药物在儿童结肠镜检查前肠道准备的应用及研究进展

代怡琳; 田云粉

doi:10.12259/j.issn.2095-610X.S20241024

药物在儿童结肠镜检查前肠道准备的应用及研究进展

doi: 10.12259/j.issn.2095-610X.S20241024

代怡琳¹,
田云粉^2, ,

1.
昆明理工大学医学院，云南昆明　650500
2.
云南省第一人民医院儿科，云南昆明　650032

基金项目: 国家自然科学基金项目（81760110）；云南省科技厅-昆明医科大学应用基础研究联合专项资助项目（202201AY070001-253）

详细信息

作者简介:
代怡琳（1998～），女，云南曲靖人，在读硕士研究生，主要从事儿科消化研究工作

通讯作者:
田云粉，E-mail：136506595@qq.com

中图分类号: R725.7
计量
- 文章访问数: 507
- HTML全文浏览量: 303
- PDF下载量: 7
- 被引次数: 0
出版历程
- 收稿日期: 2024-06-01
- 网络出版日期: 2024-10-12
- 刊出日期: 2024-10-31

Application and Research Progress of Drugs in Intestinal Preparation before Colonoscopy in Children

Yilin DAI¹,
Yunfen TIAN^{2
, ,}

1.
Kunming University of Science and Technology School of Medicine，Kunming Yunnan 650500
2.
Dept. of Pediatrics，Yunnan First People’s Hospital，Kunming Yunnan 650032，China

摘要

摘要: 结肠镜检查可以观察肠道黏膜的情况并对结肠内部的异常病变及早诊断及治疗。而肠道准备能够在结肠镜检查前通过泻药清除肠道内的粪便及其他残余杂质以提供清晰的肠道视野，进一步提高了检查的准确性及患儿的舒适度、降低了检查风险。近年来，随着结肠镜检查在儿童群体的广泛应用，泻药在儿童肠道准备中的重要价值也得到了进一步认可，但是，目前就儿童方面不同泻药及其方案的安全性和有效性缺乏专门性的系统综述。将对不同泻药在儿童结肠镜检查前肠道准备的应用情况与研究现状进行概述，以期为临床医生进行儿童肠道选择药物提供依据。
- 儿童 /
- 肠道准备 /
- 结肠镜 /
- 泻药
Abstract: Colonoscopy allows observing the condition of the intestinal mucosa and diagnose and treat abnormal lesions inside the colon early. And intestinal preparation can provide a clear intestinal view by clearing feces and other residual impurities in the intestine through laxatives before colonoscopy, further improving the accuracy of the examination and the comfort of the patient, reducing the risk of examination. In recent years, with the widespread application of colonoscopy in children, the important value of laxatives in pediatric intestinal preparation has also been further recognized. However, At present, there is a lack of specialized systematic review on the safety and effectiveness of different laxatives and their regimens for children. This article will provide an overview of the application and research status of different laxatives in intestinal preparation before colonoscopy in children, in order to provide a basis for clinical doctors to choose drugs for children's intestines.
- Children /
- Intestinal preparation /
- Colonoscopy /
- Laxative

HTML全文

参考文献(42)

