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RSS2018 Vol. 39, No. 07
2018, 39(07): 1-4.
Abstract:
Objective To investigate the effects of rutin on the proliferation of keloid fibroblasts.Methods Keloid tissue was used to induce fibroblasts and 5 concentration gradients of rutin were set: 0, 50, 100, 200 and300 μmol/L.The effects of rutin on the proliferation of keloid-derived fibroblasts were observed by CCK-8 and Ed U assays.Western blot was applied to detect the effect of rutin on TGF-β/Smad signaling pathway.Re s ults Rutin inhibited the proliferation of keloid-derived fibroblasts in a dose-dependent manner when concentration gradient was lower than 300 μmol/L (P<0.01) . The result of Ed U assay showed that the synthesis of DNA in keloid-derived fibroblasts was inhibited by rutin. At the concentration gradient of 50, 100 and 200 μmol/L, rutin could significantly inhibit the expression of TGF-β1 and Smad2 in keloid-derived fibroblasts.Conclus ion Rutin inhibits the proliferation of keloid-derived fibroblasts by regulating TGF-β/Smad signaling pathway.
Objective To investigate the effects of rutin on the proliferation of keloid fibroblasts.Methods Keloid tissue was used to induce fibroblasts and 5 concentration gradients of rutin were set: 0, 50, 100, 200 and300 μmol/L.The effects of rutin on the proliferation of keloid-derived fibroblasts were observed by CCK-8 and Ed U assays.Western blot was applied to detect the effect of rutin on TGF-β/Smad signaling pathway.Re s ults Rutin inhibited the proliferation of keloid-derived fibroblasts in a dose-dependent manner when concentration gradient was lower than 300 μmol/L (P<0.01) . The result of Ed U assay showed that the synthesis of DNA in keloid-derived fibroblasts was inhibited by rutin. At the concentration gradient of 50, 100 and 200 μmol/L, rutin could significantly inhibit the expression of TGF-β1 and Smad2 in keloid-derived fibroblasts.Conclus ion Rutin inhibits the proliferation of keloid-derived fibroblasts by regulating TGF-β/Smad signaling pathway.
2018, 39(07): 5-9.
Abstract:
Objective To study the effects of methamphetamine on the expression of 5-Hydroxytryptophan (5-HT) , interleukin-6 (IL-6) and nuclear fact kappa B (NF-κB) in rats' hippocampus. Methods Thirty SD rats were randomly allocated into normal control group, METH1 d group, METH3 d group, METH5 d group and METH7 d group, with 6 rats in each group.Intraperitoneal injections of METH [15 mg/ (kg·time) ] were conducted at9:00 am and 21:00 pm every day.After injection, scoring was performed in combination with observation on their stereotyped behavior. We established different models for rats suffering from 1-day, 3-day, 5-day, and 7-day METH acute poisoning. After 24 hours of the last intraperitoneal injections of METH, hippocampal tissues were isolated.Enzyme linked immunoorbent assay (ELISA) was applied to detect the expression level of 5-HT and IL-6 in rats hippocampus. Western blot was used to detect the expression level of NF-κBp65.Re s ults Compared with the control group, the expression of 5-HT was reduced in different METH groups, and the decrease was statistically significant in METH5 d and METH7 d groups (with P<0.05 and P<0.01 respectively) . Compared with the control group, the expression of IL-6 was increased in different METH groups, and the increase was statistically significant in METH5 d and METH7 d groups (with P<0.05 and P<0.01 respectively) . Compared with the control group, the expression of NF-κB was increased in different groups, and the increase was statistically significant only in METH7 d group (P <0.01) . Conclus ion METH administration could result in a significant reduce of 5-HT expression and increases of IL-6 and NF-κB expressions in rats hippocampus.
Objective To study the effects of methamphetamine on the expression of 5-Hydroxytryptophan (5-HT) , interleukin-6 (IL-6) and nuclear fact kappa B (NF-κB) in rats' hippocampus. Methods Thirty SD rats were randomly allocated into normal control group, METH1 d group, METH3 d group, METH5 d group and METH7 d group, with 6 rats in each group.Intraperitoneal injections of METH [15 mg/ (kg·time) ] were conducted at9:00 am and 21:00 pm every day.After injection, scoring was performed in combination with observation on their stereotyped behavior. We established different models for rats suffering from 1-day, 3-day, 5-day, and 7-day METH acute poisoning. After 24 hours of the last intraperitoneal injections of METH, hippocampal tissues were isolated.Enzyme linked immunoorbent assay (ELISA) was applied to detect the expression level of 5-HT and IL-6 in rats hippocampus. Western blot was used to detect the expression level of NF-κBp65.Re s ults Compared with the control group, the expression of 5-HT was reduced in different METH groups, and the decrease was statistically significant in METH5 d and METH7 d groups (with P<0.05 and P<0.01 respectively) . Compared with the control group, the expression of IL-6 was increased in different METH groups, and the increase was statistically significant in METH5 d and METH7 d groups (with P<0.05 and P<0.01 respectively) . Compared with the control group, the expression of NF-κB was increased in different groups, and the increase was statistically significant only in METH7 d group (P <0.01) . Conclus ion METH administration could result in a significant reduce of 5-HT expression and increases of IL-6 and NF-κB expressions in rats hippocampus.
2018, 39(07): 10-14.
Abstract:
Objective To investigate the effect of ginsenoside Rg3 on mouse neural stem cells (NSCs) proliferation in vitro.Me thods Fetal cortices of embryonic 14 d (E14) C57 BL/6 mouse were isolated for culturing primary NSCs.After being passaged twice, NSCs specific antibodies, Nestin and Sox2 were identified by immunocyto chemistry staining. CCK-8 assay and Brd U labelling assay were used to measure NSCs proliferation in response to different ginsenoside Rg3 concentrations (20 n M, 50 n M, 250 n M and 500 n M) . Re s ults Primary and passaged NSCs were successfully cultured and almost all the cells were both Nestin and Sox2 positive NSCs, which indicated high purity of NSCs. Brd U labelling assay showed the group of 50 n M Rg3 had the highest relative ratio of Brd U positive percentage, and the difference with other groups was statistically significant (P<0.01) .CCK-8 assay also showed 50 n M Rg3 group had the highest OD value, which was significantly higher than the control group (P<0.01) , 20 n M group (P<0.05) and 500 n M group (P<0.01) , while other groups had no significant difference between each other (P >0.05) . Conclus ion 50 n M ginsenoside Rg3 could significantly promote mouse NSCs proliferation in vitro.
Objective To investigate the effect of ginsenoside Rg3 on mouse neural stem cells (NSCs) proliferation in vitro.Me thods Fetal cortices of embryonic 14 d (E14) C57 BL/6 mouse were isolated for culturing primary NSCs.After being passaged twice, NSCs specific antibodies, Nestin and Sox2 were identified by immunocyto chemistry staining. CCK-8 assay and Brd U labelling assay were used to measure NSCs proliferation in response to different ginsenoside Rg3 concentrations (20 n M, 50 n M, 250 n M and 500 n M) . Re s ults Primary and passaged NSCs were successfully cultured and almost all the cells were both Nestin and Sox2 positive NSCs, which indicated high purity of NSCs. Brd U labelling assay showed the group of 50 n M Rg3 had the highest relative ratio of Brd U positive percentage, and the difference with other groups was statistically significant (P<0.01) .CCK-8 assay also showed 50 n M Rg3 group had the highest OD value, which was significantly higher than the control group (P<0.01) , 20 n M group (P<0.05) and 500 n M group (P<0.01) , while other groups had no significant difference between each other (P >0.05) . Conclus ion 50 n M ginsenoside Rg3 could significantly promote mouse NSCs proliferation in vitro.
2018, 39(07): 15-19.
Abstract:
Objective To assess the diagnostic value of the relative volume of ground glass opacities (GGO) in lungs injury by 320-row CT in paraquat intoxication.Methods A total of 48 healthy rabbits were randomly divided into four groups: one control group and three experimental groups by gavage treating with the concentration of25, 35, 45 mg/kg paraquat and equal dose of physiological saline.320-row CT examination were performed on the1 st, 7 th, 14 th and 28 th day after poisoning. Semi-quantitative analysis of the relative volume of GGO was conducted. One rabbit from each group were randomly sacrificed to obtain the lung tissue for pathological examinations at each time point.Re s ults Compared with the control group, the relative volumes of GGO in the three experimental groups were significantly greater than that in the control group at each time point (P <0.05) .Significant dose-dependence at different drug concentrationsin in the three experimental groups were found througy multiple comparison (P<0.05) . The relative volume of GGO increased with the increasing of drug dose. The lung tissues of poisoned rabbits under light microscope showed different degrees of inflammatory cell infiltration, focal hyperemia, widened alveolar septum, alveolar collapse, and partial alveolar cavity occlusion, and all the above pathological changes worsened with time.Conclus ion 320 row CT determination of relative volume of GGO can better quantify the paraquat-induced lung injury, which can provide an objective basis for clinical evaluation.
