Email
RSS2017 Vol. 38, No. 09
2017, 38(09): 1-6.
Abstract:
Objective To research the influence of different feeding space on spatial change index of estradiol and bone metabolism with in tree shrews osteoporosis after fracture.Methods Tree shrews with osteoporosis after fracture were randomly divided into fracture group (S1) , steamed dumplings without fracture group (S2) , a large cage fracture group (B1) , a large cage without fracture group (B2) four groups, in the space of different sizes in the cage for 90 days, the heart blood ELISA Kit the box according to the instructions to examine the content of serum E2, OC, PINP, CTX, TRACP-5 b, test data were statistically analyzed by SPSS 17 software.Results In the same feeding space, serum E2 (18.90±1.54, 38.25 ±3.33) of tree shrew in S1 group and B1 group were significantly lower than S2 group and B2 group (37.53±1.49, 60.40±2.42) (P<0.05) .The bone formation marker OC (3038.98±492.74, 2792.96±387.23) , PINP (27.39±3.04, 28.75±4.05) and bone absorption markers CTX (411.39±19.44, 324.67±41.32) , TRACP-5 b (2564.38±213.88, 2106.36±322.99) in S1 group and B1 groupwere significantly higher than that of S2 group and B2 group (OC 1835±247.47、1674.44±273.98, PINP 21.04 ±2.93、 19.65 ±2.29, CTX 211.95 ±19.44, 176.07 ±24.95, TRACP-5 b 1394.38 ±171.15、1404.10±210.25) (P<0.05) .Under different feeding space, Serum E2 (18.90±1.54) in S1 group was significantly lower than that of B1 group (38.25±3.33) and B2 group (60.40±2.42) (P<0.05) .CTX (411.39 ± 19.44) in S1 group was significantly higher than that of B1 group CTX (324.67±41.32) , B2 group (176.07±24.95) (P<0.05) , TRACP-5 b (2564.38±213.88) in S1 group was significantly higher than that of B1 group (2106.36±322.99) (P<0.05) .Conclusion Different feeding space size can cause the changes of estradiol and bone metabolism in tree shrews with osteoporosis after fracture.
Objective To research the influence of different feeding space on spatial change index of estradiol and bone metabolism with in tree shrews osteoporosis after fracture.Methods Tree shrews with osteoporosis after fracture were randomly divided into fracture group (S1) , steamed dumplings without fracture group (S2) , a large cage fracture group (B1) , a large cage without fracture group (B2) four groups, in the space of different sizes in the cage for 90 days, the heart blood ELISA Kit the box according to the instructions to examine the content of serum E2, OC, PINP, CTX, TRACP-5 b, test data were statistically analyzed by SPSS 17 software.Results In the same feeding space, serum E2 (18.90±1.54, 38.25 ±3.33) of tree shrew in S1 group and B1 group were significantly lower than S2 group and B2 group (37.53±1.49, 60.40±2.42) (P<0.05) .The bone formation marker OC (3038.98±492.74, 2792.96±387.23) , PINP (27.39±3.04, 28.75±4.05) and bone absorption markers CTX (411.39±19.44, 324.67±41.32) , TRACP-5 b (2564.38±213.88, 2106.36±322.99) in S1 group and B1 groupwere significantly higher than that of S2 group and B2 group (OC 1835±247.47、1674.44±273.98, PINP 21.04 ±2.93、 19.65 ±2.29, CTX 211.95 ±19.44, 176.07 ±24.95, TRACP-5 b 1394.38 ±171.15、1404.10±210.25) (P<0.05) .Under different feeding space, Serum E2 (18.90±1.54) in S1 group was significantly lower than that of B1 group (38.25±3.33) and B2 group (60.40±2.42) (P<0.05) .CTX (411.39 ± 19.44) in S1 group was significantly higher than that of B1 group CTX (324.67±41.32) , B2 group (176.07±24.95) (P<0.05) , TRACP-5 b (2564.38±213.88) in S1 group was significantly higher than that of B1 group (2106.36±322.99) (P<0.05) .Conclusion Different feeding space size can cause the changes of estradiol and bone metabolism in tree shrews with osteoporosis after fracture.
2017, 38(09): 7-10.
Abstract:
Objectives To investigate the in vitro anticancer effects of lichen bioactive compound C11H12O5 on human breast cancer cell line MCF-7, human hepatoma cell line HepG2, human lung adenocarcinoma cell line A-549, and observe the dose-effect and time-effect.Methods MTT assay was used in the in vitro anticancer study.The OD values at 24 h, 48 h, 72 h were examined and the inhibitory ratios were calculated.Results The inhibitory ratios were 14.19%, 13.84%, 28.90%, 59.50%, 80.29% in MCF-7;3.89%, 11.09%, 21.66%, 46.27% and 66.69% in HepG2 and 14.13%, 11.09%, 45.98%, 86.19%, 99.02% in A-549 at 2, 4, 8, 16, 32 μg/m L of compound C11H12O5.The IC50 were 12.43 μg/m L, 18.88 μg/m L and 6.21 μg/m L in MCF-7, HepG2 and A-549 respectively.Conclusions Compound C11H12O5 has significant in vitro anticancer effects on MCF-7, HepG2, A-549.The anticancer effects is dose dependent.A-549 is the most sensitive cell line.The timeeffect of the in vitro anticancer effect in A-549 is not evident.
Objectives To investigate the in vitro anticancer effects of lichen bioactive compound C11H12O5 on human breast cancer cell line MCF-7, human hepatoma cell line HepG2, human lung adenocarcinoma cell line A-549, and observe the dose-effect and time-effect.Methods MTT assay was used in the in vitro anticancer study.The OD values at 24 h, 48 h, 72 h were examined and the inhibitory ratios were calculated.Results The inhibitory ratios were 14.19%, 13.84%, 28.90%, 59.50%, 80.29% in MCF-7;3.89%, 11.09%, 21.66%, 46.27% and 66.69% in HepG2 and 14.13%, 11.09%, 45.98%, 86.19%, 99.02% in A-549 at 2, 4, 8, 16, 32 μg/m L of compound C11H12O5.The IC50 were 12.43 μg/m L, 18.88 μg/m L and 6.21 μg/m L in MCF-7, HepG2 and A-549 respectively.Conclusions Compound C11H12O5 has significant in vitro anticancer effects on MCF-7, HepG2, A-549.The anticancer effects is dose dependent.A-549 is the most sensitive cell line.The timeeffect of the in vitro anticancer effect in A-549 is not evident.
2017, 38(09): 11-14.
Abstract:
Objective To study the effect of "Qingre Runzao Oral Liquid " on the immune function of BALB/c mice.Methods After different doses of "Qingre Runzao Oral Liquid " intervention, we measured the serum elimination rate of carbon particles of mice in each group to evaluate phagocytic activity of the reticuloendothelial system, reticular cortex of mice phagocytic function of the system.Heterologous serum damaging effects of sheep red blood cells (hemolysis half, HC50) was performed to detect the effects of drugs on humoral immune function.ANAE staining was used to count T lymphocytes ratio of mice in each group, and observe the effect of drugs on the immune function of mice.Results Low, middle and high dose group of Qingre Runzao Oral Liquid could significantly enhance the phagocytic function of the reticuloendothelial system test in mice.Middle and high dose group could significantly increase T lymphocytes ratio of tested mice.Conclusion "Qingre Runzao Oral Liquid " can significantly improve the humoral immunity, cellular immunity and reticuloendothelial system of normal mice.
Objective To study the effect of "Qingre Runzao Oral Liquid " on the immune function of BALB/c mice.Methods After different doses of "Qingre Runzao Oral Liquid " intervention, we measured the serum elimination rate of carbon particles of mice in each group to evaluate phagocytic activity of the reticuloendothelial system, reticular cortex of mice phagocytic function of the system.Heterologous serum damaging effects of sheep red blood cells (hemolysis half, HC50) was performed to detect the effects of drugs on humoral immune function.ANAE staining was used to count T lymphocytes ratio of mice in each group, and observe the effect of drugs on the immune function of mice.Results Low, middle and high dose group of Qingre Runzao Oral Liquid could significantly enhance the phagocytic function of the reticuloendothelial system test in mice.Middle and high dose group could significantly increase T lymphocytes ratio of tested mice.Conclusion "Qingre Runzao Oral Liquid " can significantly improve the humoral immunity, cellular immunity and reticuloendothelial system of normal mice.
2017, 38(09): 15-18.
Abstract:
Objective In assisted reproduction, the X/Y sperm was sorted by multi density gradient centrifugation to examine whether the proportion of X/Y sperm was unbalanced in conventional IVF-ET.Method The use of Sperm Grad (Vitrolife, Sweden) and Sperm Rinse (Vitrolife, Sweden) to prepare 10 gradient liquid layer, were 100%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%.After the multilayer gradient was made in the centrifuge tube, the boundary between each gradient was obvious.Choose liquefaction normal, concentration of about 50×106/mL, activity rate of about 50%, low deformity rate of 5 people, after mixing semen, removing individual differences, and take 3 mL mixture gradient centrifugation.Collect each gradient bottom sperm, using two-color X/Y FISH probe (Vysis) for detection, and statistics X/Y sperm percentage.Results 100%, 95%, 90%, 85%, 80%, The proportion of X/Y sperm in each gradient was: 51.41%, 51.41%, 52.19%, 50.99%, 54.10%.Conclusions Although the proportion of X/Y sperm in each gradient was different, the difference was not obvious.In assisted reproductive technology, the use of commercialized sperm washing fluid, even if the use of multi-layer gradient centrifugation, will not cause gender imbalance.
