-site questionnaire survey and blood glucose measurement among 1, 603 older people aged ≥60 in Midu County of Yunnan province. Results The overall prevalence, awareness, treatment and control rate of diabetes among the elderly were 10.11%, 56.17%, 75.82% and 37.36%respectively. The rates of self-monitoring of blood glucose, taking medicine prescribed by doctors and hypoglycemic measures in the last two weeks were 43.96%, 80.22% and 98.90% respectively. People with higher average annual income had higher prevalence of diabetes (P<0.05) . The awareness rate of diabetes in women (67.42%) was significantly higher than that in males (42.47%, P<0.01) . Self monitoring of blood glucose in patients with house toilet (46.99%) in house was higher than those without toilet (12.50%, P<0.05) . The higher the level of education, the higher the rate of taking medicine prescribed by doctors ( P <0.05) . Patients who do not live alone and have toilet in house have a higher rate of weight control (67.07% and66.27%) than those living alone and without toilet (22.22% and 25%, P<0.05) .Conclusions The findings indicate a relatively high prevalence of diabetes and low level of self-management of diabetes among older people in Midu County. It should adopt targeted diabetes health education and intervention according to different characteristics of the population so as to improve their level of diabetes self-management.
2018, 39(01): 50-54.
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Objective To retrospectively analyze the postoperative morbidity of patients with complex intracranial aneurysms treated by stent-assisted coiling and investigate the causes and treatment strategy of postoperative morbidity. Methods 62 SAH patients with intracranial aneurysm were treated by stent-assisted coiling, 53 cases of single aneurysms, 9 cases of multi-aneurysms (8 cases of 2 aneurysms, 1 cases of 3 aneurysms) , amount to 72 aneurysms, 71 aneurysms were treated by stent-assisted coiling. Results Completed embolization 53 cases were completed with embolization partial embolization (74.64%) , Nearly all embolization 17 cases were nearly all embolization (23.94%) , partial embolization and 1 case was s (1.42%) . According to GOS, 52 patients with a score of GOS 5, 6 patients with a score of GOS 4, 3 patients with a score of GOS 3, 2 patients with a score of GOS 1. 58 (93.5%) patients survived favorably. 9 patients with complications (14.5%) , 3 patients with acute thrombosis; 2 patients with rupture of aneurysms during surgery; 3 patients with cerebral angiospasm; There was no obvious abnormality during the surgery in 1 patient, and there was a focal ischemic change followed by a mild neurological deficiency. Conclusions Stent assisted coil embolization of intracranial ruptured aneurysm is safe, effective and feasible, but we should improve clinical skills, summarize the analysis in the clinical operation experience of clinical treatment so as to reduce complications. Timely and correct treatment is also very important when complications occur.
Objective To retrospectively analyze the postoperative morbidity of patients with complex intracranial aneurysms treated by stent-assisted coiling and investigate the causes and treatment strategy of postoperative morbidity. Methods 62 SAH patients with intracranial aneurysm were treated by stent-assisted coiling, 53 cases of single aneurysms, 9 cases of multi-aneurysms (8 cases of 2 aneurysms, 1 cases of 3 aneurysms) , amount to 72 aneurysms, 71 aneurysms were treated by stent-assisted coiling. Results Completed embolization 53 cases were completed with embolization partial embolization (74.64%) , Nearly all embolization 17 cases were nearly all embolization (23.94%) , partial embolization and 1 case was s (1.42%) . According to GOS, 52 patients with a score of GOS 5, 6 patients with a score of GOS 4, 3 patients with a score of GOS 3, 2 patients with a score of GOS 1. 58 (93.5%) patients survived favorably. 9 patients with complications (14.5%) , 3 patients with acute thrombosis; 2 patients with rupture of aneurysms during surgery; 3 patients with cerebral angiospasm; There was no obvious abnormality during the surgery in 1 patient, and there was a focal ischemic change followed by a mild neurological deficiency. Conclusions Stent assisted coil embolization of intracranial ruptured aneurysm is safe, effective and feasible, but we should improve clinical skills, summarize the analysis in the clinical operation experience of clinical treatment so as to reduce complications. Timely and correct treatment is also very important when complications occur.
2018, 39(01): 55-58.
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Objective This study is aimed to compare the CT number and volume of the parotid of the NPC patients between the first CT scan and the rescanning after 20 fractions.Method 14 NPC patients who had been treated were selected for analysis. Each patient was rescanned after the treatment of 20 fractions as the same protocol of the first CT sim for replanning. The CT number and volume change of the Parotid were compared and the CT number and volume change of the brain stem were also evaluated as a reference data. The results were analyzed with SPPS19, The results were analyzed with SPPS19 for t test. Results Mean right parotid CT number of the 14 patients for pre treatment and re-plan (after 20 fractions) was 6.4 and-0.5 ( P = 0.02) separately, the mean stand deviation was 26.5 and 35.6 (P = 0.04) separately、 the mean volume was 24.6 cm3 and 16.1 cm3 ( P = 0.002) separately. Mean left parotid CT number of the 14 patients for pre treatment and re-plan was 4.4 and-1.8 ( P = 0.024) separately, the mean stand deviation is 29.7 and 35.5 ( P = 0.026) separately、 the mean volume was 24.1 cm3 and 16.7 cm3 ( P = 0.001) separately. The Mean brain stem CT number of the 14 patients for pre-treatment and re-plan was 28.7 cm3 and 28.9 cm3 ( P = 0.887) separately.Conclusion After the treatment of 20 fractions, the volume of the parotid was significantly shrinked, the CT number was significantly decreased and the SD of CT number was significantly increased. The volume, CT number and SD of the Brain stem did not have significant changes. The change of the CT number could be a new observed data for the adaptive plan during the treatment as the tumor response.
Objective This study is aimed to compare the CT number and volume of the parotid of the NPC patients between the first CT scan and the rescanning after 20 fractions.Method 14 NPC patients who had been treated were selected for analysis. Each patient was rescanned after the treatment of 20 fractions as the same protocol of the first CT sim for replanning. The CT number and volume change of the Parotid were compared and the CT number and volume change of the brain stem were also evaluated as a reference data. The results were analyzed with SPPS19, The results were analyzed with SPPS19 for t test. Results Mean right parotid CT number of the 14 patients for pre treatment and re-plan (after 20 fractions) was 6.4 and-0.5 ( P = 0.02) separately, the mean stand deviation was 26.5 and 35.6 (P = 0.04) separately、 the mean volume was 24.6 cm3 and 16.1 cm3 ( P = 0.002) separately. Mean left parotid CT number of the 14 patients for pre treatment and re-plan was 4.4 and-1.8 ( P = 0.024) separately, the mean stand deviation is 29.7 and 35.5 ( P = 0.026) separately、 the mean volume was 24.1 cm3 and 16.7 cm3 ( P = 0.001) separately. The Mean brain stem CT number of the 14 patients for pre-treatment and re-plan was 28.7 cm3 and 28.9 cm3 ( P = 0.887) separately.Conclusion After the treatment of 20 fractions, the volume of the parotid was significantly shrinked, the CT number was significantly decreased and the SD of CT number was significantly increased. The volume, CT number and SD of the Brain stem did not have significant changes. The change of the CT number could be a new observed data for the adaptive plan during the treatment as the tumor response.