Objective To assess the diagnostic value of the relative volume of ground glass opacities (GGO) in lungs injury by 320-row CT in paraquat intoxication.Methods A total of 48 healthy rabbits were randomly divided into four groups: one control group and three experimental groups by gavage treating with the concentration of25, 35, 45 mg/kg paraquat and equal dose of physiological saline.320-row CT examination were performed on the1 st, 7 th, 14 th and 28 th day after poisoning. Semi-quantitative analysis of the relative volume of GGO was conducted. One rabbit from each group were randomly sacrificed to obtain the lung tissue for pathological examinations at each time point.Re s ults Compared with the control group, the relative volumes of GGO in the three experimental groups were significantly greater than that in the control group at each time point (P <0.05) .Significant dose-dependence at different drug concentrationsin in the three experimental groups were found througy multiple comparison (P<0.05) . The relative volume of GGO increased with the increasing of drug dose. The lung tissues of poisoned rabbits under light microscope showed different degrees of inflammatory cell infiltration, focal hyperemia, widened alveolar septum, alveolar collapse, and partial alveolar cavity occlusion, and all the above pathological changes worsened with time.Conclus ion 320 row CT determination of relative volume of GGO can better quantify the paraquat-induced lung injury, which can provide an objective basis for clinical evaluation.
2018, 39(07): 20-26.
Abstract:
Objective To explore the direct and indirect effect of family, friend, culture, and other personal factors on individuals' smoking behaviors.Me thods A total of 977 Han people, Yi people and Lisu people were recruited by multistage systematic sampling. A structured questionnaire and scale were used to collect data by face-to-face interviews. Data were analyzed by chi square test, rank sum test and structural equation model methods.Re s ults People whose family members were smokers ( standardized regression coefficient ( β=0.14) , or whose parents had neutral attitude on smoking (β= 0.11) , or who had smoking friends (β=0.07) , or who had strong willingness to smoke (β= 0.26) , or who had higher acculturation score to other ethnic groups (β=0.05) , or who were elder (β= 0.13) tended to have higher rate of current smoking While people who were females (β=-0.39) , or who belonged to ethnic minority groups (β=-0.08) , or who had higher annual family income (β=-0.06) had lower rate of current smoking. Age and gender not only affected current smoking status directly, but also affected it indirectly via family income, the number of family smoker, parent attitude on smoking, their willingness of smoking and the number of smoking friend.Conclus ion Family, friends, culture, age and gender affect smoking behavior comprehensively. Tobacco control should put more emphasis on crowed strategy and construction of supportive environment.
Objective To explore the direct and indirect effect of family, friend, culture, and other personal factors on individuals' smoking behaviors.Me thods A total of 977 Han people, Yi people and Lisu people were recruited by multistage systematic sampling. A structured questionnaire and scale were used to collect data by face-to-face interviews. Data were analyzed by chi square test, rank sum test and structural equation model methods.Re s ults People whose family members were smokers ( standardized regression coefficient ( β=0.14) , or whose parents had neutral attitude on smoking (β= 0.11) , or who had smoking friends (β=0.07) , or who had strong willingness to smoke (β= 0.26) , or who had higher acculturation score to other ethnic groups (β=0.05) , or who were elder (β= 0.13) tended to have higher rate of current smoking While people who were females (β=-0.39) , or who belonged to ethnic minority groups (β=-0.08) , or who had higher annual family income (β=-0.06) had lower rate of current smoking. Age and gender not only affected current smoking status directly, but also affected it indirectly via family income, the number of family smoker, parent attitude on smoking, their willingness of smoking and the number of smoking friend.Conclus ion Family, friends, culture, age and gender affect smoking behavior comprehensively. Tobacco control should put more emphasis on crowed strategy and construction of supportive environment.
2018, 39(07): 27-32.
Abstract:
Objective To investigate the factors influencing the life quality of prostate cancer patients based on QLQ-C30 and QLQ-PR25. Me thod A total of 115 prostate cancer patients was recruited. QLQ C30 V3.0 (Chinese version) , a scale of core life quality developed by European organization for research and treatment of cancer (EORCT) , and QLQ-PR25, a scale of prostate specific module, were used to assess the life quality of the patients and single factor and multiple linear regression were applied to analyse the influence factors.Re s ults There were significant differences in some life quality scores of the patients with different age, education level, family financial status (P <0.05) , and they were correlated (P <0.05) but with low multiple correlation coefficients. Conclus ion Age, education level, family financial status are the influence factors to the life quality of prostate cancer patients, but the contributions seem to be limited and further studies on other factors are needed.
Objective To investigate the factors influencing the life quality of prostate cancer patients based on QLQ-C30 and QLQ-PR25. Me thod A total of 115 prostate cancer patients was recruited. QLQ C30 V3.0 (Chinese version) , a scale of core life quality developed by European organization for research and treatment of cancer (EORCT) , and QLQ-PR25, a scale of prostate specific module, were used to assess the life quality of the patients and single factor and multiple linear regression were applied to analyse the influence factors.Re s ults There were significant differences in some life quality scores of the patients with different age, education level, family financial status (P <0.05) , and they were correlated (P <0.05) but with low multiple correlation coefficients. Conclus ion Age, education level, family financial status are the influence factors to the life quality of prostate cancer patients, but the contributions seem to be limited and further studies on other factors are needed.
2018, 39(07): 33-36.
Abstract:
Objective To investigate and analyze the physical and mental health status of community residents in Kunming.Me thods Quality of life questionnaire (SF-8 health survey, Chinese version) was used to assess the physical and mental health status of community residents in Kunming.Re s ults Totally 1000 copies of the questionnaire were distributed and 996 copies of valid questionnaires were collected, with an effective rate of99.6%.Community health score was (53.28±5.79) points and mental health score was (53.81±5.99) points.The physiological health status of residents in different age groups was significantly different (P <0.05) , the physiological status of community residents becoming worse with the age.There were significant differences in physiological status of residents with different medical history, marital status and dietary structure (P <0.05) .The differences of physical and mental health status among residents with different physical activities were statistically significant ( P <0.05) .Conclus ion The community residents' physical and mental health status is not optimistic.The community residents with different age, marital status and diet structure have different physical and mental health status.Among them, the physical and mental health status of the elderly is poor.
Objective To investigate and analyze the physical and mental health status of community residents in Kunming.Me thods Quality of life questionnaire (SF-8 health survey, Chinese version) was used to assess the physical and mental health status of community residents in Kunming.Re s ults Totally 1000 copies of the questionnaire were distributed and 996 copies of valid questionnaires were collected, with an effective rate of99.6%.Community health score was (53.28±5.79) points and mental health score was (53.81±5.99) points.The physiological health status of residents in different age groups was significantly different (P <0.05) , the physiological status of community residents becoming worse with the age.There were significant differences in physiological status of residents with different medical history, marital status and dietary structure (P <0.05) .The differences of physical and mental health status among residents with different physical activities were statistically significant ( P <0.05) .Conclus ion The community residents' physical and mental health status is not optimistic.The community residents with different age, marital status and diet structure have different physical and mental health status.Among them, the physical and mental health status of the elderly is poor.
2018, 39(07): 37-40.
Abstract:
Objective To explore the clinical value of ultrasound-guided breast microscopic lesion biopsy in the early diagnosis of breast cancer.Me thods One hundred and twenty women with breast microscopic lesion from June 2016 to June 2017 were recruited. Ultrasonic examination and ultrasound-guided core needle biopsy and operation were performed to observe the sensitivity, specificity and accuracy of the two ultrasound diagnostic methods and to compare the correlation between different ultrasonic signs and the early diagnosis of breast cancer.Re s ults The sensitivity, specificity and accuracy of ultrasound-guided core needle biopsy was significantly better than those of ultrasonic examination (P<0.05) . Significant correlations between the early diagnosis of breast cancer and the ultrasonic signs of rough edge, hypoechoic inhomogeneity and blood flown were found (P <0.05) .Conclus ion The ultrasound-guided breast microscopic lesion biopsy is a safe and accurate method to diagnose early breast cancer, and it is worthy of clinical application.
Objective To explore the clinical value of ultrasound-guided breast microscopic lesion biopsy in the early diagnosis of breast cancer.Me thods One hundred and twenty women with breast microscopic lesion from June 2016 to June 2017 were recruited. Ultrasonic examination and ultrasound-guided core needle biopsy and operation were performed to observe the sensitivity, specificity and accuracy of the two ultrasound diagnostic methods and to compare the correlation between different ultrasonic signs and the early diagnosis of breast cancer.Re s ults The sensitivity, specificity and accuracy of ultrasound-guided core needle biopsy was significantly better than those of ultrasonic examination (P<0.05) . Significant correlations between the early diagnosis of breast cancer and the ultrasonic signs of rough edge, hypoechoic inhomogeneity and blood flown were found (P <0.05) .Conclus ion The ultrasound-guided breast microscopic lesion biopsy is a safe and accurate method to diagnose early breast cancer, and it is worthy of clinical application.