Objective In assisted reproduction, the X/Y sperm was sorted by multi density gradient centrifugation to examine whether the proportion of X/Y sperm was unbalanced in conventional IVF-ET.Method The use of Sperm Grad (Vitrolife, Sweden) and Sperm Rinse (Vitrolife, Sweden) to prepare 10 gradient liquid layer, were 100%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%.After the multilayer gradient was made in the centrifuge tube, the boundary between each gradient was obvious.Choose liquefaction normal, concentration of about 50×106/mL, activity rate of about 50%, low deformity rate of 5 people, after mixing semen, removing individual differences, and take 3 mL mixture gradient centrifugation.Collect each gradient bottom sperm, using two-color X/Y FISH probe (Vysis) for detection, and statistics X/Y sperm percentage.Results 100%, 95%, 90%, 85%, 80%, The proportion of X/Y sperm in each gradient was: 51.41%, 51.41%, 52.19%, 50.99%, 54.10%.Conclusions Although the proportion of X/Y sperm in each gradient was different, the difference was not obvious.In assisted reproductive technology, the use of commercialized sperm washing fluid, even if the use of multi-layer gradient centrifugation, will not cause gender imbalance.
2017, 38(09): 19-23.
Abstract:
Objective To discusses the differences of proliferation between fetal forebrain-and spinal cord-derived neural stem cells (NSCs) in mice.Methods The NSCs were separated by the mechanical method from the forebrain and spinal cord of 14 day C57 BL foetus, and the immunocyfluorescent staining of Nestin & Sox2 used to as the NSCs markers.Meanwhile, calculating multiplication rate and cell doubling time, with the addition of Brd U/Nestin double staining were used to test the proliferation.Results Firstly, multiplication rate of forebrain-derived NSCs significantly proliferated faster than spinal cord-derived (P<0.05) , and cell doubling time is inversely proportional to NSCs multiplication.Secondly, the 5 passages of these two sources of NSCs were the fastest.Lastly, the Brd U+ NSCs also suggested that the proliferating forebrain-derived NSCs (29.65%±3.38) were significantly more than spinal cord-derived (29.65%±3.38) (P<0.05) .Conclusion Our study suggests that the forebrain-derived NSCs have more capacity of proliferation.
Objective To discusses the differences of proliferation between fetal forebrain-and spinal cord-derived neural stem cells (NSCs) in mice.Methods The NSCs were separated by the mechanical method from the forebrain and spinal cord of 14 day C57 BL foetus, and the immunocyfluorescent staining of Nestin & Sox2 used to as the NSCs markers.Meanwhile, calculating multiplication rate and cell doubling time, with the addition of Brd U/Nestin double staining were used to test the proliferation.Results Firstly, multiplication rate of forebrain-derived NSCs significantly proliferated faster than spinal cord-derived (P<0.05) , and cell doubling time is inversely proportional to NSCs multiplication.Secondly, the 5 passages of these two sources of NSCs were the fastest.Lastly, the Brd U+ NSCs also suggested that the proliferating forebrain-derived NSCs (29.65%±3.38) were significantly more than spinal cord-derived (29.65%±3.38) (P<0.05) .Conclusion Our study suggests that the forebrain-derived NSCs have more capacity of proliferation.
2017, 38(09): 24-29.
Abstract:
Objective To prepare Panax notoginseng (PNG) sustained-release pellets and accomplish in vitro release study.Methods Single-factor test and orthogonal test was used to establish the preparation of pellets.Coating conditions were investigated by single-factor test.In vitro release study was used to research the effects of different coating thickness.Results The preparation of pellets was (PNG) :Cellulose Microcrystalline (MCC) =1:3, 45% ethanol was Wetting Agent, method was extrusion-spheronization, rate of extrusion was 45 r/min, rolling rate was 35 HZ (1 505 r/min) , rolling time was 6 minutes, vacuum drying continued for 4 hours at 60℃.Orthogonal test indicated effect order was rolling rate>rolling time>extrusion tare.15% Surelease E-7-19050 was coated pellet at 40℃, the pressure of spray was 0.4 MPa, the rate of spray was 1.0 m L/min.The in vitro release study confirmed that pellets had released sustainedly with added 17% weight.The in vitro release data were well fitted to Higuchi drug release models.Conclusions The preparation process is simple and reliable and could be used to dig deeper to develop.It could lay the foundation for study of release mechanism further.
Objective To prepare Panax notoginseng (PNG) sustained-release pellets and accomplish in vitro release study.Methods Single-factor test and orthogonal test was used to establish the preparation of pellets.Coating conditions were investigated by single-factor test.In vitro release study was used to research the effects of different coating thickness.Results The preparation of pellets was (PNG) :Cellulose Microcrystalline (MCC) =1:3, 45% ethanol was Wetting Agent, method was extrusion-spheronization, rate of extrusion was 45 r/min, rolling rate was 35 HZ (1 505 r/min) , rolling time was 6 minutes, vacuum drying continued for 4 hours at 60℃.Orthogonal test indicated effect order was rolling rate>rolling time>extrusion tare.15% Surelease E-7-19050 was coated pellet at 40℃, the pressure of spray was 0.4 MPa, the rate of spray was 1.0 m L/min.The in vitro release study confirmed that pellets had released sustainedly with added 17% weight.The in vitro release data were well fitted to Higuchi drug release models.Conclusions The preparation process is simple and reliable and could be used to dig deeper to develop.It could lay the foundation for study of release mechanism further.
2017, 38(09): 30-34.
Abstract:
Objective To investigate the expression and clinical significance in of protein markers pulmonary large cell carcinoma (PLCC) .Methods We detected the expression of protein markers of PLCC, and classified the PLCC.We also evaluated the sensibility and specificity of the protein markser.Results The PLCC expressed different protein markers:CK7, TTF1, Napsin A, CK5/6, p63, SOX2, p40, CgA and Syn.The sensibility and specificity of CK7, TTF1, Napsin A was 100%, 63.33%, 76.67% and 62.5%, 100%, 100%.The sensibility and specificity of CK5/6, p63, SOX2, p40 was 100%, 87.5%, 87.5%, 87.5% and 73.33%, 83.33%, 96.67%, 96.67%.The difference of lymph node metastasis rate of every type of pulmonary large cell carcinoma had no statistical significance (P>0.05) , the difference of mutation rate of EGFR of every type of pulmonary large cell carcinoma was statistically significant ( P <0.05) , stem carcinoma>adenocarcinoma>squamous carcinoma.Conclusion It is necessary to detect protein markers of pulmonary large cell carcinoma and their classification.It is helpful to clinical prognosis and to establish reasonable and effective individualized treatment.The sequence number of the sensibility and specificity to adenocarcinoma is Napsin A>TTF1>CK7, to squamous carcinoma is SOX2=p40>p63>CK5/6.
Objective To investigate the expression and clinical significance in of protein markers pulmonary large cell carcinoma (PLCC) .Methods We detected the expression of protein markers of PLCC, and classified the PLCC.We also evaluated the sensibility and specificity of the protein markser.Results The PLCC expressed different protein markers:CK7, TTF1, Napsin A, CK5/6, p63, SOX2, p40, CgA and Syn.The sensibility and specificity of CK7, TTF1, Napsin A was 100%, 63.33%, 76.67% and 62.5%, 100%, 100%.The sensibility and specificity of CK5/6, p63, SOX2, p40 was 100%, 87.5%, 87.5%, 87.5% and 73.33%, 83.33%, 96.67%, 96.67%.The difference of lymph node metastasis rate of every type of pulmonary large cell carcinoma had no statistical significance (P>0.05) , the difference of mutation rate of EGFR of every type of pulmonary large cell carcinoma was statistically significant ( P <0.05) , stem carcinoma>adenocarcinoma>squamous carcinoma.Conclusion It is necessary to detect protein markers of pulmonary large cell carcinoma and their classification.It is helpful to clinical prognosis and to establish reasonable and effective individualized treatment.The sequence number of the sensibility and specificity to adenocarcinoma is Napsin A>TTF1>CK7, to squamous carcinoma is SOX2=p40>p63>CK5/6.
2017, 38(09): 35-38.
Abstract:
Objective To assess the diagnostic value of a modified acid-fast staining method in tuberculouspleuritis.Methods A modified acid-fast staining protocol was used for Mycobacterium tuberculosis in pleural fluid samples.Detection rates of acid-fast bacilli (AFB) from 151 tuberculous pleural fluid samples were compared between the modified-and traditional Ziehl-Neelsen-acid-fast staining protocols.Results from the BACTEC-MGIT 960 culture system, considered the reference standard, were used to determine sensitivity and specificity of the modified staining method.Results With bacterial culture as the reference standard, sensitivity, specificity, positive predictive value (PPV) , and negative predictive value (NPV) were 72.2%, 100.0%, 100.0%, and 52.9%, respectively, for the modified method, and 0%, 100%, 0%, and 23.8%, respectively, for the traditional method.Conclusions The modified acid-fast staining method has a high detection rate for AFB, and can constitute an important diagnostic tool for tuberculouspleuritis.As a simple, rapid and accurate method, the modified acid-fast staining protocol may provide etiologic evidences for detecting tuberculouspleuritis.