2018, 39(01): 59-62.
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Objective To investigate the prevalence of primary teeth caries and oral hygiene status of preschool children in Kunming.Methods 6958 children aged 3-5 years from 30 kindergartens in Kunming were randomly selected for this study.The reserch of caries prevalence rate and soft dirt were investigated.Results The caries prevalence rate and the mean decayed, missing and filled teeth (XDMFT) values in primary teeth were58.68% and 2.61 respectively.We can see the difference of significant between Dental caries prevalence and mean debris index simplified (DI-S) scores between age groups, and there was no statistical significance of the same index between sex. There was no correlation between the investigation of dental caries and oral hygiene status.Conclusion The caries prevalence rate in 3-5 year-old children in the downtown area of Kunming city is very high, pointing out that preventive treatment against primary teeth caries should be strengthened.
Objective To investigate the prevalence of primary teeth caries and oral hygiene status of preschool children in Kunming.Methods 6958 children aged 3-5 years from 30 kindergartens in Kunming were randomly selected for this study.The reserch of caries prevalence rate and soft dirt were investigated.Results The caries prevalence rate and the mean decayed, missing and filled teeth (XDMFT) values in primary teeth were58.68% and 2.61 respectively.We can see the difference of significant between Dental caries prevalence and mean debris index simplified (DI-S) scores between age groups, and there was no statistical significance of the same index between sex. There was no correlation between the investigation of dental caries and oral hygiene status.Conclusion The caries prevalence rate in 3-5 year-old children in the downtown area of Kunming city is very high, pointing out that preventive treatment against primary teeth caries should be strengthened.
2018, 39(01): 63-68.
Abstract:
Objective To evaluate the AChE and nAChR in the NMJ and the morphology of the muscle in the bilateral triceps surae after the unilateral shock wave therapy. Method 60 male New Zealand rabbits weighing (2±0.2) Kg were used in this study. Two thousand shock waves at an energy flux density of 1.5 bar and the frequency of10 Hz were applied to their left calf muscles. Divided into six groups, both sides of the triceps muscle of calf were taken out on the day of the shock wave and the1, 2, 4, 6 and 8 weeks after the treatment. HE staining was used to observe the morphological changes of muscle tissue and the average optical density was measured after AChE stain so as to calculate the receptor count after Acetylcholine receptor immunohistochemistry. Result No abnormal morphological abnormalities were observed in all rabbits. In the first five groups, the AChE was significantly higher in the side of the shockwave treatment compairing with the control side (P<0.05) , slow decrease after 1 week after the treatment. In the first five groups, the nAChR was significantly lower in the side of the shock wave treatment compairing with the control side (P <0.05) , and gradually increased to normal after 8 weeks. Conslusion Suitable dose of shock wave will not have a greater impact on morphology of muscle tissue. After the shock wave treatment, the amount and degree of stimulate of muscle cells were decreased, and the production of action potentials was reduced. While the experimental side Ach E and AchR in shock wave treatment day to 8 weeks after treatment showed a significant trend to normal, it shows that the effect of shock wave on NMJ is transient and reversible.
Objective To evaluate the AChE and nAChR in the NMJ and the morphology of the muscle in the bilateral triceps surae after the unilateral shock wave therapy. Method 60 male New Zealand rabbits weighing (2±0.2) Kg were used in this study. Two thousand shock waves at an energy flux density of 1.5 bar and the frequency of10 Hz were applied to their left calf muscles. Divided into six groups, both sides of the triceps muscle of calf were taken out on the day of the shock wave and the1, 2, 4, 6 and 8 weeks after the treatment. HE staining was used to observe the morphological changes of muscle tissue and the average optical density was measured after AChE stain so as to calculate the receptor count after Acetylcholine receptor immunohistochemistry. Result No abnormal morphological abnormalities were observed in all rabbits. In the first five groups, the AChE was significantly higher in the side of the shockwave treatment compairing with the control side (P<0.05) , slow decrease after 1 week after the treatment. In the first five groups, the nAChR was significantly lower in the side of the shock wave treatment compairing with the control side (P <0.05) , and gradually increased to normal after 8 weeks. Conslusion Suitable dose of shock wave will not have a greater impact on morphology of muscle tissue. After the shock wave treatment, the amount and degree of stimulate of muscle cells were decreased, and the production of action potentials was reduced. While the experimental side Ach E and AchR in shock wave treatment day to 8 weeks after treatment showed a significant trend to normal, it shows that the effect of shock wave on NMJ is transient and reversible.
2018, 39(01): 69-72.
Abstract:
Objective To explore the positive cut-off value in neonatal screening for congenital hypothyroidism (CH) in the center of Neonatal Screening, so as to improve screening efficiency and reduce false positive rate. Methods Heel blood samples were taken from the newborns born after72 hours, dropped in special S&S903 filter paper and delivered to the neonatal screening center within the prescribed period of time.DELFIA was applied to detect the concentration of thyroid-stimulating hormone (TSH) .Result Totally 529918 blood sample were screened from the 2012 to the 2016.Among them 529645 newborns were normal, 203 neonates were diagnosed with CH, 70 with high TSH hyperlipidemia, the total detection rate was 1:1941, and the incidence of CH was 1:2 610. According to the results, the cut-off value of the screening of CH in the center of Neonatal Screening was 9.0 m IU/L, the sensitivity was 100%and specifility was 98.38%, misdiagnosis rate was 0%.Conclusion The cut-off value of CH was 9.0 m IU/L in the center of Neonatal Screening, which is suitable for the people in 6 Prefecture/City of Yunnan Province, and also provides the basis for neonatal scree of CH in the future.
Objective To explore the positive cut-off value in neonatal screening for congenital hypothyroidism (CH) in the center of Neonatal Screening, so as to improve screening efficiency and reduce false positive rate. Methods Heel blood samples were taken from the newborns born after72 hours, dropped in special S&S903 filter paper and delivered to the neonatal screening center within the prescribed period of time.DELFIA was applied to detect the concentration of thyroid-stimulating hormone (TSH) .Result Totally 529918 blood sample were screened from the 2012 to the 2016.Among them 529645 newborns were normal, 203 neonates were diagnosed with CH, 70 with high TSH hyperlipidemia, the total detection rate was 1:1941, and the incidence of CH was 1:2 610. According to the results, the cut-off value of the screening of CH in the center of Neonatal Screening was 9.0 m IU/L, the sensitivity was 100%and specifility was 98.38%, misdiagnosis rate was 0%.Conclusion The cut-off value of CH was 9.0 m IU/L in the center of Neonatal Screening, which is suitable for the people in 6 Prefecture/City of Yunnan Province, and also provides the basis for neonatal scree of CH in the future.
2018, 39(01): 73-76.
