2023 Vol. 44, No. 4

Original Articles Basic of Medicine
LINC00341 Inhibits the Proliferation of Lung Adenocarcinoma Cells Through the MAPK Pathway
Shiqi MA, Yi DING, Min LI, Mengci WANG, Siyu ZHANG, Shumei FENG
2023, 44(4): 1-8. doi: 10.12259/j.issn.2095-610X.S20230403
Abstract(3397) HTML PDF(22)
Abstract:
Objective To explore the underlying mechnisms and effect of LINC00341 on the proliferation of lung adenocarcinoma cells. Methods The expression of LINC00341 mRNA in lung adenocarcinoma was analyzed in public data set SEO and TCGA, and its diagnosti...
Effects of Scutellarin on MMP2,MMP9 and TIMP-1 Protein in Liver of Obese Rats with Chronic Liver Injury by High Glucose and Fat Diet
Liyuan WANG, Zhenting YANG, Qingling LI, Haiwen LI, Zhirong ZHAO, Yongrui YANG, Shude LI
2023, 44(4): 9-15. doi: 10.12259/j.issn.2095-610X.S20230408
Abstract(4294) HTML PDF(22)
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Objective To investigate the effect of scutellarin (SCU) on liver fibrosis in obese rats with chronic liver injury induced by high-fat and high-sugar diet, and to explore the possibility of SCU to ameliorate the degree of liver fibrosis by promoting ...
Effects of Store-operated Calcium Channel Molecule Orai3 on Rat Coronary Artery Smooth Muscle Cells Proliferation
Hui WANG, Wenjun ZENG, Haiping ZHANG, Ruiwei GUO
2023, 44(4): 16-22. doi: 10.12259/j.issn.2095-610X.S20230423
Abstract(3678) HTML PDF(12)
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Objective To investigate the effect of calcium store-operated calcium channel Orai3 on the proliferation of coronary artery smooth muscle cells (CASMC). Methods Coronary artery smooth muscle cells (CASMC) were cultured, and Orai3 molecule in CASMC w...
Effect of Intestinal Flora Metabolites Deoxycholic Acid on the Proliferation and Cell Cycle of Human Umbilical Cord Mesenchymal Stem Cells
Caihong LIANG, Mingyao MENG, Xinxin LI, Jingjing XIONG, Meng LI, Mei LIU, Zongliu HOU, Yongkun HUANG
2023, 44(4): 23-30. doi: 10.12259/j.issn.2095-610X.S20230402
Abstract(3691) HTML PDF(18)
Abstract:
Objective To investigate the influence of intestinal flora metabolites secondary bile acid DCA at different concentration and reaction time on the proliferation and cell cycle of human umbilical cord mesenchymal stem cells (hUC-MSCs) in vitro. Method...
Voluntary Exercise Training Attenuated the Proliferation and Growth of Human Breast Cancer with BRCA1 Mutation by Regulating Caspase-3 Activity
Tao HU, Yi WU, Wenda GENG, Yijian ZHANG, Xuan HE, Shanshan LI, Yanbin XIYANG, Liling DENG
2023, 44(4): 31-39. doi: 10.12259/j.issn.2095-610X.S20230419
Abstract(3400) HTML PDF(14)
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Objective This study aims to explore the role and mechanism of voluntary exercise training in the development and progression of breast cancer. Methods Primary human Breast Cancer gene 1-mutation (BRCA-1 mutation cancer cells were cultured in vitro...
Associations between SLC2A9 Single Nucleotide Polymorphisms and Susceptibility to Pyrazinamide Induced Hyperuricemia
Rongshuang WU, Jiangli PENG, Yonggang CHEN, Jie CHEN, Guowei MA, Xianrui LI, Xie LI, Chunhong YU
2023, 44(4): 40-47. doi: 10.12259/j.issn.2095-610X.S20230409
Abstract(3978) HTML PDF(10)
Abstract:
Objective To explore the association between gene single nucleotide polymorphisms of SLC2A9 and susceptibility to pyrazinamide induced hyperuricemia (PIHU) in Yunnan Han population. Methods The polymorphisms of SLC2A9 gene rs2280205, rs3733591, rs377...
Clinical Research
Association between Glucose Time in Range and Carotid Artery Intima-media Thickness in Type-2 Diabetes Mellitus
Fang SUN, Shiying HUANG, Shu LIU, Jingyun FU
2023, 44(4): 48-52. doi: 10.12259/j.issn.2095-610X.S20230427
Abstract(3192) HTML PDF(14)
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Objctive To investigate the association between glucose time in range and carotid artery intima-media thickness in type-2 diabetes mellitus. Methods A total of 232 patients with type 2 diabetes were selected and divided into two groups based on the ...