Objective To assess the diagnostic value of a modified acid-fast staining method in tuberculouspleuritis.Methods A modified acid-fast staining protocol was used for Mycobacterium tuberculosis in pleural fluid samples.Detection rates of acid-fast bacilli (AFB) from 151 tuberculous pleural fluid samples were compared between the modified-and traditional Ziehl-Neelsen-acid-fast staining protocols.Results from the BACTEC-MGIT 960 culture system, considered the reference standard, were used to determine sensitivity and specificity of the modified staining method.Results With bacterial culture as the reference standard, sensitivity, specificity, positive predictive value (PPV) , and negative predictive value (NPV) were 72.2%, 100.0%, 100.0%, and 52.9%, respectively, for the modified method, and 0%, 100%, 0%, and 23.8%, respectively, for the traditional method.Conclusions The modified acid-fast staining method has a high detection rate for AFB, and can constitute an important diagnostic tool for tuberculouspleuritis.As a simple, rapid and accurate method, the modified acid-fast staining protocol may provide etiologic evidences for detecting tuberculouspleuritis.
2017, 38(09): 39-43.
Abstract:
Objective To analyze the influence factors of required hospitalization among rural residents with different gender in Zhaotong, and provide evidence to make health policy for rural residents with different gender.Methods Multistage stratified random sampling method was used to sample.Household surveys were conducted by face-to-face interviews with questionnaire.The required hospitalization rates were standardized by age.χ2 test and logistic regression are used to analyze the influence factors.Results The required hospitalization rate was 8.0%.The rate of female (9.5%) was higher than that of male (6.8%) .For both of male and female: the group suffering from chronic diseases had higher required hospitalization rate than the group without chronic diseases.For male: The older, the higher required hospitalization rates.For female: the farmers and no occupation group had higher rate than the other occupational group; the divorced and widowed group had higher rate than the unmarried group and married group; the bigger the number of family members, the smaller the required hospitalization rate.The middle-income group and the high-income group, Han nationality, the junior middle school education level group, the married group of female had higher required hospitalization rates than those of male.Conclusions Age and suffering from chronic diseases are the male's influence factors of required hospitalization.Occupation, marital status, number of family members and suffering from chronic diseases are the female's influence factors of required hospitalization.
Objective To analyze the influence factors of required hospitalization among rural residents with different gender in Zhaotong, and provide evidence to make health policy for rural residents with different gender.Methods Multistage stratified random sampling method was used to sample.Household surveys were conducted by face-to-face interviews with questionnaire.The required hospitalization rates were standardized by age.χ2 test and logistic regression are used to analyze the influence factors.Results The required hospitalization rate was 8.0%.The rate of female (9.5%) was higher than that of male (6.8%) .For both of male and female: the group suffering from chronic diseases had higher required hospitalization rate than the group without chronic diseases.For male: The older, the higher required hospitalization rates.For female: the farmers and no occupation group had higher rate than the other occupational group; the divorced and widowed group had higher rate than the unmarried group and married group; the bigger the number of family members, the smaller the required hospitalization rate.The middle-income group and the high-income group, Han nationality, the junior middle school education level group, the married group of female had higher required hospitalization rates than those of male.Conclusions Age and suffering from chronic diseases are the male's influence factors of required hospitalization.Occupation, marital status, number of family members and suffering from chronic diseases are the female's influence factors of required hospitalization.
2017, 38(09): 44-48.
Abstract:
Objective To explore and analyze the physical and mental health status of medical staffs in Yunnan province.Method Self-made health scale and symptom self-assessment scale (SCL-90) including 10 factors were respectively used to investigate the physical and mental health of medical staffs in general hospitals in Yunnan province.Results 480 questionnaires were distributed, 430 qualified questionnaires were taken back, and effective rate was 89.58%.The physical and mental health status of medical staffs were poor, they had very poor sleep and diet, weak fitness consciousness and bad exercise habits.Compared with domestic norm, the average total score of self rating scale and the various symptoms factors, the somatization factors, depression and anxiety scores of medical staffs were significantly higher (P < 0.05) .The force, interpersonal relationship, depression, anxiety, and psychotic factors scores of medical staffs at different posts had statistically significant difference (P <0.05) .Conclusion Medical staffs have poor physical and mental health status, and medical staffs at different posts had significantly different physical and mental health status, the mental health status of nurse is especially worse.
Objective To explore and analyze the physical and mental health status of medical staffs in Yunnan province.Method Self-made health scale and symptom self-assessment scale (SCL-90) including 10 factors were respectively used to investigate the physical and mental health of medical staffs in general hospitals in Yunnan province.Results 480 questionnaires were distributed, 430 qualified questionnaires were taken back, and effective rate was 89.58%.The physical and mental health status of medical staffs were poor, they had very poor sleep and diet, weak fitness consciousness and bad exercise habits.Compared with domestic norm, the average total score of self rating scale and the various symptoms factors, the somatization factors, depression and anxiety scores of medical staffs were significantly higher (P < 0.05) .The force, interpersonal relationship, depression, anxiety, and psychotic factors scores of medical staffs at different posts had statistically significant difference (P <0.05) .Conclusion Medical staffs have poor physical and mental health status, and medical staffs at different posts had significantly different physical and mental health status, the mental health status of nurse is especially worse.
2017, 38(09): 49-53.
Abstract:
Objective To study the relationship between mental health status and food choice of the migrant school children.Methods Mental Health Diagnosis test (MHT) and the 2011 China Economic, Population, Nutrition and health survey questionnaire were used to investigate 348 students of grade 3-5 in a primary school, Kunming.Results 62.4% of investigated students had anxiety in study.And the mental health status of the migrant school children was statistically significant between different grades (P < 0.05) .The main mental health problems of grade 3 students were anxiety to study and phobic tendency, the main mental health problem of grade 4 students was loneliness tendency, the main mental health problems of grade 5 students were anxiety with other people, self accusation tendency, allergy tendency, physical symptoms and impulse tendency.The students with allergic propensity score greater than or equal to eight points preferred to drink beverage;the students with physical symptom score greater than or equal to eight points did not like to eat vegetables, but like drinking (P < 0.05) .Conclusions The main mental health problems of the migrant school children are study anxiety, self accusation tendency and other psychological health problems in a primary school in Kunming.The allergic tendency and physical symptoms have the effect with the food choice.
Objective To study the relationship between mental health status and food choice of the migrant school children.Methods Mental Health Diagnosis test (MHT) and the 2011 China Economic, Population, Nutrition and health survey questionnaire were used to investigate 348 students of grade 3-5 in a primary school, Kunming.Results 62.4% of investigated students had anxiety in study.And the mental health status of the migrant school children was statistically significant between different grades (P < 0.05) .The main mental health problems of grade 3 students were anxiety to study and phobic tendency, the main mental health problem of grade 4 students was loneliness tendency, the main mental health problems of grade 5 students were anxiety with other people, self accusation tendency, allergy tendency, physical symptoms and impulse tendency.The students with allergic propensity score greater than or equal to eight points preferred to drink beverage;the students with physical symptom score greater than or equal to eight points did not like to eat vegetables, but like drinking (P < 0.05) .Conclusions The main mental health problems of the migrant school children are study anxiety, self accusation tendency and other psychological health problems in a primary school in Kunming.The allergic tendency and physical symptoms have the effect with the food choice.
2017, 38(09): 54-58.
Abstract:
Objectives To study the job burnout status and the characteristics of doctors in Yunnan provincial 3 A hospitals and provide specific recommendations for clinicians' mental health and vocational development.Methods The investigation was conducted among 518 doctors in three Yunnan provincial 3 A hospitals with Maslach Burnout Inventory (MBI) , and the results of different groups were compared.Results 76.64%doctors showed burnout state, 71.43% doctors showed higher level of emotional exhaustion;the job burnout of the doctors who worked for 11-20 years is the most serious, the high level of emotional exhaustion of the doctors who worked for 4-5 years should arouse attention;sex (t=-2.05, df=505, P=0.041) , administrative positions (t=-2.64, df=510, P=0.009) , resign intention (t=5.97, df=506, P=0.000) , length of service (F=3.12, P=0.005;F=3.93, P=0.001) , academic title (F=8.93, P=0.000;F=3.31, P=0.037) , economic status (F=4.47, P=0.012) , academic qualification (F=7.22, P=0.001) and the main working area (F=4.45, P=0.004) variables had influence on job burnout.Conclusions The prevalence and severity on job burnout of doctors should be concemed.Measures should be taken to prevent or cure job bumout.
Objectives To study the job burnout status and the characteristics of doctors in Yunnan provincial 3 A hospitals and provide specific recommendations for clinicians' mental health and vocational development.Methods The investigation was conducted among 518 doctors in three Yunnan provincial 3 A hospitals with Maslach Burnout Inventory (MBI) , and the results of different groups were compared.Results 76.64%doctors showed burnout state, 71.43% doctors showed higher level of emotional exhaustion;the job burnout of the doctors who worked for 11-20 years is the most serious, the high level of emotional exhaustion of the doctors who worked for 4-5 years should arouse attention;sex (t=-2.05, df=505, P=0.041) , administrative positions (t=-2.64, df=510, P=0.009) , resign intention (t=5.97, df=506, P=0.000) , length of service (F=3.12, P=0.005;F=3.93, P=0.001) , academic title (F=8.93, P=0.000;F=3.31, P=0.037) , economic status (F=4.47, P=0.012) , academic qualification (F=7.22, P=0.001) and the main working area (F=4.45, P=0.004) variables had influence on job burnout.Conclusions The prevalence and severity on job burnout of doctors should be concemed.Measures should be taken to prevent or cure job bumout.
2017, 38(09): 59-65.