[1]	Thakkar K,Holub J L,Gilger M A,et al. Quality indicators for pediatric colonoscopy: results from a multicenter consortium[J]. Gastrointestinal Endoscopy,2016,83(3):533-541. doi: 10.1016/j.gie.2015.06.028
[2]	Hassan C,Bretthauer M,KaminskiI M F,et al. Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) guideline[J]. Endoscopy,2013,45(2):142-150. doi: 10.1055/s-0032-1326186
[3]	Shwaartz C,Fields A C,Sobrero M,et al. Does bowel preparation for inflammatory bowel disease surgery matter?[J]. Colorectal Disease,2017,19(9):832-839. doi: 10.1111/codi.13693
[4]	Davis G R,Santaana C A,MorawskiI S G,et al. Development of a lavage solution associated with minimal water and electrolyte absorption or secretion [J]. Gastroenterology,1980,78(5 Pt 1): 991-995.
[5]	王瑞锋,周方,王欢,等. 自适应式生物反馈疗法联合口服复方聚乙二醇4000电解质散治疗儿童出口梗阻型便秘的前瞻性随机对照研究[J]. 中国当代儿科杂志,2022,24(4):377-381.
[6]	中国医师协会内镜医师分会消化内镜专业委员会,中国抗癌协会肿瘤内镜学专业委员会. 中国消化内镜诊疗相关肠道准备指南(2019,上海)[J]. 中华医学杂志,2019,99(26):2024-2035.
[7]	麻醉状态下儿童择期结肠镜检查肠道准备专家共识核心专家组. 麻醉状态下儿童择期结肠镜检查肠道准备专家共识[J] 中国循证儿科杂志. 2021,16(2): 81-87.
[8]	中华医学会消化内镜学分会儿科协作组,中国医师协会内镜医师分会儿科消化内镜专业委员会. 中国儿童消化内镜诊疗相关肠道准备快速指南(2020) [J] 中华消化内镜杂志]. 2021,38(2): 85-97.
[9]	杨荣英,何结平,袁淑卿. 少年儿童结肠镜检查前肠道准备不良的相关因素分析[J]. 中国内镜杂志,2019,25(5):32-36.
[10]	张丽艳,林小辛. 不同肠镜术前准备方法在小儿消化肠镜检查的前肠道准备[J]. 中国卫生标准管理,2019,10(23):46-88.
[11]	Lawrance I C,Willert R P,Murray K. Bowel cleansing for colonoscopy: Prospective randomized assessment of efficacy and of induced mucosal abnormality with three preparation agents[J]. Endoscopy,2011,43(5):412-418. doi: 10.1055/s-0030-1256193
[12]	Cheng J,Tao K,Shuai X,et al. Sodium phosphate versus polyethylene glycol for colonoscopy bowel preparation: An updated meta-analysis of randomized controlled trials[J]. Surgical endoscopy and other interventional techniques,2016,30(9):4033-4041. doi: 10.1007/s00464-015-4716-6
[13]	张亚琪. 结直肠手术病人应用磷酸钠盐与硫酸镁行肠道准备效果的对比研究[J]. 护理研究,2008,22(7):614-615.
[14]	Askarpour S,Peyvasthe M,Dastyar A A,et al. Bowel preparation for colorectal surgery: With and without mannitol[J]. Gastroenterology Review-Przeglad Gastroenterologiczny,2013,8(5):305-307.
[15]	中华医学会消化内镜学分会儿科协作组. 中国儿童胃镜结肠镜检查规范操作专家共识[J]. 中华消化内镜杂志,2019,36(1):6-9.
[16]	王敏,张法红,李之印,等. 复方匹可硫酸钠在肠镜检查前肠道清洁中的应用价值探讨[J]. 中国实用内科杂志,2022,42(4):306-309.
[17]	马培奇. 美FDA批准新的结肠镜检查术前准备用结肠清洁剂Prepopik[J] 上海医药. 2012,(23): 30.
[18]	孙冰洋. Prepopik [J] 中国药物化学杂志. 2013,23(1): 76.
[19]	姜文秀,熊伟民,张幸佳,等. 结肠镜检查前复方匹可硫酸钠与聚乙二醇4000肠道准备效果比较[J]. 中国新药与临床杂志,2020,39(11):680-683.
[20]	鄢雪峰,李其志,芦茜,等. 复方匹克硫酸钠与复方聚乙二醇电解质散(Ⅰ)在肠道准备中的应用[J]. 中国医学创新,2023,20(2):112-115.
[21]	Mathus-Vliegen E,Pellise M,Heresbach D,et al. Consensus guidelines for the use of bowel preparation prior to colonic diagnostic procedures: Colonoscopy and small bowel video capsule endoscopy[J]. Current Medical Research and Opinion,2013,29(8):931-945. doi: 10.1185/03007995.2013.803055
[22]	Colonic gas explosion during therapeutic colonoscopy with electrocautery [J]. 世界胃肠病学杂志(英文版). 2007,13(40): 5295-5298.
[23]	中华医学会消化内镜学分会儿科协作组,中国医师协会内镜医师分会儿科消化内镜专业委员会. 中国儿童消化内镜诊疗相关肠道准备快速指南(2020,西安) [J] 中国循证医学杂志. 2021,21(3): 249-259.
[24]	Park S. Adjuncts to colonic cleansing before colonoscopy [J]. World Journal of Gastroenterology,2014,20(11): 2735-2740.
[25]	Coskun Y,YukselL I. Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative prospective randomized study[J]. Journal of Gastroenterology and Hepatology,2020,35(11):1923-1929. doi: 10.1111/jgh.15101
[26]	Amato A,Radaelli F,Paggi S,et al. Half doses of PEG-ES and senna vs. high-dose senna for bowel cleansing before colonoscopy: A randomized,investigator-blinded trial[J]. American Journal of Gastroenterology,2010,105(3):675-681. doi: 10.1038/ajg.2009.598
[27]	毛蔚,刘佳. 2种肠道准备方法在小儿肠道手术中的效果比较[J]. 实用临床护理学电子杂志,2019,4(7):84-86.
[28]	Van Gorkom B A,Karrenbeald A,Limburg A J,et al. The effect of sennosides on colonic mucosal histology and bowel preparation[J]. Zeitschrift fur Gastroenterologie,1998,36(1):13-18.
[29]	欧阳文献,陈昌斌,陈志勇,等. 不同方式的肠道准备在儿童结肠镜检查中的效果观察[J]. 中华消化内镜杂志,2011,28(8):466-467.
[30]	王晓冬,李立钦. 乳果糖口服液用于小儿结肠镜术前肠道准备[J]. 中国实用医药,2013,8(22):161-163.
[31]	Cesare H. Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2019[J]. Endoscopy,2019,51(8):775-794. doi: 10.1055/a-0959-0505
[32]	段伯平,欧阳文献,徐斌. 乳果糖口服溶液用于儿童结肠镜检查前肠道准备[J]. 护理学杂志,2010,25(21):40-41.
[33]	张琎,陈明锴. 乳果糖在结肠镜检查前肠道准备的应用及研究进展[J]. 中华消化内镜杂志,2021,38(4):333-6.
[34]	中华医学会,中华医学会杂志社,中华医学会消化病学分会,慢性便秘基层诊疗指南(2019年)[J]. 中华全科医师杂志. 2020,19(12): 1100-1107.
[35]	Koppen I J N,Vriesman M H,Saps M,et al. Prevalence of functional defecation disorders in children: A Systematic review and meta-Analysis [J]. The Journal of Pediatrics,2018,198: 121-130. e6.
[36]	Lu J,Cao Q,Wang X,et al. Application of oral lactulose in combination with polyethylene glycol electrolyte powder for colonoscopy bowel preparation in patients with constipation[J]. American Journal of Therapeutics,2016,23(4):e1020-1024. doi: 10.1097/MJT.0000000000000351
[37]	P J P. Golytely lavage versus a standard colonoscopy preparation. Effect on normal colonic mucosal histology [J]. Gastroenterology . 1985,88(2): 545-548.
[38]	Parra-Blanco A. Achieving the best bowel preparation for colonoscopy[J]. World Journal of Gastroenterology,2014,20(47):17709-17026. doi: 10.3748/wjg.v20.i47.17709
[39]	Marschall H U,Bartels F. Life-threatening complications of nasogastric administration of polyethylene glycol-electrolyte solutions (Golytely) for bowel cleansing[J]. Gastrointestinal Endoscopy,1998,47(5):408-410. doi: 10.1016/S0016-5107(98)70229-9
[40]	高洁霞. 祛泡剂在儿童消化内镜中的应用进展[J]. 中国当代儿科杂志,2023,25(5):541-5.
[41]	陈光毅,李秀梅,陈进忠,等胃黏膜清洁剂联合体位操对胃镜检查效果的影响[J]. 护理学杂志. 2021,36(20): 40-41,72.
[42]	张松,钟文其,彭春艳,等. 西甲硅油乳剂在结肠镜检查肠道准备中的应用价值[J]. 中华消化内镜杂志,2017,34(9):645-648.

