2021 Vol. 42, No. 7

Original Articles Basic of Medicine
Effect of Norathyriol on the Epithelial-mesenchymal Transition of HK-2 Cells Induced by TGF-β1
Ai-ping XU, Hua LIN, Li-hui GAO, Ling LI, Meng-wei CHENG, Ge WANG, Juan YANG, Yan-fen NIU
2021, 42(7): 1-6. doi: 10.12259/j.issn.2095-610X.S20210701
Abstract(4193) HTML PDF(135) Cited By (2)
Abstract:
Objective To study the effects of norathyriol on epithelial-mesenchymal transition of HK-2 cells induced by TGF-β1. Methods MTT assay was used to detect the effect of norathyriol on HK-2 cell viability. The HK-2 cells were divided into normal group...
Correlation between CYP11B2 Gene -344 C/T Polymorphism and Essential Hypertension in Yi Minority of Yunnan Shuanghe Township
Hong-yu PENG, Zhi-xiang FAN, Yan-jie ZHANG, Xin SHU, Fu-lin ZHANG, Li LONG
2021, 42(7): 7-12. doi: 10.12259/j.issn.2095-610X.S20210702
Abstract(2967) HTML PDF(18)
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Objective To investigate the correlation between CYP11B2 gene -344C/T polymorphism and essential hypertension in Yi people of Yunnan Shuanghe Township. Methods We collected peripheral blood of 308 Yi residents of Shuanghe township, Jinning county, ...
Effectiveness of Low Intensity Focused Ultrasound Stimulation of Nucleus Accumbens in Mice
Yun-yan LAN, Yu-ran FENG, Yu ZHENG, Zhen-dong YANG, Yi ZHAO, Mei ZHU
2021, 42(7): 13-19. doi: 10.12259/j.issn.2095-610X.S20210703
Abstract(2879) HTML PDF(45)
Abstract:
Objective To investigate the effectiveness of ultrasound stimulation for neural regulation from the aspects of behavioral pathology and neurobiochemistry by using low intensity focused ultrasound to stimulate the nucleus accumbens of normal mice. M...
Signal Pathway Related Mechanism of Vein Graft Failure in Coronary Artery Bypass Grafting
Hu ZHANG, An-rui PENG, Jia-ji ZHONG, Bo HUANG
2021, 42(7): 20-24. doi: 10.12259/j.issn.2095-610X.S20210704
Abstract(4105) HTML PDF(26)
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Objective To explore the signal pathway of vein graft failure in coronary artery bypass grafting. Methods 40 rabbits were randomly divided into two groups. Group A was sham operation group; Group B was model group in which rabbit model of CABG was es...
Anesthetic Effects and Mechanism of Hydromorphone Combined with Propofol on Colorectal Dilatation Model
Dan-ni ZHANG, Xia-guang DUAN, Chun-guang HAO, Xiao-jun ZHI, Hai-feng ZHU, Zai-qing HUANG
2021, 42(7): 25-30. doi: 10.12259/j.issn.2095-610X.S20210705
Abstract(3643) HTML PDF(17) Cited By (1)
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Objective To study the anesthetic effect of hydrocodone combined with propofol for painless colonoscopy and to investigate the mechanism of the analgesic effect produced by hydrocodone. Methods Clean grade male SD rats were randomly divided into four...
Clinical Research
The Correlation between the Imaging Characteristics of Imported COVID-19 at First Diagnosis and Clinical Severity Grading
Li WU, Yun-hui YANG, Jing ZHANG, Zhang-cong YANG, Yu SU, Yong-jian WEN, Yu-chun WU, Peng WANG, Zhi-peng LI, Wei ZHAO, Dan HAN, Rui-dong WANG, Bo HE
2021, 42(7): 49-56. doi: 10.12259/j.issn.2095-610X.S20210708
Abstract(3984) HTML PDF(16)
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Objective To investigate the correlation between the imaging characteristics of the first diagnosis of imported novel coronavirus pneumonia (COVID-19) and clinical severity grading. Methods A retrospective analysis was performed on the clinical and...
Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020
Hai-lin HUANG, Xiao-juan LI, Jian-wen YIN, Hong-chao JIANG
2021, 42(7): 83-87. doi: 10.12259/j.issn.2095-610X.S20210713
Abstract(5723) HTML PDF(24) Cited By (14)
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Objective To study the distribution and drug sensitivity of Salmonella and Shigella in bacterial infectious diarrhea in children in Kunming and provide reliable basis for clinical rational drug use. Methods Salmonella and Shigella were cultured fro...
