Email
RSS2016 Vol. 37, No. 02
2016, 37(02)
Abstract:
［Abstract］Obesity has been a global public health concern. Obesity is not only one of chronic diseases, but also a major risk factor for the development of non-communicable diseases such as hypertension, diabetes, coronary heart disease，and stroke. The aim of this study was to analyze the prevalence of obesity and burden of obesity-related chronic diseases，and examine the influence of obesity and obesity-related chronic diseases on social economy and individuals' health from three levels: individual level，family level and society level.
［Abstract］Obesity has been a global public health concern. Obesity is not only one of chronic diseases, but also a major risk factor for the development of non-communicable diseases such as hypertension, diabetes, coronary heart disease，and stroke. The aim of this study was to analyze the prevalence of obesity and burden of obesity-related chronic diseases，and examine the influence of obesity and obesity-related chronic diseases on social economy and individuals' health from three levels: individual level，family level and society level.
2016, 37(02)
Abstract:
Objective To investigate the distribution of MCP-1 -2518 gene A/G polymorphism in a Yi nationality population of Yunnan province，and to found the basis of pathogenesis about many diseases associated with it.Methods We recruited 310 healthy subjects of Yi nationality in rural area of Jinning，Yunnan province. The MCP-1 -2518 gene A/G polymorphism was determined by PCR-RFLP technique. Frequencies for the AA，GA，GG genotypes and allele frequencies for the A，G alleles were calculated．Results In healthy people of Yunnan province，frequencies for the AA，GA and GG gene types were 20.0%，49.7%and 30.3%．Derived allele frequencies for the A and G allele were 44.8% and 55.2%．Compared with the data from other countries， the distribution of MCP-1-2518 gene A/G genotypes and the allele frequencies in Yunnan Yi people differed significantly from that in Pole， Indian， Korean， Japanese， Brazilian， European，American，Turkish，German and Greek（P＜0.05），while did not differ significantly from that in Han Chinese， Taiwan residents and people in Hong Kong （P＞0.05）. Conclusion The frequency of genotype or the allele of MCP-1 -2518 A/G polymorphism is different significantly in different ethnic populations and national populations.
2016, 37(02)
Abstract:
［Abstract］Objective To study the effect of TGF-β2 and geneX on the proliferation and osteogenic differentiation of BrdU-labeled Bone Mesenchymal Stem Cells. Methods The whole bone adherent culture method was used to isolate，passage and identify bone mesenchymal stem cells. After grouped induction culture， the morphology， growth kinetics （Methyl Thiazolyl Tetrazolium，MTT）， alkaline phosphatase （ALP） and calcium quantification of BMSCs were observed and the osteogenic differentiation was observed by Von-Kossa staining. Results（1） The absorbance value（OD）of BMSCs in four groups showed statistically significant differences among different cell groups（P <0.05）. （2）The alkaline phosphatase（ALP）and calcium quantitative test results after osteogenesis induction showed statistically significant differences among different cell groups（P <0.05）. （3） Cell Von-Kossa staining showed that large amounts of calcium nodules in group D， more calcium nodules in group C，partial calcium nodules group B， a small amount of calcium nodules in group A， and no calcium nodules in control group. Conclusions （1）TGF-β2 can promote the proliferation of bone mesenchymal stem cells and induce them to differentiate into osteoblasts. （2） GeneX can promote bone mesenchymal stem cells to differentiate into bone cells，and osteogenic differentiation is more obvious in the cytokine TGF-β2 joint action.
［Abstract］Objective To study the effect of TGF-β2 and geneX on the proliferation and osteogenic differentiation of BrdU-labeled Bone Mesenchymal Stem Cells. Methods The whole bone adherent culture method was used to isolate，passage and identify bone mesenchymal stem cells. After grouped induction culture， the morphology， growth kinetics （Methyl Thiazolyl Tetrazolium，MTT）， alkaline phosphatase （ALP） and calcium quantification of BMSCs were observed and the osteogenic differentiation was observed by Von-Kossa staining. Results（1） The absorbance value（OD）of BMSCs in four groups showed statistically significant differences among different cell groups（P <0.05）. （2）The alkaline phosphatase（ALP）and calcium quantitative test results after osteogenesis induction showed statistically significant differences among different cell groups（P <0.05）. （3） Cell Von-Kossa staining showed that large amounts of calcium nodules in group D， more calcium nodules in group C，partial calcium nodules group B， a small amount of calcium nodules in group A， and no calcium nodules in control group. Conclusions （1）TGF-β2 can promote the proliferation of bone mesenchymal stem cells and induce them to differentiate into osteoblasts. （2） GeneX can promote bone mesenchymal stem cells to differentiate into bone cells，and osteogenic differentiation is more obvious in the cytokine TGF-β2 joint action.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the effects of CSWT on myocardial collateral circulation and global cardiac function after acute myocardial infarction at the early stage. Methods Thirty 3～5 months and 26～32kg domestic miniature pigs were enrolled in this study. The selected 30 pigs were randomly divided into three groups: CSWT group，pseudo-CSWT group and pseudo operation group. CSWT group was further divided into three subgroups according to treatment protocols. The collateral circulation vessel Rentrop score and global cardiac function were measured and evaluated by coronary artery angiography and left ventricular angiography，and then were compared among these groups，respectively. Results Compared with pseudo-CSWT group， collateral vessel Rentrop score was significantly higher in CSWT group［（2.05±0.11）vs（0.98±0.09），P = 0.03］. There was no significant difference in the collateral vessel Rentrop score between pseudo-CSWT group and pseudo-operation group［（0.98±0.09）Vs（0.86±0.03），P＞0.05］. There were significant differences in the collateral vessel Rentrop score among different subgroups in CSWT group，and the improving effects in subgroup of prolonged duration CSWT were better than other two subgroups. At the same time，the global cardiac function，including LVESV and LVEDV were significantly higher while and LVEF was lower in the CSWT group，pseudo-CSWT group than those in the sham operation. LVESV，LVEDV and LVEF in CSWT group were significantly better than those in pseudo-CSWT group. Conclusions Extracorporeal cardiac shock wave therapy could improve reconstructing micro-vascular circulation of ischemia myocardial，while result in an improvement in global cardiac function，especially，prolonged duration CSWT at early stage of acute myocardial infarction could better improve myocardial collateral vascular circulation. This may be one of the most important mechanisms for CSWT in improving of remodeling after ischemia heart disease in early stage.
［Abstract］Objective To investigate the effects of CSWT on myocardial collateral circulation and global cardiac function after acute myocardial infarction at the early stage. Methods Thirty 3～5 months and 26～32kg domestic miniature pigs were enrolled in this study. The selected 30 pigs were randomly divided into three groups: CSWT group，pseudo-CSWT group and pseudo operation group. CSWT group was further divided into three subgroups according to treatment protocols. The collateral circulation vessel Rentrop score and global cardiac function were measured and evaluated by coronary artery angiography and left ventricular angiography，and then were compared among these groups，respectively. Results Compared with pseudo-CSWT group， collateral vessel Rentrop score was significantly higher in CSWT group［（2.05±0.11）vs（0.98±0.09），P = 0.03］. There was no significant difference in the collateral vessel Rentrop score between pseudo-CSWT group and pseudo-operation group［（0.98±0.09）Vs（0.86±0.03），P＞0.05］. There were significant differences in the collateral vessel Rentrop score among different subgroups in CSWT group，and the improving effects in subgroup of prolonged duration CSWT were better than other two subgroups. At the same time，the global cardiac function，including LVESV and LVEDV were significantly higher while and LVEF was lower in the CSWT group，pseudo-CSWT group than those in the sham operation. LVESV，LVEDV and LVEF in CSWT group were significantly better than those in pseudo-CSWT group. Conclusions Extracorporeal cardiac shock wave therapy could improve reconstructing micro-vascular circulation of ischemia myocardial，while result in an improvement in global cardiac function，especially，prolonged duration CSWT at early stage of acute myocardial infarction could better improve myocardial collateral vascular circulation. This may be one of the most important mechanisms for CSWT in improving of remodeling after ischemia heart disease in early stage.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate and analyze the effect of Liraglutide on the expression of fatty acids β-oxidation key enzymes，Acyl Coenzyme A Oxidase1（ACOX1）and Peroxisome Proliferators-Activated Receptor α（PPARα），in high fat food induced Non-alcoholic Fatty Liver Disease（ NAFLD）in rats，in order to investigate whether it can treat NAFLD through the above ways．Methods Severty rats were randomly divided into control， model and liraglutide group，after NAFLD model was successfully established，liraglutide treatment group received liraglutide 60 ug/(kg.d)treatment， model group and control group were given saline injections. 4 weeks and 8 weeks later，the rats were sacrificed to detect the correlated indexes．Results Liver pathology showed that cells were smooth and arranged regularly，cell size was uniform，and no fatty infiltration in control group，the presence of significant liver fat deposition in model group，4 weeks after treatment，liver fat deposition significantly reduced， 8 weeks after treatment，liver fat deposition significantly reduced further，but there was still a certain difference compared to the control group. After treatment，liver function and blood lipids were significantly improved；4 weeks after treatment，compared with the model group，in the treatment group liver PPARα and ACOX1 protein and mRNA expression increased， but the difference was not statistically significant， 8 weeks after treatment，both of them were significantly increased（P＜0.05）. Conclusion Liraglutide can significantly improve the high-fat diet-induced lipid，improve liver function， which may be related with the upregulation of fatty acids β-oxidation key enzymes PPARα and ACOX1， thus contributing to the discharge of the accumulated fatty acid in liver.
［Abstract］Objective To investigate and analyze the effect of Liraglutide on the expression of fatty acids β-oxidation key enzymes，Acyl Coenzyme A Oxidase1（ACOX1）and Peroxisome Proliferators-Activated Receptor α（PPARα），in high fat food induced Non-alcoholic Fatty Liver Disease（ NAFLD）in rats，in order to investigate whether it can treat NAFLD through the above ways．Methods Severty rats were randomly divided into control， model and liraglutide group，after NAFLD model was successfully established，liraglutide treatment group received liraglutide 60 ug/(kg.d)treatment， model group and control group were given saline injections. 4 weeks and 8 weeks later，the rats were sacrificed to detect the correlated indexes．Results Liver pathology showed that cells were smooth and arranged regularly，cell size was uniform，and no fatty infiltration in control group，the presence of significant liver fat deposition in model group，4 weeks after treatment，liver fat deposition significantly reduced， 8 weeks after treatment，liver fat deposition significantly reduced further，but there was still a certain difference compared to the control group. After treatment，liver function and blood lipids were significantly improved；4 weeks after treatment，compared with the model group，in the treatment group liver PPARα and ACOX1 protein and mRNA expression increased， but the difference was not statistically significant， 8 weeks after treatment，both of them were significantly increased（P＜0.05）. Conclusion Liraglutide can significantly improve the high-fat diet-induced lipid，improve liver function， which may be related with the upregulation of fatty acids β-oxidation key enzymes PPARα and ACOX1， thus contributing to the discharge of the accumulated fatty acid in liver.