Abstract:
Objective To study the relationship between single nucleotide polymorphisms (SNPs) of ERCC1 Asn118 Asn (rs11615) , ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn (rs1799793) and ERCC2 Lys751 Gln (rs13181) and osteosarcoma survival with the osteosarcoma patients.Methods 161 patients with osteosarcoma in our hospital from January 2010 to Decemher 2015 and 163 heahhy adults were enrolled in this study.2 m L peripheral blood samples were taken from each person.The RT-q PCR method was used to detect the genotype and allele frequency distribution of ERCC1 Asn118 Asn (rs11615) , ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn (rs1799793) and ERCC2 Lys751 Gln (rs13181) in osteosarcoma patients and normal population.Osteosarcoma patients were divided into several groups according to the clinical parameters such as age, gender, histology, tumor location, Enneking classification, tumormetastasis and therapy, and analyzed the relations between the genetic polymorphism and clinical parameters.Results For ERCC1 Asn118 Asn, thevariant genotype T/T was strongly significantly associated with a higher disease-free survival when compared with the wild-type C/C, with an adjusted OR (95% CI) of 0.37 (0.15-0.85) .ERCC2 751 A/A genotype showed increased disease-free survival of osteosarcoma (HR=0.45; 95% CI=0.11-0.88) .However, we did not find significant association of ERCC1 Gln504 Lys and ERCC2 Asp312 Asn polymorphisms with prognosis of osteosarcoma.Conclusions The genetic polymorphism of ERCC gene at ERCC1 Asn118 Asn T/T, ERCC2 Lys751 Gln A/A is associated with osteosarcoma disease-free survival (SFS) , can be used as clinical prognostic markers for osteosarcoma patients with cisplatin treatment.But ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn have no correlation with osteosarcoma disease-free survival (SFS) .
Objective To study the relationship between single nucleotide polymorphisms (SNPs) of ERCC1 Asn118 Asn (rs11615) , ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn (rs1799793) and ERCC2 Lys751 Gln (rs13181) and osteosarcoma survival with the osteosarcoma patients.Methods 161 patients with osteosarcoma in our hospital from January 2010 to Decemher 2015 and 163 heahhy adults were enrolled in this study.2 m L peripheral blood samples were taken from each person.The RT-q PCR method was used to detect the genotype and allele frequency distribution of ERCC1 Asn118 Asn (rs11615) , ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn (rs1799793) and ERCC2 Lys751 Gln (rs13181) in osteosarcoma patients and normal population.Osteosarcoma patients were divided into several groups according to the clinical parameters such as age, gender, histology, tumor location, Enneking classification, tumormetastasis and therapy, and analyzed the relations between the genetic polymorphism and clinical parameters.Results For ERCC1 Asn118 Asn, thevariant genotype T/T was strongly significantly associated with a higher disease-free survival when compared with the wild-type C/C, with an adjusted OR (95% CI) of 0.37 (0.15-0.85) .ERCC2 751 A/A genotype showed increased disease-free survival of osteosarcoma (HR=0.45; 95% CI=0.11-0.88) .However, we did not find significant association of ERCC1 Gln504 Lys and ERCC2 Asp312 Asn polymorphisms with prognosis of osteosarcoma.Conclusions The genetic polymorphism of ERCC gene at ERCC1 Asn118 Asn T/T, ERCC2 Lys751 Gln A/A is associated with osteosarcoma disease-free survival (SFS) , can be used as clinical prognostic markers for osteosarcoma patients with cisplatin treatment.But ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn have no correlation with osteosarcoma disease-free survival (SFS) .
2017, 38(09): 66-70.
Abstract:
Objective To observate and analyze the significance of serum total bilirubin level detected in cerebral emergencies.Methods A total of 62 patients with cerebral infarction (incidence ≤2 weeks) in the People's Hospital of Dehong from September 2013 to July 2015 were selected as the observation group, another 62 cases of examination of patients were selected as a control group.Then we compared the biochemical indexes including serum total bilirubin, blood lipids and blood sugar within 72 h after admission between two groups of patients.Results For patients in the observation group, serum levels o f triglyceride, total cholesterol, high density lipoprotein cholesterol, diastolic blood pressure, systolic blood pressure, fasting blood glucose were significantly higher than the control group [ (1.85±0.36) mmol/L vs (1.36 ±0.21) mmol/L, (4.9 ±1.5) mmol/L vs (4.5±1.1) mmol/L, (1.56±0.39) mmol/L vs (1.43±0.28) mmol/L, (83.1±11.5) mm Hg vs (75.2±10.3) mm Hg, (132.5±22.4) mm Hg vs (117.3±19.8) mm Hg, (5.9±0.3) mmol/L vs (5.3±0.9) mmol/L, Low density lipoprotein cholesterol was lower than the control group [ (2.01±0.29) mmol/L vs (2.41 ±0.37) mmol/L].Serum total bilirubin, direct bilirubin, indirect bilirubin of observation group was significantly higher than the control group [ (15.1±3.8) μmol/L vs (12.1±3.5) μmol/L, (4.6±1.1) μmol/L vs (3.9±1.3) μmol/L, (10.5±2.1) μmol/L vs (8.1±1.4) μmol/L], the difference was statistically significant (P<0.05) .Varying degrees of neurological impairment with total bilirubin, directbilirubin, indirect bilirubin had no significant difference (P>0.05) .Good prognosis group total bilirubin, directbilirubin, indirect bilirubin levels were significantly higher than the poor prognosis group [ (16.1±3.7) μmol/L vs (11.9±2.9) μmol/L, (4.9±1.1) μmol/L vs (3.6±1.1) μmol/L, (11.2±2.1) μmol/L vs (8.2±2.3) μmol/L], the difference was statistically significant (P<0.05) .Conclusion Serum levels of total bilirubin in patients is beneficial for the early diagnosis and treatment of patients with cerebral infarction, and determine the prognosis.
Objective To observate and analyze the significance of serum total bilirubin level detected in cerebral emergencies.Methods A total of 62 patients with cerebral infarction (incidence ≤2 weeks) in the People's Hospital of Dehong from September 2013 to July 2015 were selected as the observation group, another 62 cases of examination of patients were selected as a control group.Then we compared the biochemical indexes including serum total bilirubin, blood lipids and blood sugar within 72 h after admission between two groups of patients.Results For patients in the observation group, serum levels o f triglyceride, total cholesterol, high density lipoprotein cholesterol, diastolic blood pressure, systolic blood pressure, fasting blood glucose were significantly higher than the control group [ (1.85±0.36) mmol/L vs (1.36 ±0.21) mmol/L, (4.9 ±1.5) mmol/L vs (4.5±1.1) mmol/L, (1.56±0.39) mmol/L vs (1.43±0.28) mmol/L, (83.1±11.5) mm Hg vs (75.2±10.3) mm Hg, (132.5±22.4) mm Hg vs (117.3±19.8) mm Hg, (5.9±0.3) mmol/L vs (5.3±0.9) mmol/L, Low density lipoprotein cholesterol was lower than the control group [ (2.01±0.29) mmol/L vs (2.41 ±0.37) mmol/L].Serum total bilirubin, direct bilirubin, indirect bilirubin of observation group was significantly higher than the control group [ (15.1±3.8) μmol/L vs (12.1±3.5) μmol/L, (4.6±1.1) μmol/L vs (3.9±1.3) μmol/L, (10.5±2.1) μmol/L vs (8.1±1.4) μmol/L], the difference was statistically significant (P<0.05) .Varying degrees of neurological impairment with total bilirubin, directbilirubin, indirect bilirubin had no significant difference (P>0.05) .Good prognosis group total bilirubin, directbilirubin, indirect bilirubin levels were significantly higher than the poor prognosis group [ (16.1±3.7) μmol/L vs (11.9±2.9) μmol/L, (4.9±1.1) μmol/L vs (3.6±1.1) μmol/L, (11.2±2.1) μmol/L vs (8.2±2.3) μmol/L], the difference was statistically significant (P<0.05) .Conclusion Serum levels of total bilirubin in patients is beneficial for the early diagnosis and treatment of patients with cerebral infarction, and determine the prognosis.
2017, 38(09): 71-73.
Abstract:
Objective To assess the microsurgical resection of dumbbell-shape spinal schwannoma through enlarged intervertebral foramen approach.Methods We performed a retrospective review of 16 patients with dumbbell-shape spinal schwannomas who underwent microsurgical treatment by enlarged intervertebral foramen approach from March 2012 to December 2015 in our department.Preoperative imaging revealed the tumor bestriding intra-and extra-spinal canal, and the intervertebral foramen had been enlarged noticeably.Among which 8 were cervical, 3 were thoracic and 5 were lumbar spinal schwannomas.Results All tumors were removed completely.There was no intraoperative death.The average operation time was 3.2 hours, the average perioperative blood loss was 240 ml, the average hospital stay was 7.8 days postoperation.The average follow-up period was 10.7 months (ranged, 3 months to 36 months) .The symptoms and signs were improved and relieved significantly and no obvious complication or spinal deformity was found.Conclusion The dumbbell-shape spinal schwannoma predominantly located in extraintervertebral foramen could be removed via enlarged intervertebral foramen approach.This approach can aviod the destruction of spine bone structure, excessive exposure during operation and obtain maximum maintenance of spine stability.
Objective To assess the microsurgical resection of dumbbell-shape spinal schwannoma through enlarged intervertebral foramen approach.Methods We performed a retrospective review of 16 patients with dumbbell-shape spinal schwannomas who underwent microsurgical treatment by enlarged intervertebral foramen approach from March 2012 to December 2015 in our department.Preoperative imaging revealed the tumor bestriding intra-and extra-spinal canal, and the intervertebral foramen had been enlarged noticeably.Among which 8 were cervical, 3 were thoracic and 5 were lumbar spinal schwannomas.Results All tumors were removed completely.There was no intraoperative death.The average operation time was 3.2 hours, the average perioperative blood loss was 240 ml, the average hospital stay was 7.8 days postoperation.The average follow-up period was 10.7 months (ranged, 3 months to 36 months) .The symptoms and signs were improved and relieved significantly and no obvious complication or spinal deformity was found.Conclusion The dumbbell-shape spinal schwannoma predominantly located in extraintervertebral foramen could be removed via enlarged intervertebral foramen approach.This approach can aviod the destruction of spine bone structure, excessive exposure during operation and obtain maximum maintenance of spine stability.