Changes of Rifampicin Concentration in Cerebrospinal Fluid of Patients with Tuberculous Meningoencephalitis
Yang LI, Hua HE, Yan-ling ZHANG, Ying HUANG, Jun-long WANG
2021, 42(7): 110-114. doi: 10.12259/j.issn.2095-610X.S20210718
Abstract(3195) HTML PDF(15) Cited By (2)
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Objective To investigate the concentration and efficacy of rifampicin (RIF) in cerebrospinal fluid during intrathecal injection of RIF in the treatment of tuberculous meningitis. Methods Forty patients with tuberculous meningitis were randomly divi...
Association of Mismatch Repair Deficiency and Clinicopathological Parameters in Patients withLeft and Right-side Sporadic Colon Cancer
Lei LIANG, Xin PU, Wen-liang LI, Shu-min MA, Xiao-ting LIU, Xuan-yu MENG, Zhi-yong KOU, Jun YANG
2021, 42(7): 31-42. doi: 10.12259/j.issn.2095-610X.S20210706
Abstract(3588) HTML PDF(19) Cited By (2)
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Objective To analyze the correlation between mismatch repair-deficient (dMMR) and clinicopathological characteristics in left and right-side sporadic colorectal cancers. Methods The clinicopathological data of 1922 patients who were pathologically co...
Top Closure Tension-relief System with Regulated Oxygen-enriched Negative Pressure-assisted Wound Therapy for the Treatment of Refractory Wounds
Xin-feng ZHANG, Xiao-li ZHANG, Meng-li LI, Hua-you LUO, Ruo SHU, Yi LEI
2021, 42(7): 43-48. doi: 10.12259/j.issn.2095-610X.S20210707
Abstract(2711) HTML PDF(15) Cited By (2)
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Objective To investigate the clinical efficacy of Top Closure tension-relief system combined with regulated oxygen-enriched negative pressure-assisted wound therapy in the treatment of refractory wounds. Methods From August 2018 to July 2020, 36 pati...
Association between Calcitonin Receptor Gene Polymorphism and Type 2 Diabetes with Osteoporosis in Kunming
Bo-yi LI, Ling NIU, Rong MA, Xian ZHANG, Fang LIU, Yan TANG, Cui-juan MIAO, Zhu-jun HAN, Cheng ZHANG
2021, 42(7): 57-63. doi: 10.12259/j.issn.2095-610X.S20210709
Abstract(4314) HTML PDF(17) Cited By (3)
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Objective To study the relationship between calcitonin receptor (CTR) gene polymorphism and type 2 diabetes (T2DM) with osteoporosis in Kunming area, and to explore the genetic predisposing factors of T2DM with osteoporosis. Methods A total of 237 T2...
Synovial Volume Quantitative Analysis of MRI and Serological Comparison in the Evaluation of Juvenile Idiopathic Arthritis
Li-xiang REN, You-deng PU, Jia-qi WANG, Ya-jun WANG, Hui-mei YUAN, Yi-chen HUANG, Qing LI, San-li YI
2021, 42(7): 64-69. doi: 10.12259/j.issn.2095-610X.S20210710
Abstract(3593) HTML PDF(21) Cited By (2)
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Objective To establish volume quantitative analysis and explore the value of MRI with synovial quantitative analysis for treatment evaluation of juvenile idiopathic arthritis (JIA). Methods Quantitative analysis model pretest and clinical prospective...
The Relationship between Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area
Ling NIU, Bo-yi LI, Jing-qiu MAO, Yan TANG, Rong MA, Fang LIU, Chen ZHANG, Zhu-jun HAN, Cui-juan MIAO, Xian ZHANG
2021, 42(7): 70-76. doi: 10.12259/j.issn.2095-610X.S20210711
Abstract(4403) HTML PDF(14) Cited By (4)
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Objective To study the relationship between vitamin D receptor (VDR) gene polymorphism and type 2 diabetes mellitus (T2DM) with osteoporosis in Kunming area, and to explore the genetic susceptibility factors of T2DM with osteoporosis. Methods We sele...
Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD
Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI
2021, 42(7): 77-82. doi: 10.12259/j.issn.2095-610X.S20210712
Abstract(3455) HTML PDF(18) Cited By (3)
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Objective To investigate the influencing factors of liver injury in patients with chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD). Methods The clinical data of 225 patients with CHB complicated with NAFLD admitted to the Third...
Correlation between Serum 25-hydroxyvitamin D and Peripheral Neuropathy in Type 2 Diabetes
Xiao-rui YANG, Qian XIANG, Ya QIU, Yan LUAN, Xian ZHANG, Yan GUO
2021, 42(7): 88-93. doi: 10.12259/j.issn.2095-610X.S20210714
Abstract(3999) HTML PDF(21) Cited By (11)
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Objective To investigate the correlation between 25 (OH) D level and the occurrence of DPN. Methods A total of 138 patients with type 2 diabetes mellitus (T2DM) were selected as the study subjects. According to the clinical symptoms and neurogram res...