2016, 37(02)
Abstract:
［Abstract］Objective To research the physical characteristic of the freshman of the Yi，Bai，Han nationality and its relationship with depression. Methods By the method of cluster sampling，1，712 freshman， include 566 Yi nationality，543 Bai nationality and 603 Han nationality， were measured with Adolescent physical self scale and Beck depression inventory. The data were analyzed by analysis of variance and Spearman correlation. Results （1） By analysis of the physical self characteristic of freshman of Yi，Bai and Han nationality，we found that: there were significant differences in physical characteristic in terms of specific dimensions （F＝5.247，P＜0.01）that there was a higher satisfaction level in Han than in Yi and in Bai about the self stature characteristic by pairwise comparision. （2） The satisfaction level of the boy was higher than of the girl in the self stature characteristic of these three nationalities（F＝4.248，P＜0.05）. （3） In the dimension of physical self about the freshman of Yi， Bai，Han nationality， there was a discrepancy with different levels of depression in the facial characteristic（F＝2.283，P＜0.05） and the negative characteristic（F＝2.396，P＜0.05）， their scores was step-like decreased: no depression＞mild depression＞moderate depression＞major depression.（4）The freshman of Yi，Bai and Han nationality had a significant negative correlation with depression in the dimensions of physical self （P＜0.01）. Conclusions The level of satisfaction in stature characteristic，the Han student is higher than the Yi and Bai， boy is higher than girl. For freshman of those three ethnic groups， the higher level of satisfaction with their physical self， the lower possibility of depression，in addition that the facial characteristic and negative characteristic affect the level of depression.
［Abstract］Objective To research the physical characteristic of the freshman of the Yi，Bai，Han nationality and its relationship with depression. Methods By the method of cluster sampling，1，712 freshman， include 566 Yi nationality，543 Bai nationality and 603 Han nationality， were measured with Adolescent physical self scale and Beck depression inventory. The data were analyzed by analysis of variance and Spearman correlation. Results （1） By analysis of the physical self characteristic of freshman of Yi，Bai and Han nationality，we found that: there were significant differences in physical characteristic in terms of specific dimensions （F＝5.247，P＜0.01）that there was a higher satisfaction level in Han than in Yi and in Bai about the self stature characteristic by pairwise comparision. （2） The satisfaction level of the boy was higher than of the girl in the self stature characteristic of these three nationalities（F＝4.248，P＜0.05）. （3） In the dimension of physical self about the freshman of Yi， Bai，Han nationality， there was a discrepancy with different levels of depression in the facial characteristic（F＝2.283，P＜0.05） and the negative characteristic（F＝2.396，P＜0.05）， their scores was step-like decreased: no depression＞mild depression＞moderate depression＞major depression.（4）The freshman of Yi，Bai and Han nationality had a significant negative correlation with depression in the dimensions of physical self （P＜0.01）. Conclusions The level of satisfaction in stature characteristic，the Han student is higher than the Yi and Bai， boy is higher than girl. For freshman of those three ethnic groups， the higher level of satisfaction with their physical self， the lower possibility of depression，in addition that the facial characteristic and negative characteristic affect the level of depression.
2016, 37(02)
Abstract:
［Abstract］Objective To explore the correlation between vitamin D receptor （VDR） gene polymorphism and type 2 diabetes mellitus of the Han nationality in Kunming region. Methods One-hundred-twenty-six Kunming individuals（90 T2DMs and 36 controls）were enrolled in this randomized controlled trial. rs7975232 single nucleotide polymorphism （SN+J8Ps） of the VDR was tested by using Polymerase chain reaction of restriction fragment length polymorphism（PCR-RFLP）， the genotype and its frequencies were compared between the two groups．Results（1）There were statistically significant association in three kinds of genotype of ApaI of VDR gene polymorphism between two groups（P＜0.001）. The C/A genotype was more common in T2DM patients （62.2% vs 38.9%）. （2）Statistic analysis software showed that the frequency of C/A genotype of ApaI was higher than that in the control group（OR=1.36， 95%CI: 0.54-1.71）. Whats more， age in T2DM group were also higher than that in the control group（OR= 1.09，95% CI: 1.03-1.18 ）. 25OHD3 in T2DM group was lower than that in the control group （OR=0.84，95%CI:0.73-0.93），suggesting that C/A genotype and age are risk factors of T2DM. Meanwhile 25OHD3 may be a preventive factor of T2DM．Conclusions（1）There is a significant correlation between C/A genotype of rs7875232 and the prevalence of T2DM of the Han nationality in Kunming region.（2）25OHD3 is a protective factor of T2DM and the aging is a risk factor of T2DM.
［Abstract］Objective To explore the correlation between vitamin D receptor （VDR） gene polymorphism and type 2 diabetes mellitus of the Han nationality in Kunming region. Methods One-hundred-twenty-six Kunming individuals（90 T2DMs and 36 controls）were enrolled in this randomized controlled trial. rs7975232 single nucleotide polymorphism （SN+J8Ps） of the VDR was tested by using Polymerase chain reaction of restriction fragment length polymorphism（PCR-RFLP）， the genotype and its frequencies were compared between the two groups．Results（1）There were statistically significant association in three kinds of genotype of ApaI of VDR gene polymorphism between two groups（P＜0.001）. The C/A genotype was more common in T2DM patients （62.2% vs 38.9%）. （2）Statistic analysis software showed that the frequency of C/A genotype of ApaI was higher than that in the control group（OR=1.36， 95%CI: 0.54-1.71）. Whats more， age in T2DM group were also higher than that in the control group（OR= 1.09，95% CI: 1.03-1.18 ）. 25OHD3 in T2DM group was lower than that in the control group （OR=0.84，95%CI:0.73-0.93），suggesting that C/A genotype and age are risk factors of T2DM. Meanwhile 25OHD3 may be a preventive factor of T2DM．Conclusions（1）There is a significant correlation between C/A genotype of rs7875232 and the prevalence of T2DM of the Han nationality in Kunming region.（2）25OHD3 is a protective factor of T2DM and the aging is a risk factor of T2DM.
2016, 37(02)
Abstract:
［Abstract］Objective To analyze the relationship between prevalence of diabetes and body mass index （BMI） and waist circumference（WC）in rural Yunnan Province. Methods Multistage stratified random sampling method was used to select representative sample of 2 479 rural residents aged 35 years and over from Da Yao County. Each participant received questionnaire interview and physical examination. Results The overall prevalence of diabetes was 6.1%，and was 7.1% for males，5.1% for females in the study region. Males had higher prevalence of diabetes than females（P＜0.05）. Prevalence of diabetes increased with age，whereas decreased when income rising（P＜0.01）. Prevalence rates of low body weight and central obesity were higher in women than in men （P＜0.01），and decreased with income（P＜0.01）. The risk of diabetes increased with BMI and WC（P＜0.01）.Obese and central obese people had 2.285 and 2.98 times higher risk of being diabetic than their counterparts. Conclusion It is necessary to take measures to reduce prevalence of both obesity and central obesity，so as to decrease the occurrence of diabetes.
［Abstract］Objective To analyze the relationship between prevalence of diabetes and body mass index （BMI） and waist circumference（WC）in rural Yunnan Province. Methods Multistage stratified random sampling method was used to select representative sample of 2 479 rural residents aged 35 years and over from Da Yao County. Each participant received questionnaire interview and physical examination. Results The overall prevalence of diabetes was 6.1%，and was 7.1% for males，5.1% for females in the study region. Males had higher prevalence of diabetes than females（P＜0.05）. Prevalence of diabetes increased with age，whereas decreased when income rising（P＜0.01）. Prevalence rates of low body weight and central obesity were higher in women than in men （P＜0.01），and decreased with income（P＜0.01）. The risk of diabetes increased with BMI and WC（P＜0.01）.Obese and central obese people had 2.285 and 2.98 times higher risk of being diabetic than their counterparts. Conclusion It is necessary to take measures to reduce prevalence of both obesity and central obesity，so as to decrease the occurrence of diabetes.
2016, 37(02)
Abstract:
［Abstract］Objective To compare and discuss the different results among four kinds of experimental methods（saline water method，Antiglobulin method，Polybrene method ，Microcolumn gel test） in Rh(D) negative confirmation experiment， and analyze their effects . Methods We selected 96 cases whose results of Rh(D) blood typing in the early screening specimen were negative in the department of blood transfusion of the first people's hospital of yunnan province between January 2012 and December 2012. And we used saline wator method,antiglobulin method，polybrene method， microcolumn gel test to make Rh(D) the negative confirmation experiment and typing experiments at the same time. Results 96 cases were all confirmed the negative results through Saline method. 84 cases of 96 were confirmed the negative results through Polybrene method. 82 cases of 96 were confirmed the negative results through Anti-human globulin test. 81 cases of 96 were confirmed the negative results through Microcolumn gel test. Conclusions Saline water method is simple but has poor specificity．Polybrene method is simple and rapid， but it will miss the IgG antibody of weaker antibody titer. The operation of antiglobulin method is complex， but its sensitivity and specificity are good. Microcolumn gel test for detection of IgG antibody in the serum has the characteristics of high sensitivity，strong specificity，and simple operation . In practice， combination of various methods can more guarantee the accuracy of the results.
［Abstract］Objective To compare and discuss the different results among four kinds of experimental methods（saline water method，Antiglobulin method，Polybrene method ，Microcolumn gel test） in Rh(D) negative confirmation experiment， and analyze their effects . Methods We selected 96 cases whose results of Rh(D) blood typing in the early screening specimen were negative in the department of blood transfusion of the first people's hospital of yunnan province between January 2012 and December 2012. And we used saline wator method,antiglobulin method，polybrene method， microcolumn gel test to make Rh(D) the negative confirmation experiment and typing experiments at the same time. Results 96 cases were all confirmed the negative results through Saline method. 84 cases of 96 were confirmed the negative results through Polybrene method. 82 cases of 96 were confirmed the negative results through Anti-human globulin test. 81 cases of 96 were confirmed the negative results through Microcolumn gel test. Conclusions Saline water method is simple but has poor specificity．Polybrene method is simple and rapid， but it will miss the IgG antibody of weaker antibody titer. The operation of antiglobulin method is complex， but its sensitivity and specificity are good. Microcolumn gel test for detection of IgG antibody in the serum has the characteristics of high sensitivity，strong specificity，and simple operation . In practice， combination of various methods can more guarantee the accuracy of the results.
2016, 37(02)
Abstract:
［Abstract］Objective To observe and discuss the application time with non-invasive mechanical ventilation in acute coronary syndrome patients with hypoxemia. Methods We selected 46 cases of ACS patients with hypoxaemia who were diagnosed in our hospital from July 2014 ~July 2015，After using the mask oxygen，bi-level positive airway pressure ventilation through oronasal mask was given to these patients when pulse oxygen saturation continued to decline to ≤90%. Then we observed the changes of breathing rate，pulse oxygen saturation and arterial blood gas analysis and other indicators before and after 2 hours of Mechanical ventilation and ventilation. Results Respiratory rate，pulse oxygen saturation，arterial partial pressure of oxygen and clinical symptoms were improved after 2 hours in 46 cases of ACS patients with hypoxaemia who were treated by Non-invasive mechanical ventilation. Conclusion Application of non-invasive mechanical ventilation in the treatment，can safely and quickly correct hypoxemia and respiratory failure in ACS patients with hypoxaemia whose pulse oxygen saturation continued to decline to ≤90% after using the mask oxygen.