2017, 38(09): 74-78.
Abstract:
Objective To explore the application and effect assessment of high-frequency mono-polar electronic scalpel (HMES) in infant with ankyloglossia diorthosis.Methods From 2014 to 2015, we enrolled 246 patients aged between 1 to 36 month who underwent ankyloglossia diorthosis by HMES.Results 246 patients were successfully completed surgery and no infection and hemorrhage occurred after operation, and the incision healed well.Conclusions The HMES has a good cutting ability and hemostasis effect for soft tissue.Due to many advantages, such as clear surgical field, less trauma, quick hemostasis, high operation accuracy, the high-frequency mono-polar electronic scalpel is in favor of shortening operative time in terms of infant ankyloglossia diorthosis as well as reducing postoperative complications.The HMES is a safe and effective method for infant ankyloglossia diorthosis, and it is worthy of popularization.
Objective To explore the application and effect assessment of high-frequency mono-polar electronic scalpel (HMES) in infant with ankyloglossia diorthosis.Methods From 2014 to 2015, we enrolled 246 patients aged between 1 to 36 month who underwent ankyloglossia diorthosis by HMES.Results 246 patients were successfully completed surgery and no infection and hemorrhage occurred after operation, and the incision healed well.Conclusions The HMES has a good cutting ability and hemostasis effect for soft tissue.Due to many advantages, such as clear surgical field, less trauma, quick hemostasis, high operation accuracy, the high-frequency mono-polar electronic scalpel is in favor of shortening operative time in terms of infant ankyloglossia diorthosis as well as reducing postoperative complications.The HMES is a safe and effective method for infant ankyloglossia diorthosis, and it is worthy of popularization.
2017, 38(09): 79-82.
Abstract:
Objective To observe the correlation between the exhaled nitric oxide (FeNO) and mycoplasma load in bronchialveolar lavage fluid (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP) .Methods 42 inpatients in affiliated children's hospital of kunming medical university were enrolled from January to November in 2016, and 50 healthy children were selected as control group.Then the value of FeNO were compared between two groups.MP DNA in BALF was detected quantitatively by fluorescent real-time PCR.Children with MPP were divided into two groups of low MP-DNA load group and high MP-DNA load group according to the copies of MP DNA in BALF less than or equal to106 copies/m L or not.The value of FeNO were compared between groups with different copies of MP DNA.We also compared the level of FeNO between normal MPP group and refractory Mycoplasma pneumonia pneumonia (RMPP) group.Results The level of FeNO from the patients with MPP[ (27.48±5.34) bbp]was significantly higher than that of control group[ (14.24±4.21) bbp].The level of FeNO between the low MP-DNA load group[ (27.58±4.74) bbp] and the high MP-DNA load group[ (27.33±6.20) bbp]had no statistical significance.The level of FeNO from the patients with RMPP[ (29.88±4.51) bbp]was higher than that of normal MPP group[ (26.00±5.35) bbp].Conclusion MP infection increase the production of FeNO, andit demonstrates that there is no relationship between the value of FeNO with the MP-DNA load.Compared with normal MPP, the damage to the small airway maybe more prominent in RMPP.
Objective To observe the correlation between the exhaled nitric oxide (FeNO) and mycoplasma load in bronchialveolar lavage fluid (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP) .Methods 42 inpatients in affiliated children's hospital of kunming medical university were enrolled from January to November in 2016, and 50 healthy children were selected as control group.Then the value of FeNO were compared between two groups.MP DNA in BALF was detected quantitatively by fluorescent real-time PCR.Children with MPP were divided into two groups of low MP-DNA load group and high MP-DNA load group according to the copies of MP DNA in BALF less than or equal to106 copies/m L or not.The value of FeNO were compared between groups with different copies of MP DNA.We also compared the level of FeNO between normal MPP group and refractory Mycoplasma pneumonia pneumonia (RMPP) group.Results The level of FeNO from the patients with MPP[ (27.48±5.34) bbp]was significantly higher than that of control group[ (14.24±4.21) bbp].The level of FeNO between the low MP-DNA load group[ (27.58±4.74) bbp] and the high MP-DNA load group[ (27.33±6.20) bbp]had no statistical significance.The level of FeNO from the patients with RMPP[ (29.88±4.51) bbp]was higher than that of normal MPP group[ (26.00±5.35) bbp].Conclusion MP infection increase the production of FeNO, andit demonstrates that there is no relationship between the value of FeNO with the MP-DNA load.Compared with normal MPP, the damage to the small airway maybe more prominent in RMPP.
2017, 38(09): 83-86.
Abstract:
Objective To study and observe the clinical effect of octreotide in the patients with acute pancreatitis and its influence on the pancreatic blood flow.Methods 82 patients with acute pancreatitis in our hospital from October 2015 to July 2016 were set as the research object, and 82 patients were divided into control group 41 cases and observation group 41 cases according to the principle of random allocation.Patients in the control group were treated with routine treatment of acute pancreatitis, while patients in the observation group were treated with octreotide on the basic treatment, then the total clinical effective rates, pancreatic head and tail blood flow indexes before and after the treatment of two groups were analyzed and compared.Results The total clinical effective rates of observation group with mild and severe pancreatitis were higher than those of control group, the pancreatic head and tail blood flow indexes at different time after the treatment were all obviously higher than those of control group, all P<0.05, the differences were all significant.Conclusion The clinical effect of octreotide on the patients with acute pancreatitis is better, and it can significantly improve the pancreatic blood flow state, so its application value in the patients with acute pancreatitis is higher.
Objective To study and observe the clinical effect of octreotide in the patients with acute pancreatitis and its influence on the pancreatic blood flow.Methods 82 patients with acute pancreatitis in our hospital from October 2015 to July 2016 were set as the research object, and 82 patients were divided into control group 41 cases and observation group 41 cases according to the principle of random allocation.Patients in the control group were treated with routine treatment of acute pancreatitis, while patients in the observation group were treated with octreotide on the basic treatment, then the total clinical effective rates, pancreatic head and tail blood flow indexes before and after the treatment of two groups were analyzed and compared.Results The total clinical effective rates of observation group with mild and severe pancreatitis were higher than those of control group, the pancreatic head and tail blood flow indexes at different time after the treatment were all obviously higher than those of control group, all P<0.05, the differences were all significant.Conclusion The clinical effect of octreotide on the patients with acute pancreatitis is better, and it can significantly improve the pancreatic blood flow state, so its application value in the patients with acute pancreatitis is higher.
2017, 38(09): 87-91.
Abstract:
Objective To explore the modeling of diabetic cystopathy (DCP) and the changes of urodynamics in rats with DCP.Methods 40 female rats (200-250 g) were divided into two groups: group A, the controlled group (22 rats) and group B (18 rats) , the experimental group.The model of DCP (experimental group) was established with the intraperitoneal injection of streptozotocin (STZ) after 4 weeks feeding of high-sugar high-fat.Group A was injected citrate buffer intraperitoneally (the same dose of STZ) after 4 weeks normal feeding.Both groups were tested the blood sugar through the tail vein, 1 time a week, four times altogether.Twelve weeks later, the bladder capacity, bladder pressure and leakage point pressure were tested with urodynamic instument.The results were tested 3 times.Results The blood sugar of group B was higher obviously than group A.And the successful modeling rate of DCP with STZ was 100%.Compared wth group A, the filling bladder capacity was higher significantly, the bladder pressure and leakage point pressure were lower significantly in group B.Conclusion The successful modeling rate of DCP with STZ is high and the urethra and bladder function changes are significant in DCP rats.
Objective To explore the modeling of diabetic cystopathy (DCP) and the changes of urodynamics in rats with DCP.Methods 40 female rats (200-250 g) were divided into two groups: group A, the controlled group (22 rats) and group B (18 rats) , the experimental group.The model of DCP (experimental group) was established with the intraperitoneal injection of streptozotocin (STZ) after 4 weeks feeding of high-sugar high-fat.Group A was injected citrate buffer intraperitoneally (the same dose of STZ) after 4 weeks normal feeding.Both groups were tested the blood sugar through the tail vein, 1 time a week, four times altogether.Twelve weeks later, the bladder capacity, bladder pressure and leakage point pressure were tested with urodynamic instument.The results were tested 3 times.Results The blood sugar of group B was higher obviously than group A.And the successful modeling rate of DCP with STZ was 100%.Compared wth group A, the filling bladder capacity was higher significantly, the bladder pressure and leakage point pressure were lower significantly in group B.Conclusion The successful modeling rate of DCP with STZ is high and the urethra and bladder function changes are significant in DCP rats.
2017, 38(09): 92-95.