Abstract:
Objective To study the effect of pre-operative internal iliac artery capsule combined with the lower segment of the uterus with annular suture on the treatment of postpartum hemorrhage caused by dangerous placenta previa and the long-term effect of the operation. Methods from January 1, 2015 to March 31, 2017, the second people's Hospital of Yunnan province for Cesarean danger in placenta of patients using preset internal iliac artery balloon combined with lower uterine segment ring-shaped suture in the treatment of 22 cases of patients as research group, Lower uterine segment multiple is not used in loop suture for treatment, but has a preset internal iliac artery balloon 18 cases of dangerous patients with placenta previa, as retrospective analysis clinical data of the comparison group. Results Mean blood loss in 22 patients 1329.54±290 ml. Does not occur in all patients around organ damage and other complications. 1 examples of hysterectomy. 5.23 days postoperative average hospital stay.After 3 months of follow-up ultrasound, uterus shape well. In 18 patients in the control group average blood loss1451.11 ±311 ml of blood loss were significantly higher in the study group, there was a statistically significant difference (P<0.05) . 2 examples of hysterectomy in the control group. Uterine reservations there was statistically significant (P<0.05) . Conclusion Combined preset internal iliac artery balloon uterus circular suturing for the dangerous result of placenta previa with placenta accreta intraoperative uterine bleeding for better effect.
Objective To study the effect of pre-operative internal iliac artery capsule combined with the lower segment of the uterus with annular suture on the treatment of postpartum hemorrhage caused by dangerous placenta previa and the long-term effect of the operation. Methods from January 1, 2015 to March 31, 2017, the second people's Hospital of Yunnan province for Cesarean danger in placenta of patients using preset internal iliac artery balloon combined with lower uterine segment ring-shaped suture in the treatment of 22 cases of patients as research group, Lower uterine segment multiple is not used in loop suture for treatment, but has a preset internal iliac artery balloon 18 cases of dangerous patients with placenta previa, as retrospective analysis clinical data of the comparison group. Results Mean blood loss in 22 patients 1329.54±290 ml. Does not occur in all patients around organ damage and other complications. 1 examples of hysterectomy. 5.23 days postoperative average hospital stay.After 3 months of follow-up ultrasound, uterus shape well. In 18 patients in the control group average blood loss1451.11 ±311 ml of blood loss were significantly higher in the study group, there was a statistically significant difference (P<0.05) . 2 examples of hysterectomy in the control group. Uterine reservations there was statistically significant (P<0.05) . Conclusion Combined preset internal iliac artery balloon uterus circular suturing for the dangerous result of placenta previa with placenta accreta intraoperative uterine bleeding for better effect.
2018, 39(01): 77-80.
Abstract:
Objective To analyze the effect of chemerin on the pharyngeal fat deposition by comparing the level of chemerin of fat tissue in pharynx between the patients with OSAHS and non-snorer. Methods OSAHS patients finished PSG and non-snoring patients with tonsillitis as controlled group were examined to observe their chemerin level of space veli palatine. Comparisons of the chemerin level and the indexes of MS were made to analyze the relationship between chemerin and MS. Results The level of chemerin of space veli palatine in OSAHS patients was higher than that of the control groups. And the level of chemerin within the OSAHS patients also had positive correlation with TG、HOMA-IR and uric acid. We also found that the TG, HDL-C, FINS, HOMA-IR and the uric acid had statistical differences (P <0.05) between the two groups. Conclusion The level of chemerin of OSAHS group is exceed the control group and positively related with indexes of MS. Chemerin may take part in the development of fat deposition in pharynx of OSAHS patients, which may be through MS pathway.
Objective To analyze the effect of chemerin on the pharyngeal fat deposition by comparing the level of chemerin of fat tissue in pharynx between the patients with OSAHS and non-snorer. Methods OSAHS patients finished PSG and non-snoring patients with tonsillitis as controlled group were examined to observe their chemerin level of space veli palatine. Comparisons of the chemerin level and the indexes of MS were made to analyze the relationship between chemerin and MS. Results The level of chemerin of space veli palatine in OSAHS patients was higher than that of the control groups. And the level of chemerin within the OSAHS patients also had positive correlation with TG、HOMA-IR and uric acid. We also found that the TG, HDL-C, FINS, HOMA-IR and the uric acid had statistical differences (P <0.05) between the two groups. Conclusion The level of chemerin of OSAHS group is exceed the control group and positively related with indexes of MS. Chemerin may take part in the development of fat deposition in pharynx of OSAHS patients, which may be through MS pathway.
2018, 39(01): 81-84.
Abstract:
Objective To observe the short-term effect of Paris polyphylla Smith var. yunnanensis powder combined with anti-tuberculosis drugs in the observation of superficial lymph node tuberculosis. Methods A total of170 patients were randomly divided into two groups: 80 in the control group and 90 in the observation group. The observation group consisted of nodular type, infiltrating type and abscess type, each of which had 30 cases. The control group were treated with Isoniazid, Rifampicin, Pyrazinamide and Ethambutol. Besides the four medications, the observation group were treated with external application of Paris polyphylla Smith var. yunnanensis.Results The response rate was 30.00% in the control group and 64.44% in the observation group. The response rate in the observation group was higher than that in the control group, with a statistically significant difference (P<0.01) . In the observation group, the response rates of abscess, infiltration and nodule were 76.67%, 73.33% and 43.33%, respectively.By the comparative analysis, the response rate of infiltration was higher than that of nodule (P<0.05) , with a significant difference; the response rate of abscess was also higher than that of nodule (P<0.05) , with a significant difference. There was no significant difference between the response rates of abscess and infiltration (P>0.5) .Conclusions The external application of Paris polyphylla Smith var. yunnanensis powder combined with anti-tuberculosis drugs is curative in the observation of superficial lymph node tuberculosis, especially in the types ofinfiltrating and abscess.
Objective To observe the short-term effect of Paris polyphylla Smith var. yunnanensis powder combined with anti-tuberculosis drugs in the observation of superficial lymph node tuberculosis. Methods A total of170 patients were randomly divided into two groups: 80 in the control group and 90 in the observation group. The observation group consisted of nodular type, infiltrating type and abscess type, each of which had 30 cases. The control group were treated with Isoniazid, Rifampicin, Pyrazinamide and Ethambutol. Besides the four medications, the observation group were treated with external application of Paris polyphylla Smith var. yunnanensis.Results The response rate was 30.00% in the control group and 64.44% in the observation group. The response rate in the observation group was higher than that in the control group, with a statistically significant difference (P<0.01) . In the observation group, the response rates of abscess, infiltration and nodule were 76.67%, 73.33% and 43.33%, respectively.By the comparative analysis, the response rate of infiltration was higher than that of nodule (P<0.05) , with a significant difference; the response rate of abscess was also higher than that of nodule (P<0.05) , with a significant difference. There was no significant difference between the response rates of abscess and infiltration (P>0.5) .Conclusions The external application of Paris polyphylla Smith var. yunnanensis powder combined with anti-tuberculosis drugs is curative in the observation of superficial lymph node tuberculosis, especially in the types ofinfiltrating and abscess.