［Abstract］Objective To observe and discuss the application time with non-invasive mechanical ventilation in acute coronary syndrome patients with hypoxemia. Methods We selected 46 cases of ACS patients with hypoxaemia who were diagnosed in our hospital from July 2014 ~July 2015，After using the mask oxygen，bi-level positive airway pressure ventilation through oronasal mask was given to these patients when pulse oxygen saturation continued to decline to ≤90%. Then we observed the changes of breathing rate，pulse oxygen saturation and arterial blood gas analysis and other indicators before and after 2 hours of Mechanical ventilation and ventilation. Results Respiratory rate，pulse oxygen saturation，arterial partial pressure of oxygen and clinical symptoms were improved after 2 hours in 46 cases of ACS patients with hypoxaemia who were treated by Non-invasive mechanical ventilation. Conclusion Application of non-invasive mechanical ventilation in the treatment，can safely and quickly correct hypoxemia and respiratory failure in ACS patients with hypoxaemia whose pulse oxygen saturation continued to decline to ≤90% after using the mask oxygen.
2016, 37(02)
Abstract:
［Abstract］Objective To observe the clinical effects of VATS treatment for primary non-small cell lung cance. Methods We randomly selected 180 primary non-small cell lung cancer patients from October 2012 to May 2014 in our hospital in this study. According to the random number table method，patients were divided into observation group and control group, the observation group was treated with surgery VATS approach，the control group was treated with conventional thoracotomy. Then we compared the operation time，intraoperative blood loss，postoperative pethidine amount of postoperative chest drainage than 10 mL days，length of stay，hospital costs between the two groups. Results The operation time in the observation group was slightly longer than patients in the control group（P＞0.05）；the hospitalization costs were slightly higher than the control group（P＜0.05）. The experimental group patients' Dezocine use amount, the days of postoperative chest drainage than 50ml, hospitalization time were lower than the control group（P＜0.05）. There was no significant difference in the number of lymph node dissection in patients between the two groups（P＞0.05）. Conclusions VATS treatment of primary non-small cell lung cancer has small wounds, faster recovery, shorter hospital stay, and can be used as a reliable and effective method for the treatment of primary non-small cell lung cancer, and should be popularized.
［Abstract］Objective To observe the clinical effects of VATS treatment for primary non-small cell lung cance. Methods We randomly selected 180 primary non-small cell lung cancer patients from October 2012 to May 2014 in our hospital in this study. According to the random number table method，patients were divided into observation group and control group, the observation group was treated with surgery VATS approach，the control group was treated with conventional thoracotomy. Then we compared the operation time，intraoperative blood loss，postoperative pethidine amount of postoperative chest drainage than 10 mL days，length of stay，hospital costs between the two groups. Results The operation time in the observation group was slightly longer than patients in the control group（P＞0.05）；the hospitalization costs were slightly higher than the control group（P＜0.05）. The experimental group patients' Dezocine use amount, the days of postoperative chest drainage than 50ml, hospitalization time were lower than the control group（P＜0.05）. There was no significant difference in the number of lymph node dissection in patients between the two groups（P＞0.05）. Conclusions VATS treatment of primary non-small cell lung cancer has small wounds, faster recovery, shorter hospital stay, and can be used as a reliable and effective method for the treatment of primary non-small cell lung cancer, and should be popularized.
2016, 37(02)
Abstract:
［Abstract］Objective To evaluate the application value of ureteral occlusion device in ureteroscopic holium laser lithotripsy for treatment of upper-middle ureteral calculi. Methods Fifty-six patients with upper-middle ureteral calculi were randomly divided into two groups in this study. Twenty-eight patients in observation group were treated with ureteroscopic holium laser lithotripsy combined with ureteral occlusion device，28 patients in control group were treated with ureteroscopic holium laser lithotripsy. The effect of lithotripsy and postoperative complication were compared．Results The operation time and stone-up rate in observation group were shorter and lower than those in control group, the stone clearance rate in observation group was significantly higher than that in control group （P＜0.05）. The incidence of complications in observation group was significantly lower than that in control group （P＜0.05）. Conclusions The ureteral occlusion device combined with ureteroscopic holium laser lithotripsy is effective in preventing the movement of calculus, improving the rate and safety of stone clearance, reducing incidence of complications during ureteroscopic holium laser lithotripsy. It is worthy of clinical promotion.
［Abstract］Objective To evaluate the application value of ureteral occlusion device in ureteroscopic holium laser lithotripsy for treatment of upper-middle ureteral calculi. Methods Fifty-six patients with upper-middle ureteral calculi were randomly divided into two groups in this study. Twenty-eight patients in observation group were treated with ureteroscopic holium laser lithotripsy combined with ureteral occlusion device，28 patients in control group were treated with ureteroscopic holium laser lithotripsy. The effect of lithotripsy and postoperative complication were compared．Results The operation time and stone-up rate in observation group were shorter and lower than those in control group, the stone clearance rate in observation group was significantly higher than that in control group （P＜0.05）. The incidence of complications in observation group was significantly lower than that in control group （P＜0.05）. Conclusions The ureteral occlusion device combined with ureteroscopic holium laser lithotripsy is effective in preventing the movement of calculus, improving the rate and safety of stone clearance, reducing incidence of complications during ureteroscopic holium laser lithotripsy. It is worthy of clinical promotion.
2016, 37(02)
Abstract:
［Abstract］Objective To compare the clinical effect of loop electrosurgical excision procedure（LEEP） and cold knife conization（CKC） on treating patients with cervical intraepithelial neoplasia（CIN）. Methods Eighty-six patients with CIN treated in our hospital during May 2012 and May 2014 were enrolled in this study. The patients were divided into observation group and control group depending on the surgical treatment. Forty-three patients in observation group were treated with LEEP and 43 patients in control group were treated with traditional CKC. The clinical efficacy，change of pathology and complications of two groups were compared. Results The operative time， blood loss，hospitalization time and healing time of observation group were significantly lower than those of control group （P＜0.05）. The consistent rate of pathological and colposcopy biopsy in observation group was 79.07% and 86.05% in control group， there was no significant difference between two groups（P＞0.05）. The incidence of complications of observation group was 4.65%， which was significantly lower than 16.27% of control group（P＜0.05）. Two groups had same values in treatment effect， there were no significant differences in cure rate， residue rate and recurrence rate（P＞0.05）. Conclusions LEEP is an effective method for treating CIN. Compared with CKC， LEEP has shorter operation time， hospitalization time and healing time; also has lower intraoperative blood loss and incidence of complications. It has high clinical value and worth of popularization and application.
［Abstract］Objective To compare the clinical effect of loop electrosurgical excision procedure（LEEP） and cold knife conization（CKC） on treating patients with cervical intraepithelial neoplasia（CIN）. Methods Eighty-six patients with CIN treated in our hospital during May 2012 and May 2014 were enrolled in this study. The patients were divided into observation group and control group depending on the surgical treatment. Forty-three patients in observation group were treated with LEEP and 43 patients in control group were treated with traditional CKC. The clinical efficacy，change of pathology and complications of two groups were compared. Results The operative time， blood loss，hospitalization time and healing time of observation group were significantly lower than those of control group （P＜0.05）. The consistent rate of pathological and colposcopy biopsy in observation group was 79.07% and 86.05% in control group， there was no significant difference between two groups（P＞0.05）. The incidence of complications of observation group was 4.65%， which was significantly lower than 16.27% of control group（P＜0.05）. Two groups had same values in treatment effect， there were no significant differences in cure rate， residue rate and recurrence rate（P＞0.05）. Conclusions LEEP is an effective method for treating CIN. Compared with CKC， LEEP has shorter operation time， hospitalization time and healing time; also has lower intraoperative blood loss and incidence of complications. It has high clinical value and worth of popularization and application.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the effect of propofor combined with ShuFen on analgesic， analepsia and adverse reactions of laparoscopic myomectomy. Methods A retrospective analysis method was used to analyze the clinical data of 100 patients with hysteromyoma from March 2014 - June 2015，and the enrolled 100 patients were randomly divided into observation group（50 cases）and control group（50 cases）. Patients in the observation group were treated by propofol combined ShuFen treatment, and patients in the control group were treated by single propofol treatment. Then we observed the analgesic effect，waking time after operatioon, breathing recovery time, orientation recovery time and the incidence of adverse reactions of patients in two groups. Results Through the observation，we found that there was a statistically significant difference in the postoperative analgesia effect between the observation group and the control group（P < 0.05）. The orientation recovery time and postoperative awakening time and respiratory recovery time in the observation group were significantly lower than those in the control group（P < 0.05）. There was a statistically significant difference in the incidence of adverse reaction between the control group and observation group（P < 0.05）. Conclusion Propofol combined with ShuFen has good analgesic effect in laparoscopic uterine fibroids rejecting operation，it can not only shorten the patients' consciousness recovery time and the orientation recovery time，but also can effectively reduce the incidence of adverse reactions in patients at the same time，so it is worth popularization and application in clinic.
［Abstract］Objective To investigate the effect of propofor combined with ShuFen on analgesic， analepsia and adverse reactions of laparoscopic myomectomy. Methods A retrospective analysis method was used to analyze the clinical data of 100 patients with hysteromyoma from March 2014 - June 2015，and the enrolled 100 patients were randomly divided into observation group（50 cases）and control group（50 cases）. Patients in the observation group were treated by propofol combined ShuFen treatment, and patients in the control group were treated by single propofol treatment. Then we observed the analgesic effect，waking time after operatioon, breathing recovery time, orientation recovery time and the incidence of adverse reactions of patients in two groups. Results Through the observation，we found that there was a statistically significant difference in the postoperative analgesia effect between the observation group and the control group（P < 0.05）. The orientation recovery time and postoperative awakening time and respiratory recovery time in the observation group were significantly lower than those in the control group（P < 0.05）. There was a statistically significant difference in the incidence of adverse reaction between the control group and observation group（P < 0.05）. Conclusion Propofol combined with ShuFen has good analgesic effect in laparoscopic uterine fibroids rejecting operation，it can not only shorten the patients' consciousness recovery time and the orientation recovery time，but also can effectively reduce the incidence of adverse reactions in patients at the same time，so it is worth popularization and application in clinic.