Abstract:
Objective To explore the efficacy and safety of Paliperidone extended-release tablets (Paliperidone ER) and Risperidone tablets in treatment of childhood and adolescents first episode schizophrenia.Methods 66 children with first-episode schizophrenia were randomly divided into Paliperidone group (n=33, treated with Paliperidone ER) and Risperidone group (n=33, orally took Risperidone tablets) and treated for 8 weeks.The efficacy and adverse reactions were assessed with positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS) before and 1, 2, 4, 8 weeks after the treatment.Results The total score and the factor scores of PANSS in the two groups were significantly decreased after the treatment (P<0.05 or P<0.01) .At the first weekend, the score of PANSS was significantly lower in Paliperidone group than that in the Risperidone group (P<0.05) .The other factors had no significant differences (P>0.05) .In comparison of the adverse reactions between the two groups, the adverse drug reaction incidence of Paliperidone group was lower than that of Risperidone group (P <0.01) .Conclusions Paliperidone ER in the treatment of childhood and adolescents first episode schizophrenia has a rapid effect, less adverse reactions, and a high safety.
Objective To explore the efficacy and safety of Paliperidone extended-release tablets (Paliperidone ER) and Risperidone tablets in treatment of childhood and adolescents first episode schizophrenia.Methods 66 children with first-episode schizophrenia were randomly divided into Paliperidone group (n=33, treated with Paliperidone ER) and Risperidone group (n=33, orally took Risperidone tablets) and treated for 8 weeks.The efficacy and adverse reactions were assessed with positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS) before and 1, 2, 4, 8 weeks after the treatment.Results The total score and the factor scores of PANSS in the two groups were significantly decreased after the treatment (P<0.05 or P<0.01) .At the first weekend, the score of PANSS was significantly lower in Paliperidone group than that in the Risperidone group (P<0.05) .The other factors had no significant differences (P>0.05) .In comparison of the adverse reactions between the two groups, the adverse drug reaction incidence of Paliperidone group was lower than that of Risperidone group (P <0.01) .Conclusions Paliperidone ER in the treatment of childhood and adolescents first episode schizophrenia has a rapid effect, less adverse reactions, and a high safety.
2017, 38(09): 96-99.
Abstract:
Objective To investigate the effect of nerve block on the treatment of herpes zoster (HZ) and prevention of postherpetic neuralgia (PHN) , and to explore the factors that affect the occurrence of PHN.Methods From january 2015 to September 2016 in our hospital 80 acute HZ patients for the first time in the treatment of pain, were randomly assigned to the case group (nerve block + conventional medical treatment) 40 cases, and the control group (conventional medical treatment) 40 cases.The incidence of neuralgia in the two groups was analyzed, and the relationship between the age, sex, herpes, prodromal pain, initial pain, scab time, pain relief rate and PHN.Results PHN occurred in 4 cases (10.0%) in the case group and 19 cases (47.5%) in the control group (P <0.001) . (6.33 ± 0.86 days vs.7.15 ± 0.66 days, P <0.001) .The number of hospital days decreased (7.43 ± 1.80 days vs.12.90 ± 2.36 days, P <0.001) .Ageing (OR: 8.24, 95% CI:1.62-41.96) and prolonged crusting time (OR: 17.99, 95% CI: 2.14-151.43) , are risk factors for PHN, significantly increased the incidence of PHN.The VAS remission rate after 1 week (OR <0.000, 95% CI:0.000-0.001) was a protective factor for PHN and was negatively correlated with PHN.Conclusions Aging and onset of severe pain in patients should pay attention to the prevention of PHN.Nerve block helps to reduce the number of hospital stay in HZ patients, shorten the scab time, and reduce the incidence of PHN.
Objective To investigate the effect of nerve block on the treatment of herpes zoster (HZ) and prevention of postherpetic neuralgia (PHN) , and to explore the factors that affect the occurrence of PHN.Methods From january 2015 to September 2016 in our hospital 80 acute HZ patients for the first time in the treatment of pain, were randomly assigned to the case group (nerve block + conventional medical treatment) 40 cases, and the control group (conventional medical treatment) 40 cases.The incidence of neuralgia in the two groups was analyzed, and the relationship between the age, sex, herpes, prodromal pain, initial pain, scab time, pain relief rate and PHN.Results PHN occurred in 4 cases (10.0%) in the case group and 19 cases (47.5%) in the control group (P <0.001) . (6.33 ± 0.86 days vs.7.15 ± 0.66 days, P <0.001) .The number of hospital days decreased (7.43 ± 1.80 days vs.12.90 ± 2.36 days, P <0.001) .Ageing (OR: 8.24, 95% CI:1.62-41.96) and prolonged crusting time (OR: 17.99, 95% CI: 2.14-151.43) , are risk factors for PHN, significantly increased the incidence of PHN.The VAS remission rate after 1 week (OR <0.000, 95% CI:0.000-0.001) was a protective factor for PHN and was negatively correlated with PHN.Conclusions Aging and onset of severe pain in patients should pay attention to the prevention of PHN.Nerve block helps to reduce the number of hospital stay in HZ patients, shorten the scab time, and reduce the incidence of PHN.
2017, 38(09): 100-104.
Abstract:
Objective To investigate the effect of SCARF or reverse SCARF osteotomy operation of Hallux Valgus on the stage of knee osteoarthritis patients in the lesion side.Methods Retrospective analysis was used to recruit the 45 patients who were diagnosed as moderate or severe Hallux Valgus accompanying Knee osteoarthritis on the lesion side and had complete data.We divided the 22 cases who received the SCARF (or reverse SCARF) osteotomy operation into operation group and divided the 23 cases who received the no-operation treatments into no-operation group.T test was used to compare the difference of Hallux Valgus common malformation angles between of two groups before and after the resident treatment.χ2 test was used to compare the difference between two groups on stages of knee osteoarthritis before and after the resident treatment.Results Follow-up for 2-3 yearsr: (1) Compared with the no-operation group, the amelioration of Hallux Valgus common malformation angles measured of operation patient group, the difference had statistical significance (P <0.01) . (2) Compared with the no-operation group the accelerating speed of knee osteoarthritis in the lesion side of operation patient group was delayed, the relation of staging before and after the treatment had significant difference (P <0.01) . (3) Compared with the operation group, the accelerating speed of knee osteoarthritis in the lesion side of operation patient group was increased without the relation of staging before and after the treatment and had no significant difference (P>0.05) . (4) After the treatment, the constitution rate difference of Knee Osteoarthritis between the two groups had statistical significance (P<0.01) .Conclusion For the patients who suffered from Hallux Valgus and Knee Osteoarthritis in the lesion side, active applying the SCARF or reverse SCARF osteotomy operation of Hallux Valgus may not only cure the local symptoms of Hallux Valgus but also delay the pathological accelerating speed of Knee Osteoarthritis in the lesion side.
Objective To investigate the effect of SCARF or reverse SCARF osteotomy operation of Hallux Valgus on the stage of knee osteoarthritis patients in the lesion side.Methods Retrospective analysis was used to recruit the 45 patients who were diagnosed as moderate or severe Hallux Valgus accompanying Knee osteoarthritis on the lesion side and had complete data.We divided the 22 cases who received the SCARF (or reverse SCARF) osteotomy operation into operation group and divided the 23 cases who received the no-operation treatments into no-operation group.T test was used to compare the difference of Hallux Valgus common malformation angles between of two groups before and after the resident treatment.χ2 test was used to compare the difference between two groups on stages of knee osteoarthritis before and after the resident treatment.Results Follow-up for 2-3 yearsr: (1) Compared with the no-operation group, the amelioration of Hallux Valgus common malformation angles measured of operation patient group, the difference had statistical significance (P <0.01) . (2) Compared with the no-operation group the accelerating speed of knee osteoarthritis in the lesion side of operation patient group was delayed, the relation of staging before and after the treatment had significant difference (P <0.01) . (3) Compared with the operation group, the accelerating speed of knee osteoarthritis in the lesion side of operation patient group was increased without the relation of staging before and after the treatment and had no significant difference (P>0.05) . (4) After the treatment, the constitution rate difference of Knee Osteoarthritis between the two groups had statistical significance (P<0.01) .Conclusion For the patients who suffered from Hallux Valgus and Knee Osteoarthritis in the lesion side, active applying the SCARF or reverse SCARF osteotomy operation of Hallux Valgus may not only cure the local symptoms of Hallux Valgus but also delay the pathological accelerating speed of Knee Osteoarthritis in the lesion side.
2017, 38(09): 105-108.
Abstract:
Objective To invastigate effect of ultrasound-guided cricothyroid membrane puncture airway surface anesthesia on nasotracheal intubation response.Methods Sixty patients undergoing elective pharyngeal throat surgery were randomly divided into ultrasound group and blind group (n=30) .Ultrasound group patients were given 2% lidocaine 2 m L by ultrasound-guided undergoing cricothyroid membrane puncture, while blind group patients were treated by traditional palpation method.HR, MAP and heart rate systolic pressure product (RPP) were recorded at sedative (T0) , after administrating (T1) , intubation immediately (T2) , 2 minutes after intubation (T3) , 5 minutes after intubation (T4) .Cough score and incidence of postoperative sore throat were recorded.Results HR, MAP and RPP of the two groups had no significant differences in the same time points (P>0.05) .Compared with the blind group, the degree of cough and incidence of postoperative sore throat were lighter in the ultrasound group (P<0.05) .Conclusion The effect of ultrasound-guided cricothyroid membrane puncture surface anesthesia on nasotracheal intubation response is similar to that of traditional palpation method, but the incidence of related complications is lower.