2018, 39(07): 41-46.
Abstract:
Objective To compare the screening effects of TCT, HC2-HR-HPV and colposcopy and to evaluate the value of colposcopy in the screening of high-grade cervical lesions in the women with HIV infection.Me thods A total of 591 HIV-infected women underwent TCT, HC2-HR-HPV testing and colposcopy procedure.Localized biopsy was performed on the patients with positive results in colposcopy.The patients with negative results for the first colposcopy and unsatisfied with colposcopy would undergo colposcopy again only when TCT showed ACS-H, LSIL, HSIL or TCT showed ASC-US with HR-HPV infection, and multiple punch point biopsy and endocervical curettage (ECC) were performed. Results of TCT, HC2-HR-HPV test and the first colposcopy in the diagnosis of high-grade cervical lesions (≥CINII) were compared.Re s ults In the 591 HIV-infected women, 210 patients (35.53%) had HR-HPV infection, 62 patients (10.49%) had CINI, and 46 patients (7.78%) had CINII. The sensitivity, specificity and positive predictive value in the first colposcopy were significantly better than those in TCT and HC2-HR-HPV testing (P<0.05) . Missing rates in the first colposcopy and HC2-HR-HPV testing were similar but were significantly lower than that in TCT testing (P<0.05) . Areas under the ROC curve in the first colposcopy and TCT testing but were significantly larger than that in HC2-HR-HPV testing (P <0.05) .Conclus ions The infection rate of HR-HPV and the incidence of high-grade cervical lesions in HIV-infected women are high. Colposcopy is high in specificity, low in missing rate and with the advantages of low charge, time-saving and immediate diagnosis and treatment, which provides high clinical value in the detection and screening of high-grade cervical lesions in HIV-infected women.
Objective To compare the screening effects of TCT, HC2-HR-HPV and colposcopy and to evaluate the value of colposcopy in the screening of high-grade cervical lesions in the women with HIV infection.Me thods A total of 591 HIV-infected women underwent TCT, HC2-HR-HPV testing and colposcopy procedure.Localized biopsy was performed on the patients with positive results in colposcopy.The patients with negative results for the first colposcopy and unsatisfied with colposcopy would undergo colposcopy again only when TCT showed ACS-H, LSIL, HSIL or TCT showed ASC-US with HR-HPV infection, and multiple punch point biopsy and endocervical curettage (ECC) were performed. Results of TCT, HC2-HR-HPV test and the first colposcopy in the diagnosis of high-grade cervical lesions (≥CINII) were compared.Re s ults In the 591 HIV-infected women, 210 patients (35.53%) had HR-HPV infection, 62 patients (10.49%) had CINI, and 46 patients (7.78%) had CINII. The sensitivity, specificity and positive predictive value in the first colposcopy were significantly better than those in TCT and HC2-HR-HPV testing (P<0.05) . Missing rates in the first colposcopy and HC2-HR-HPV testing were similar but were significantly lower than that in TCT testing (P<0.05) . Areas under the ROC curve in the first colposcopy and TCT testing but were significantly larger than that in HC2-HR-HPV testing (P <0.05) .Conclus ions The infection rate of HR-HPV and the incidence of high-grade cervical lesions in HIV-infected women are high. Colposcopy is high in specificity, low in missing rate and with the advantages of low charge, time-saving and immediate diagnosis and treatment, which provides high clinical value in the detection and screening of high-grade cervical lesions in HIV-infected women.
2018, 39(07): 47-51.
Abstract:
Objective To analyze the correlation between cardiovascular calcification and malnutrition and micro-inflammatory state, and to explore the related risk factors of cardiovascular calcification in patients with maintenance peritoneal dialysis.Methods From January 2016 to December 2017, 81 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) at the Second Affiliated Hospital of Kunming Medical University were enrolled in the study. The related laboratory tests and body measurements were performed in the81 patients. Cardiac Valve Calcification (CVC) was estimated by transthoracic echocardiography and abdomen lateral radiographs to understand the status of abdominal aortic calcification (AAC) . Nutritional status was assessed by modified quantitative subjective global assessment table (MQSGA) , which was divided into normal nutrition (<10 points) , mild to moderate malnutrition (11-20 points) , and severe malnutrition (21-35 points) group. Results Twenty-four patients (29.6%) in the normal group, forty-one patients (50.6%) in the mild to moderate group, and sixteen patients (19.8%) in the severe group were found.The incidence of valve calcification, abdominal aorta calcification and cardiovascular calcification were 45.7%, 24.7%, and 55.6% respectively. Significant difference was found in malnutrition and micro-inflammatory state between the two groups with and without valve calcification. Age (P = 0.006) , dialysis age (P = 0.048) , prealbumin (P = 0.015) , phosphorus (P = 0.007) , calcium-phosphorus product (P = 0.013) and hs-CRP (P = 0.004) were significantly different between valvular and non-valvular calcification group. Conclusion Malnutrition and micro-inflammatory states can be found in most peritoneal dialysis patients.The more severe the malnutrition and micro-inflammatory state are, the higher the incidence of cardiovascular calcification is.Advanced age, years of dialysis, low prealbumin, high phosphorus, high calcium-phosphorus product, and elevated hs-CRP can be the independent risk factor of cardiovascular calcification.
Objective To analyze the correlation between cardiovascular calcification and malnutrition and micro-inflammatory state, and to explore the related risk factors of cardiovascular calcification in patients with maintenance peritoneal dialysis.Methods From January 2016 to December 2017, 81 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) at the Second Affiliated Hospital of Kunming Medical University were enrolled in the study. The related laboratory tests and body measurements were performed in the81 patients. Cardiac Valve Calcification (CVC) was estimated by transthoracic echocardiography and abdomen lateral radiographs to understand the status of abdominal aortic calcification (AAC) . Nutritional status was assessed by modified quantitative subjective global assessment table (MQSGA) , which was divided into normal nutrition (<10 points) , mild to moderate malnutrition (11-20 points) , and severe malnutrition (21-35 points) group. Results Twenty-four patients (29.6%) in the normal group, forty-one patients (50.6%) in the mild to moderate group, and sixteen patients (19.8%) in the severe group were found.The incidence of valve calcification, abdominal aorta calcification and cardiovascular calcification were 45.7%, 24.7%, and 55.6% respectively. Significant difference was found in malnutrition and micro-inflammatory state between the two groups with and without valve calcification. Age (P = 0.006) , dialysis age (P = 0.048) , prealbumin (P = 0.015) , phosphorus (P = 0.007) , calcium-phosphorus product (P = 0.013) and hs-CRP (P = 0.004) were significantly different between valvular and non-valvular calcification group. Conclusion Malnutrition and micro-inflammatory states can be found in most peritoneal dialysis patients.The more severe the malnutrition and micro-inflammatory state are, the higher the incidence of cardiovascular calcification is.Advanced age, years of dialysis, low prealbumin, high phosphorus, high calcium-phosphorus product, and elevated hs-CRP can be the independent risk factor of cardiovascular calcification.
2018, 39(07): 58-60.
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Objective To explore the diagnostic value of 3 D-BRAVO enhanced imaging in cerebral venous sinus thrombosis (CVST) by comparing the results of conventional imaging and 3 D-BRAVO enhanced imaging.Me thods Retrospective analysis was conducted to analyze the imaging results of 29 cases diagnosed with CVST.All the cases were scanned with T1 WI, T2 WI, FLAIR, MRV, conventional enhanced and 3 D-BRAVO enhanced imaging.Re s ults CVST were found in 12 cases with conventional scan and conventional enhanced imaging, 13 cases with MRV and all the 29 cases with 3 D-BRAVO.Conclus ion The technology of 3 D-BRAVO enhanced imaging could provide better detectionresult, which significantly improve early diagnosis of CVST and provide intuitive imaging evidence for clinical treatment and prognosis evaluation.
Objective To explore the diagnostic value of 3 D-BRAVO enhanced imaging in cerebral venous sinus thrombosis (CVST) by comparing the results of conventional imaging and 3 D-BRAVO enhanced imaging.Me thods Retrospective analysis was conducted to analyze the imaging results of 29 cases diagnosed with CVST.All the cases were scanned with T1 WI, T2 WI, FLAIR, MRV, conventional enhanced and 3 D-BRAVO enhanced imaging.Re s ults CVST were found in 12 cases with conventional scan and conventional enhanced imaging, 13 cases with MRV and all the 29 cases with 3 D-BRAVO.Conclus ion The technology of 3 D-BRAVO enhanced imaging could provide better detectionresult, which significantly improve early diagnosis of CVST and provide intuitive imaging evidence for clinical treatment and prognosis evaluation.