Effect of Two Sequential Estrogen Therapy on Endometrium and Prognosis after Intrauterine Adhesion
Jin-bao XIAO, Jun-da ZHAO, Jun-qi MA
2021, 42(7): 94-97. doi: 10.12259/j.issn.2095-610X.S20210715
Abstract(4157) HTML PDF(13) Cited By (11)
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Objective To compare the therapeutic effect and prognosis of Femostong and Honglilai combined with Duphaton in patients with intrauterine adhesions. Methods A total of 70 patients with intrauterine adhesions admitted to the first Affiliated Hospital ...
Effects of Folic Acid Combined with Alendronate on Bone Metabolism,CCl4 and Fibroblast Growth Factor Levels in Postmenopausal Osteoporosis Patients
Yong LIAO, Yi-yun GUO, Hong-yu ZHOU, Hai-po FENG, Gen-ding CHEN, Shui-qing YANG
2021, 42(7): 98-103. doi: 10.12259/j.issn.2095-610X.S20210716
Abstract(3613) HTML PDF(12) Cited By (2)
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Objective To investigate the effects of folic acid combined with alendronate sodium on bone metabolism, CCL4 and fibroblast growth factor levels in postmenopausal osteoporosis patients. Methods A total of 154 postmenopausal osteoporosis patients admi...
Related Factors Affecting Adverse Events of Symptomatic Carotid Artery Stenosis
Yan-ping LI, Yi ZENG, Xiao-lin DONG, Huan WEI, Qing-yun LI, Ming-shun AN, Li-ping ZHAN, Jian-hui LI, Gang WU, Yang LI, Jing-hui LI
2021, 42(7): 104-109. doi: 10.12259/j.issn.2095-610X.S20210717
Abstract(3233) HTML PDF(13) Cited By (1)
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Objective To study the related influencing factors of adverse events of symptomatic carotid stenosis, and to explore the effect of stenting on adverse events of symptomatic carotid stenosis and the value of event-related evoked potentials in the diag...
Efficacy of Multiple Non-invasive Diagnostic Models in the Diagnosis of Hepatic Fibrosis in Patients with Chronic Liver Diseases
Qin XIE, Yan-ping LIANG, Yin ZHANG, Zeng-hui XU, Li-ying YOU
2021, 42(7): 115-120. doi: 10.12259/j.issn.2095-610X.S20210719
Abstract(3481) HTML PDF(33) Cited By (8)
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Objective To investigate the diagnostic value of APRI, FIB-4, Forns, GPR, S-index, King, RPR non-invasive models in the diagnosis of liver fibrosis in patients with chronic liver disease. Methods The clinical data of 67 patients with chronic liver di...
Effects of Different Doses of Ulinastatinon Postoperative Cognitive Function and HMGB1 in Elderly Patients
Li-yuan AN, Bing LI, Gang SU
2021, 42(7): 121-125. doi: 10.12259/j.issn.2095-610X.S20210720
Abstract(3492) HTML PDF(11) Cited By (1)
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Objective To study the effects of different doses of Ulinastatin on postoperative cognitive function and HMBG1 in elderly patients. Methods From May 2020 to September 2020, 60 elderly patients older than 60 years of age were selected for elective sur...
Nursing Forum
Application of Improved Position Pad in Reducing the Incidence of Pressure Injury in Prone Position
Bin SHAO, Zhi-wei TANG, Jing ZHANG, Pei-xian DONG, Yun-ping CHAO
2021, 42(7): 161-165. doi: 10.12259/j.issn.2095-610X.S20210727
Abstract(2984) HTML PDF(20) Cited By (9)
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Objective To study the effect of modified position pad on reducing the occurrence of stress injury in prone position of neurosurgery. Methods From September 2017 to March 2019, 58 patients diagnosed as posterior fossa tumor in the first Department ...
Effect of Standard Nutrition Intervention on Quality of Life in Patients with Rhinitis after Radiotherapy
Jiang WU, Yan-yan FEI, Shui-fen DAI, Li YANG, Qian ZHOU, Ling ZHANG, Tao SHI
2021, 42(7): 166-169. doi: 10.12259/j.issn.2095-610X.S20210728
Abstract(4281) HTML PDF(11) Cited By (15)
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Objective To explore the effect of standardized nutrition management on the quality of life of patients with nasopharyngeal carcinoma after radiotherapy. Methods 160 patients with nasopharyngeal carcinoma who received radiotherapy in a 3A tumor hospi...
Clinical Effect of Comprehensive Intervention of Structural Nutrition on Perioperative Cochlear Implant Patients
Na LIAO, Lei-ji LI, Jing FEI, Fang WANG, Min WANG, Hai-yan WAN
2021, 42(7): 170-175. doi: 10.12259/j.issn.2095-610X.S20210729
Abstract(4637) HTML PDF(7)
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Objective To understand the influence of perioperative comprehensive structural nutrition intervention for cochlear implant patients on the complications, medical costs and satisfaction of cochlear implant patients, so as to provide reference for exp...