Objective To invastigate effect of ultrasound-guided cricothyroid membrane puncture airway surface anesthesia on nasotracheal intubation response.Methods Sixty patients undergoing elective pharyngeal throat surgery were randomly divided into ultrasound group and blind group (n=30) .Ultrasound group patients were given 2% lidocaine 2 m L by ultrasound-guided undergoing cricothyroid membrane puncture, while blind group patients were treated by traditional palpation method.HR, MAP and heart rate systolic pressure product (RPP) were recorded at sedative (T0) , after administrating (T1) , intubation immediately (T2) , 2 minutes after intubation (T3) , 5 minutes after intubation (T4) .Cough score and incidence of postoperative sore throat were recorded.Results HR, MAP and RPP of the two groups had no significant differences in the same time points (P>0.05) .Compared with the blind group, the degree of cough and incidence of postoperative sore throat were lighter in the ultrasound group (P<0.05) .Conclusion The effect of ultrasound-guided cricothyroid membrane puncture surface anesthesia on nasotracheal intubation response is similar to that of traditional palpation method, but the incidence of related complications is lower.
2017, 38(09): 109-112.
Abstract:
Objective To study the variation of corneal endothelial cellsafterpenetrating keratoplasty from donation after cardiac death (DCD) .Methods 191 cases of corneal graftwere textedafter penetrating keratoplasty1-4 weeks; 5-12 weeks; 4-6 months; 7-12 months later from donation after cardiac death with corneal endothelial microscope.Results 1.48 patients in 191 cases of patients with corneal endothelial microscopeweredetected, 143 cases of patients could not be detected, the detection rate was 25%;2.48 cases after1-4 weeks, 5-12 weeks, 4-6 monthsand 7-12 months the density of endothelial cells were (2271.15±321.47) mm2, (1971.33±358.18) mm2, (1 826.59±303.92) mm2, (1753.14±306.31) mm2, and the average cell area increased from (388.45 ±95.26) μm to (638.63 ±124.73) μm 7-12 months after operation, cell size variation coefficient (CV value) increased from 30.15% to 65.04%, the proportion of hexagonal cells decreased from 52.59 ±7.26% to 40.01 ±11.35%.Conclusion (1) corneal endothelial endoscopy for early corneal endothelial cells of patients with recognition rate is low, poor sensitivity, confocal microscopy evaluation could be used instead of corneal endothelial microsco when the cornea was edema; (2) Corneal endothelial cell density decreased gradually and the percentage of hexagonal cells was descend and CV value were increased after penetratingkeratoplasty; (3) Follow-up should be strengthened after penetrating keratoplasty from donation after cardiac death (DCD) 1 a later especially three months later, when there were signs of early rejection, timely anti rejection treatment was very important for reducing early rejection.
Objective To study the variation of corneal endothelial cellsafterpenetrating keratoplasty from donation after cardiac death (DCD) .Methods 191 cases of corneal graftwere textedafter penetrating keratoplasty1-4 weeks; 5-12 weeks; 4-6 months; 7-12 months later from donation after cardiac death with corneal endothelial microscope.Results 1.48 patients in 191 cases of patients with corneal endothelial microscopeweredetected, 143 cases of patients could not be detected, the detection rate was 25%;2.48 cases after1-4 weeks, 5-12 weeks, 4-6 monthsand 7-12 months the density of endothelial cells were (2271.15±321.47) mm2, (1971.33±358.18) mm2, (1 826.59±303.92) mm2, (1753.14±306.31) mm2, and the average cell area increased from (388.45 ±95.26) μm to (638.63 ±124.73) μm 7-12 months after operation, cell size variation coefficient (CV value) increased from 30.15% to 65.04%, the proportion of hexagonal cells decreased from 52.59 ±7.26% to 40.01 ±11.35%.Conclusion (1) corneal endothelial endoscopy for early corneal endothelial cells of patients with recognition rate is low, poor sensitivity, confocal microscopy evaluation could be used instead of corneal endothelial microsco when the cornea was edema; (2) Corneal endothelial cell density decreased gradually and the percentage of hexagonal cells was descend and CV value were increased after penetratingkeratoplasty; (3) Follow-up should be strengthened after penetrating keratoplasty from donation after cardiac death (DCD) 1 a later especially three months later, when there were signs of early rejection, timely anti rejection treatment was very important for reducing early rejection.
2017, 38(09): 113-118.
Abstract:
Objective To observe the maxillary alveolar bone density changes in patients with mild-to-moderate chronic periodontal disease and different periodontal biotypes at alignment and leveling arch stage.Methods 20 cases of adult female patients were selected randomly and were divided into group in accordance to the periodontal status, periodontal biotypes and different teeth movement.The maxillary alveolar bone density was measured by Cone beam CT (CBCT) .Results After treatment, bone mineral density in different periodontal status was decreased (P<0.05) ;reduce periodontal disease to the labial movement in the root apical, labial palatal bone density ratio was greater than the thickness of thin type gingival type (P<0.05) ;lower lip to mobile thin gingival periodontal disease group in the root of neck the middle and apical labial and palatal alveolar bone density was greater than the ratio of periodontal health group (P<0.05) ;mobile palatal periodontal disease group in the root of neck lip, palate side reduction ratio is greater than the periodontal health group (P<0.05) ;lower lip thickness of gingival and periodontal disease to the mobile group in the labial and root neck in the root, the tip of thepalatal bone density was greater than the ratio of periodontal health group (P<0.05) ; mobile palatal periodontal disease group in the root decreased rate was larger than the labial periodontal health group (P <0.05) .Conclusions The alveolar bone density may be greatly changed in the periodontal disease group after the leveling and aligning of orthodontic treatment.At the beginning of the orthodontic treatment, we should pay more attention on the periodontal biotype to avoid maxillary alveolar bone absorbing.
Objective To observe the maxillary alveolar bone density changes in patients with mild-to-moderate chronic periodontal disease and different periodontal biotypes at alignment and leveling arch stage.Methods 20 cases of adult female patients were selected randomly and were divided into group in accordance to the periodontal status, periodontal biotypes and different teeth movement.The maxillary alveolar bone density was measured by Cone beam CT (CBCT) .Results After treatment, bone mineral density in different periodontal status was decreased (P<0.05) ;reduce periodontal disease to the labial movement in the root apical, labial palatal bone density ratio was greater than the thickness of thin type gingival type (P<0.05) ;lower lip to mobile thin gingival periodontal disease group in the root of neck the middle and apical labial and palatal alveolar bone density was greater than the ratio of periodontal health group (P<0.05) ;mobile palatal periodontal disease group in the root of neck lip, palate side reduction ratio is greater than the periodontal health group (P<0.05) ;lower lip thickness of gingival and periodontal disease to the mobile group in the labial and root neck in the root, the tip of thepalatal bone density was greater than the ratio of periodontal health group (P<0.05) ; mobile palatal periodontal disease group in the root decreased rate was larger than the labial periodontal health group (P <0.05) .Conclusions The alveolar bone density may be greatly changed in the periodontal disease group after the leveling and aligning of orthodontic treatment.At the beginning of the orthodontic treatment, we should pay more attention on the periodontal biotype to avoid maxillary alveolar bone absorbing.
2017, 38(09): 119-123.
Abstract:
Objective To study the influences of different doses of Ambroxol Hydrochloride Injection on the inflammatory cotokines in the treatment of elderly patients with chronic obstructive pulmonary disease patients with acute exacerbation.Methods 62 cases of elderly patients with chronic obstructive pulmonary disease with acute exacerbation in our hospital from May 2015 to May 2016 were selected and randomly divided into Group A and B, 31 cases in each group.The Group A was given Ambroxol Hydrochloride Injection treatment, 330 mg per time, and Group B was given 90 mg Ambroxol Hydrochloride Injection treatment.The IL-6, IL-8, and TNF-α Index on the1 st day, 4 th day and 7 th day after the treatment in these two groups were compared.Results On the 1 st day, the sputum IL-6, IL-8 and TNF-αafter treatment had no statistically significant difference between two groups (P>0.05) .On the first 4 th day and 7 th day, the decrease of the indicators of patients in A group was significantly better than group B patients, and the difference was statistically significant (P<0.05) .There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05) .Conclusion The application of large doses of short Ambroxol Hydrochloride Injection can quickly improve the clinical symptoms in acute exacerbation of elderly patients with chronic obstructive pulmonary disease, and reduce the patient's sputum IL-6, IL-8 and TNF-α index, has better anti-inflammatory effect and deserves wide application.
Objective To study the influences of different doses of Ambroxol Hydrochloride Injection on the inflammatory cotokines in the treatment of elderly patients with chronic obstructive pulmonary disease patients with acute exacerbation.Methods 62 cases of elderly patients with chronic obstructive pulmonary disease with acute exacerbation in our hospital from May 2015 to May 2016 were selected and randomly divided into Group A and B, 31 cases in each group.The Group A was given Ambroxol Hydrochloride Injection treatment, 330 mg per time, and Group B was given 90 mg Ambroxol Hydrochloride Injection treatment.The IL-6, IL-8, and TNF-α Index on the1 st day, 4 th day and 7 th day after the treatment in these two groups were compared.Results On the 1 st day, the sputum IL-6, IL-8 and TNF-αafter treatment had no statistically significant difference between two groups (P>0.05) .On the first 4 th day and 7 th day, the decrease of the indicators of patients in A group was significantly better than group B patients, and the difference was statistically significant (P<0.05) .There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05) .Conclusion The application of large doses of short Ambroxol Hydrochloride Injection can quickly improve the clinical symptoms in acute exacerbation of elderly patients with chronic obstructive pulmonary disease, and reduce the patient's sputum IL-6, IL-8 and TNF-α index, has better anti-inflammatory effect and deserves wide application.
2017, 38(09): 124-128.