2018, 39(07): 61-66.
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Objective To explore the effect of statins on lower airway bacterial colonization (LABC) in elderly patients with stable chronic obstructive pulmonary disease (COPD) of different severity by analyzing the bacteriological changes of LABC in those patients and its relationship with acute exacerbation, inflammatory reaction and lung function impairment.Methods A total of 96 patients with stable COPD were enrolled and quantitative and qualitative bacteriological analysis of patients' sputum and bronchoalveolar lavage fluid (BALF) were performed.According to the test results, patients were divided into four groups: patients with LABC positive receiving statin treatment, patients with LABC positive receiving conventional therapy, patients with LABC negative receiving statin treatment, and patients with LABC negative receiving conventional therapy.The serum levels of IL-6, IL-8, hs-CRP, TNF-α and lung function were examined before and after the experiment.Results There were 40 patients with LABC positive in 96 patients, with bacterial colonization rate of 45.98%.The serum level of IL-6, IL-8, TNF-α and hs-CRP in patients with LABC positive were significantly higher than those in patients with LABC negative (P <0.05) .Lung function in patients with LABC positive was significantly poorer than that in patients with LABC negative (P <0.05) .One-year follow-up showed that the serum levels of IL-6, IL-8, TNF-α and hs-CRP in patients with statin treatment were significantly lower than those in patients with conventional therapy (P<0.05) and better improvements of lung function were observed in patients with statin treatment (P>0.05) .The risk of acute exacerbation in patients with statin treatment was significantly higher than those in patients with conventional treatment (P<0.05) .The bacteria engraftment rate of the patients with LABC positive receiving statin treatment was significantly higher than that in patients with conventional therapy (P<0.05) while it was lower in the patients with LABC negative receiving statin treatment.Conclusion The levels of IL-6, IL-8, TNF-α, hs-CRP in elderly patients with stable COPD and LABC positive are higher than those with LABC negative.Treatment combined with statins helps to inhibit LABC or proliferation, reduce inflammatory reaction and acute exacerbation, delay the decline of lung function, and improve clinical symptoms.
Objective To explore the effect of statins on lower airway bacterial colonization (LABC) in elderly patients with stable chronic obstructive pulmonary disease (COPD) of different severity by analyzing the bacteriological changes of LABC in those patients and its relationship with acute exacerbation, inflammatory reaction and lung function impairment.Methods A total of 96 patients with stable COPD were enrolled and quantitative and qualitative bacteriological analysis of patients' sputum and bronchoalveolar lavage fluid (BALF) were performed.According to the test results, patients were divided into four groups: patients with LABC positive receiving statin treatment, patients with LABC positive receiving conventional therapy, patients with LABC negative receiving statin treatment, and patients with LABC negative receiving conventional therapy.The serum levels of IL-6, IL-8, hs-CRP, TNF-α and lung function were examined before and after the experiment.Results There were 40 patients with LABC positive in 96 patients, with bacterial colonization rate of 45.98%.The serum level of IL-6, IL-8, TNF-α and hs-CRP in patients with LABC positive were significantly higher than those in patients with LABC negative (P <0.05) .Lung function in patients with LABC positive was significantly poorer than that in patients with LABC negative (P <0.05) .One-year follow-up showed that the serum levels of IL-6, IL-8, TNF-α and hs-CRP in patients with statin treatment were significantly lower than those in patients with conventional therapy (P<0.05) and better improvements of lung function were observed in patients with statin treatment (P>0.05) .The risk of acute exacerbation in patients with statin treatment was significantly higher than those in patients with conventional treatment (P<0.05) .The bacteria engraftment rate of the patients with LABC positive receiving statin treatment was significantly higher than that in patients with conventional therapy (P<0.05) while it was lower in the patients with LABC negative receiving statin treatment.Conclusion The levels of IL-6, IL-8, TNF-α, hs-CRP in elderly patients with stable COPD and LABC positive are higher than those with LABC negative.Treatment combined with statins helps to inhibit LABC or proliferation, reduce inflammatory reaction and acute exacerbation, delay the decline of lung function, and improve clinical symptoms.
2018, 39(07): 67-71.
Abstract:
Objective To provide evidence for normative plans of post abortion care (PAC) by collecting data of the contraceptive knowledge of 843 women with unwanted pregnancy. Me thods This study recruited 843 women with unwanted pregnancy from March to September 2016 in Kunming Maternal and Child Health Hospital.Face-to-face interview and questionnaire were applied. Re s ults (1) The score of the contraceptive knowledge was7.23 ±2.81, which was in positive correlation with age and education level (P <0.05) . (2) Repeated induced-abortion rate was 54.59%, mainly in the women of 20 to 40 years old, which was significantly related to the age, education level and residential status (P<0.05) .The younger the woman was, the higher the repeated induced-abortion rate went, so was the education level. Repeated induced-abortion rate of the floating population was significantly higher than that of the non-floating population (P <0.05) . (3) The contraceptive knowledge score of the women who had college educational background, did not give birth and had repeated induced-abortion history was higher than that of the women who first had induced-abortion (P <0.05) . Conclus ion The contraceptive knowledge of the women with unwanted pregnancy is related to the age, education level and residential status. Varied measures should be taken to improve the awareness rate of contraceptive knowledge and effective contraceptive rate and to reduce the occurrence of repeated abortion.
Objective To provide evidence for normative plans of post abortion care (PAC) by collecting data of the contraceptive knowledge of 843 women with unwanted pregnancy. Me thods This study recruited 843 women with unwanted pregnancy from March to September 2016 in Kunming Maternal and Child Health Hospital.Face-to-face interview and questionnaire were applied. Re s ults (1) The score of the contraceptive knowledge was7.23 ±2.81, which was in positive correlation with age and education level (P <0.05) . (2) Repeated induced-abortion rate was 54.59%, mainly in the women of 20 to 40 years old, which was significantly related to the age, education level and residential status (P<0.05) .The younger the woman was, the higher the repeated induced-abortion rate went, so was the education level. Repeated induced-abortion rate of the floating population was significantly higher than that of the non-floating population (P <0.05) . (3) The contraceptive knowledge score of the women who had college educational background, did not give birth and had repeated induced-abortion history was higher than that of the women who first had induced-abortion (P <0.05) . Conclus ion The contraceptive knowledge of the women with unwanted pregnancy is related to the age, education level and residential status. Varied measures should be taken to improve the awareness rate of contraceptive knowledge and effective contraceptive rate and to reduce the occurrence of repeated abortion.
2018, 39(07): 72-75.
Abstract:
Objectives To retrospectively analyze the effects of different anesthetic methods on parturient and fetus with cesarean section due to placenta previa and to provide a feasible reference for clinical anesthesia.Me thods From January 2015 to October 2017, 73 cases of parturient undergoing cesarean section due to placenta previa were selected and divided into intraspinal anesthesia group and general anesthesia group. The intraoperative conditions of parturient of the two groups were observed and compared, including the operation time, intraoperative blood loss, infusion volume and application rate of pressor agent, as well as the neonatal conditions, including omphalotomy (I-D) time, umbilical arterial blood p H, PCO2, PO2 and Apgar score 1 min and 5 min after delivery.Re s ults There were 45 cases in general anesthesia group, 28 cases in intraspinal anesthesia group (13 cases with epidural and 15 cases combined with spinal and epidural anesthesia) . Two cases were changed to general anesthesia after intraspinal anesthesia because of incomplete retardation and four cases were also changed to general anesthesia because of large amount of bleeding. There was no significant difference in general conditions between the two groups. The operative time, intraoperative blood loss, application rate of pressor agent and infusion volume in the general anesthesia group were significantly higher than those in the intraspinal anesthesia group (P < 0.05) .There was no significant difference in the omphalotomy (I-D) time, umbilical arterial blood p H, PCO2, PO2 and Apgar score 1 min and 5 min after delivery between the two groups (P>0.05) .Conclus ion For patients with complete placenta previa or large estimated preoperativebleeding volume, it is safer to choose general anesthesia for puerpera and newborns, but for other types of patients, the choosing of anesthesia methods should depend on specific conditions.