2018, 39(01): 85-91.
Abstract:
Objective To evaluate the significance of liver biopsy and B ultrasonograpgy in the diagnosis of fatty liver. Methods The results of 62 patients with liver steatosis diagnosed by liver puncture biopsy but not by B-ultrasonograpgy were contrastively analyzed and combined with liver function, blood lipids, blood glucose, and body mass index. Results The 62 cases which were not diagnosed as fatty liver by B-ultrasonograpgy were proved to be 5%-33% liver steatosis after liver puncture biopsy. Among the 62 cases, 23 cases were indicated by the B-ultrasonograpgy that the liver parenchyma echo did not see abnormalities, 18 cases showed the liver parenchyma echo slightly was enlarged, 17 cases showed the liver parenchyma echo density was a bit enhanced and4 cases were diffuse liver damage, which respectively were 37.01%、29.03%、27.42% and 6.45%. Pathologically it indicated that 45 cases were 5% ≤liver steatosis≤19%. Among the 45 cases, 18 cases were indicated by the B-ultrasonograpgy that the liver parenchyma echo was not seen abnormalities, 8 cases showed the liver parenchyma echo slightly was enlarged, 17 cases showed the liver parenchyma echo density was a bit enhanced, and 2 cases were diffuse liver damage, and the change of ultrasound was mainly showed by the liver parenchyma echo not seen abnormalities and the enhanced liver parenchyma echo density. Pathologically it indicated that 17 cases were 20%≤liver steatosis≤33%, 6 cases were indicated by the B-ultrasonograpgy that the liver parenchyma echo did not see abnormalities, 5 cases showed the liver parenchyma echo slightly was enlarged, 5 cases showed the liver parenchyma echo density was a bit enhanced, and 1 case was diffuse liver damage, and the change of ultrasound was mainly showed by the liver parenchyma echo not seen abnormalities, the slightly enlarged liver parenchyma echo and the enhanced liver parenchyma echo density. By analyzing the influence to the ultrasound changes by patients' liver function, body mass index, blood fat and blood sugar, and with logistic regression analysis through a disorderly classification, it was found that the larger value of the glutamine transferase, alkaline phosphatase, body mass index, triglyceride and low density lipoprotein cholesterol, the higher possibility of diffuse liver damage, and the higher level of fatty degeneration, the higher possibility of diffuse liver damage. Conclusion In the diagnosis of fatty liver, when the fatty degeneration is below 1/3, B-ultrasonic examination can't show characteristic changes of fatty liver. It should be closely observed or take liver puncture biopsy to make a definite diagnosis of fatty liver.
Objective To evaluate the significance of liver biopsy and B ultrasonograpgy in the diagnosis of fatty liver. Methods The results of 62 patients with liver steatosis diagnosed by liver puncture biopsy but not by B-ultrasonograpgy were contrastively analyzed and combined with liver function, blood lipids, blood glucose, and body mass index. Results The 62 cases which were not diagnosed as fatty liver by B-ultrasonograpgy were proved to be 5%-33% liver steatosis after liver puncture biopsy. Among the 62 cases, 23 cases were indicated by the B-ultrasonograpgy that the liver parenchyma echo did not see abnormalities, 18 cases showed the liver parenchyma echo slightly was enlarged, 17 cases showed the liver parenchyma echo density was a bit enhanced and4 cases were diffuse liver damage, which respectively were 37.01%、29.03%、27.42% and 6.45%. Pathologically it indicated that 45 cases were 5% ≤liver steatosis≤19%. Among the 45 cases, 18 cases were indicated by the B-ultrasonograpgy that the liver parenchyma echo was not seen abnormalities, 8 cases showed the liver parenchyma echo slightly was enlarged, 17 cases showed the liver parenchyma echo density was a bit enhanced, and 2 cases were diffuse liver damage, and the change of ultrasound was mainly showed by the liver parenchyma echo not seen abnormalities and the enhanced liver parenchyma echo density. Pathologically it indicated that 17 cases were 20%≤liver steatosis≤33%, 6 cases were indicated by the B-ultrasonograpgy that the liver parenchyma echo did not see abnormalities, 5 cases showed the liver parenchyma echo slightly was enlarged, 5 cases showed the liver parenchyma echo density was a bit enhanced, and 1 case was diffuse liver damage, and the change of ultrasound was mainly showed by the liver parenchyma echo not seen abnormalities, the slightly enlarged liver parenchyma echo and the enhanced liver parenchyma echo density. By analyzing the influence to the ultrasound changes by patients' liver function, body mass index, blood fat and blood sugar, and with logistic regression analysis through a disorderly classification, it was found that the larger value of the glutamine transferase, alkaline phosphatase, body mass index, triglyceride and low density lipoprotein cholesterol, the higher possibility of diffuse liver damage, and the higher level of fatty degeneration, the higher possibility of diffuse liver damage. Conclusion In the diagnosis of fatty liver, when the fatty degeneration is below 1/3, B-ultrasonic examination can't show characteristic changes of fatty liver. It should be closely observed or take liver puncture biopsy to make a definite diagnosis of fatty liver.
2018, 39(01): 92-95.
Abstract:
Objective To investigate the effect of patient controlled subcutaneous analgesia (PCSA) of Sufentamil and Parecoxib sodium on the postoperative delirium in patients after the spinal surgery. Methods 240 patients with ASA Ⅱ-Ⅲ age 18-64 yrs after the spinal surgery were divided into two groups: group NO-PCSA (analgesic management: patients were accepted pethidine 25-50 mg intramuscular injection n = 120) ; group PCSA (analgesic management: patient controlled subcutaneous analgesia was started since skin suture with the following composition: Sufentanil 0.9 ug/ (kg.d) + Parecoxib sodium 120 mg + Tropisetron 10 mg + normal saline 150 m L. The PCSA setting was as follows: background infusion at 2 m L/h, a bolus dose of 0.5 m L, lockout interval 15 min. If the VAS was greater than 5, patient was accepted pethidine 25-50 mg intramuscular injection n = 120) .The effect of analgesia was assessed by visual analogue scale (VAS) . The delirium was assessed by the confusion assessment, VAS and delirium were recorded with in 2, 24, 48, 72 hours postoperatively. Results During the analgesia period, the VAS and the incidence of postoperative delirium were significantly lower in group PCSA than those in group NO-PCSA (P <0.05) . Conclusion PCSA of Sufentamil and Parecoxib sodium have a good postoperative analgesic effect in patients after the spinal surgery. It is an effective measure and the incidence of postoperative delirium can be decreased by reliefing postoperative pain.