相关文章(20)

[1]	胡伟, 李金男, 杨伟, 苏黎, 喻卓, 陈志松. 儿童肌部室间隔缺损的介入治疗研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240307
[2]	王继, 宾松涛, 谭力. 电子支气管镜下乙酰半胱氨酸对儿童重症肺炎的疗效, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240615
[3]	刘兴祝, 杨燕飞, 张兴, 葛丽萍, 王峰, 吴玉芹. 云南地区川崎病儿童不同病程脂代谢水平及相关因素分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230211
[4]	崔继华, 李抒瑾, 宋玉, 杨艳飞, 孙艳会, 孙晶晶, 凌昱. 气质特点在注意缺陷多动障碍儿童中的预测价值, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230518
[5]	李露, 田云粉. 肠道菌群与儿童非酒精性脂肪性肝病的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230708
[6]	张莹, 高虹, 张翠香, 陈泽莹, 邹红群, 李丽琼, 杨巨品, 胡月新. 儿童幽门螺杆菌感染情况及其与缺铁性贫血的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220418
[7]	马海锋, 江魁明. 3.0T磁共振术前诊断儿童胰胆管合流异常的价值, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20221014
[8]	拜娴, 崔瑶, 周庆, 李晓丽, 李玥晓, 刘娟, 张石楠. 云南省傈僳族儿童乳牙龋的唾液微生物研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220301
[9]	刘四香, 黄永坤, 王明英, 胡红卫, 马敏, 凌昱. 功能性便秘患儿的肠道菌群分析及治疗干预, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220309
[10]	齐贞光, 李晓云, 张巍巍. 利那洛肽联合复方聚乙二醇电解质在慢性便秘患者肠道准备中的临床应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20221116
[11]	宾松涛, 吴澄清, 谭力, 郝芮, 李明, 张霞. 儿童中心气道狭窄84例的病因及诊疗方法, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211231
[12]	宾松涛, 李明, 谭力, 吴澄清, 王继, 胡晓琴. 儿童坏死性肺炎46例临床分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210102
[13]	邱炜, 陈莹, 胡秀, 赵红宇. 云南某地区儿童及青少年铅中毒现状及影响因素分析, 昆明医科大学学报.
[14]	戴梅. 昆明市儿童哮喘的危险因素分析, 昆明医科大学学报.
[15]	杨少灵. 白血病儿童重症肺炎60例临床诊治分析, 昆明医科大学学报.
[16]	白志瑶. 儿童EB病毒抗体检测122例临床分析, 昆明医科大学学报.
[17]	盛晓翠. 儿童泌尿系感染的病原菌分析, 昆明医科大学学报.
[18]	何丽芸. 儿童社区获得性肺炎病例肺炎链球菌分离株的耐药分析, 昆明医科大学学报.
[19]	. 闭合复位克氏针固定治疗儿童肱骨髁上不稳定骨折, 昆明医科大学学报.
[20]	. 病人自控镇痛技术在结肠镜检查中的临床应用, 昆明医科大学学报.