2016, 37(02)
Abstract:
［Abstract］Objective To explore a method to efficiently improve the diagnosis level of uterine dysplasia through a combination of a variety of methods, and compare its effect with other methods. Methods Three-dimensional ultrasonography and hysterosalpingography was performed in 65 patients with medical history of sterility，abortion，colporrhagia, premature birth and diagnosed with congenital Uterine dysplasia through transvaginal two-dimensional ultrasonography. Hysteroscope and laparoscope were also used in these patients with the comparison of their operative results. Results In 65 cases of patients with uterine dysplasia，there were 45 cases of mediastinal uterus，8 cases of arcuate uterus，5 cases of single Angle \ residual Angle uterus，4 cases of double uterus，2 cases of double Angle uterus, 8 cases of arcuate uterine, and 1 case of normal uterine cavity. Vaginal 3D imaging and hysteroscopy or laparoscopic surgery results were basically identical. Angiography in the diagnosis of uterine and uterine tubal iodine oil dysplastic type had limitations，mediastinum uterus was often misdiagnosed as single Angle's uterus，there were 8 cases of sample single Angle uterus and 1 case of double Angle uterus，difference was statistically significant （P < 0.05）. The diagnosis coincidence rate of transvaginal two-dimensional ultrasound for uterine dysplasia was lower, the difference was statistically significant（P < 0.05）. Conclusions The transvaginal three-dimensional ultrasonography is superior to transvaginal two-dimensional ultrasonography and hysterosalpingography technology in diagnosis of uterine malformation. And ultrasonic diagnosis could be regarded as the first choice because of its low cost and noninvasion, the combined application of various methods will improve the accuracy of diagnosis on uterine dysplasia.
［Abstract］Objective To explore a method to efficiently improve the diagnosis level of uterine dysplasia through a combination of a variety of methods, and compare its effect with other methods. Methods Three-dimensional ultrasonography and hysterosalpingography was performed in 65 patients with medical history of sterility，abortion，colporrhagia, premature birth and diagnosed with congenital Uterine dysplasia through transvaginal two-dimensional ultrasonography. Hysteroscope and laparoscope were also used in these patients with the comparison of their operative results. Results In 65 cases of patients with uterine dysplasia，there were 45 cases of mediastinal uterus，8 cases of arcuate uterus，5 cases of single Angle \ residual Angle uterus，4 cases of double uterus，2 cases of double Angle uterus, 8 cases of arcuate uterine, and 1 case of normal uterine cavity. Vaginal 3D imaging and hysteroscopy or laparoscopic surgery results were basically identical. Angiography in the diagnosis of uterine and uterine tubal iodine oil dysplastic type had limitations，mediastinum uterus was often misdiagnosed as single Angle's uterus，there were 8 cases of sample single Angle uterus and 1 case of double Angle uterus，difference was statistically significant （P < 0.05）. The diagnosis coincidence rate of transvaginal two-dimensional ultrasound for uterine dysplasia was lower, the difference was statistically significant（P < 0.05）. Conclusions The transvaginal three-dimensional ultrasonography is superior to transvaginal two-dimensional ultrasonography and hysterosalpingography technology in diagnosis of uterine malformation. And ultrasonic diagnosis could be regarded as the first choice because of its low cost and noninvasion, the combined application of various methods will improve the accuracy of diagnosis on uterine dysplasia.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the effect of three-dimensional power Doppler transvaginal ultrasound（3DPD-TVS）quantitative analysis of ovarian masses perfusion parameters and evaluate the value of it in identification of the malignant and benign ovarian masses. Methods 101 ovarian masses were examined with 3DPD-TVS and the corresponding parameters: the resistance index （RI），vascularization index （VI） ，flow index （ FI）,vascularization flow index （VFI） were analyzed. Then the results were compared with the postoperative pathological results．Results VI，FI，VFI values with ovarian malignant tumor group were significantly higher than those in benign tumor group ，the difference was statistically significant （P＜0.05）. RI showed no significant difference between malignant tumor group and benign masses group（P＞0.05）．Conclusion Transvaginal three-dimensional power Doppler ultrasound can be used to objectively and quantitatively analyze of ovarian masses and provide certain reference value for the identification of malignant and benign ovarian masses.
［Abstract］Objective To investigate the effect of three-dimensional power Doppler transvaginal ultrasound（3DPD-TVS）quantitative analysis of ovarian masses perfusion parameters and evaluate the value of it in identification of the malignant and benign ovarian masses. Methods 101 ovarian masses were examined with 3DPD-TVS and the corresponding parameters: the resistance index （RI），vascularization index （VI） ，flow index （ FI）,vascularization flow index （VFI） were analyzed. Then the results were compared with the postoperative pathological results．Results VI，FI，VFI values with ovarian malignant tumor group were significantly higher than those in benign tumor group ，the difference was statistically significant （P＜0.05）. RI showed no significant difference between malignant tumor group and benign masses group（P＞0.05）．Conclusion Transvaginal three-dimensional power Doppler ultrasound can be used to objectively and quantitatively analyze of ovarian masses and provide certain reference value for the identification of malignant and benign ovarian masses.
2016, 37(02)
Abstract:
［Abstract］Objective To explore the value of serum CA125 in patients with high-risk endometrial carcinoma after concomitant chemoradiotherapy（CRT）and radiotherapy（RT） alone. Methods We detected the serum CA125 levels of 21 cases of postoperative DDP+5FU concurrent chemotherapy and 22 cases of postoperative radiotherapy for high-risk endometrial cancer，before and after operation，before and after chemoradiotherapy and/or radiotherapy. Results The serum CA125 levels of patients after concurrent chemoradiotherapy were significantly lower than before and after operation（P < 0.05）. The serum CA125 levels of patients after radiotherapy were lower than before and after operation，but the difference had no statistical significance（P > 0.05）. The average follow-up was 30 months，there were 6 cases of recurrence in radiotherapy group，1 cases of recurrence in the chemoradiotherapy group. Conclusions Detection of serum CA125 levels of patients with high-risk endometrial cancer before surgery，adjuvant therapy is helpful to postoperative. After treatment，regular detection of serum CA125 can predict the risk of recurrence of uterine endometrial carcinoma.
［Abstract］Objective To explore the value of serum CA125 in patients with high-risk endometrial carcinoma after concomitant chemoradiotherapy（CRT）and radiotherapy（RT） alone. Methods We detected the serum CA125 levels of 21 cases of postoperative DDP+5FU concurrent chemotherapy and 22 cases of postoperative radiotherapy for high-risk endometrial cancer，before and after operation，before and after chemoradiotherapy and/or radiotherapy. Results The serum CA125 levels of patients after concurrent chemoradiotherapy were significantly lower than before and after operation（P < 0.05）. The serum CA125 levels of patients after radiotherapy were lower than before and after operation，but the difference had no statistical significance（P > 0.05）. The average follow-up was 30 months，there were 6 cases of recurrence in radiotherapy group，1 cases of recurrence in the chemoradiotherapy group. Conclusions Detection of serum CA125 levels of patients with high-risk endometrial cancer before surgery，adjuvant therapy is helpful to postoperative. After treatment，regular detection of serum CA125 can predict the risk of recurrence of uterine endometrial carcinoma.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the application of blood purification of septic encephalopathy（SAE）of neuron specific enolase（NSE）influence，for clinicians to provide an early diagnosis of septic encephalopathy and treatment methods for the SAE means，improve the rate of septic encephalopathy treatment to reduce morbidity and mortality．Methods 150 cases of septic encephalopathy admitted in our hospital were randomly divided into observation group and control group，75 cases in each group．Patients in the control group received primary disease and vital organ support and comprehensive treatment，patients in the observation group received additional blood purification treatment．The cerebrospinal fluid（CSF） samples of two groups of children diagnosed after 24 hours and 7 days after treatment were collected for routine，biochemical（Gul，LDH，LA）and neuron specific enolase（NSE）check，the blood samples 1，2，3，5，7 days after diagnosis were collected for detection of NSE．Results No abnormal biochemical test results were found，Gul was significantly lower than that of normal children （P＜0.05），lactate dehydrogenase（LDH）and La was significantly higher than that of normal children（P＜ 0.05），7 d after the treatment，Gul，LDH，La index in the observation group was similar to normal children（P＞0.05），in control group，7 days after treatment，Gul，LDH，La recovery was significantly lower than those in the observation group；cerebrospinal fluid and peripheral blood NSE levels were compared，and the result showed，3 days before treatment，the patients，NSE levels had no significant difference between two groups，5 d，7 d after treatment the NSE level in observation group was significantly lower than that of the control group，the difference was statistically significant（P＜0.05）．Conclusion Children with septic encephalopathy have higher blood and CSF NSE increased significantly，blood purification treatment can accelerate the reduction of NSE concentration and improve the cerebrospinal fluid Gul，LDH，La index，plays an important role in the treatment of septic encephalopathy．
［Abstract］Objective To investigate the application of blood purification of septic encephalopathy（SAE）of neuron specific enolase（NSE）influence，for clinicians to provide an early diagnosis of septic encephalopathy and treatment methods for the SAE means，improve the rate of septic encephalopathy treatment to reduce morbidity and mortality．Methods 150 cases of septic encephalopathy admitted in our hospital were randomly divided into observation group and control group，75 cases in each group．Patients in the control group received primary disease and vital organ support and comprehensive treatment，patients in the observation group received additional blood purification treatment．The cerebrospinal fluid（CSF） samples of two groups of children diagnosed after 24 hours and 7 days after treatment were collected for routine，biochemical（Gul，LDH，LA）and neuron specific enolase（NSE）check，the blood samples 1，2，3，5，7 days after diagnosis were collected for detection of NSE．Results No abnormal biochemical test results were found，Gul was significantly lower than that of normal children （P＜0.05），lactate dehydrogenase（LDH）and La was significantly higher than that of normal children（P＜ 0.05），7 d after the treatment，Gul，LDH，La index in the observation group was similar to normal children（P＞0.05），in control group，7 days after treatment，Gul，LDH，La recovery was significantly lower than those in the observation group；cerebrospinal fluid and peripheral blood NSE levels were compared，and the result showed，3 days before treatment，the patients，NSE levels had no significant difference between two groups，5 d，7 d after treatment the NSE level in observation group was significantly lower than that of the control group，the difference was statistically significant（P＜0.05）．Conclusion Children with septic encephalopathy have higher blood and CSF NSE increased significantly，blood purification treatment can accelerate the reduction of NSE concentration and improve the cerebrospinal fluid Gul，LDH，La index，plays an important role in the treatment of septic encephalopathy．
Comparison of the Effect of Chinese and Western Medicine and Western medicine on Senile Osteoporosis
2016, 37(02)
Abstract:
［Abstract］Objective To compare the effect of Chinese and Western medicine and Western medicine on senile osteoporosis. Methods One hundred and twenty patients with senile osteoporosis in hospital were selected，patients were divided into control group（60 cases） and observation group（60 cases），control group patients were given treatment of western medicine，observation group patients were given treatment of integrated traditional Chinese and Western medicine，the effect of the two groups were compared. Results The total effective rate of the observation group（93.4%） was significantly higher than that of control group（80.0%），P ＜0.05，the VAS pain scores（0.67±0.24） in the observation group was significantly lower than that in control group（1.82±0.84），P ＜0.05. Patients' BMD（0.67±0.11）g/cm2 in the observation group was significantly higher than control group（0.61±0.10） g/cm2，P＜0.05. Common adverse reactions were fever，rash，chest tightness. Conclusion In the treatment of senile osteoporosis，the combination of traditional Chinese and Western medicine treatment can improve the treatment effect，has the promotion value.