Objectives To retrospectively analyze the effects of different anesthetic methods on parturient and fetus with cesarean section due to placenta previa and to provide a feasible reference for clinical anesthesia.Me thods From January 2015 to October 2017, 73 cases of parturient undergoing cesarean section due to placenta previa were selected and divided into intraspinal anesthesia group and general anesthesia group. The intraoperative conditions of parturient of the two groups were observed and compared, including the operation time, intraoperative blood loss, infusion volume and application rate of pressor agent, as well as the neonatal conditions, including omphalotomy (I-D) time, umbilical arterial blood p H, PCO2, PO2 and Apgar score 1 min and 5 min after delivery.Re s ults There were 45 cases in general anesthesia group, 28 cases in intraspinal anesthesia group (13 cases with epidural and 15 cases combined with spinal and epidural anesthesia) . Two cases were changed to general anesthesia after intraspinal anesthesia because of incomplete retardation and four cases were also changed to general anesthesia because of large amount of bleeding. There was no significant difference in general conditions between the two groups. The operative time, intraoperative blood loss, application rate of pressor agent and infusion volume in the general anesthesia group were significantly higher than those in the intraspinal anesthesia group (P < 0.05) .There was no significant difference in the omphalotomy (I-D) time, umbilical arterial blood p H, PCO2, PO2 and Apgar score 1 min and 5 min after delivery between the two groups (P>0.05) .Conclus ion For patients with complete placenta previa or large estimated preoperativebleeding volume, it is safer to choose general anesthesia for puerpera and newborns, but for other types of patients, the choosing of anesthesia methods should depend on specific conditions.
2018, 39(07): 76-79.
Abstract:
Objective To understand the detection of clinically isolated carbapenem-resistant Klebsiella pneumonia (CRKP) , and propose a strategy for drug treatment, so as to provide evidence for treatment and prevention of CRKP nosocomial infections.Me thods The isolated CRKP specimens from inpatients from 2013 to2017 were collected in a local hospital. Detection rate and sources of specimens were analyzed. Re s ults Totally2, 237 strains of Klebsiella pneumonia were detected, and 76 (accounting for 3.40%) were CRKP strains. The detection rate of CRKP from 2013 to 2017 showed an upward trend gradually, and the difference was statistically significant (P <0.01) . A positive correlation was observed between the detection rate of CRKP and DDDS of carbapenems, and the difference was statistically significant (P<0.05) . The main infection of CRKP occurred in respiratory tract and urinary tract, and detection of CRKP was mainly from ICU, neurosurgery and geriatrics departments. Conclus ion CRKP infection increase year by year, which should receive sufficient clinical and infection control attention. Therapy of CRKP infection is mainly based on the combined tigecycline or polymyxin.
Objective To understand the detection of clinically isolated carbapenem-resistant Klebsiella pneumonia (CRKP) , and propose a strategy for drug treatment, so as to provide evidence for treatment and prevention of CRKP nosocomial infections.Me thods The isolated CRKP specimens from inpatients from 2013 to2017 were collected in a local hospital. Detection rate and sources of specimens were analyzed. Re s ults Totally2, 237 strains of Klebsiella pneumonia were detected, and 76 (accounting for 3.40%) were CRKP strains. The detection rate of CRKP from 2013 to 2017 showed an upward trend gradually, and the difference was statistically significant (P <0.01) . A positive correlation was observed between the detection rate of CRKP and DDDS of carbapenems, and the difference was statistically significant (P<0.05) . The main infection of CRKP occurred in respiratory tract and urinary tract, and detection of CRKP was mainly from ICU, neurosurgery and geriatrics departments. Conclus ion CRKP infection increase year by year, which should receive sufficient clinical and infection control attention. Therapy of CRKP infection is mainly based on the combined tigecycline or polymyxin.
2018, 39(07): 80-85.
Abstract:
Objective To investigate the psychological health status of the patients with breast hyperplasia, breast fibnoma or breast cancer and to explore the correlations of those breast diseases with the personnality traits and depression and anxiety status of the patients. Methods From July 2017 to August2017, 740 patients with breast diseases and 112 healthy people were randomly selected in the third affiliated hospital of Kunming Medical University. 9-item patient health questionnaire scale (PHQ-9) , 7-item generalized anxiety disorder scale (GAD-7) , and neuroticism extraversion openness scale (NEO) were employed to measure their psychological health status.Results (1) The detection rate of depression and anxiety accounted for 34.3% and 38.3% in the patients with breast hyperplasia, 47.4% and 59% in the patients with breast fibnorma and 44.6% and 31.5% in the patients with breast cancer respectively. Depression and anxiety status of the patients with breast fibroma was significantly higher than that of healthy people (t=16.533, P<0.01;t=18.693, P<0.01) and that of patients with breast hyperplasia (t=9.367, P<0.01;t=22.702, P<0.01) . The depression status of the patients with breast cancer was significantly higher than that of the healthy people (t=12.332, P<0.05) while the anxiety status of the patients with breast cancer was significantly lower than that of the patients with breast hyperplasia (t=10.052, P<0.01) . (2) There was no significant difference in the score of PHQ-9 and GAD-7 among the four groups (P>0.05) . (3) There was no significant difference in the score of NEO among the four groups (P >0.05) . (4) Pearson correlation analysis showed that the scores of PHQ-9 and GAD-7 in the patients with breast diseases were in significant positive correlation with neuroticism factors and in significant negative correlation with openness factors, agreeableness factors and conscientiousness factors (P<0.05) . Conclusion Patients with breast diseases are commonly in poor psychological health status, especially with depression and anxiety status which is affected by different personality characteristics. The patients with neuroticism need more psychological intervention.
Objective To investigate the psychological health status of the patients with breast hyperplasia, breast fibnoma or breast cancer and to explore the correlations of those breast diseases with the personnality traits and depression and anxiety status of the patients. Methods From July 2017 to August2017, 740 patients with breast diseases and 112 healthy people were randomly selected in the third affiliated hospital of Kunming Medical University. 9-item patient health questionnaire scale (PHQ-9) , 7-item generalized anxiety disorder scale (GAD-7) , and neuroticism extraversion openness scale (NEO) were employed to measure their psychological health status.Results (1) The detection rate of depression and anxiety accounted for 34.3% and 38.3% in the patients with breast hyperplasia, 47.4% and 59% in the patients with breast fibnorma and 44.6% and 31.5% in the patients with breast cancer respectively. Depression and anxiety status of the patients with breast fibroma was significantly higher than that of healthy people (t=16.533, P<0.01;t=18.693, P<0.01) and that of patients with breast hyperplasia (t=9.367, P<0.01;t=22.702, P<0.01) . The depression status of the patients with breast cancer was significantly higher than that of the healthy people (t=12.332, P<0.05) while the anxiety status of the patients with breast cancer was significantly lower than that of the patients with breast hyperplasia (t=10.052, P<0.01) . (2) There was no significant difference in the score of PHQ-9 and GAD-7 among the four groups (P>0.05) . (3) There was no significant difference in the score of NEO among the four groups (P >0.05) . (4) Pearson correlation analysis showed that the scores of PHQ-9 and GAD-7 in the patients with breast diseases were in significant positive correlation with neuroticism factors and in significant negative correlation with openness factors, agreeableness factors and conscientiousness factors (P<0.05) . Conclusion Patients with breast diseases are commonly in poor psychological health status, especially with depression and anxiety status which is affected by different personality characteristics. The patients with neuroticism need more psychological intervention.
2018, 39(07): 91-94.
Abstract:
Objective To explore the application value of enhanced recovery after surgery (ERAS) in the infants with congenital duodenal obstruction. Me thods The clinical data of 71 infants with congenital duodenal obstruction who underwent operation in Kunming Children's Hospital from January 2015 to December 2017 were retrospectively analyzed. The infants were divided, according to the will of their parents, into ERAS group (n=32) and the control group (n=39) , and a new type of perioperative surgical intervention was adopted in ERAS group while traditional perioperative treatment was applied in the control group. First lactation, length of hospital stay, hospital expenses, complications and postoperative body weight growth were observed.Re s ults There was significant difference in the first lactation between the two groups (P<0.05) , (59±12) h and in ERAS group (138±31) h in control group (P<0.05) .The total length of hospital stay and hospital expenses in ERAS group (9.5± 2.5) d and (15.3±2.5) thousand RMB) were significantly lower than those in the control group (16±2.7) d and (19.6±3.1) thousand RMB) (P<0.05) . Follow-up was conducted 8 to 12 weeks after discharge and no significant difference of postoperative complications and postoperative body weight growth of the infants between two groups was found (P > 0.05) , but the body weight of infants in ERAS group increased faster than that in control group.Conclus ion As a safe and feasible approach, ERAS in the infants with congenital duodenal obstruction can shorten the length of hospital stay and reduce hospital expenses and the incidence of complications.