Objective To investigate the effect of patient controlled subcutaneous analgesia (PCSA) of Sufentamil and Parecoxib sodium on the postoperative delirium in patients after the spinal surgery. Methods 240 patients with ASA Ⅱ-Ⅲ age 18-64 yrs after the spinal surgery were divided into two groups: group NO-PCSA (analgesic management: patients were accepted pethidine 25-50 mg intramuscular injection n = 120) ; group PCSA (analgesic management: patient controlled subcutaneous analgesia was started since skin suture with the following composition: Sufentanil 0.9 ug/ (kg.d) + Parecoxib sodium 120 mg + Tropisetron 10 mg + normal saline 150 m L. The PCSA setting was as follows: background infusion at 2 m L/h, a bolus dose of 0.5 m L, lockout interval 15 min. If the VAS was greater than 5, patient was accepted pethidine 25-50 mg intramuscular injection n = 120) .The effect of analgesia was assessed by visual analogue scale (VAS) . The delirium was assessed by the confusion assessment, VAS and delirium were recorded with in 2, 24, 48, 72 hours postoperatively. Results During the analgesia period, the VAS and the incidence of postoperative delirium were significantly lower in group PCSA than those in group NO-PCSA (P <0.05) . Conclusion PCSA of Sufentamil and Parecoxib sodium have a good postoperative analgesic effect in patients after the spinal surgery. It is an effective measure and the incidence of postoperative delirium can be decreased by reliefing postoperative pain.
2018, 39(01): 96-99.
Abstract:
Objective To study the effects of exchange transfusion on renal function, inflammatory factors and blood internal environment in children with hyperbilirubinemia. Methods Neonates with hyperbilirubinemia treated in neonatal intensive care unit of the hospital between February 2015 and March 2017 were selected as the research subjects and divided into two groups by random number table method. Combined group received exchange transfusion combined with blue ray irradiation, and control group received blue ray irradiation. The serum levels of bilirubin, renal function indexes, inflammatory response indexes and oxidative stress response indexes were measured 24 hours after the treatment. Results 24 hours after the treatment, serum TBIL, BUN, Cr, β2-MG, Cys C, TRF, CRP, IL-6, TNF-α, MDA and AOPP levels of combined group were greatly lower than those of control group whereas SOD, CAT and GSH-Px contents were greatly higher than those of control group. Conclusion Exchange transfusion can improve the renal function and inhibit the inflammatory and oxidative stress response in children with hyperbilirubinemia.
Objective To study the effects of exchange transfusion on renal function, inflammatory factors and blood internal environment in children with hyperbilirubinemia. Methods Neonates with hyperbilirubinemia treated in neonatal intensive care unit of the hospital between February 2015 and March 2017 were selected as the research subjects and divided into two groups by random number table method. Combined group received exchange transfusion combined with blue ray irradiation, and control group received blue ray irradiation. The serum levels of bilirubin, renal function indexes, inflammatory response indexes and oxidative stress response indexes were measured 24 hours after the treatment. Results 24 hours after the treatment, serum TBIL, BUN, Cr, β2-MG, Cys C, TRF, CRP, IL-6, TNF-α, MDA and AOPP levels of combined group were greatly lower than those of control group whereas SOD, CAT and GSH-Px contents were greatly higher than those of control group. Conclusion Exchange transfusion can improve the renal function and inhibit the inflammatory and oxidative stress response in children with hyperbilirubinemia.
The Effect of Early Nasal Jejunum Nutrition on the Inflammatory Markers of Severe Acute Pancreatitis
2018, 39(01): 100-103.
Abstract:
Objective The present study aims to investigate the effect of the early nasal jejunum nutrition (NJN) on the inflammatory markers of severe acute pancreatitis (SAP) and to research if the NJN improves the recovery of SAP. Method SAP inpatients were observed during 2016. One group who accepted the NJN was experimental group and another group who did not accept the NJN was control group.The difference of serum albumin (ALB) , procalcitonin (PCT) , C reactive was compared to observe the effect of the early nasal jejunum nutrition (NJN) on the inflammatory markers of severe Acute Pancreatitis protein (CRP) , interleukin 6 (IL-6) and serum amylase (AMY) between the highest and lowest levels in two group respectively and the time of diet recovery between two groups. Results (1) The difference of interleukin 6 (IL-6) between the highest and lowest levels in experimental group was significantly smaller than that of the control group;the difference of ALB, CRP and PCT between the highest and lowest levels in experimental group was not different from the control group;2) The time of diet recovery of experimental group was shorter than that of the control group. Conclusion The early NJN can reduce the IL-6 level and the time of diet recovery, and then, improve the SAP recovery.
Objective The present study aims to investigate the effect of the early nasal jejunum nutrition (NJN) on the inflammatory markers of severe acute pancreatitis (SAP) and to research if the NJN improves the recovery of SAP. Method SAP inpatients were observed during 2016. One group who accepted the NJN was experimental group and another group who did not accept the NJN was control group.The difference of serum albumin (ALB) , procalcitonin (PCT) , C reactive was compared to observe the effect of the early nasal jejunum nutrition (NJN) on the inflammatory markers of severe Acute Pancreatitis protein (CRP) , interleukin 6 (IL-6) and serum amylase (AMY) between the highest and lowest levels in two group respectively and the time of diet recovery between two groups. Results (1) The difference of interleukin 6 (IL-6) between the highest and lowest levels in experimental group was significantly smaller than that of the control group;the difference of ALB, CRP and PCT between the highest and lowest levels in experimental group was not different from the control group;2) The time of diet recovery of experimental group was shorter than that of the control group. Conclusion The early NJN can reduce the IL-6 level and the time of diet recovery, and then, improve the SAP recovery.
2018, 39(01): 104-108.
Abstract:
Objective To observe the effect of Q-Switching Nd:YAG treatment in pigmented dermatoses and its influence for melanin metabolism. Methods 114 patients with pigmented dermatoses in our hospital from October 2015 to August 2016 were selected as the study object, and were randomly divided into the control group (57 cases) and the observation group (57 cases) .The control group were treated with intense pulsed light therapy while the observation group were treated with Q-Switching Nd:YAG treatment on the treatment of control group.Then the total effective rates, recurrence rates, adverse reaction rates, skin lesion scores and serum melanin metabolism related indexes before and after the treatment of two groups were analyzed and compared. Results Clinically, the total effective rates of observation group were higher than those of control group (P<0.05) and the recurrence rate of observation group was lower than that of control group (P<0.05) .The adverse reaction rates of two groups were compared and the differences were not statistically significant ( P >0.05) .The skin lesion scores and serum melanin metabolism related indexes of two groups before the treatment were compared and the differences were not statistically significant (P>0.05) .The serum melanin metabolism related indexes of two groups after the treatment were all better than those of control group ( P <0.05) . Conclusion The clinical effect of Q-Switching Nd:YAG treatment in the patients with pigmented dermatoses is better, and it has the active influence for the melanin metabolism, so it has higher clinical value in the treatment of pigmented dermatoses.