Study on Fluencing Factors of Colorectal Polyp Canceration
Na KONG, Yinglei MIAO, Liping HE, Junkun NIU, Xiangqian DONG, Fan ZHANG
2023, 44(4): 53-61. doi: 10.12259/j.issn.2095-610X.S20230401
Abstract(3405) HTML PDF(22)
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Objective To investigate the influencing factors of colorectal polyp canceration, to improve the early diagnosis and treatment of colorectal cancer, and to reduce the incidence. Methods Patients diagnosed with intestinal polyps during hospitalizatio...
The Value of Urinary AD7c-NTP and P300 in the Diagnosis of AD-derived MCI
Xiaoyu TUO, Chao LI, Liping GUO, Huajun ZHAO
2023, 44(4): 62-68. doi: 10.12259/j.issn.2095-610X.S20230407
Abstract(3181) HTML PDF(20)
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Objective To investigate the value of urine AD7c-NTP level test combined with ERP P300 in the diagnosis of AD-derived mild cognitive impairment (MCI). Methods 78 healthy subjects in control group, 72 in MCI group and 108 in AD group were selected an...
Caregiver Burden Characteristics and Influencing Factors in Conservative Treatment of Adolescent Idiopathic Scoliosis
Ziwen YIN, Lei WANG, huidong WU, Kehong ZHAO, Yanyang WANG, Xiaomei LIU, Yonghong YANG
2023, 44(4): 69-74. doi: 10.12259/j.issn.2095-610X.S20230413
Abstract(3523) HTML PDF(12)
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Objective The purpose of this study was to investigate the care burden and influencing factors of the primary caregivers for patients with adolescent idiopathic scoliosis (AIS) treated conservatively, and to explore the correlation between care burde...
Clinical Data Analysis of 108 Patients with Primary Hyperparathyroidism
Qingxia YANG, Changrong WU, Juanzhang LUO, Wei WANG, Yahong WANG, Ruimei SUN
2023, 44(4): 75-81. doi: 10.12259/j.issn.2095-610X.S20230411
Abstract(3213) HTML PDF(6)
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Objective To analyze the clinical data of patients with PHPT in Yunnan Cancer Hospital, to explore the clinical characteristics, and improve the understanding, diagnosis and treatment of this disease. Methods The clinical data of 108 PHPT patients ...
Analysis of Pelvic Organ Prolapse and Related Factors in Primipara in Early Postpartum Period
Aitao YIN, Yongping LU, Miao HUANG, Xiangbi LI, Jiao YIN, Fei XU
2023, 44(4): 82-87. doi: 10.12259/j.issn.2095-610X.S20230412
Abstract(3290) HTML PDF(9)
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Objective To investigate the correlation between delivery factors and early postpartum pelvic organ prolapse (POP) in primipara. Methods From January 2021 to June 2022, primiparas who underwent routine ultrasound examination at the Affiliated Hospit...
Effect of Ultrasound-guided Transmuscular Quadratus Lumborum Block for Postoperative Analgesia in Pediatric Patient Undergoing Hip Surgery
Yunli YANG, Na LI, Changming QIU, Junjie PU, Wei NIE, Zhigui LI
2023, 44(4): 88-92. doi: 10.12259/j.issn.2095-610X.S20230426
Abstract(4107) HTML PDF(9)
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Objective To evaluate the analgesic effect of ultrasound-guided transmuscular quadratus lumborum block in pediatric patients for hip surgery. Methods 60 children with elective hip operation, aged 1-3 years, ASAⅠ~Ⅱ, were randomly divided into 2 group...
Association between Unmet Needs and Dyadic Coping of Breast Cancer Patients and Spouses after Radical Mastectomy
Mei YAN, Qiongyao GUAN, Yuanxiao WANG, Liqi GU, Lei ZHE, Lijuan LIU, Runzhen HAO, Yan SU, Sisi HUANG
2023, 44(4): 93-99. doi: 10.12259/j.issn.2095-610X.S20230410
Abstract(3416) HTML PDF(9)
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Objective To investigate the interaction between the level of unmet needs and dyadic coping of breast cancer patients and their spouses after radical mastectomy, and to provide reference for health care workers to develop intervention programs to hel...