Objective To explore the application value of enhanced recovery after surgery (ERAS) in the infants with congenital duodenal obstruction. Me thods The clinical data of 71 infants with congenital duodenal obstruction who underwent operation in Kunming Children's Hospital from January 2015 to December 2017 were retrospectively analyzed. The infants were divided, according to the will of their parents, into ERAS group (n=32) and the control group (n=39) , and a new type of perioperative surgical intervention was adopted in ERAS group while traditional perioperative treatment was applied in the control group. First lactation, length of hospital stay, hospital expenses, complications and postoperative body weight growth were observed.Re s ults There was significant difference in the first lactation between the two groups (P<0.05) , (59±12) h and in ERAS group (138±31) h in control group (P<0.05) .The total length of hospital stay and hospital expenses in ERAS group (9.5± 2.5) d and (15.3±2.5) thousand RMB) were significantly lower than those in the control group (16±2.7) d and (19.6±3.1) thousand RMB) (P<0.05) . Follow-up was conducted 8 to 12 weeks after discharge and no significant difference of postoperative complications and postoperative body weight growth of the infants between two groups was found (P > 0.05) , but the body weight of infants in ERAS group increased faster than that in control group.Conclus ion As a safe and feasible approach, ERAS in the infants with congenital duodenal obstruction can shorten the length of hospital stay and reduce hospital expenses and the incidence of complications.
2018, 39(07): 95-100.
Abstract:
Objective To investigate the mid-and-long term impact of minimally invasive lithotomy and cholecystectomy on the living status of patients with cholelithiasis. Me thods From January 2008 to January 2013, 214 cases who had received minimally invasive surgery in cholecyst (either minimally invasive lithotomy or minimally invasive cholecystectomy) and complied with study eligibility were recruited in the study. They were divided into minimally invasive lithotomy group and minimally invasive cholecystectomy group with 107 cases in each group. All the surgeries were performed by an experienced senior chief physician. Follow-up in half a year, 3 years and 5 years after surgery was conducted to evaluate the complications of cholecyst, liver and pancreas in patients, as well as their LDQ digestive function between the two groups. Re s ults There was no significant different in the complications of cholecyst, liver and pancreas in patients of two groups in 6 months after surgery (P >0.05) .while, the LDQ digestive function was worse in patients receiving minimally invasive lithotomy group than in minimally invasive cholecystectomy group 6 months after surgery (P <0.05) . In 3 years and 5 years after the surgery, evaluation on complications of cholecyst, liver and pancreas in both groups showed significant difference (P<0.05) , however, the evaluation of LDQ digestive function showed no difference between the two groups (P >0.05) . Conclusion From a long-term perspective, for patients with complex cholecystolithiasis, physicians may choose the minimally invasive cholecystectomy for better effects.
Objective To investigate the mid-and-long term impact of minimally invasive lithotomy and cholecystectomy on the living status of patients with cholelithiasis. Me thods From January 2008 to January 2013, 214 cases who had received minimally invasive surgery in cholecyst (either minimally invasive lithotomy or minimally invasive cholecystectomy) and complied with study eligibility were recruited in the study. They were divided into minimally invasive lithotomy group and minimally invasive cholecystectomy group with 107 cases in each group. All the surgeries were performed by an experienced senior chief physician. Follow-up in half a year, 3 years and 5 years after surgery was conducted to evaluate the complications of cholecyst, liver and pancreas in patients, as well as their LDQ digestive function between the two groups. Re s ults There was no significant different in the complications of cholecyst, liver and pancreas in patients of two groups in 6 months after surgery (P >0.05) .while, the LDQ digestive function was worse in patients receiving minimally invasive lithotomy group than in minimally invasive cholecystectomy group 6 months after surgery (P <0.05) . In 3 years and 5 years after the surgery, evaluation on complications of cholecyst, liver and pancreas in both groups showed significant difference (P<0.05) , however, the evaluation of LDQ digestive function showed no difference between the two groups (P >0.05) . Conclusion From a long-term perspective, for patients with complex cholecystolithiasis, physicians may choose the minimally invasive cholecystectomy for better effects.
2018, 39(07): 101-105.
Abstract:
Objective To investigate the clinical effect of percutaneous transluminal angioplasty (PTA) combined with autologous peripheral blood stem cell transplantation (ABSCT) in treating chronic lower limb ischemia.Me thods A total of 48 patients with chronic lower limb ischemia were voluntarily allocated into 3 groups: 19 patients treated with ABSCT combined with PTA, named as combined treatment group; 10 patients treated with ABSCT alone, named as single ABSCT group; and 19 patients treated with PTA alone, named as single PTA group. Patients in 3 groups received conventional therapy. Limb pain, cold feeling, intermittent claudication, ankle brachial index (ABI) and the number of collateral vessel formation of patients in 3 groups were assessed before and after treatment. Comparison of clinical effects was performed in 3 groups.Re s ults Limb pain scores, cold feeling scores and intermittent claudication scores of the patients in 3 groups significantly decreased after treatment (P <0.05) . ABI score and the number of collateral vessel formation significantly increased (P<0.05) . The combined treatment group showed obvious improvement in all the measured assessmentindicators (P<0.05) . The total effective rate of combined treatment group was 89.5% while that in PTA group and ABSCT group were 78.9% and 60.0%, respectively. The total effective rate in combined treatment group was higher than that in both PTA group and ABSCT group (P <0.05) . Conclus ion When treating chronic lower limb ischemia, combination use of PTA and transplantation of ABSCT is safe and effective, and its treatment effect is superior to single PTA as well as single ABSCT.
Objective To investigate the clinical effect of percutaneous transluminal angioplasty (PTA) combined with autologous peripheral blood stem cell transplantation (ABSCT) in treating chronic lower limb ischemia.Me thods A total of 48 patients with chronic lower limb ischemia were voluntarily allocated into 3 groups: 19 patients treated with ABSCT combined with PTA, named as combined treatment group; 10 patients treated with ABSCT alone, named as single ABSCT group; and 19 patients treated with PTA alone, named as single PTA group. Patients in 3 groups received conventional therapy. Limb pain, cold feeling, intermittent claudication, ankle brachial index (ABI) and the number of collateral vessel formation of patients in 3 groups were assessed before and after treatment. Comparison of clinical effects was performed in 3 groups.Re s ults Limb pain scores, cold feeling scores and intermittent claudication scores of the patients in 3 groups significantly decreased after treatment (P <0.05) . ABI score and the number of collateral vessel formation significantly increased (P<0.05) . The combined treatment group showed obvious improvement in all the measured assessmentindicators (P<0.05) . The total effective rate of combined treatment group was 89.5% while that in PTA group and ABSCT group were 78.9% and 60.0%, respectively. The total effective rate in combined treatment group was higher than that in both PTA group and ABSCT group (P <0.05) . Conclus ion When treating chronic lower limb ischemia, combination use of PTA and transplantation of ABSCT is safe and effective, and its treatment effect is superior to single PTA as well as single ABSCT.
2018, 39(07): 106-110.
Abstract:
Objective To observe the effect of binocular surgery microscope and otoendoscope on perioperative indexes, hearing recovery and complications in the patients with artificial stapes surgery. Me thods A total of 160 patients undergoing artificial stapes surgery in the hospital were recruited and were divided into group A (n = 80) and group B (n = 80) according to different magnifying devices used during the surgery. The binocular surgery microscope was used in group A while the otoendoscope was used in group B. The perioperative indexes (surgical time, postoperative recovery time and hospital stay) were compared between the two groups. The changes of hearing and complications in the two groups before surgery and at 3 months after the surgery were observed.Re s ults The surgical time and postoperative recovery time of group A were significantly shorter than those of group B (P < 0.05) . There was no significant difference in hospital stay between the two groups (P > 0.05) . Three months after surgery, the air mediated hearing threshold and air bone gap in the two group significantly decreased (P< 0.05) , but there was no significant difference between the two groups (P > 0.05) . There was no significant difference in the total incidence of postoperative complications between the two groups (P > 0.05) , and all the complications completely disappeared after treatment. Conclus ion Compared with otoendoscope, the time of artificial stapes surgery under binocular surgery microscope is shorter and patients can recover quickly fromanesthesia after surgery. Effects of the two magnifying devices are similar in terms of hearing recovery and with few complications.
Objective To observe the effect of binocular surgery microscope and otoendoscope on perioperative indexes, hearing recovery and complications in the patients with artificial stapes surgery. Me thods A total of 160 patients undergoing artificial stapes surgery in the hospital were recruited and were divided into group A (n = 80) and group B (n = 80) according to different magnifying devices used during the surgery. The binocular surgery microscope was used in group A while the otoendoscope was used in group B. The perioperative indexes (surgical time, postoperative recovery time and hospital stay) were compared between the two groups. The changes of hearing and complications in the two groups before surgery and at 3 months after the surgery were observed.Re s ults The surgical time and postoperative recovery time of group A were significantly shorter than those of group B (P < 0.05) . There was no significant difference in hospital stay between the two groups (P > 0.05) . Three months after surgery, the air mediated hearing threshold and air bone gap in the two group significantly decreased (P< 0.05) , but there was no significant difference between the two groups (P > 0.05) . There was no significant difference in the total incidence of postoperative complications between the two groups (P > 0.05) , and all the complications completely disappeared after treatment. Conclus ion Compared with otoendoscope, the time of artificial stapes surgery under binocular surgery microscope is shorter and patients can recover quickly fromanesthesia after surgery. Effects of the two magnifying devices are similar in terms of hearing recovery and with few complications.