Objective To observe the effect of Q-Switching Nd:YAG treatment in pigmented dermatoses and its influence for melanin metabolism. Methods 114 patients with pigmented dermatoses in our hospital from October 2015 to August 2016 were selected as the study object, and were randomly divided into the control group (57 cases) and the observation group (57 cases) .The control group were treated with intense pulsed light therapy while the observation group were treated with Q-Switching Nd:YAG treatment on the treatment of control group.Then the total effective rates, recurrence rates, adverse reaction rates, skin lesion scores and serum melanin metabolism related indexes before and after the treatment of two groups were analyzed and compared. Results Clinically, the total effective rates of observation group were higher than those of control group (P<0.05) and the recurrence rate of observation group was lower than that of control group (P<0.05) .The adverse reaction rates of two groups were compared and the differences were not statistically significant ( P >0.05) .The skin lesion scores and serum melanin metabolism related indexes of two groups before the treatment were compared and the differences were not statistically significant (P>0.05) .The serum melanin metabolism related indexes of two groups after the treatment were all better than those of control group ( P <0.05) . Conclusion The clinical effect of Q-Switching Nd:YAG treatment in the patients with pigmented dermatoses is better, and it has the active influence for the melanin metabolism, so it has higher clinical value in the treatment of pigmented dermatoses.
2018, 39(01): 109-112.
Abstract:
Objective To explore the mechanism of Danning Tablet on intestinal flora migration to eliminate biliary inflammation and prevent gallstone formation. Methods 104 cases of cholelithiasis admitted to the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine were treated by choledocholithiasis but the master tube was cut and T tube drainage was performed from January 2014 to December 2016. Within a month did not take gallbladder drugs. Randomly divided into the Danning group and the control group, Danning group in addition to conventional treatment of biliary tract after surgery, in the first 2 days after starting to drink liquid according to the instruction manual dose of oral Danning tablets; the control group was given only biliary surgery After routine care, avoid taking gall bladder drugs. All patients were collected on the 7 th day and the 14 th day after operation, about100 m L fasting T-tube was collected. Pay attention to the day before the collection of bile T tube pre-clamp to prevent the drainage of T tube affect the bile enterohepatic circulation. Detection of bile composition in the flora, observed before and after the flora differences, long-term follow-up of cholelithiasis recurrence. Results: The changes of the components before and after treatment: On the seventh day, the two groups of HS and UCB% were higher than the control group, the difference was statistically significant (P<0.05) . On the 14 th day in the treatment group, the three items of TBS, UCB% and HS were higher than the control group, but CH, LI and Z were lower than the control group, the difference was statistically significant (P<0.05) . The trend of stone formation before and after treatment: Compared with UCB% in control group, there was no significant change in LI and Z, but the HS value decreased, the difference was statistically significant (P<0.05) . There was no significant change of HS and UCB% in the treatment group, but the LI and Z values decreased, the difference was statistically significant (P<0.05) . Conclusion Dan Ning Tablets can prevent cholesterol gallstone formation by regulating the intestinal flora, and affect the cholesterol content in bile, that plays a important role in prevention of cholesterol gallstone.
Objective To explore the mechanism of Danning Tablet on intestinal flora migration to eliminate biliary inflammation and prevent gallstone formation. Methods 104 cases of cholelithiasis admitted to the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine were treated by choledocholithiasis but the master tube was cut and T tube drainage was performed from January 2014 to December 2016. Within a month did not take gallbladder drugs. Randomly divided into the Danning group and the control group, Danning group in addition to conventional treatment of biliary tract after surgery, in the first 2 days after starting to drink liquid according to the instruction manual dose of oral Danning tablets; the control group was given only biliary surgery After routine care, avoid taking gall bladder drugs. All patients were collected on the 7 th day and the 14 th day after operation, about100 m L fasting T-tube was collected. Pay attention to the day before the collection of bile T tube pre-clamp to prevent the drainage of T tube affect the bile enterohepatic circulation. Detection of bile composition in the flora, observed before and after the flora differences, long-term follow-up of cholelithiasis recurrence. Results: The changes of the components before and after treatment: On the seventh day, the two groups of HS and UCB% were higher than the control group, the difference was statistically significant (P<0.05) . On the 14 th day in the treatment group, the three items of TBS, UCB% and HS were higher than the control group, but CH, LI and Z were lower than the control group, the difference was statistically significant (P<0.05) . The trend of stone formation before and after treatment: Compared with UCB% in control group, there was no significant change in LI and Z, but the HS value decreased, the difference was statistically significant (P<0.05) . There was no significant change of HS and UCB% in the treatment group, but the LI and Z values decreased, the difference was statistically significant (P<0.05) . Conclusion Dan Ning Tablets can prevent cholesterol gallstone formation by regulating the intestinal flora, and affect the cholesterol content in bile, that plays a important role in prevention of cholesterol gallstone.
2018, 39(01): 113-117.
Abstract:
Objective To investigate the effect of oxaliplatin injection combined with S-1 on levels of carcinoembryonic antigen (CEA) , cancer antigen 199 (CA199) and tumor associated materials (TAM) and the quality of life of patients with advanced gastric cancer. Methods The clinical data of 70 patients with advanced gastric cancer treated in our hospital from January 2013 to June 2016 were retrospectively analyzed. According to different chemotherapy regimens, the patients were divided into the study group (n = 35, treated with oxaliplatin injection combined with S-1) and the control group (n = 35, treated with S-1) . The short-term curative effect in the two groups was evaluated, and levels of serum tumor markers were detected before and after the treatment.The toxicity and quality of life were evaluated. Results The total effective rate of treatment and disease control rate in the study group were significantly higher than those in the control group (45.71% and 88.57% vs 2.86% vs71.43%) (P < 0.05) . There were no significant differences in levels of serum CEA, CA199 and TAM between the two groups before the treatment (P > 0.05) . After the treatment, levels of serum CEA, CA199 and CEA were significantly decreased (P < 0.05) , and the decrease was significantly greater in the study group than in the control group (P < 0.05) . During and after the treatment, nausea and vomiting was more severe in the study group than in the control group (P < 0.05) , while the incidence rates of neutropenia, thrombocytopenia, peripheral neuritis and liver or kidney function damage showed no statistically significant difference (P > 0.05) . After the treatment, the improvement rate of KPS score in the study group was significantly higher than that in the control group (60% VS 31.42%) , and the overall improvement of the quality of life was significantly better than that in the control group (P < 0.05) . Conclusion Oxaliplatin injection combined with S-1 can effectively inhibit the growth and metastasis of tumor cells, remit the condition and improve the clinical efficacy with high safety in patients with advanced gastric cancer. It also can improve the quality of life of patients.