［Abstract］Objective To compare the effect of Chinese and Western medicine and Western medicine on senile osteoporosis. Methods One hundred and twenty patients with senile osteoporosis in hospital were selected，patients were divided into control group（60 cases） and observation group（60 cases），control group patients were given treatment of western medicine，observation group patients were given treatment of integrated traditional Chinese and Western medicine，the effect of the two groups were compared. Results The total effective rate of the observation group（93.4%） was significantly higher than that of control group（80.0%），P ＜0.05，the VAS pain scores（0.67±0.24） in the observation group was significantly lower than that in control group（1.82±0.84），P ＜0.05. Patients' BMD（0.67±0.11）g/cm2 in the observation group was significantly higher than control group（0.61±0.10） g/cm2，P＜0.05. Common adverse reactions were fever，rash，chest tightness. Conclusion In the treatment of senile osteoporosis，the combination of traditional Chinese and Western medicine treatment can improve the treatment effect，has the promotion value.
2016, 37(02)
Abstract:
［Abstract］Objective To observe clinical efficacy and safety of Etofenamate gel vs. Diclofcnac Sodium in the treatment of knee osteoarthritis. Methods Sixty patients with knee osteoarthritis were randomized into trial group（30cases） and control group（30cases）. The trial group was given Etofenamate Gel with roast lamp. The controlled group was treated with Diclofenac Sodium , orally for treatment. Clinical efficacy，Lequesne index， joint tenderness pain and the incidence of adverse events were observed in 2 groups．Result Compared with after treatment, the total effective rate（83.3% in trial group and 76.7% in control graup），joint tenderness pain and the incidence of adverse drug reaction，and lequesne index［（3.2±1.6）in trial group and （5.1±1.8）in control group］had statistically significant differences between 2 groups（P＜0.05）. Conclusion Etofenamate gel with roast lamp has significant clinical efficacy and good safety in the treatment of knee osteoarthritis，and is worth promoting .
［Abstract］Objective To observe clinical efficacy and safety of Etofenamate gel vs. Diclofcnac Sodium in the treatment of knee osteoarthritis. Methods Sixty patients with knee osteoarthritis were randomized into trial group（30cases） and control group（30cases）. The trial group was given Etofenamate Gel with roast lamp. The controlled group was treated with Diclofenac Sodium , orally for treatment. Clinical efficacy，Lequesne index， joint tenderness pain and the incidence of adverse events were observed in 2 groups．Result Compared with after treatment, the total effective rate（83.3% in trial group and 76.7% in control graup），joint tenderness pain and the incidence of adverse drug reaction，and lequesne index［（3.2±1.6）in trial group and （5.1±1.8）in control group］had statistically significant differences between 2 groups（P＜0.05）. Conclusion Etofenamate gel with roast lamp has significant clinical efficacy and good safety in the treatment of knee osteoarthritis，and is worth promoting .
2016, 37(02)
Abstract:
［Abstract］Objective To explore the treatment of hormone refractory immune thrombocytopenia．Methods A retrospective analysis was performed on clinical data of 75 cases of patients with ineffective hormone therapy in our hospital from February 2013 to February 2015， and the patients were divided into control group （37 cases） and observation group（38 cases）according to treatment methods，and were given treatment of vincristine treatment and recombinant human thrombopoietin，respectively. Clinical effect of the two groups were observed and compared. Results After different treatment，the curative effect，the total efficiency of observation group was 84.21%， significantly higher than 64.86% in the control group，the difference was statistically significant（P < 0.05），before treatment， no significant difference was found in the platelet counts of the 2 groups of patients， the difference was not statistically significant（P > 0.05）. Compared with before treatment，on 7d， 14d， 21d after different treatment， the levels of platelet count of patients in 2 groups were significantly increased. And the levels of platelet count of patients in the observation group were significantly higher than those in the control group on 7d，14d，21d after different treatment（P < 0.05）. The incidence of adverse reactions in the observation group was significantly lower than that in the control group（P < 0.05）. Conclusion For hormone refractory immune thrombocytopenic patients， recombinant human thrombopoietin treatment has better clinical efficacy than vincristine treatment.
［Abstract］Objective To explore the treatment of hormone refractory immune thrombocytopenia．Methods A retrospective analysis was performed on clinical data of 75 cases of patients with ineffective hormone therapy in our hospital from February 2013 to February 2015， and the patients were divided into control group （37 cases） and observation group（38 cases）according to treatment methods，and were given treatment of vincristine treatment and recombinant human thrombopoietin，respectively. Clinical effect of the two groups were observed and compared. Results After different treatment，the curative effect，the total efficiency of observation group was 84.21%， significantly higher than 64.86% in the control group，the difference was statistically significant（P < 0.05），before treatment， no significant difference was found in the platelet counts of the 2 groups of patients， the difference was not statistically significant（P > 0.05）. Compared with before treatment，on 7d， 14d， 21d after different treatment， the levels of platelet count of patients in 2 groups were significantly increased. And the levels of platelet count of patients in the observation group were significantly higher than those in the control group on 7d，14d，21d after different treatment（P < 0.05）. The incidence of adverse reactions in the observation group was significantly lower than that in the control group（P < 0.05）. Conclusion For hormone refractory immune thrombocytopenic patients， recombinant human thrombopoietin treatment has better clinical efficacy than vincristine treatment.
2016, 37(02)
Abstract:
［Abstract］Objective To study the effect of tubular stomach on dynamics parameter and gastric emptying function after esophageal carcinoma operation．Methods The enrolled 80 patients with esophageal carcinoma operation in our hospital were randomized into the control group（whole stomach esophagus anastomosis） and the observation group（tubular stomach esophagus anastomosis）. The changes of stomach dynamics parameters and gastric emptying function on pre- and post-operation， and the postoperative complications in two groups were compared. Results Compared with the pre-operation， the thoracic stomach resting pressure， peristalsis systolic pressure and peristaltic frequency were significantly decreased on the post-operation in two groups （P<0.05）. Compared with the control group，the thoracic stomach resting pressure，peristalsis systolic pressure on post-operative in the observation group were obviously increased in the observation group（P＜0.05）. Compared with the control group，the thoracic stomach emptying rate on 30 min，60min， 90min after operation were significantly increased in the observation group（P＜0.05）. Compared with the control group， the incidence of reflux esophagitis and chest syndrome was significantly reduced in the observation group（P＜0.05）. Conclusion The tubular stomach esophagus anastomosis can promote the recovery of stomach dynamics and gastric emptying function，reduce the incidence of postoperative complications，and is worthy of clinical promotion.
［Abstract］Objective To study the effect of tubular stomach on dynamics parameter and gastric emptying function after esophageal carcinoma operation．Methods The enrolled 80 patients with esophageal carcinoma operation in our hospital were randomized into the control group（whole stomach esophagus anastomosis） and the observation group（tubular stomach esophagus anastomosis）. The changes of stomach dynamics parameters and gastric emptying function on pre- and post-operation， and the postoperative complications in two groups were compared. Results Compared with the pre-operation， the thoracic stomach resting pressure， peristalsis systolic pressure and peristaltic frequency were significantly decreased on the post-operation in two groups （P<0.05）. Compared with the control group，the thoracic stomach resting pressure，peristalsis systolic pressure on post-operative in the observation group were obviously increased in the observation group（P＜0.05）. Compared with the control group，the thoracic stomach emptying rate on 30 min，60min， 90min after operation were significantly increased in the observation group（P＜0.05）. Compared with the control group， the incidence of reflux esophagitis and chest syndrome was significantly reduced in the observation group（P＜0.05）. Conclusion The tubular stomach esophagus anastomosis can promote the recovery of stomach dynamics and gastric emptying function，reduce the incidence of postoperative complications，and is worthy of clinical promotion.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the relationship between the level of AASI and baPWV，PPI and explore the meaning of these indexes for arteriosclerosis assessment in elderly hypertensive patients. Methods Eighty-nine elderly essential hypertension patients who were outpatients and inpatients in our hospital were included in this study from May 2014 to February 2015. Ambulatory blood pressure monitoring and noninvasive arteriosclerosis detection were measured and the relationship between AASI and baPWV，PPI was also analyzed. Results The level of baPWV of 89 patients was（1603.41±19.84）cm/s，AASI was（0.61±0.15），and PPI was （0.44±0.06）. Spearman correlation analysis showed that AASI was negatively correlated with the average diastolic blood pressure（r = 0.157，P < 0.05）. BaPWV，PPI，mean arterial blood pressure and mean systolic blood pressure was positively correlated with AASI （r = 0.685，0.701，0.648，0.701，P < 0.01）. AASI，baPWV and PPI had higher correlation coefficient．Conclusion AASI can reflect the extent of atherosclerosis，and BaPWV and PPI may increase with the increase of AASI.
［Abstract］Objective To investigate the relationship between the level of AASI and baPWV，PPI and explore the meaning of these indexes for arteriosclerosis assessment in elderly hypertensive patients. Methods Eighty-nine elderly essential hypertension patients who were outpatients and inpatients in our hospital were included in this study from May 2014 to February 2015. Ambulatory blood pressure monitoring and noninvasive arteriosclerosis detection were measured and the relationship between AASI and baPWV，PPI was also analyzed. Results The level of baPWV of 89 patients was（1603.41±19.84）cm/s，AASI was（0.61±0.15），and PPI was （0.44±0.06）. Spearman correlation analysis showed that AASI was negatively correlated with the average diastolic blood pressure（r = 0.157，P < 0.05）. BaPWV，PPI，mean arterial blood pressure and mean systolic blood pressure was positively correlated with AASI （r = 0.685，0.701，0.648，0.701，P < 0.01）. AASI，baPWV and PPI had higher correlation coefficient．Conclusion AASI can reflect the extent of atherosclerosis，and BaPWV and PPI may increase with the increase of AASI.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the clinical effect of laparoscopic min-cholecystolithotomy on the gastrointestinal function recovery of patients with gallbladder stone. Methods 372 patients with gallbladder stone were enrolled in this study. 186 patients in observation group were treated by min-cholecystolithotomy，while 186 patients in control group were treated by laparoscopic cholecystectomy. The operation time，intraoperative bleeding volume，postoperative hospital stay， diet recovery time，gastrointestinal function and postoperative follow-up were compared. Results The intraoperative bleeding volume and diet recovery time in observation group were significantly less or shorter than those in control group（P＜0.05）；the time of intestinal sound recovery，first exhaust and defecation of observation group were significantly shorter than those of control group（P＜0.05）. The incidence of gastrointestinal adverse reactions in observation group was significantly reduced compared with control group （P＜0.05）. The incidence of abdominal distension，diarrhea，bile duct injury and choledocholithiasis was 4.30% in observation group，which was significantly lower than that in control group（P＜0.05）. Conclusions Laparoscopic min-cholecystolithotomy has such advantages as less blood loss，shorter diet recovery time， faster gastrointestinal function recovery and lower incidence of complications， and it has clinical application value.
［Abstract］Objective To investigate the clinical effect of laparoscopic min-cholecystolithotomy on the gastrointestinal function recovery of patients with gallbladder stone. Methods 372 patients with gallbladder stone were enrolled in this study. 186 patients in observation group were treated by min-cholecystolithotomy，while 186 patients in control group were treated by laparoscopic cholecystectomy. The operation time，intraoperative bleeding volume，postoperative hospital stay， diet recovery time，gastrointestinal function and postoperative follow-up were compared. Results The intraoperative bleeding volume and diet recovery time in observation group were significantly less or shorter than those in control group（P＜0.05）；the time of intestinal sound recovery，first exhaust and defecation of observation group were significantly shorter than those of control group（P＜0.05）. The incidence of gastrointestinal adverse reactions in observation group was significantly reduced compared with control group （P＜0.05）. The incidence of abdominal distension，diarrhea，bile duct injury and choledocholithiasis was 4.30% in observation group，which was significantly lower than that in control group（P＜0.05）. Conclusions Laparoscopic min-cholecystolithotomy has such advantages as less blood loss，shorter diet recovery time， faster gastrointestinal function recovery and lower incidence of complications， and it has clinical application value.