2018, 39(07): 111-113.
Abstract:
Objectives To explore the value of tricuspid annulus displacement measured by speckle tracking on evaluating the right ventricular systolic function in children with pectus excavatum (PE) . Me thods Pectus excavatum patients group (PE group) recruited 38 patients with pectus excavatum and treated with cardiac surgery from February to August in 2017 and 50 healthy children with matchedage were randomly enrolled as control group.Tricuspid ring ventricular septal systolic peak displacement (TMAD1) , tricuspid ring right ventricular free wall (TMAD2) systolic peak displacement, tricuspid ring attachment midpoint displacement (TMADm) and right ventricular systolic peak longitudinal shortening fraction (TMAD%) were measured. Re s ults The value of TMAD1, TMAD2, TMADm and TMAD% in PE group was lower than those in control group (P<0.05) . After the patients in PE group underwent surgeries, the value of TMAD1, TMAD2, TMADm and TMAD % increased but there was no significant difference (P>0.05) . Conclus ions Speckle tracking can accurately and clearly evaluate right ventricle systolic function in the children with pectus excavatum, but further study is needed to explore the value of the post-operative data.
Objectives To explore the value of tricuspid annulus displacement measured by speckle tracking on evaluating the right ventricular systolic function in children with pectus excavatum (PE) . Me thods Pectus excavatum patients group (PE group) recruited 38 patients with pectus excavatum and treated with cardiac surgery from February to August in 2017 and 50 healthy children with matchedage were randomly enrolled as control group.Tricuspid ring ventricular septal systolic peak displacement (TMAD1) , tricuspid ring right ventricular free wall (TMAD2) systolic peak displacement, tricuspid ring attachment midpoint displacement (TMADm) and right ventricular systolic peak longitudinal shortening fraction (TMAD%) were measured. Re s ults The value of TMAD1, TMAD2, TMADm and TMAD% in PE group was lower than those in control group (P<0.05) . After the patients in PE group underwent surgeries, the value of TMAD1, TMAD2, TMADm and TMAD % increased but there was no significant difference (P>0.05) . Conclus ions Speckle tracking can accurately and clearly evaluate right ventricle systolic function in the children with pectus excavatum, but further study is needed to explore the value of the post-operative data.
2018, 39(07): 114-118.
Abstract:
Objective To investigate the correlation of the concentration of blood/urine beta-trace protein (βTP) in the prediction of contrast-induced nephropathy. Methods This study enrolled 88 patients with interventional diagnosis or treatment from september to December 2016 in the first hospital of Kunming and the patients were divided into two groups: CIN group (nn = 7) and non-CIN group (n = 81) . The concentration of blood/urine βTP was measured by ELISA method and the results was analysed with SPSS.Re s ults There was significant difference in the level of blood βTP before the operation, 2 h after operation and 24 h after the operation between the two groups (P<0.05) , so was that in the level of urine βTP (P<0.05) . The area under ROC curve (AUC) of blood βTP 2 h after the operation was 0.761, the diagnostic value was 567.568, and the sensitivity and specificity were 71.4% and 81.5% while the area of ROC curve (AUC) of urine βTP 2 h after the operation was0.967, the diagnostic value was 1428.893, and the sensitivity and specificity were 100% and 97.5%.Conclus ion The concentration of blood/urine βTP 2 h after the operation can be used as a new indicator to predict contrast-induced nephropathy. The sensitivity and specificity of urine βTP is better than those of blood βTP, and urine samples are easier to be collected than blood samples.
Objective To investigate the correlation of the concentration of blood/urine beta-trace protein (βTP) in the prediction of contrast-induced nephropathy. Methods This study enrolled 88 patients with interventional diagnosis or treatment from september to December 2016 in the first hospital of Kunming and the patients were divided into two groups: CIN group (nn = 7) and non-CIN group (n = 81) . The concentration of blood/urine βTP was measured by ELISA method and the results was analysed with SPSS.Re s ults There was significant difference in the level of blood βTP before the operation, 2 h after operation and 24 h after the operation between the two groups (P<0.05) , so was that in the level of urine βTP (P<0.05) . The area under ROC curve (AUC) of blood βTP 2 h after the operation was 0.761, the diagnostic value was 567.568, and the sensitivity and specificity were 71.4% and 81.5% while the area of ROC curve (AUC) of urine βTP 2 h after the operation was0.967, the diagnostic value was 1428.893, and the sensitivity and specificity were 100% and 97.5%.Conclus ion The concentration of blood/urine βTP 2 h after the operation can be used as a new indicator to predict contrast-induced nephropathy. The sensitivity and specificity of urine βTP is better than those of blood βTP, and urine samples are easier to be collected than blood samples.
2018, 39(07): 119-123.
Abstract:
Objective To evaluate the therapeutic efficacy and safety of absolute ethanol sclerotherapy for arteriovenous malformations in the head and neck. Me thods We made a retrospective analysis of 21 patients (12 male, 9 female, age range 5 59 years; mean age 19 years) with arteriovenous malformations who underwent absolute ethanol sclerotherapy in the second affiliated hospital of Xa'an Jiautong University between January 2014 and June 2016. Therapeutic outcomes were evaluated by clinical responses of symptoms and signs, as well as the degree of devascularization on angiography or contrast-enhanced computed tomography. Treatment complications were recorded detailedly. Re s ults Six patients (29%) were cured, 12 patients (57%) improved, and 2 patients (10%) had no change and no patient showed aggravation after treatment. One patient was lost to follow-up and 7 patients (33%) had one or more complications, including skin necrosis in 5 patients (24%) , (24%) , tension blisters in 3 patients (14%) and peripheral nerve injury in 3 patients (14%) . All of the complications were recovered in 3 months. There was no irreversible necrosis and permanent impairment of function. Conclus ion Absolute ethanol sclerotherapy embolotherapy is an effective treatment for head and neck arteriovenous malformations, but it carries a potential risk of serious complications, so systemic disciplinary careful evaluation and detailed treatment plan must be required before each therapy.
Objective To evaluate the therapeutic efficacy and safety of absolute ethanol sclerotherapy for arteriovenous malformations in the head and neck. Me thods We made a retrospective analysis of 21 patients (12 male, 9 female, age range 5 59 years; mean age 19 years) with arteriovenous malformations who underwent absolute ethanol sclerotherapy in the second affiliated hospital of Xa'an Jiautong University between January 2014 and June 2016. Therapeutic outcomes were evaluated by clinical responses of symptoms and signs, as well as the degree of devascularization on angiography or contrast-enhanced computed tomography. Treatment complications were recorded detailedly. Re s ults Six patients (29%) were cured, 12 patients (57%) improved, and 2 patients (10%) had no change and no patient showed aggravation after treatment. One patient was lost to follow-up and 7 patients (33%) had one or more complications, including skin necrosis in 5 patients (24%) , (24%) , tension blisters in 3 patients (14%) and peripheral nerve injury in 3 patients (14%) . All of the complications were recovered in 3 months. There was no irreversible necrosis and permanent impairment of function. Conclus ion Absolute ethanol sclerotherapy embolotherapy is an effective treatment for head and neck arteriovenous malformations, but it carries a potential risk of serious complications, so systemic disciplinary careful evaluation and detailed treatment plan must be required before each therapy.
2018, 39(07): 124-128.
Abstract:
The blood-brain barrier (BBB) is a special protective barrier existing between the blood and brain tissues. The primary function of BBB is to selectively prevent most solutes in the blood from invading the central nervous system (CNS) and avoid damage to CNS, thereby effectively maintaining the stability and normal physiological function of CNS environment. However, in some CNS diseases, BBB also blocks most therapeutic drugs from entering the central nervous system, which would affect the treatment effect. Therefore, how to open BBB safely and reversibly has become the focus of research in recent years. Recent studies have shown that focused ultrasound-microbubbles therapy (FUS-MB) can open BBB transiently, locally, reversibly and noninvasively, and open up a new approach for targeted therapy of intracranial diseases. This article reviewed relevant research progress and mechanism of BBB opening with FUS-MB technology.
The blood-brain barrier (BBB) is a special protective barrier existing between the blood and brain tissues. The primary function of BBB is to selectively prevent most solutes in the blood from invading the central nervous system (CNS) and avoid damage to CNS, thereby effectively maintaining the stability and normal physiological function of CNS environment. However, in some CNS diseases, BBB also blocks most therapeutic drugs from entering the central nervous system, which would affect the treatment effect. Therefore, how to open BBB safely and reversibly has become the focus of research in recent years. Recent studies have shown that focused ultrasound-microbubbles therapy (FUS-MB) can open BBB transiently, locally, reversibly and noninvasively, and open up a new approach for targeted therapy of intracranial diseases. This article reviewed relevant research progress and mechanism of BBB opening with FUS-MB technology.