Objective To investigate the effect of oxaliplatin injection combined with S-1 on levels of carcinoembryonic antigen (CEA) , cancer antigen 199 (CA199) and tumor associated materials (TAM) and the quality of life of patients with advanced gastric cancer. Methods The clinical data of 70 patients with advanced gastric cancer treated in our hospital from January 2013 to June 2016 were retrospectively analyzed. According to different chemotherapy regimens, the patients were divided into the study group (n = 35, treated with oxaliplatin injection combined with S-1) and the control group (n = 35, treated with S-1) . The short-term curative effect in the two groups was evaluated, and levels of serum tumor markers were detected before and after the treatment.The toxicity and quality of life were evaluated. Results The total effective rate of treatment and disease control rate in the study group were significantly higher than those in the control group (45.71% and 88.57% vs 2.86% vs71.43%) (P < 0.05) . There were no significant differences in levels of serum CEA, CA199 and TAM between the two groups before the treatment (P > 0.05) . After the treatment, levels of serum CEA, CA199 and CEA were significantly decreased (P < 0.05) , and the decrease was significantly greater in the study group than in the control group (P < 0.05) . During and after the treatment, nausea and vomiting was more severe in the study group than in the control group (P < 0.05) , while the incidence rates of neutropenia, thrombocytopenia, peripheral neuritis and liver or kidney function damage showed no statistically significant difference (P > 0.05) . After the treatment, the improvement rate of KPS score in the study group was significantly higher than that in the control group (60% VS 31.42%) , and the overall improvement of the quality of life was significantly better than that in the control group (P < 0.05) . Conclusion Oxaliplatin injection combined with S-1 can effectively inhibit the growth and metastasis of tumor cells, remit the condition and improve the clinical efficacy with high safety in patients with advanced gastric cancer. It also can improve the quality of life of patients.
2018, 39(01): 118-122.
Abstract:
Objective To improve the detection accuracy of cerebral venous thrombosis (CVT) in the first imaging examination and to guide the treatment and improve the outcome. Methods Imagings of 17 CVT cases were retrospectively analyzed and the missed diagnosis and misdiagnosis reasons were summarized. Results All the 17 cases were taken CT examination. 7 cases were missed diagnosed and misdiagnosed. 2 of 7 cases were diagnosed as subarachnoid hemorrhage. 1 of 7 cases was diagnosed as the left occipital subacute subdural hematoma. 1 of 7 cases was diagnosed as the right frontal and parietal and occipital lobes cerebral hemorrhage. 1 of 7 cases was diagnosed as the left parietal and occipital lobes cerebral hemorrhage and broken into ventricles. 2 of 7 cases were diagnosed as negative. Conclusion To summerize the reasons of missed diagnosis and misdiag aosis of CVT can improve the detection accuracy in the first imaging examination.
Objective To improve the detection accuracy of cerebral venous thrombosis (CVT) in the first imaging examination and to guide the treatment and improve the outcome. Methods Imagings of 17 CVT cases were retrospectively analyzed and the missed diagnosis and misdiagnosis reasons were summarized. Results All the 17 cases were taken CT examination. 7 cases were missed diagnosed and misdiagnosed. 2 of 7 cases were diagnosed as subarachnoid hemorrhage. 1 of 7 cases was diagnosed as the left occipital subacute subdural hematoma. 1 of 7 cases was diagnosed as the right frontal and parietal and occipital lobes cerebral hemorrhage. 1 of 7 cases was diagnosed as the left parietal and occipital lobes cerebral hemorrhage and broken into ventricles. 2 of 7 cases were diagnosed as negative. Conclusion To summerize the reasons of missed diagnosis and misdiag aosis of CVT can improve the detection accuracy in the first imaging examination.
2018, 39(01): 123-126.
Abstract:
Objective To study the influence of tarsal gland massage on postoperative curative effect of femtosecond laser combined with excimer laser keratomileusis. Methods A prospective study was conducted on patients who underwent the same surgical approach by the same surgeon. 78 eligible patients were randomly divided into two groups: 39 patients in experimental group, equal to 78 eyes, were given tarsal gland massage before the operation; and the other 39 patients in control group, equal to 78 eyes, were not given tarsal gland massage before the operation. The presence condition of postoperative interlayer eyelid fat of the two groups of patients was investigated. After that, the patients were divided into two groups according to above eyelid fat condition: with eyelid fat group and without eyelid fat group, and the visual acuity recovery status were compared between the two groups.Results In the control group after the operation, 3 patients could not be contacted in the follow-up study, but a total of 36 patients, equal to 72 eyes were observed by slit lamp, and there were totally 10 eyes with interlayer eyelid fat, accounting for 13.89 %;Whereas, 2 patients could not be contacted in the experimental group, but a total of 37 patients, equal to 74 eyes were observed, and there were only 2 eyes with interlayer eyelid fat, accounting for 2.7%. The P value of comparison between these two groups was less than 0.01, which had statistical differences. There was significant difference between the two groups (P <0.05) in the recovery of visual acuity within one month after the operation. Conclusion Tarsal gland massage can effectively reduce the residual of interlayer eyelid fat after the operation of femtosecond laser combined with excimer laser keratomileusis, thereby it can avoid the delay of vision recovery and effectively improve the postoperative curative effect.
Objective To study the influence of tarsal gland massage on postoperative curative effect of femtosecond laser combined with excimer laser keratomileusis. Methods A prospective study was conducted on patients who underwent the same surgical approach by the same surgeon. 78 eligible patients were randomly divided into two groups: 39 patients in experimental group, equal to 78 eyes, were given tarsal gland massage before the operation; and the other 39 patients in control group, equal to 78 eyes, were not given tarsal gland massage before the operation. The presence condition of postoperative interlayer eyelid fat of the two groups of patients was investigated. After that, the patients were divided into two groups according to above eyelid fat condition: with eyelid fat group and without eyelid fat group, and the visual acuity recovery status were compared between the two groups.Results In the control group after the operation, 3 patients could not be contacted in the follow-up study, but a total of 36 patients, equal to 72 eyes were observed by slit lamp, and there were totally 10 eyes with interlayer eyelid fat, accounting for 13.89 %;Whereas, 2 patients could not be contacted in the experimental group, but a total of 37 patients, equal to 74 eyes were observed, and there were only 2 eyes with interlayer eyelid fat, accounting for 2.7%. The P value of comparison between these two groups was less than 0.01, which had statistical differences. There was significant difference between the two groups (P <0.05) in the recovery of visual acuity within one month after the operation. Conclusion Tarsal gland massage can effectively reduce the residual of interlayer eyelid fat after the operation of femtosecond laser combined with excimer laser keratomileusis, thereby it can avoid the delay of vision recovery and effectively improve the postoperative curative effect.
2018, 39(01): 127-130.
Abstract:
Objective To study the effect of unmovable splint therapy in patients with moderate and severe periodontitis. Methods Twenty periodontitis cases with loosened anterior teeth were treated with unmovable splints after the basic periodontal therapy. The clinical effect and periodontal index were evaluated in the sixth month, the first year, the second year and the third year. Result The success rate was 90 percent three years after the restoration.Conclusion Unmovable splint therapy is one of the effective therapies in the treatment of periodontitis.
Objective To study the effect of unmovable splint therapy in patients with moderate and severe periodontitis. Methods Twenty periodontitis cases with loosened anterior teeth were treated with unmovable splints after the basic periodontal therapy. The clinical effect and periodontal index were evaluated in the sixth month, the first year, the second year and the third year. Result The success rate was 90 percent three years after the restoration.Conclusion Unmovable splint therapy is one of the effective therapies in the treatment of periodontitis.
2018, 39(01): 131-135.