2016, 37(02)
Abstract:
［Abstract］Objective To learn the influencing factors of the time of using antibiotics for treating bacterial ventilator associated pneumonia．Methods We selected the patients with bacterial ventilator associated pneumoniain who admitted in ICU from January 2011 to December 2014 . Then we investigated the possible factors influencing the time of using antibiotics，such as demographic characteristics，APECHII score，the plan of treatment , the situation of Prevention and control，etc. Results The appearance of multiple drug-resistant bacteria, positive sputum culture，higher score of APECHII and tracheotomy extended the time of using antibiotics, while using the antibiotics with allicin shortened the time of using antibiotics. Tracheotomy was the most influencing factors of the time of using the antibiotics，while APECHII score was the less influencing factors. Conclusion Rational use of antibiotics and combined antibiotics with allicin is beneficial to treat the bacterial ventilator associated pneumonia, and improve the level of critically patients.
［Abstract］Objective To learn the influencing factors of the time of using antibiotics for treating bacterial ventilator associated pneumonia．Methods We selected the patients with bacterial ventilator associated pneumoniain who admitted in ICU from January 2011 to December 2014 . Then we investigated the possible factors influencing the time of using antibiotics，such as demographic characteristics，APECHII score，the plan of treatment , the situation of Prevention and control，etc. Results The appearance of multiple drug-resistant bacteria, positive sputum culture，higher score of APECHII and tracheotomy extended the time of using antibiotics, while using the antibiotics with allicin shortened the time of using antibiotics. Tracheotomy was the most influencing factors of the time of using the antibiotics，while APECHII score was the less influencing factors. Conclusion Rational use of antibiotics and combined antibiotics with allicin is beneficial to treat the bacterial ventilator associated pneumonia, and improve the level of critically patients.
2016, 37(02)
Abstract:
［Abstract］Objective To evaluate the clinical value of T lymphocyte subsets analysis in bronchoalveolar lavage fluid （BALF） and peripheral blood （PB） in patients with pulmonary tuberculosis. Methods Forty-seven patients with pulmonary tuberculosis （observation group） and 21 normal persons （control group） were enrolled in this study. T lymphocyte subsets in BALF and PB of patients were detected by flow cytometry （FCM）， and the differences were compared. Results The CD4 and CD4/CD8 ratios in BALF and PB of observation group were significantly lower than control group （P＜0.05）， and CD8 in observation group was significantly higher in BALF than in PB （P＜0.05）. After 2 months' treatments， the CD4 and CD4/CD8 ratios in BALF and PB of observation group were significantly increase，and the CD8 in BALF was reduced （P＜0.05）. T lymphocyte subsets in BALF showed significantly higher clinical value in diagnosis of pulmonary tuberculosis than that in PB （P＜0.05）， after ROC curve analysis. Conclusion Analysis of T lymphocyte subsets in BALF and PB is helpful for clinic diagnosis and observation of patients with pulmonary tuberculosis.
［Abstract］Objective To evaluate the clinical value of T lymphocyte subsets analysis in bronchoalveolar lavage fluid （BALF） and peripheral blood （PB） in patients with pulmonary tuberculosis. Methods Forty-seven patients with pulmonary tuberculosis （observation group） and 21 normal persons （control group） were enrolled in this study. T lymphocyte subsets in BALF and PB of patients were detected by flow cytometry （FCM）， and the differences were compared. Results The CD4 and CD4/CD8 ratios in BALF and PB of observation group were significantly lower than control group （P＜0.05）， and CD8 in observation group was significantly higher in BALF than in PB （P＜0.05）. After 2 months' treatments， the CD4 and CD4/CD8 ratios in BALF and PB of observation group were significantly increase，and the CD8 in BALF was reduced （P＜0.05）. T lymphocyte subsets in BALF showed significantly higher clinical value in diagnosis of pulmonary tuberculosis than that in PB （P＜0.05）， after ROC curve analysis. Conclusion Analysis of T lymphocyte subsets in BALF and PB is helpful for clinic diagnosis and observation of patients with pulmonary tuberculosis.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the clinical value of ultra-selective renal artery coil and coil + gelatin sponge embolization for severe renal hemorrhage after percutaneous nephrolithotomy lithotripsy（PCNL）. Methods We retrospectively analyze the data of 51 patients with severe renal hemorrhage after percutaneous nephrolithotomy lithotripsy who received simple coil and coil + gelatin sponge superselective renal artery embolization from March 2013 to March 2015 in the Interventional Chamber of the Second Affiliated Hospital of Kunming Medical University. The hemostatic effect，the incidence of complications and embolism precautions were analyzed．Results Simple coil embolization was used for 39 patients and spring ring + gelatin sponge embolization was used for 12 patients, and 49 cases of thrombosis were successful（a success rate of 96%），gross hematuria disappeared 1 to 7 days after embolization and microscopic hematuria disappeared and hemoglobin levels increased steadily 3 to 14 days after embolization. There were no serious complications, and no significant changes in blood pressure during one month to one year follow-up. Conclusion Superselective coil embolization of renal artery is a permanent embolization, and is a safe and effective method for severe renal hemorrhage after PCNL.
［Abstract］Objective To investigate the clinical value of ultra-selective renal artery coil and coil + gelatin sponge embolization for severe renal hemorrhage after percutaneous nephrolithotomy lithotripsy（PCNL）. Methods We retrospectively analyze the data of 51 patients with severe renal hemorrhage after percutaneous nephrolithotomy lithotripsy who received simple coil and coil + gelatin sponge superselective renal artery embolization from March 2013 to March 2015 in the Interventional Chamber of the Second Affiliated Hospital of Kunming Medical University. The hemostatic effect，the incidence of complications and embolism precautions were analyzed．Results Simple coil embolization was used for 39 patients and spring ring + gelatin sponge embolization was used for 12 patients, and 49 cases of thrombosis were successful（a success rate of 96%），gross hematuria disappeared 1 to 7 days after embolization and microscopic hematuria disappeared and hemoglobin levels increased steadily 3 to 14 days after embolization. There were no serious complications, and no significant changes in blood pressure during one month to one year follow-up. Conclusion Superselective coil embolization of renal artery is a permanent embolization, and is a safe and effective method for severe renal hemorrhage after PCNL.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the effects of TB drugs combined with rifapentine on the immune function， inflammatory factors，VEGF and MMP-9 of patients with pulmonary tuberculosis. Methods Sixty cases of tuberculosis patients were randomly divided into control group（n = 30） and observation group （n = 30）. The control group was given rifapentine，while the treatment group was given tuberculosis pill treatment based on rifapentine. The immune function， inflammatory factors，VEGF and MMP-9 levels of patients before and six months after treatment between the two groups. Results After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the two groups were increased significantly（P＜0.05）. After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the observation group were significantly higher than those in the control group（P＜0.05）. Compared with before treatment， after treatment INF-γ levels were significantly increased（P＜0.05）， IL-4， CRP， TNF-α levels were significantly lower （P＜0.05）. Compared to the control group after treatment and observation Group INF-γ levels were significantly higher （P＜0.05）， while IL-4， CRP， TNF-α levels lower（P＜0.05）. Compared with before treatment， the serum MMP-9， VEGF levels were significantly lower after treatment （P＜0.05）. Compared with the control group， the serum MMP-9， VEGF levels of patients in the observation group were significantly lower after treatment（P＜0.05）. Conclusions Tuberculosis drug combined with rifapentine can significantly improve the immune function of TB patients， reduce inflammation， reduce VEGF and MMP-9 levels， so as to effectively control the disease， has important significance， and is worthy of further application.
［Abstract］Objective To investigate the effects of TB drugs combined with rifapentine on the immune function， inflammatory factors，VEGF and MMP-9 of patients with pulmonary tuberculosis. Methods Sixty cases of tuberculosis patients were randomly divided into control group（n = 30） and observation group （n = 30）. The control group was given rifapentine，while the treatment group was given tuberculosis pill treatment based on rifapentine. The immune function， inflammatory factors，VEGF and MMP-9 levels of patients before and six months after treatment between the two groups. Results After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the two groups were increased significantly（P＜0.05）. After treatment， the levels of CD3+， CD4+ and CD4/CD8 of patients in the observation group were significantly higher than those in the control group（P＜0.05）. Compared with before treatment， after treatment INF-γ levels were significantly increased（P＜0.05）， IL-4， CRP， TNF-α levels were significantly lower （P＜0.05）. Compared to the control group after treatment and observation Group INF-γ levels were significantly higher （P＜0.05）， while IL-4， CRP， TNF-α levels lower（P＜0.05）. Compared with before treatment， the serum MMP-9， VEGF levels were significantly lower after treatment （P＜0.05）. Compared with the control group， the serum MMP-9， VEGF levels of patients in the observation group were significantly lower after treatment（P＜0.05）. Conclusions Tuberculosis drug combined with rifapentine can significantly improve the immune function of TB patients， reduce inflammation， reduce VEGF and MMP-9 levels， so as to effectively control the disease， has important significance， and is worthy of further application.
2016, 37(02)
Abstract:
［Abstract］Objective To observe the efficacy and safety of fusidic acid cream and halometasone cream in the treatment of psoriasis vulgaris. Methods Fifty-four patients with psoriasis vulgaris were enrolled in this study and were divided into observation group and control group. 26 patients in observation group were treated with halometasone cream, 28 patients in control group were treated with fusidic acid cream combined with halometasone cream. The psoriasis area and severity index（PASI）and abverse events of treatment were recorded. At the same time，34 normal people taking physical examination were selected as health group，the infections of pathogenic microorganism were compared between psoriasis vulgaris patients and normal people. Results The pathogenic infection rate of patients with psoriasis vulgaris was 72.22%, the infection rate was 75.00% in observation group and 69.23% in control group. The infection rate in health group was 38.24%，the difference in the pathogenic infection rate was statistically significant between paitents with psoriasis vulgaris and normal people（P＜0.05）. After treatment, the rate of negative infections was 95.24% in observation group and 72.22% in control group, there was significant difference between two groups（P＜0.05）. The PASI scores and VAS scores of observation group were significantly lower than those of control group（P＜0.05）. The total effective rate of treatment was 71.43% in observation group and 34.62% in control group，the difference was statistically significant（P＜0.05）. There was no significant difference in rate of adverse events between observation group and control group（P＞0.05）. Conclusion The pathogenic infection is closely correlated with psoriasis vulgaris，fusidic acid cream combined with halometasone cream has good efficacy and safety in treatment of psoriasis vulgaris and worth of popularization and application.