Effect of Rehabilitation Thearpy on the Psychological and Medical Coping Styles of Patients with Temporomandibular Joint Reversible Anterior Disc Displacement
Yunting PANG, Li ZHANG, Yong CHEN, Linjia XUE, Lirong YUE, Qiu LUO
2023, 44(4): 100-105. doi: 10.12259/j.issn.2095-610X.S20230404
Abstract(3707) HTML PDF(10)
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Objective To explore the effect of rehabilitation therapy on the psychological and medical coping styles of patients with reversible anterior disc displacement of temporomandibular joint, so as to provide some theoretical support for clinical treatme...
Analysis on the Blood Lead Levels and It’s Association with Hypertension in 176 Non-occupational Adult Patients
Xiufang WANG, Hongling SHI, Wengang ZHOU, Tianyun LIU, Weimei ZHU, Yanhui FENG, Kerong CHEN, Sheng ZHOU
2023, 44(4): 106-111. doi: 10.12259/j.issn.2095-610X.S20230424
Abstract(2589) HTML PDF(11)
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Objective To investigate the blood lead level and its distribution in non-occupational adults, and to analyze the association of excessive blood lead with hypertension. Methods The concentration of lead in blood was detected by GFAAS, and the potent...
To Investigate the Application Effect of Dapagliflozin in Elderly Patients with HFpEF and Type 2 Diabetes Mellitus and Its Effect on Inflammatory Factors
Jianpei SU, Miyu HE, Yongli WANG, Qi WU, Weimeng TIAN, Jin LI, Bijuan LIANG
2023, 44(4): 112-116. doi: 10.12259/j.issn.2095-610X.S20230405
Abstract(4144) HTML PDF(9)
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Objective To investigate the efficacy of dapagliflozin in elderly heart failure patients with preserved ejection fraction (HFpEF) complicated with type 2 diabetes mellitus (T2DM) and its effect on inflammatory factors. Methods From March 2021 to Sep...
Clinical Application of Ultrasound-guided Peripherally Inserted Central Venous Catheter in Neonates with Vascular Access Difficulties
Libo ZHU, Yanhua XU, Jinfen LI, Xue HU, Chunyan LU, Kun LU, Liuyan DUAN, Huanyi LI
2023, 44(4): 117-122. doi: 10.12259/j.issn.2095-610X.S20230415
Abstract(3610) HTML PDF(23)
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Objective To investigate the clinical application of peripherally inserted central catheter (PICC) guided by ultrasound in neonates with vascular access difficulties. Methods From January 2019 to April 2021, 104 neonates with vascular access difficu...
Efficacy of Rituximab Combined with Methylprednisolone in the Treatment of Autoimmune Encephalitis and Its Effect on Peripheral Blood PD-1 and PD-L1
Xia ZHANG, Wensha NIE, Huiping WANG, Zuohua WANG, Chunxia WANG, Yuxia ZHENG
2023, 44(4): 123-127. doi: 10.12259/j.issn.2095-610X.S20230428
Abstract(2964) HTML PDF(11)
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Objective To investigate the efficacy of rituximab combined with methylprednisolone in the treatment of autoimmune encephalitis (AE) and its effect on programmed death factor-1 (PD-1) and programmed death factor ligand 1 (PD-L1) in peripheral blood. ...
Screening of Congenital Heart Disease at Different Time in Neonates in Anning Area by Auscultation Combined with Pulse Oximetry
Jianhong XU, Zhengmin REN, Yanjiao ZHAO, Shiyun LI, Ruijuan ZHANG, Faguo ZHANG
2023, 44(4): 128-132. doi: 10.12259/j.issn.2095-610X.S20230425
Abstract(3069) HTML PDF(5)
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Objective To study the value of heart murmur auscultation (MUR) combined with pulse oximetry (POX) in the screening of congenital heart disease (CHD) at different time periods after birth in Anning area. Methods A total of 1833 newborns born in the ...
Analysis of Serum G-17 and PG Levels in Ethnic Minority Patients with Gastric Cancer in Lijiang Area
Xiaoji LI, Xuefang YANG, Qian LIU, Chongxiang HE, Yong YANG, Guorong LI
2023, 44(4): 133-138. doi: 10.12259/j.issn.2095-610X.S20230429
Abstract(3451) HTML PDF(16)
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Objective This study aims to analyze the level of G-17 and PG in ethnic minority gastric cancer patients in Lijiang, and to investigate their value in gastric cancer screening. Methods Selected from July 2020 to August 2022, Lijiang people’s hospita...