Abstract:
Objective To improve the recognition level, diagnostic therapeutic level of IgD-λ+λ type mutiple myeloma, and also reduce the rate of missed diagnosis and misdiagnosis.Methods We retrospectively reported and analyzed two cases double clones of IgD-λ+λ type multiple myelomadiagnosed in our hospital from January to November in 2014.Results There were 79 cases of multiple myeloma patients during observing time.Two patients in this study, male one was 45 years old while the female one 51 years old when they first came to be diagnosed.Both of them were diagnosed of double clones of IgD-λ+λ stage Ⅲ B group.Clinical manifestation included anemia, ostealgia, renal failure, thin and weak.Serum calcium and LDH levels were increased in different degree.The levels of immune globulin IgG, IgA, IgM were decreased and immunofixation electrophresis showed two monoclonal zone.Then they were both diagnosed IgD-λ+λ type mutiple myelom.One patient reached PR after four courses VADT chemotherapy and now is still alive.Another one didn't accept any treatment because of poverty.Conclusions The double clones IgD-λ+λ type multiple myelomais is a kind of rare plasma cell disorder, sicientists now haven't reached a profond understanding about its clinical features, laboratory features diagnositic criteria and therapeutic prognosis.More clinical cases are needed to summarize and analyze in the future study.
Objective To improve the recognition level, diagnostic therapeutic level of IgD-λ+λ type mutiple myeloma, and also reduce the rate of missed diagnosis and misdiagnosis.Methods We retrospectively reported and analyzed two cases double clones of IgD-λ+λ type multiple myelomadiagnosed in our hospital from January to November in 2014.Results There were 79 cases of multiple myeloma patients during observing time.Two patients in this study, male one was 45 years old while the female one 51 years old when they first came to be diagnosed.Both of them were diagnosed of double clones of IgD-λ+λ stage Ⅲ B group.Clinical manifestation included anemia, ostealgia, renal failure, thin and weak.Serum calcium and LDH levels were increased in different degree.The levels of immune globulin IgG, IgA, IgM were decreased and immunofixation electrophresis showed two monoclonal zone.Then they were both diagnosed IgD-λ+λ type mutiple myelom.One patient reached PR after four courses VADT chemotherapy and now is still alive.Another one didn't accept any treatment because of poverty.Conclusions The double clones IgD-λ+λ type multiple myelomais is a kind of rare plasma cell disorder, sicientists now haven't reached a profond understanding about its clinical features, laboratory features diagnositic criteria and therapeutic prognosis.More clinical cases are needed to summarize and analyze in the future study.
2017, 38(09): 129-133.
Abstract:
Cerebrospinal fluid leakage (CSF) is a common complication of lumbar spine surgery.Over the past decades, there has been significant advancement in understanding the basis, management and techniques of treatment for post-operative CSF leak following lumbar spine surgery.In this article, we review previous lumbar surgery or after surgery in literatures related to different factors and treatment of cerebrospinal fluid leakage, for selection of care and treatment methods and technology are presented and emphasis on the current treatment trends.This article also discusses the factors that cause the leakage of cerebrospinal fluid, the basic concepts and methods of practice.Cerebrospinal fluid leakage after operation of various management techniques and different prognosis in this paper made a good statement.However, there is no ideal treatment options available, in each case, the choice of every kind of treatment technology depends on each surgeon's experience, understanding of each patient's condition, nature and the location of cerebrospinal fluid leakage and relys on the existing facilities and equipment.
Cerebrospinal fluid leakage (CSF) is a common complication of lumbar spine surgery.Over the past decades, there has been significant advancement in understanding the basis, management and techniques of treatment for post-operative CSF leak following lumbar spine surgery.In this article, we review previous lumbar surgery or after surgery in literatures related to different factors and treatment of cerebrospinal fluid leakage, for selection of care and treatment methods and technology are presented and emphasis on the current treatment trends.This article also discusses the factors that cause the leakage of cerebrospinal fluid, the basic concepts and methods of practice.Cerebrospinal fluid leakage after operation of various management techniques and different prognosis in this paper made a good statement.However, there is no ideal treatment options available, in each case, the choice of every kind of treatment technology depends on each surgeon's experience, understanding of each patient's condition, nature and the location of cerebrospinal fluid leakage and relys on the existing facilities and equipment.
2017, 38(09): 134-139.
Abstract:
Mesothelin is a cell surface glycoprotein, with little expression in normal tissues, but highly expressed in tumors such as ovarian cancer, pancreatic cancer and malignant mesothelioma.Therefore, mesothelin helps those tumors' early diagnosis, and is related to tumor staging and prognosis.The use of immunotoxin, anti-mesothelin chimeric antibodies, antibody-drug conjugates, chimeric antigen receptor T cells, mesothelin tumor vaccines is progressing towards maturation in the treatment of mesothelin-rich tumors.This article aims to review the research progress of mesothelin in ovarian cancer, pancreatic cancer, malignant mesothelioma diagnosis and treatment.
Mesothelin is a cell surface glycoprotein, with little expression in normal tissues, but highly expressed in tumors such as ovarian cancer, pancreatic cancer and malignant mesothelioma.Therefore, mesothelin helps those tumors' early diagnosis, and is related to tumor staging and prognosis.The use of immunotoxin, anti-mesothelin chimeric antibodies, antibody-drug conjugates, chimeric antigen receptor T cells, mesothelin tumor vaccines is progressing towards maturation in the treatment of mesothelin-rich tumors.This article aims to review the research progress of mesothelin in ovarian cancer, pancreatic cancer, malignant mesothelioma diagnosis and treatment.
2017, 38(09): 140-143.
Abstract:
Objective To summarize the allergic reaction and nursing measures of clinical commonly used non ionic iodine contrast agent.Methods Between May 2012 and December 2015, 170 cases of allergic reactions occurred within 24 hours after the injection of nonionic iodine contrast agent.The factors, such as the type, concentration and flow rate of the contrast agents, and the nursing measures were analyzed.Results The incidence of total adverse reactions of iopromide, iohexol, and iopamidol were 0.38% and 0.35%, 0.44%, respectively.The total adverse reactions rate of iopamidol was slightly higher than the iopromide and iohexol, the three drugs had no statistical difference (P > 0.05) .The incidence of laryngeal edema and allergic shock in iopromide group were seven in one hundred thousand and three in thousand, rare adverse reactions.Conclusion A small part of patients who used non ionic iodine contrast agent may appeare allergic reactions in different degrees, so we should be careful, strengthen the care, gurrantee the clinical drug safety of iodine contrast agent.
Objective To summarize the allergic reaction and nursing measures of clinical commonly used non ionic iodine contrast agent.Methods Between May 2012 and December 2015, 170 cases of allergic reactions occurred within 24 hours after the injection of nonionic iodine contrast agent.The factors, such as the type, concentration and flow rate of the contrast agents, and the nursing measures were analyzed.Results The incidence of total adverse reactions of iopromide, iohexol, and iopamidol were 0.38% and 0.35%, 0.44%, respectively.The total adverse reactions rate of iopamidol was slightly higher than the iopromide and iohexol, the three drugs had no statistical difference (P > 0.05) .The incidence of laryngeal edema and allergic shock in iopromide group were seven in one hundred thousand and three in thousand, rare adverse reactions.Conclusion A small part of patients who used non ionic iodine contrast agent may appeare allergic reactions in different degrees, so we should be careful, strengthen the care, gurrantee the clinical drug safety of iodine contrast agent.
2017, 38(09): 144-148.
Abstract:
Objective To observe the effect of evidence-based extension intervention nursing model on low-salt diet compliance in elderly hypertensive patients.Methods We selected 640 cases of elderly hypertensive patients in the department of geriatrics, Yan'an Affiliated Hospital of Kunming Medical University, from March2014 to March 2017.The 640 cases were divided into control group (320 cases) and observation group (320 cases) randomly.Observation group was given evidence-based intervention in low-salt diet education and control group was given traditional low-salt diet education.Two groups were then divided into seven stages (on the day of discharge, two weeks after discharge, one month after discharge, three months after discharge, six months after discharge, nine months after discharge, one year after discharge) .We analyzed low-salt cognitive scores, low-salt behavioral scores and salt-intake/d comparably.Results Except two weeks after discharge, in other six stages of two groups had statistically significant difference (P<0.01) in low-salt cognitive scores; In seven stages, two groups had statistically significance difference (P<0.01) in low-salt behavioral scores;In seven stages, two groups had statistically significance difference (P<0.01) in salt-intake/d.Conclusions Evidence-based extension intervention nursing model can effectively improve the low-salt cognitive and behavioral scores, decrease salt-intake/d, and improve the compliance with low-salt diet of the elderly hypertensive patients after discharge.
Objective To observe the effect of evidence-based extension intervention nursing model on low-salt diet compliance in elderly hypertensive patients.Methods We selected 640 cases of elderly hypertensive patients in the department of geriatrics, Yan'an Affiliated Hospital of Kunming Medical University, from March2014 to March 2017.The 640 cases were divided into control group (320 cases) and observation group (320 cases) randomly.Observation group was given evidence-based intervention in low-salt diet education and control group was given traditional low-salt diet education.Two groups were then divided into seven stages (on the day of discharge, two weeks after discharge, one month after discharge, three months after discharge, six months after discharge, nine months after discharge, one year after discharge) .We analyzed low-salt cognitive scores, low-salt behavioral scores and salt-intake/d comparably.Results Except two weeks after discharge, in other six stages of two groups had statistically significant difference (P<0.01) in low-salt cognitive scores; In seven stages, two groups had statistically significance difference (P<0.01) in low-salt behavioral scores;In seven stages, two groups had statistically significance difference (P<0.01) in salt-intake/d.Conclusions Evidence-based extension intervention nursing model can effectively improve the low-salt cognitive and behavioral scores, decrease salt-intake/d, and improve the compliance with low-salt diet of the elderly hypertensive patients after discharge.