［Abstract］Objective To observe the efficacy and safety of fusidic acid cream and halometasone cream in the treatment of psoriasis vulgaris. Methods Fifty-four patients with psoriasis vulgaris were enrolled in this study and were divided into observation group and control group. 26 patients in observation group were treated with halometasone cream, 28 patients in control group were treated with fusidic acid cream combined with halometasone cream. The psoriasis area and severity index（PASI）and abverse events of treatment were recorded. At the same time，34 normal people taking physical examination were selected as health group，the infections of pathogenic microorganism were compared between psoriasis vulgaris patients and normal people. Results The pathogenic infection rate of patients with psoriasis vulgaris was 72.22%, the infection rate was 75.00% in observation group and 69.23% in control group. The infection rate in health group was 38.24%，the difference in the pathogenic infection rate was statistically significant between paitents with psoriasis vulgaris and normal people（P＜0.05）. After treatment, the rate of negative infections was 95.24% in observation group and 72.22% in control group, there was significant difference between two groups（P＜0.05）. The PASI scores and VAS scores of observation group were significantly lower than those of control group（P＜0.05）. The total effective rate of treatment was 71.43% in observation group and 34.62% in control group，the difference was statistically significant（P＜0.05）. There was no significant difference in rate of adverse events between observation group and control group（P＞0.05）. Conclusion The pathogenic infection is closely correlated with psoriasis vulgaris，fusidic acid cream combined with halometasone cream has good efficacy and safety in treatment of psoriasis vulgaris and worth of popularization and application.
2016, 37(02)
Abstract:
［Abstract］Objective To observe the difference between proximal femoral nail anti-rotation （PFNA） Internal Fixation and sliding dynamic hip screw（DHS）in the treatment of osteoporotic Intertrochanteric Fractures. Methods The data of 80 patients with osteoporotic intertrochanteric fracture in our department （from November 2012 to November 2013） were retrospectively analyzed. By using the random parallel method，we divided 80 clinic patients into two groups: the treatment group（PFNA group）and the control group. Patients in the two groups were given anti-osteoporosis treatment， patients in the control group were given DHS internal fixation， patients in the PFNA group were given PFNA internal fixation. Then we compared the general surgery conditions， postoperative Harris scores and the clinical efficacy between the two groups．Results Compared with the control group， the PFNA group was better in the operation time，the length of incision， amount of bleeding during operation， average hospital day and Harris grade. The differences were statistically significant（P＜0.05）. Conclusion On the basis of anti-osteoporosis tveatment，PFNA internal fixation can thus be the first choice in the femoral intertrochanteric fracture operation.
［Abstract］Objective To observe the difference between proximal femoral nail anti-rotation （PFNA） Internal Fixation and sliding dynamic hip screw（DHS）in the treatment of osteoporotic Intertrochanteric Fractures. Methods The data of 80 patients with osteoporotic intertrochanteric fracture in our department （from November 2012 to November 2013） were retrospectively analyzed. By using the random parallel method，we divided 80 clinic patients into two groups: the treatment group（PFNA group）and the control group. Patients in the two groups were given anti-osteoporosis treatment， patients in the control group were given DHS internal fixation， patients in the PFNA group were given PFNA internal fixation. Then we compared the general surgery conditions， postoperative Harris scores and the clinical efficacy between the two groups．Results Compared with the control group， the PFNA group was better in the operation time，the length of incision， amount of bleeding during operation， average hospital day and Harris grade. The differences were statistically significant（P＜0.05）. Conclusion On the basis of anti-osteoporosis tveatment，PFNA internal fixation can thus be the first choice in the femoral intertrochanteric fracture operation.
2016, 37(02)
Abstract:
［Abstract］Objective To analyze the clinical effect of endobutton system reconstituting coracoclavicular ligament in treatment of upper type Rockwood III acromioclavicular joint dislocation. Methods We retrospectively analyzed the data of 22 patients with Rockwood III-VI acromio+J65clavicular joint dislocation treated with endobutton system reconstituting coracoclavicular ligament from January 2012 to June 2014， including 7 cases of Rockwood type III，10 cases of Rockwood IV， 3 cases of Rockwood V and 2 cases of Rockwood 2. The operation time， postoperative shoulder joint activity， X-ray and postoperative complications were observed. The shoulder function on 3 months and 6 months after operation was evaluated by Constant-Murley scores. Results All the 22 patients with different classification of acromioclavicular joint dislocation were followed up， for 6 to 18 months， with an average of 12 months， the operation time was 45-70 min， with an average of 55 min， and no complications such as plate fracture， emergence， dislocation， shoulder peak impact， and postoperative pain occurred. The Constant-Murley score of shoulder function 3 moths and 6 months after operation was （90.06±3.7） and（95.12±1.6）， respectively. Conclusion Endobutton system reconstituting coracoclavicular ligament for treatment of acromioclavicular joint dislocation has good curative effect，and has the advantages of simple operation，less complications，and satisfactory recovery of shoulder joint function，is an ideal elastic fixed way for biological stability recovery of the acromioclavicular joint dislocation.
［Abstract］Objective To analyze the clinical effect of endobutton system reconstituting coracoclavicular ligament in treatment of upper type Rockwood III acromioclavicular joint dislocation. Methods We retrospectively analyzed the data of 22 patients with Rockwood III-VI acromio+J65clavicular joint dislocation treated with endobutton system reconstituting coracoclavicular ligament from January 2012 to June 2014， including 7 cases of Rockwood type III，10 cases of Rockwood IV， 3 cases of Rockwood V and 2 cases of Rockwood 2. The operation time， postoperative shoulder joint activity， X-ray and postoperative complications were observed. The shoulder function on 3 months and 6 months after operation was evaluated by Constant-Murley scores. Results All the 22 patients with different classification of acromioclavicular joint dislocation were followed up， for 6 to 18 months， with an average of 12 months， the operation time was 45-70 min， with an average of 55 min， and no complications such as plate fracture， emergence， dislocation， shoulder peak impact， and postoperative pain occurred. The Constant-Murley score of shoulder function 3 moths and 6 months after operation was （90.06±3.7） and（95.12±1.6）， respectively. Conclusion Endobutton system reconstituting coracoclavicular ligament for treatment of acromioclavicular joint dislocation has good curative effect，and has the advantages of simple operation，less complications，and satisfactory recovery of shoulder joint function，is an ideal elastic fixed way for biological stability recovery of the acromioclavicular joint dislocation.
2016, 37(02)
Abstract:
［Abstract］Objective To study the diagnostic value of plasma fibrinogen （FIB） and D-dimer （DD） for the progressive stroke．Methods The 40 patients with progressive stroke，40 patients with complete stroke， and 80 cases of health examination Hebei Xingtai Third Hospital our hospital from Jan 2014 to May 2015 were respectively regarded as the subjects of A group， B group， and C group，respectively. On 24h，3d，7d and 14d after admission，the plasma fibrinogen and D-dimer levels in all groups were detected and compared，the NIHSS scores in A group and B group were compared after admission. Results Compared with C group， the FIB levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）；compared with B group， the FIB levels on 24h， 3d， 7d were significantly increased in A group（P＜0.05）；the FIB levels reached to the peak on 3d after admission，began to decrease on 7d after admission， and basically returned to normal on 14d after admission in A group. The FIB levels were gradually admitted to the peak on 24h after admission，began to decrease on 3d after admission， and basically returned to normal on 7d after admission in B group. compared with C group，the DD levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）; compared with B group，the DD levels on 24h， 3d，7d were significantly increased in A group （P＜0.05）; the DD levels gradually increased on 24h after admission， were admitted to the peak on 7d after admission， and basically returned to normal on 14d after admission in A group. The DD levels gradually increased on 24h after admission，reached to the peak on 3d after admission， and basically returned to normal on 7d after admission in B group；compared with B group，the NIHSS scores on 3d，7d，14d after admission were significantly reduced in A group（P＜0.05）. Conclusion The monitoring of plasma fibrinogen and D-dimer can help for the early prediction of progressive stroke.
［Abstract］Objective To study the diagnostic value of plasma fibrinogen （FIB） and D-dimer （DD） for the progressive stroke．Methods The 40 patients with progressive stroke，40 patients with complete stroke， and 80 cases of health examination Hebei Xingtai Third Hospital our hospital from Jan 2014 to May 2015 were respectively regarded as the subjects of A group， B group， and C group，respectively. On 24h，3d，7d and 14d after admission，the plasma fibrinogen and D-dimer levels in all groups were detected and compared，the NIHSS scores in A group and B group were compared after admission. Results Compared with C group， the FIB levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）；compared with B group， the FIB levels on 24h， 3d， 7d were significantly increased in A group（P＜0.05）；the FIB levels reached to the peak on 3d after admission，began to decrease on 7d after admission， and basically returned to normal on 14d after admission in A group. The FIB levels were gradually admitted to the peak on 24h after admission，began to decrease on 3d after admission， and basically returned to normal on 7d after admission in B group. compared with C group，the DD levels were significantly increased on 24h， 3d， 7d after admission in A group and the FIB levels were obviously increased on 24h， 3d after admission in B group（P＜0.05）; compared with B group，the DD levels on 24h， 3d，7d were significantly increased in A group （P＜0.05）; the DD levels gradually increased on 24h after admission， were admitted to the peak on 7d after admission， and basically returned to normal on 14d after admission in A group. The DD levels gradually increased on 24h after admission，reached to the peak on 3d after admission， and basically returned to normal on 7d after admission in B group；compared with B group，the NIHSS scores on 3d，7d，14d after admission were significantly reduced in A group（P＜0.05）. Conclusion The monitoring of plasma fibrinogen and D-dimer can help for the early prediction of progressive stroke.