Single Nucleotide Polymorphisms in Children with Attention Deficit Hyperactivity Disorder Comorbid Emotion Problems
Shujin LI, Yanfei YANG, Min SU, Yu LING, Yanqiong RAO, Jihua CUI
2023, 44(4): 139-147. doi: 10.12259/j.issn.2095-610X.S20230420
Abstract(3529) HTML PDF(7)
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Objective To explore the correlation between 15 candidate gene single nucleotide polymorphisms with emotion problems in ADHD children. Methods A total of 139 children with ADHD who met the DSM-V diagnostic criteria were selected from Kunming Children...
AIDS Research
Influencing Factors of Echocardiographic Abnormalities in HIV/AIDS Patients
Shuishui PAN, Jinsong BAI, Chongxi LI, Zhiqiong AI, Bo TIAN, Changlei MU, Yihan LIU, Jun LIU
2023, 44(4): 148-153. doi: 10.12259/j.issn.2095-610X.S20230422
Abstract(3465) HTML PDF(10)
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Objective The influencing factors of abnormal echocardiography in HIV/AIDS patients were analyzed retrospectively. Methods A total of 386 patients with HIV/AIDS who received echocardiography in the Third People's Hospital of Kunming City from Decemb...
Reviews
Urodynamics in the Diagnosis and Treatment of Overactive Bladder among Females
Lan MAO, Hui ZHAN, Ting LUAN, Haifeng WANG, HaoNan DONG, Jiansong WANG
2023, 44(4): 154-158. doi: 10.12259/j.issn.2095-610X.S20230421
Abstract(2580) HTML PDF(15)
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Overactive bladder (OAB) is a common condition in women. Current guidelines recommend the use of urodynamics (UDS) only in complex cases, but recent studies have shown that UDS plays a key role in the diagnosis and treatment of idiopathic OAB in fema...

Research Progress on the Mechanisms of Autophagy in Hepatocellular Carcinoma
Yixuan CHEN, Lin WANG, Xiuhong XIA, Zaikun PENG, Yi DING, Runjiao SHI, Xuefen LEI
2023, 44(4): 159-164. doi: 10.12259/j.issn.2095-610X.S20230416
Abstract(3803) HTML PDF(51)
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Hepatocellular carcinoma(HCC), characterized by high malignancy and rapid development, is one of the most common malignant tumors in the world. In most cases the tumor is inoperable when diagnois is made. Therefore, non-surgical treatment plays an in...
Teaching Research
Application Effect of OBE Concept on the Nursing Clinical Practice Education
Hongli FANG, Li DENG, Huifang GAO, Ying TIAN, Xiaojia WU
2023, 44(4): 165-169. doi: 10.12259/j.issn.2095-610X.S20230417
Abstract(4191) HTML PDF(40)
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Objective To explore the application effect of OBE (outcome-based education) concept on the nursing clinical practice education. Methods A total of 206 nursing interns form the First affiliated hospital of Kunming Medical University were selected as ...
Effect of Diversified Clinical Education Model in Physiotherapy for Pediatriac Patients
Xin TANG, Weihua JI, Fanyuan MENG, Xuan XU, Yao LIU
2023, 44(4): 170-175. doi: 10.12259/j.issn.2095-610X.S20230406
Abstract(3178) HTML PDF(10)
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Objective To establish the diversified clinical education model in physiotherapy for pediatric patients and to examine the effect in improving skills of students. Methods The undergraduate students majoring in physiotherapy who were admitted to Kunm...
Nursing Forum
Oral Exercise Intervention on Feeding Effect,Growth and Development in Low Birth Weight Infants
Yu’e ZHOU, Tuan LI, Li MA, Tianyun LIU
2023, 44(4): 176-180. doi: 10.12259/j.issn.2095-610X.S20230414
Abstract(3208) HTML PDF(7)
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Objective To analyze the effect of oral exercise intervention on feeding, growth and development in low birth weight infants. Methods A total of 86 of low birth weight infants from December 2020 to December 2022 admitted in the neonatal ward of a ho...
Development of Perioperative Nursing Procedures List for Robot-assisted Thoracoscopic Surgery
Kunlan GUO, Yanjun LI, Yixuan LI, Luanrui WEI, Xiangxiu TAN
2023, 44(4): 181-186. doi: 10.12259/j.issn.2095-610X.S20230418
Abstract(4135) HTML PDF(12)
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Objective To establish a scientific, effective and feasible list of robot-assisted thoracoscopic surgery perioperative nursing procedures, and provide reference for robot-assisted thoracoscopic surgery perioperative nursing work through Delphi expert...