Effect of Multiple Preoperative Visiting Patterns on Psychological Stress in Patients with Valve Replacement
Xin-tong FU, Zhu-hui NA, Jing-hong PI, Min ZHANG, Yan LIU, Qiu-han LIU, Bi-si SHAN, Wen-min CHEN
2021, 42(7): 176-180. doi: 10.12259/j.issn.2095-610X.S20210730
Abstract(3988) HTML PDF(7) Cited By (17)
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Objective To investigate the effect of multiple preoperative visiting patterns on psychological stress in patients with cardiac valve replacement. Methods A total of 100 patients with simple valve replacement admitted to our department from May 2019 ...
AIDS Research
Effect of HIV Post-exposure Prophylaxis in Kunming City in 2019
Bo TIAN, Jun LIU, Chong-xi LI, Rong HE, Shan-qun GU, Wei-bo WANG
2021, 42(7): 126-129. doi: 10.12259/j.issn.2095-610X.S20210721
Abstract(3423) HTML PDF(17) Cited By (4)
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Objective To understand the treatment status and effect of HIV post-exposure prophylaxis in Kunming city in 2019. The proportion of the 28-day course completed and the influencing factors. It provides a reference for the wide application of HIV post-...
Clinical Efficacy and Safety of Sofosbuvir and Vipatavir in the Treatment of Patients with Chronic Hepatitis C and HCV/HIV co-infection
Yong-rui YANG, Hai-wen LI, Zhi-rong ZHAO, Lu WANG, Ting JIA, Zhi-jian DONG, Xiao-fei LI, Ni-hong LU
2021, 42(7): 130-136. doi: 10.12259/j.issn.2095-610X.S20210722
Abstract(4046) HTML PDF(11) Cited By (9)
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Objective To observe the efficacy and safety of SofosbuvirVelpatasvir in the treatment to chronic hepatitis C combining with HCV/HIV. Methods 419 patients with chronic hepatitis C and 56 patients with HCV/HIV that were admitted to Kunming Third Peopl...
Reviews
Research Progress of Orphan Receptor GPR88 in Related Diseases
Di ZENG, Han-rui SHAO, Ying-ying ZOU, Yong-hua RUAN
2021, 42(7): 137-142. doi: 10.12259/j.issn.2095-610X.S20210723
Abstract(3834) HTML PDF(39)
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GPR88 is an orphan receptor of the Class A rhodopsin family, belonging to the G protein-coupled receptors (GPCRs) family. Existing studies have shown that it is involved in the occurrence and development of a variety of diseases, and at the same time...
Progress in Clinical Research on Drug Resistance and Reversal of Endocrine Therapy in Breast Cancer
Wen-jing SUN, Man-ting HU, Na LI, Fei GE, Wen-lin CHEN, Yang LIU
2021, 42(7): 143-149. doi: 10.12259/j.issn.2095-610X.S20210724
Abstract(4293) HTML PDF(53) Cited By (4)
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In the initial stage of clinical treatment of hormone receptor positive HR + breast cancer, good prognosis is often achieved by endocrine therapy. Once recurrence and metastasis occur, the overall prognosis is not ideal. Therefore, the efficacy of en...
The Interaction of Bacteria in the Process of Plaque Formation and Pathogenicity
Zhe-feng GAO, Ya-yan LEI, Yu SUN, Dan-wei LI, Hong-bing HE
2021, 42(7): 150-156. doi: 10.12259/j.issn.2095-610X.S20210725
Abstract(3953) HTML PDF(20) Cited By (4)
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Dental plaque is the main factor leading to a variety of oral diseases. In oral diseases, periodontal disease, and pulp tissue, we can find plaque structures composed of a variety of bacteria. These plaque structures are extremely complex, with rich ...
Teaching Research
Application of Innovative Teaching of “TBL,Workshop” in the Teaching of Speech Therapy
Hong-ling SHI, Yu LI, Ting-juan ZHANG, Lei YANG, Bai-jing LIU, Feng-yun YANG, Yu-yun ZHAO, Ke-rong CHEN, Li-rong BI, Xiao-yu LI, Jia-pu WANG
2021, 42(7): 157-160. doi: 10.12259/j.issn.2095-610X.S20210726
Abstract(2846) HTML PDF(18) Cited By (5)
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Objective To explore the application effects of team-based learning (TBL) and workshop teaching models (Workshop) in speech therapy teaching courses. Methods Sixty students in the same class of 2017 Rehabilitation Therapy in Dali University were divi...