Abstract:
Gene silencing is a phenomenon in which the specific genes in organisms are not expressed or reduced for various reasons. It is an important mechanism to control gene expression by epigenetic control. At present, scientists intend to explore the treatment of difficult diseases through gene silencing technology, and the research has become a hot spot. With the rapid development of gene engineering, gene silencing technology has been replaced by new technologies. This paper aims to introduce the ribozyme technology, antisense oligonucleic acid technology, gene knockout, RNA interference technology and their applications in gene silencing technology.
Gene silencing is a phenomenon in which the specific genes in organisms are not expressed or reduced for various reasons. It is an important mechanism to control gene expression by epigenetic control. At present, scientists intend to explore the treatment of difficult diseases through gene silencing technology, and the research has become a hot spot. With the rapid development of gene engineering, gene silencing technology has been replaced by new technologies. This paper aims to introduce the ribozyme technology, antisense oligonucleic acid technology, gene knockout, RNA interference technology and their applications in gene silencing technology.
2018, 39(01): 136-139.
Abstract:
Objective To observe the effects of applying 3 D printing technology to interventional neuroradiology teaching so as to evaluate the feasibility and efficiency of the technology.Methods Computed tomography angiography was transformed into three-dimensional images and printed out as the case models. The3 D printed models were used in the teaching for interventional neuroradiology.Results The 3 D printed entity model in diseases of the nervous systemnot only helps students deepen the understanding of anatomy and operation process, but also can significantly improve students' learning enthusiasm and help master teaching contents (P<0.05) .Conclusions The 3 D print technique based on CT angiography has remarkable effect in the education of interventional neuroradiology.
Objective To observe the effects of applying 3 D printing technology to interventional neuroradiology teaching so as to evaluate the feasibility and efficiency of the technology.Methods Computed tomography angiography was transformed into three-dimensional images and printed out as the case models. The3 D printed models were used in the teaching for interventional neuroradiology.Results The 3 D printed entity model in diseases of the nervous systemnot only helps students deepen the understanding of anatomy and operation process, but also can significantly improve students' learning enthusiasm and help master teaching contents (P<0.05) .Conclusions The 3 D print technique based on CT angiography has remarkable effect in the education of interventional neuroradiology.
2018, 39(01): 140-143.
Abstract:
Objective To investigate the status of psychological quality of college students ' innovation and entrepreneurship, identify the elements of the psychological quality and problems and countermeasures against the psychological quality training in medical schools. Methods A questionair was made and administered to Kunming Medical University students and Chi-square analysis was used to analyze the gender, major, grade, and entrepreneurial intention differences between different groups of students so as to analyze the psychological factors affecting College students ' undertaking intention. Results A total of 1150 questionnaires, 1099 was recovered, the effective recovery rate was 95.6%. Psychological quality score was (76.9±9.0) , good mental qualities only was8.2%, entrepreneurial environment, factors of psychological quality of good-willed persons were only 0.5% and15.5%. Female entrepreneurial intentions were better than those of men (P<0.001) . Science students' undertaking intention was superior to liberal arts students (P =0.025) , knowledge of entrepreneurship difference between knowledge of business groups and P<0.005, there was a statistically significant difference, about the environment worse group entrepreneurial intention superior knowledge of business groups. Conclusions As students' psychological qualities are poor, have poor psychological quality, in teaching we should strengthen the cultivation of medical students' entrepreneurial ability and correct understanding of entrepreneurship, create a good business environment, increase the entrepreneurship policy advocacy efforts, and create a good business environment and atmosphere so as to strengthen the entrepreneurship education, improve entrepreneurship courses so that students fully understand the cognitive and psychological qualities, stimulate the entrepreneurial motivation, lay the Foundation for entrepreneurship.
Objective To investigate the status of psychological quality of college students ' innovation and entrepreneurship, identify the elements of the psychological quality and problems and countermeasures against the psychological quality training in medical schools. Methods A questionair was made and administered to Kunming Medical University students and Chi-square analysis was used to analyze the gender, major, grade, and entrepreneurial intention differences between different groups of students so as to analyze the psychological factors affecting College students ' undertaking intention. Results A total of 1150 questionnaires, 1099 was recovered, the effective recovery rate was 95.6%. Psychological quality score was (76.9±9.0) , good mental qualities only was8.2%, entrepreneurial environment, factors of psychological quality of good-willed persons were only 0.5% and15.5%. Female entrepreneurial intentions were better than those of men (P<0.001) . Science students' undertaking intention was superior to liberal arts students (P =0.025) , knowledge of entrepreneurship difference between knowledge of business groups and P<0.005, there was a statistically significant difference, about the environment worse group entrepreneurial intention superior knowledge of business groups. Conclusions As students' psychological qualities are poor, have poor psychological quality, in teaching we should strengthen the cultivation of medical students' entrepreneurial ability and correct understanding of entrepreneurship, create a good business environment, increase the entrepreneurship policy advocacy efforts, and create a good business environment and atmosphere so as to strengthen the entrepreneurship education, improve entrepreneurship courses so that students fully understand the cognitive and psychological qualities, stimulate the entrepreneurial motivation, lay the Foundation for entrepreneurship.
2018, 39(01): 144-148.
Abstract:
Objective To analyze the nursing effect of the standardized CNP (Clinical nursing pathway) in the hair transplantation surgery during the perioperative period. Method The nursing process of 48 autologous hair transplantation cases in our center would be retrospective analyzed from September 2016 to September 2017. The patients were divided into the control group (24 cases) and experimental group (24 cases) , which the former with conventional nursing, the latter with CNP. Afterwards, to study the effect of standardized CNP on hair transplantation according to the statistical analysis of data including the patients' basic information; patient satisfaction; doctors' satisfaction; unit operation time and unit area planting density. Result The results indicated the experimental group with CNP improved the satisfaction of both patients and doctors, meanwhile reducing the operation time and improve the unit area planting density. The application of CNP can improve the nursing process and operating results effectively as well as the satisfaction of patients and doctors. It is worthy to be promoted and generalized in clinical treatment.Conclusion The application of CPN could effectively improve the nursing process, as well as the satisfaction of patients and doctors, and improve the overall surgical efficiency. It's worth to be applied in the clinical therapy.
Objective To analyze the nursing effect of the standardized CNP (Clinical nursing pathway) in the hair transplantation surgery during the perioperative period. Method The nursing process of 48 autologous hair transplantation cases in our center would be retrospective analyzed from September 2016 to September 2017. The patients were divided into the control group (24 cases) and experimental group (24 cases) , which the former with conventional nursing, the latter with CNP. Afterwards, to study the effect of standardized CNP on hair transplantation according to the statistical analysis of data including the patients' basic information; patient satisfaction; doctors' satisfaction; unit operation time and unit area planting density. Result The results indicated the experimental group with CNP improved the satisfaction of both patients and doctors, meanwhile reducing the operation time and improve the unit area planting density. The application of CNP can improve the nursing process and operating results effectively as well as the satisfaction of patients and doctors. It is worthy to be promoted and generalized in clinical treatment.Conclusion The application of CPN could effectively improve the nursing process, as well as the satisfaction of patients and doctors, and improve the overall surgical efficiency. It's worth to be applied in the clinical therapy.