2016, 37(02)
Abstract:
［Abstract］Objective To study the efficacy and safety of alpha lipoic acid combined with methycobal for patients with type-2 diabetes combined with diabetic peripheral neuropathy．Methods The 80 patients with type-2 diabetes combined with diabetic peripheral neuropathy in our hospital during the period from Feb 2012 to Feb 2014 were randomized into the control group（methycobal）and the observation group （methycobal combined with alpha lipoic acid ），40 patients per group．The clinical efficacy，nerve conduction velocity and symptom TSS scores，pain VAS scores on pre- and post-treatment in two groups were compared． Results Compared with the control group，the total effective rate was significantly increased in the observation group with statistical difference（P＜0.05）；compared with the control group，the movement and sensory nerve conduction velocities were significantly increased on post-treatment in the observation group with statistical difference （P＜0.05）；compared with the control group，the TSS scores and VAS scores were obviously decreased on post-treatment in the observation group with statistical difference（P＜0.05）．There were no obvious adverse reactions during the treatment period．Conclusion The treatment of alpha lipoic acid combined with methycobal for patients with type-2 diabetes combined with diabetic peripheral neuropathy has the characteristics such as significant efficacy and high safety，can improve the peripheral neuropathy symptoms，and is worthy of clinical promotion．
［Abstract］Objective To study the efficacy and safety of alpha lipoic acid combined with methycobal for patients with type-2 diabetes combined with diabetic peripheral neuropathy．Methods The 80 patients with type-2 diabetes combined with diabetic peripheral neuropathy in our hospital during the period from Feb 2012 to Feb 2014 were randomized into the control group（methycobal）and the observation group （methycobal combined with alpha lipoic acid ），40 patients per group．The clinical efficacy，nerve conduction velocity and symptom TSS scores，pain VAS scores on pre- and post-treatment in two groups were compared． Results Compared with the control group，the total effective rate was significantly increased in the observation group with statistical difference（P＜0.05）；compared with the control group，the movement and sensory nerve conduction velocities were significantly increased on post-treatment in the observation group with statistical difference （P＜0.05）；compared with the control group，the TSS scores and VAS scores were obviously decreased on post-treatment in the observation group with statistical difference（P＜0.05）．There were no obvious adverse reactions during the treatment period．Conclusion The treatment of alpha lipoic acid combined with methycobal for patients with type-2 diabetes combined with diabetic peripheral neuropathy has the characteristics such as significant efficacy and high safety，can improve the peripheral neuropathy symptoms，and is worthy of clinical promotion．
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the status of the bone mineral density（BMD）of children in child health service clinic，to provide reference for the proper period and gender for prevention of the defection of insufficient BMD. Methods Form march 2014 to may 2015 ，bone mineral density of 2519 healthy children in Kunming children's hospital was tested by using sunlight Moistens Tm-Tooo p type of quantitative ultrasound bone density doctor. The BMD values were analyzed according to the age and gender groups. Results（1）SOS gradually increased with the age（P＜0.05）. （2）The defection rate of insufficient BMD was higher among girls than among boys. （3）The critical period of insufficient BMD was the group of 0 to 6 months，the second was the group of 7 to12 months. Conclusions（1）Children less than 1 year of age is the main crowd prevention bone deficiences；（2）Prevention of bone deficiences need early intervention,especially in the month of birth 6.
［Abstract］Objective To investigate the status of the bone mineral density（BMD）of children in child health service clinic，to provide reference for the proper period and gender for prevention of the defection of insufficient BMD. Methods Form march 2014 to may 2015 ，bone mineral density of 2519 healthy children in Kunming children's hospital was tested by using sunlight Moistens Tm-Tooo p type of quantitative ultrasound bone density doctor. The BMD values were analyzed according to the age and gender groups. Results（1）SOS gradually increased with the age（P＜0.05）. （2）The defection rate of insufficient BMD was higher among girls than among boys. （3）The critical period of insufficient BMD was the group of 0 to 6 months，the second was the group of 7 to12 months. Conclusions（1）Children less than 1 year of age is the main crowd prevention bone deficiences；（2）Prevention of bone deficiences need early intervention,especially in the month of birth 6.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the effect of hysteroscopy and laparoscopy in the diagnosis and treatment of previous cesarean scar defect．Methods We retrospectively analyzed the data of 21 patients of previous cesarean scar defect from January 2010 to October 2014，in the Second people's Hospital of Yunnan Province. All patients were examined by hysteroscopy. 12 cases of patients with no fertility requirements were treated by electric cutting and plastic surgery with hysteroscopy. 9 cases of patients with fertility requirements were treated by hysteroscopy combined laparoscopic repair operation. Results The 21 patients were diagnosed by hysteroscopy. Among them，12 patients were treated with electric cutting by hysteroscopy ,the operation time was 25~45min.The average of the operation time was 35±10 min，.The blood loss was 2~10 ml. The average of the blood loss was6±4 ml. Among them，9 patients were treated with hysteroscopy combined laparoscopic，the operation time was 90~165min.The average of the operation time was 127.5±37.5 min.The blood loss was 30～80 mL.The average of the blood loss was 55±25 mL. With postoperative follow-up office visit of 6 months，the postoperative 1 menstrual period of 21 patients recovered back to normal，and all were in the normal range in a half years. After 6 months，recurrence were found in 3 cases with simple hysteroscopic treatment，and no recurrence in the patients treated with hysteroscopycombined laparoscopic treatment. Conclusions Hysteroscopy examination is expected to become the gold standard of examination of the previous cesarean scar defect. Two kinds of operation can effectively relieve symptoms in the short term，and each has advantages. Electrotomy with hysteroscope is convenient in operation，short operation time and less intraoperative bleeding. Repair surgery with hysteroscopy combined laparoscopy has obvious curative effect and low rate of recurrence. The two methods are worthy to be popularized in clinic. But the long-term effect needs to be further observed.
［Abstract］Objective To investigate the effect of hysteroscopy and laparoscopy in the diagnosis and treatment of previous cesarean scar defect．Methods We retrospectively analyzed the data of 21 patients of previous cesarean scar defect from January 2010 to October 2014，in the Second people's Hospital of Yunnan Province. All patients were examined by hysteroscopy. 12 cases of patients with no fertility requirements were treated by electric cutting and plastic surgery with hysteroscopy. 9 cases of patients with fertility requirements were treated by hysteroscopy combined laparoscopic repair operation. Results The 21 patients were diagnosed by hysteroscopy. Among them，12 patients were treated with electric cutting by hysteroscopy ,the operation time was 25~45min.The average of the operation time was 35±10 min，.The blood loss was 2~10 ml. The average of the blood loss was6±4 ml. Among them，9 patients were treated with hysteroscopy combined laparoscopic，the operation time was 90~165min.The average of the operation time was 127.5±37.5 min.The blood loss was 30～80 mL.The average of the blood loss was 55±25 mL. With postoperative follow-up office visit of 6 months，the postoperative 1 menstrual period of 21 patients recovered back to normal，and all were in the normal range in a half years. After 6 months，recurrence were found in 3 cases with simple hysteroscopic treatment，and no recurrence in the patients treated with hysteroscopycombined laparoscopic treatment. Conclusions Hysteroscopy examination is expected to become the gold standard of examination of the previous cesarean scar defect. Two kinds of operation can effectively relieve symptoms in the short term，and each has advantages. Electrotomy with hysteroscope is convenient in operation，short operation time and less intraoperative bleeding. Repair surgery with hysteroscopy combined laparoscopy has obvious curative effect and low rate of recurrence. The two methods are worthy to be popularized in clinic. But the long-term effect needs to be further observed.
2016, 37(02)
Abstract:
［Abstract］The separation of sperm cells from mixtures is the key and difficult point of detecting sexual crime cases, a variety of common separation methods will be summarized，and their advantages and disadvantages will be analysed，then we will summarize research advances of separation methods of sperm cells from mixtures．
［Abstract］The separation of sperm cells from mixtures is the key and difficult point of detecting sexual crime cases, a variety of common separation methods will be summarized，and their advantages and disadvantages will be analysed，then we will summarize research advances of separation methods of sperm cells from mixtures．
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the application of personalized care with health education in prevention and control nursing of children with hand， foot and mouth disease. Methods Sixty cases of foot and mouth disease admitted in our hospital from June 2012 to January 2015 were randomly divided into two groups: observation group and control group. The children patients in the control group were given conventional treatment， while the patients in the observation group received personalized care with health education based on the conventional treatment， then the therapeutic effect was compared between two groups. Results The difference in the therapeutic effect was statistically significant between the two groups（P＜0.05）， the effective rate of the observation group was 96.67%， and the cure rate was 86.67%， significantly higher than 76.67%， 43.33%， the differences were statistically significant（P＜0.05）. The healing time and rash subsided time of the observation group were （5.67 ± 2.38） d，（3.12 ± 0.89） d， respectively，shorter than the control group（11.23 ± 2.67） d，（5.67 ± 0.99） d， the differences were statistically significant（ P＜0.05）.Conclusion Personalized care with the health education in treatment of children with hand， foot and mouth disease plays an important role in shortening the time to cure and rash disappearing.
［Abstract］Objective To investigate the application of personalized care with health education in prevention and control nursing of children with hand， foot and mouth disease. Methods Sixty cases of foot and mouth disease admitted in our hospital from June 2012 to January 2015 were randomly divided into two groups: observation group and control group. The children patients in the control group were given conventional treatment， while the patients in the observation group received personalized care with health education based on the conventional treatment， then the therapeutic effect was compared between two groups. Results The difference in the therapeutic effect was statistically significant between the two groups（P＜0.05）， the effective rate of the observation group was 96.67%， and the cure rate was 86.67%， significantly higher than 76.67%， 43.33%， the differences were statistically significant（P＜0.05）. The healing time and rash subsided time of the observation group were （5.67 ± 2.38） d，（3.12 ± 0.89） d， respectively，shorter than the control group（11.23 ± 2.67） d，（5.67 ± 0.99） d， the differences were statistically significant（ P＜0.05）.Conclusion Personalized care with the health education in treatment of children with hand， foot and mouth disease plays an important role in shortening the time to cure and rash disappearing.
2016, 37(02)
Abstract:
［Abstract］Objective To investigate the related nursing measures of thrombolytic and anticoagulant therapy in acute pulmonary embolism，and to observe its effect. Methods Forty-eight patients with acute pulmonary embolism treated in the hospital in 2013 January -2014 year in July were enrolled in the study,and all patients were treated by thrombolytic and anticoagulant therapy，they were randomly divided into two groups with 24 cases in each group，the control group received routine nursing care，the observation group adopted psychological nursing before thrombolysis，oxygen and diet nursing care，medication nursing and the implementation of the puncture site nursing of thrombolytic therapy，the implementation of prevention of complications and nursing after thrombolysis，to compare curative effect.between two groups．Results The total effective rate of observation group was 20 cases（83.3%）and was significantly higher than the control group of 13 cases（54.2%），P＜0.05. The spirit，diet，sleep and mental status scores were （4.58 + 0.28），（4.35 + 0.43），（4.41 + 0.22），（4.47 + 0.22）in the observation group and were higher than in the control group，P＜0.05. The observation group ' anxiety level was significantly better than the control group，P＜0.05. Conclusion During thrombolytic and anticoagulant therapy for acute pulmonary embolism treatment，We should pay aftention to the nursing measures，standardize the implementation of psychological nursing and medication nursing has an important significance to alleviate the condition，so it has the important clinical value.
［Abstract］Objective To investigate the related nursing measures of thrombolytic and anticoagulant therapy in acute pulmonary embolism，and to observe its effect. Methods Forty-eight patients with acute pulmonary embolism treated in the hospital in 2013 January -2014 year in July were enrolled in the study,and all patients were treated by thrombolytic and anticoagulant therapy，they were randomly divided into two groups with 24 cases in each group，the control group received routine nursing care，the observation group adopted psychological nursing before thrombolysis，oxygen and diet nursing care，medication nursing and the implementation of the puncture site nursing of thrombolytic therapy，the implementation of prevention of complications and nursing after thrombolysis，to compare curative effect.between two groups．Results The total effective rate of observation group was 20 cases（83.3%）and was significantly higher than the control group of 13 cases（54.2%），P＜0.05. The spirit，diet，sleep and mental status scores were （4.58 + 0.28），（4.35 + 0.43），（4.41 + 0.22），（4.47 + 0.22）in the observation group and were higher than in the control group，P＜0.05. The observation group ' anxiety level was significantly better than the control group，P＜0.05. Conclusion During thrombolytic and anticoagulant therapy for acute pulmonary embolism treatment，We should pay aftention to the nursing measures，standardize the implementation of psychological nursing and medication nursing has an important significance to alleviate the condition，so it has the important clinical value.