2018, 39(07): 129-132.
Abstract:
With the expansion of consumer markets and groups in last decades, Dendrobium species as traditional Chinese medicine herbs have been becoming increasingly popular for its outstanding pharmacological and health effects. This review will detail the important functions of Dendrobium compound preparation, Dendrobium candidum, Dendrobium nobile Lindl, Dendrobium chrysotoxum Lindl, Dendrobium huoshanense, Dendrobium moniliforme and Dendrobium denneanum in the term of prevention and cure about diabetes.
With the expansion of consumer markets and groups in last decades, Dendrobium species as traditional Chinese medicine herbs have been becoming increasingly popular for its outstanding pharmacological and health effects. This review will detail the important functions of Dendrobium compound preparation, Dendrobium candidum, Dendrobium nobile Lindl, Dendrobium chrysotoxum Lindl, Dendrobium huoshanense, Dendrobium moniliforme and Dendrobium denneanum in the term of prevention and cure about diabetes.
2018, 39(07): 137-140.
Abstract:
Objective To explore the training mode of Bachelor of Medicine and Bachelor of Surgery (MBBS) international students by discussion-based teaching associated with standardized clinical pathway and standardized patients program. Methods This study recruited 60 MBBS international students from 2016 to 2018 and they were randomly divided them into two groups: study group and control group, 30 for each group.Standardized clinical pathway was adopted in medical history-taking and problem-based case discussion mode and diagnosis and examination in English on standardized patients in study group was used while traditional ward round mode was applied in the control group. Effects of teaching were assessed and three capacity modules, medical history-taking, physical examination and case discussion, were evaluated.Results Students had positive responses to the discussion-based teaching associated with standardized clinical pathway and standardized patients program. There were significant differences in three modules between the two groups (P <0.05) .Conclusions Discussion-based teaching associated with standardized clinical pathway and standardized patients program helps to arouse the students' interest, improve self-study ability and cultivate the clinical reasoning ability and is feasible in clinical training and worth promoting.
Objective To explore the training mode of Bachelor of Medicine and Bachelor of Surgery (MBBS) international students by discussion-based teaching associated with standardized clinical pathway and standardized patients program. Methods This study recruited 60 MBBS international students from 2016 to 2018 and they were randomly divided them into two groups: study group and control group, 30 for each group.Standardized clinical pathway was adopted in medical history-taking and problem-based case discussion mode and diagnosis and examination in English on standardized patients in study group was used while traditional ward round mode was applied in the control group. Effects of teaching were assessed and three capacity modules, medical history-taking, physical examination and case discussion, were evaluated.Results Students had positive responses to the discussion-based teaching associated with standardized clinical pathway and standardized patients program. There were significant differences in three modules between the two groups (P <0.05) .Conclusions Discussion-based teaching associated with standardized clinical pathway and standardized patients program helps to arouse the students' interest, improve self-study ability and cultivate the clinical reasoning ability and is feasible in clinical training and worth promoting.
2018, 39(07): 141-145.
Abstract:
Objective To investigate the application of nurse-physician collaboration in the perioperative period of ocular endoscope-assisted vitrectomy among patients with ocular trauma. Methods This study recruited56 patients with severe ocular trauma from January 2015 to January 2017 in our hospital. All patients were randomly allocated into the study group (n =28) and control group (n =28) according to a random number table. All patients with ocular trauma received the surgery of ocular endoscope-assisted vitrectomy. Patients in the control group were treated with routine eye nursing care, and those in the study group were treated with nurse-physician collaborative cares on the basis of routine nursing care. The patients' depression, anxiety, vision and treatment compliance were assessed. Data was analyzed by SPSS 20.0 statistical software.Results The preoperative depression (P = 0.864) and anxiety (P = 0.745) showed no significant difference between the two groups. Receiving nurse-physician collaborative service, the SDS depression scores (P = 0.017) and SAS anxiety score (P = 0.027) were lower in the study group than those in the control group. And the vision of patients had no difference between two groups when dismissed from the hospital (P<0.05) . Besides, the study group showed better compliance to treatment than the control group, with statistically significant difference (P <0.05) . Conclusion Nurse-physician collaborative cares for patients receiving endoscope-assisted vitrectomy could effectively reduce the patients' anxiety and depression and improve their compliance to treatment and trust to physicians.
Objective To investigate the application of nurse-physician collaboration in the perioperative period of ocular endoscope-assisted vitrectomy among patients with ocular trauma. Methods This study recruited56 patients with severe ocular trauma from January 2015 to January 2017 in our hospital. All patients were randomly allocated into the study group (n =28) and control group (n =28) according to a random number table. All patients with ocular trauma received the surgery of ocular endoscope-assisted vitrectomy. Patients in the control group were treated with routine eye nursing care, and those in the study group were treated with nurse-physician collaborative cares on the basis of routine nursing care. The patients' depression, anxiety, vision and treatment compliance were assessed. Data was analyzed by SPSS 20.0 statistical software.Results The preoperative depression (P = 0.864) and anxiety (P = 0.745) showed no significant difference between the two groups. Receiving nurse-physician collaborative service, the SDS depression scores (P = 0.017) and SAS anxiety score (P = 0.027) were lower in the study group than those in the control group. And the vision of patients had no difference between two groups when dismissed from the hospital (P<0.05) . Besides, the study group showed better compliance to treatment than the control group, with statistically significant difference (P <0.05) . Conclusion Nurse-physician collaborative cares for patients receiving endoscope-assisted vitrectomy could effectively reduce the patients' anxiety and depression and improve their compliance to treatment and trust to physicians.
2018, 39(07): 146-148.
Abstract:
Objective To analyze the effects of applying mobile nursing stations in providing clinical nursing service for HIV/AIDS patients.Me thods Four mobile nursing stations were applied in the wards of HIV/AIDS Department of the third people's hospital of Kunming. We evaluated the satisfaction of physicians, nurses, and patients towards the application of mobile nursing stations, and compared the changes of their satisfaction before and after their use. Re s ult After using the mobile nursing stations, the satisfaction among physicians, nurses and patients was significantly different in the wards of HIV/AIDS Department (P <0.05) .Conclus ion The application of mobile nursing stations could simplify workflow, improve nursing safety, and reduce the workload of nurses during clinical nursing service in the wards of HIV/AIDS Department, which consequently increase the satisfaction of physicians, nurses and AIDS patients.
Objective To analyze the effects of applying mobile nursing stations in providing clinical nursing service for HIV/AIDS patients.Me thods Four mobile nursing stations were applied in the wards of HIV/AIDS Department of the third people's hospital of Kunming. We evaluated the satisfaction of physicians, nurses, and patients towards the application of mobile nursing stations, and compared the changes of their satisfaction before and after their use. Re s ult After using the mobile nursing stations, the satisfaction among physicians, nurses and patients was significantly different in the wards of HIV/AIDS Department (P <0.05) .Conclus ion The application of mobile nursing stations could simplify workflow, improve nursing safety, and reduce the workload of nurses during clinical nursing service in the wards of HIV/AIDS Department, which consequently increase the satisfaction of physicians, nurses and AIDS patients.
2018, 39(07): 52-57.
Abstract:
Objective To observe the risk factors and prevalence rate of hypertension in Bai ethnic group in Dali, Yunnan. Methods Bai ethnic minority villagers aged over 50 and been living in the villages in Dali for more than 6 months each year were recruited by cluster sampling and their blood pressure were taken.Data of the risk factors including occupation, smoking, drinking, family history, height and weight were collected and then analyzed with multiple factor logistic regression (P<0.05). Results The prevalence rate of all the villagers enrolled was 41.7%, with male prevalence rate being 41.5%, and female rate being 41.9%. Multiple factor Logistic regression analysis showed that age, obesity, family history, smoking and drinking were risk factors of the hypertension (P<0.05). Conclusions The prevalence rate of hypertension in Bai ethnic adults is higher than some regions of China. The prevention and treatment of hypertension should be reinforced.
2018, 39(07): 133-136.
Abstract:
目的 对比2届MBBS留学生口腔医学教学效果, 为MBBS的口腔教学改革提供依据.方法 对2011级和2012级2届MBBS留学生的课堂出勤、课堂表现、课后作业、期末笔试卷面成绩的得分进行对比分析.其中2012级的课堂表现评估改为口头分组汇报评估.结果 137名留学生接受了口腔医学的课堂教学, 其中绝大多数为印度籍.2012级分组汇报的成绩显著高于2011级的课堂表现成绩 (P<0.05) ;2012级期末笔试卷面成绩与课堂出勤、课后作业得分存在正相关 (P<0.05) ;2011级在期末笔试卷面成绩与其他各项得分均未出现显著性相关.结论 评估方式的改变影响教学效果.
